John T. Vaage

  • Department head; Professor

Publications 2021

Lie BA, Viken MK, Egeland T, Undlien DE, Vaage JT (2021)
OBITUARY Erik Thorsby (1938-2021)
HLA, 98 (1), 3-4
DOI 10.1111/tan.14290

Publications 2019

Kjeldsen-Kragh J, Titze TL, Lie BA, Vaage JT, Kjær M (2019)
HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women
Blood Adv, 3 (7), 945-951
DOI 10.1182/bloodadvances.2019032227, PubMed 30923048

Publications 2018

Dai KZ, Ryan JC, Naper C, Vaage JT (2018)
Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats
J Immunol, 200 (8), 2847-2859
DOI 10.4049/jimmunol.1701464, PubMed 29531166

Publications 2017

Sudworth A, Vaage JT, Inngjerdingen M, Kveberg L (2017)
Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset
J Leukoc Biol, 102 (6), 1289-1298
DOI 10.1189/jlb.1HI0517-177RR, PubMed 28747319

Publications 2016

Sudworth A, Dai KZ, Vaage JT, Kveberg L (2016)
Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody
Front Immunol, 7, 572
DOI 10.3389/fimmu.2016.00572, PubMed 28003815

Publications 2014

Kveberg L, Sudworth A, Todros-Dawda I, Inngjerdingen M, Vaage JT (2014)
Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut
Eur J Immunol, 45 (2), 501-12
DOI 10.1002/eji.201444710, PubMed 25382546

Leibelt S, Friede ME, Rohe C, Gütle D, Rutkowski E, Weigert A, Kveberg L, Vaage JT, Hornef MW, Steinle A (2014)
Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors
Mucosal Immunol, 8 (2), 232-42
DOI 10.1038/mi.2014.60, PubMed 24985083

Todros-Dawda I, Kveberg L, Vaage JT, Inngjerdingen M (2014)
The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions
PLoS One, 9 (5), e97844
DOI 10.1371/journal.pone.0097844, PubMed 24832104

Publications 2013

Smelt MJ, Faas MM, de Haan BJ, de Haan A, Vaage JT, de Vos P (2013)
The role of alloresponsive Ly49+ NK cells in rat islet allograft failure in the presence and absence of cytomegalovirus
Cell Transplant, 23 (11), 1381-94
DOI 10.3727/096368913X670930, PubMed 23866824

Publications 2012

Daws MR, Dai KZ, Zinöcker S, Naper C, Kveberg L, Hedrich HJ, Rolstad B, Vaage JT (2012)
Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1
J Immunol, 189 (11), 5178-84
DOI 10.4049/jimmunol.1201983, PubMed 23100519

Inngjerdingen M, Kveberg L, Vaage JT (2012)
A novel NKR-P1B(bright) NK cell subset expresses an activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) phenotype and is prevalent in blood, liver, and gut-associated lymphoid organs of rats
J Immunol, 188 (6), 2499-508
DOI 10.4049/jimmunol.1003939, PubMed 22308308

Zinöcker S, Vaage JT (2012)
Rat mesenchymal stromal cells inhibit T cell proliferation but not cytokine production through inducible nitric oxide synthase
Front Immunol, 3, 62
DOI 10.3389/fimmu.2012.00062, PubMed 22566943

Zinöcker S, Wang MY, Rolstad B, Vaage JT (2012)
Mesenchymal stromal cells fail to alleviate experimental graft-versus-host disease in rats transplanted with major histocompatibility complex-mismatched bone marrow
Scand J Immunol, 76 (5), 464-70
DOI 10.1111/j.1365-3083.2012.02758.x, PubMed 22803811

Publications 2011

Fossum S, Saether PC, Vaage JT, Daws MR, Dissen E (2011)
Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains
Immunogenetics, 63 (12), 809-20
DOI 10.1007/s00251-011-0553-5, PubMed 21720914

Inngjerdingen M, Kveberg L, Naper C, Vaage JT (2011)
Natural killer cell subsets in man and rodents
Tissue Antigens, 78 (2), 81-8
DOI 10.1111/j.1399-0039.2011.01714.x, PubMed 21726202

Kveberg L, Dai KZ, Inngjerdingen M, Brooks CG, Fossum S, Vaage JT (2011)
Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse
Immunogenetics, 63 (7), 429-36
DOI 10.1007/s00251-011-0520-1, PubMed 21409442

Shegarfi H, Dai KZ, Daws MR, Ryan JC, Vaage JT, Rolstad B, Naper C (2011)
The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages
J Leukoc Biol, 89 (4), 617-23
DOI 10.1189/jlb.1010593, PubMed 21248147

Zinöcker S, Wang MY, Gaustad P, Kvalheim G, Rolstad B, Vaage JT (2011)
Mycoplasma contamination revisited: mesenchymal stromal cells harboring Mycoplasma hyorhinis potently inhibit lymphocyte proliferation in vitro
PLoS One, 6 (1), e16005
DOI 10.1371/journal.pone.0016005, PubMed 21264307

Publications 2010

Kveberg L, Jiménez-Royo P, Naper C, Rolstad B, Butcher GW, Vaage JT, Inngjerdingen M (2010)
Two complementary rat NK cell subsets, Ly49s3+ and NKR-P1B+, differ in phenotypic characteristics and responsiveness to cytokines
J Leukoc Biol, 88 (1), 87-93
DOI 10.1189/jlb.0110039, PubMed 20395458

Naper C, Kveberg L, Engh E, Nestvold J, Rolstad B, Vaage JT (2010)
Partial NK cell tolerance induced by radioresistant host cells in rats transplanted with MHC-mismatched bone marrow
Int Immunol, 22 (12), 973-80
DOI 10.1093/intimm/dxq452, PubMed 21118904

Shegarfi H, Dai KZ, Inngjerdingen M, Ryan JC, Vaage JT, Rolstad B, Naper C (2010)
The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells
Eur J Immunol, 40 (12), 3535-43
DOI 10.1002/eji.201040651, PubMed 21108473

Publications 2009

Kveberg L, Dai KZ, Westgaard IH, Daws MR, Fossum S, Naper C, Vaage JT (2009)
Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding
Eur J Immunol, 39 (2), 541-51
DOI 10.1002/eji.200838891, PubMed 19130483

Publications 2008

Nestvold JM, Omdal BK, Dai KZ, Martens A, Benestad HB, Vaage JT, Rolstad B (2008)
A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease
Transplantation, 85 (1), 102-11
DOI 10.1097/, PubMed 18192919

Publications 2006

Kveberg L, Bäck CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC, Vaage JT, Naper C (2006)
The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats
J Immunol, 176 (7), 4133-40
DOI 10.4049/jimmunol.176.7.4133, PubMed 16547249

Kveberg L, Dai KZ, Dissen E, Ryan JC, Rolstad B, Vaage JT, Naper C (2006)
Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity
Immunogenetics, 58 (11), 905-16
DOI 10.1007/s00251-006-0154-x, PubMed 17028855

Sollid LM, Vaage JT (2006)
Cross-dressing T cells go wild
Nat Med, 12 (6), 611-2
DOI 10.1038/nm0606-611, PubMed 16761002

Publications 2005

Naper C, Dai KZ, Kveberg L, Rolstad B, Niemi EC, Vaage JT, Ryan JC (2005)
Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands
J Immunol, 174 (5), 2702-11
DOI 10.4049/jimmunol.174.5.2702, PubMed 15728478

Nylenna O, Flornes LM, Westgaard IH, Woon PY, Naper C, Vaage JT, Gauguier D, Ryan JC, Dissen E, Fossum S (2005)
Killer cell lectin-like receptors and the natural killer cell gene complex
Adv Exp Med Biol, 564, 23-4
DOI 10.1007/0-387-25515-X_7, PubMed 16400803

Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S (2005)
The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex
Eur J Immunol, 35 (1), 261-72
DOI 10.1002/eji.200425429, PubMed 15593300

Publications 2004

Helgeland L, Dissen E, Dai KZ, Midtvedt T, Brandtzaeg P, Vaage JT (2004)
Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut
Eur J Immunol, 34 (12), 3389-400
DOI 10.1002/eji.200425122, PubMed 15517613

Nejad S, Bryceson Y, Dissen E, Sundvold-Gjerstad V, Naper C, Rolstad B, Spurkland A, Vaage JT (2004)
cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells
Immunogenetics, 56 (5), 338-42
DOI 10.1007/s00251-004-0695-9, PubMed 15300336

Westgaard IH, Berg SF, Vaage JT, Wang LL, Yokoyama WM, Dissen E, Fossum S (2004)
Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta
J Leukoc Biol, 76 (6), 1200-6
DOI 10.1189/jlb.0903428, PubMed 15356098

Publications 2002

Naper C, Hayashi S, Joly E, Butcher GW, Rolstad B, Vaage JT, Ryan JC (2002)
Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c)
Eur J Immunol, 32 (7), 2031-6
DOI 10.1002/1521-4141(200207)32:7<2031::AID-IMMU2031>3.0.CO;2-H, PubMed 12115624

Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC (2002)
Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands
J Immunol, 169 (1), 22-30
DOI 10.4049/jimmunol.169.1.22, PubMed 12077224

Naper C, Hayashi S, Løvik G, Kveberg L, Niemi EC, Rolstad B, Dissen E, Ryan JC, Vaage JT (2002)
Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells
J Immunol, 168 (10), 5147-54
DOI 10.4049/jimmunol.168.10.5147, PubMed 11994469

Publications 2001

Løvik G, Vaage JT, Rolstad B, Naper C (2001)
The effect of in vivo depletion of NKR-P1+ or CD8+ lymphocytes on the acute rejection of allogeneic lymphocytes (ALC) in the rat
Scand J Immunol, 54 (4), 341-7
DOI 10.1046/j.1365-3083.2001.00979.x, PubMed 11555400

Rolstad B, Naper C, Løvik G, Vaage JT, Ryan JC, Bäckman-Petersson E, Kirsch RD, Butcher GW (2001)
Rat natural killer cell receptor systems and recognition of MHC class I molecules
Immunol Rev, 181, 149-57
DOI 10.1034/j.1600-065x.2001.1810112.x, PubMed 11513136

Torgersen KM, Vaage JT, Rolstad B, Taskén K (2001)
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains
Cell Signal, 13 (3), 213-20
DOI 10.1016/s0898-6568(01)00131-0, PubMed 11282460

Publications 2000

Løvik G, Vaage JT, Dissen E, Szpirer C, Ryan JC, Rolstad B (2000)
Characterization and molecular cloning of rat C1qRp, a receptor on NK cells
Eur J Immunol, 30 (12), 3355-62
DOI 10.1002/1521-4141(2000012)30:12<3355::AID-IMMU3355>3.0.CO;2-1, PubMed 11093152

Publications 1999

Helgeland L, Johansen FE, Utgaard JO, Vaage JT, Brandtzaeg P (1999)
Oligoclonality of rat intestinal intraepithelial T lymphocytes: overlapping TCR beta-chain repertoires in the CD4 single-positive and CD4/CD8 double-positive subsets
J Immunol, 162 (5), 2683-92
PubMed 10072512

Leong LY, Le Rolle AF, Deverson EV, Powis SJ, Larkins AP, Vaage JT, Stokland A, Lambracht-Washington D, Rolstad B, Joly E, Butcher GW (1999)
RT1-U: identification of a novel, active, class Ib alloantigen of the rat MHC
J Immunol, 162 (2), 743-52
PubMed 9916694

Naper C, Ryan JC, Kirsch R, Butcher GW, Rolstad B, Vaage JT (1999)
Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset
Eur J Immunol, 29 (6), 2046-53
DOI 10.1002/(SICI)1521-4141(199906)29:06<2046::AID-IMMU2046>3.0.CO;2-Z, PubMed 10382768

Publications 1998

Engh E, Benestad HB, Strøm-Gundersen I, Vaage JT, Bell EB, Rolstad B (1998)
Role of classical (RT1.A) and nonclassical (RT1.C) MHC class I regions in natural killer cell-mediated bone marrow allograft rejection in rats
Transplantation, 65 (3), 319-24
DOI 10.1097/00007890-199802150-00005, PubMed 9484746

Naper C, Ryan JC, Nakamura MC, Lambracht D, Rolstad B, Vaage JT (1998)
Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells
J Immunol, 160 (1), 219-24
PubMed 9551974

Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT (1998)
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
J Exp Med, 187 (7), 1157-61
DOI 10.1084/jem.187.7.1157, PubMed 9529333

Publications 1997

Helgeland L, Brandtzaeg P, Rolstad B, Vaage JT (1997)
Sequential development of intraepithelial gamma delta and alpha beta T lymphocytes expressing CD8 alpha beta in neonatal rat intestine: requirement for the thymus
Immunology, 92 (4), 447-56
DOI 10.1046/j.1365-2567.1997.00379.x, PubMed 9497485

Helgeland L, Vaage JT, Rolstad B, Halstensen TS, Midtvedt T, Brandtzaeg P (1997)
Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization
Scand J Immunol, 46 (4), 349-57
DOI 10.1046/j.1365-3083.1997.d01-133.x, PubMed 9350285

Knudsen E, Seierstad T, Vaage JT, Naper C, Benestad HB, Rolstad B, Maghazachi AA (1997)
Cloning, functional activities and in vivo tissue distribution of rat NKR-P1+ TCR alpha beta + cells
Int Immunol, 9 (7), 1043-51
DOI 10.1093/intimm/9.7.1043, PubMed 9237113

Rolstad B, Vaage JT (1997)
The role of natural killer cells in allograft responses to MHC antigens in the rat
Res Immunol, 148 (3), 159-64
DOI 10.1016/s0923-2494(97)84218-6, PubMed 9255867

Rolstad B, Vaage JT, Naper C, Lambracht D, Wonigeit K, Joly E, Butcher GW (1997)
Positive and negative MHC class I recognition by rat NK cells
Immunol Rev, 155, 91-104
DOI 10.1111/j.1600-065x.1997.tb00942.x, PubMed 9059885

Torgersen KM, Salcedo M, Vaage JT, Naper C, Rolstad B, Ljunggren HG, Höglund P (1997)
Major histocompatibility complex class I-independent killing of xenogeneic targets by rat allospecific natural killer cells
Transplantation, 63 (1), 119-23
DOI 10.1097/00007890-199701150-00022, PubMed 9000672

Torgersen KM, Vaage JT, Levy FO, Hansson V, Rolstad B, Taskén K (1997)
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
J Biol Chem, 272 (9), 5495-500
DOI 10.1074/jbc.272.9.5495, PubMed 9038153

Publications 1996

Helgeland L, Vaage JT, Rolstad B, Midtvedt T, Brandtzaeg P (1996)
Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine
Immunology, 89 (4), 494-501
DOI 10.1046/j.1365-2567.1996.d01-783.x, PubMed 9014812

Naper C, Rolstad B, Wonigeit K, Butcher GW, Vaage JT (1996)
Genes in two MHC class I regions control recognition of a single rat NK cell allodeterminant
Int Immunol, 8 (11), 1779-85
DOI 10.1093/intimm/8.11.1779, PubMed 8943573

Publications 1995

Løvik G, Vaage JT, Naper C, Benestad HB, Rolstad B (1995)
Recruitment of alloreactive natural killer cells to the rat peritoneum by a transfected cell line secreting rat recombinant interleukin-2
J Immunol Methods, 179 (1), 59-69
DOI 10.1016/0022-1759(94)00270-7, PubMed 7868925

Naper C, Vaage JT, Lambracht D, Løvik G, Butcher GW, Wonigeit K, Rolstad B (1995)
Alloreactive natural killer cells in the rat: complex genetics of major histocompatibility complex control
Eur J Immunol, 25 (5), 1249-56
DOI 10.1002/eji.1830250518, PubMed 7774627

Vaage JT (1995)
Biological properties of rat large granular lymphocytes: MHC control of NK allorecognition
Immunobiological laboratory, Departemnt [i.e. Department]of Anatomy, Institute of Basic Medical Sciences, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 95180586x, ISBN 82-91061-64-5

Publications 1994

Vaage JT, Naper C, Løvik G, Lambracht D, Rehm A, Hedrich HJ, Wonigeit K, Rolstad B (1994)
Control of rat natural killer cell-mediated allorecognition by a major histocompatibility complex region encoding nonclassical class I antigens
J Exp Med, 180 (2), 641-51
DOI 10.1084/jem.180.2.641, PubMed 8046337

Publications 1993

Løvik G, Vaage JT, Naper C, Rolstad B (1993)
Natural killer cell alloreactivity in the rat: I. Potent in vivo recruitment of rat natural killer cells with an interleukin-2-producing cell line in intraperitoneal diffusion chambers
Transplant Proc, 25 (5), 2800-1
PubMed 8212239

Vaage JT, Løvik G, Naper C, Hedrich HJ, Wonigeit K, Rolstad B (1993)
Natural killer cell alloreactivity in the rat: II. Predominant role of the RT1.C region in determining target cell susceptibility and specificity
Transplant Proc, 25 (5), 2802-3
PubMed 8212240

Publications 1991

Vaage JT, Dissen E, Ager A, Fossum S, Rolstad B (1991)
Allospecific recognition of hemic cells in vitro by natural killer cells from athymic rats: evidence that allodeterminants coded for by single major histocompatibility complex haplotypes are recognized
Eur J Immunol, 21 (9), 2167-75
DOI 10.1002/eji.1830210927, PubMed 1716212

Publications 1990

Dissen E, Vaage JT, Taskén K, Jahnsen T, Rolstad B, Fossum S (1990)
Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors
Int Immunol, 2 (5), 453-60
DOI 10.1093/intimm/2.5.453, PubMed 2150758

Vaage JT, Dissen E, Ager A, Roberts I, Fossum S, Rolstad B (1990)
T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly alpha/beta+ and are thymus dependent
Eur J Immunol, 20 (5), 1193-6
DOI 10.1002/eji.1830200538, PubMed 2162777

Publications 1989

Vaage JT, Reynolds CW, Reynolds D, Fossum S, Rolstad B (1989)
The proliferation and life-span of rat large granular lymphocytes: effects of cytokines
Eur J Immunol, 19 (10), 1895-902
DOI 10.1002/eji.1830191021, PubMed 2583227

Publications 1988

Vaage JT, Fossum S, Rolstad B (1988)
Proliferation of large granular lymphocytes in the rat
Adv Exp Med Biol, 237, 457-61
DOI 10.1007/978-1-4684-5535-9_70, PubMed 3254059

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