Publications
Publications published since 2000 from OUS - Department of Cancer Immunology
446 publications found
Publications 2022
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Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
JAIDS, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817 -
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
Mol. Oncol., 16 (1), 88-103
DOI 10.1002/1878-0261.13047
Publications 2021
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Nat. Biotechnol.
DOI 10.1038/s41587-021-01089-x -
A Systemic Protein Deviation Score Linked to PD-1(+) CD8(+) T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Med, 2 (2), 180-+
DOI 10.1016/j.medj.2020.10.006 -
CD4(+)T cells persist for years in the human small intestine and display a T(H)1 cytokine profile
Mucosal Immunol., 14 (2), 402-410
DOI 10.1038/s41385-020-0315-5 -
The Presence of Activated T Cell Subsets prior to Transplantation Is Associated with Increased Rejection Risk in Pancreas Transplant Recipients
J. Immunol., 207 (10), 2501-2511
DOI 10.4049/jimmunol.2001103 -
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
OncoImmunology, 10 (1), 1936757
DOI 10.1080/2162402X.2021.1936757 -
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol. Ther., 29 (3), 1199-1213
DOI 10.1016/j.ymthe.2020.11.019 -
A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL
Blood Adv., 5 (22), 4771-4782
DOI 10.1182/bloodadvances.2021004777 -
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat. Commun., 12 (1), 6774
DOI 10.1038/s41467-021-27029-6 -
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci. Transl. Med., 13 (582), eabb0036
DOI 10.1126/scitranslmed.abb0036 -
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front. Cell. Infect. Microbiol., 11, 669623
DOI 10.3389/fcimb.2021.669623 -
Combinatorial CAR design improves target restriction
J. Biol. Chem., 296, 100116
DOI 10.1074/jbc.RA120.016234 -
Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression
J Immunol. Res., 2021, 9920234
DOI 10.1155/2021/9920234 -
An extended APOBEC3A mutation signature in cancer
Nat. Commun., 12 (1), 1602
DOI 10.1038/s41467-021-21891-0 -
Systems approach reveals distinct and shared signaling networks of the four PGE(2) receptors in T cells
Sci. Signal., 14 (703), eabc8579
DOI 10.1126/scisignal.abc8579 -
Phosphoproteomics-Based Characterization of Prostaglandin E-2 Signaling in T Cells
Mol. Pharmacol., 99 (5), 370-382
DOI 10.1124/molpharm.120.000170 -
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4(+) T Cells in HIV-Infected Immunological Non-Responders
Front. Immunol., 12, 744155
DOI 10.3389/fimmu.2021.744155 -
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
Nat. Commun., 12 (1), 5172
DOI 10.1038/s41467-021-25469-8 -
Advances in immune therapies in hematological malignancies
J. Intern. Med.
DOI 10.1111/joim.13395 -
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol. Oncol.
DOI 10.1002/1878-0261.13153 -
"Built-in" PD-1 blocker to rescue NK-92 activity from PD-L1-mediated tumor escape mechanisms
Faseb J., 35 (9), e21750
DOI 10.1096/fj.202100025R -
Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
mAbs, 13 (1), 1893888
DOI 10.1080/19420862.2021.1893888 -
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Sci Rep, 11 (1), 6317
DOI 10.1038/s41598-021-85613-8 -
COVID-19 in patients with CLL: improved survival outcomes and update on management strategies
Blood, 138 (18), 1768-+
DOI 10.1182/blood.2021011841 -
mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies
Commun. Biol., 4 (1), 424
DOI 10.1038/s42003-021-01938-0 -
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Cancer Res., 81 (22), 5733-5744
DOI 10.1158/0008-5472.CAN-21-0061 -
Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy Comment
EBioMedicine, 67, 103351
DOI 10.1016/j.ebiom.2021.103351 -
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
Cancers, 13 (13), 3356
DOI 10.3390/cancers13133356 -
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models (vol 13, 3356, 2021)
Cancers, 13 (21), 5513
DOI 10.3390/cancers13215513 -
Overcoming resistance to targeted therapies in chronic lymphocytic leukemia
Blood Adv., 5 (1), 334-343
DOI 10.1182/bloodadvances.2020003423 -
What It Takes to Transform a T Cell
Cancer Res., 81 (12), 3160-3161
DOI 10.1158/0008-5472.CAN-21-0784 -
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma
Cancer Cell, 39 (10), 1422-+
DOI 10.1016/j.ccell.2021.08.011 -
Natural killer cell receptors regulate responses of HLA-E-restricted T cells
Sci. Immunol., 6 (58), eabe9057
DOI 10.1126/sciimmunol.abe9057 -
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
Cell Reports, 36 (6), 109525
DOI 10.1016/j.celrep.2021.109525 -
Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma
Cytotherapy, 23 (4), 329-338
DOI 10.1016/j.jcyt.2020.09.009 -
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Cell Stem Cell, 28 (12), 2062-+
DOI 10.1016/j.stem.2021.08.013 -
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
Trials, 22 (1), 642
DOI 10.1186/s13063-021-05587-w
Publications 2020
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Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature
DOI 10.1038/s41586-020-03054-1 -
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154 -
An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells
Int. J. Mol. Sci., 21 (3), 708
DOI 10.3390/ijms21030708 -
TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
Front. Immunol., 11, 753
DOI 10.3389/fimmu.2020.00753 -
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers, 12 (2), 377
DOI 10.3390/cancers12020377 -
Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies
mAbs, 12 (1), 1795505
DOI 10.1080/19420862.2020.1795505 -
Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency
Front. Immunol., 11, 574738
DOI 10.3389/fimmu.2020.574738 -
Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
Front. Immunol., 11, 561553
DOI 10.3389/fimmu.2020.561553 -
The Oncometabolite 5 '-Deoxy-5 '-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
Front. Immunol., 11, 2128
DOI 10.3389/fimmu.2020.02128 -
Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy: an international study of 264 real-world patients
Br. J. Haematol., 189 (4), 661-671
DOI 10.1111/bjh.16425 -
Machine learning derived input-function in a dynamic F-18-FDG PET study of mice
Biomed. Phys. Eng. Express, 6 (1), 015020
DOI 10.1088/2057-1976/ab6496 -
ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer
J. Transl. Med., 18 (1), 269
DOI 10.1186/s12967-020-02421-w -
ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer
J. Transl. Med., 18 (1), 252
DOI 10.1186/s12967-020-02424-7 -
Prospects for NK Cell Therapy of Sarcoma
Cancers, 12 (12), 3719
DOI 10.3390/cancers12123719 -
Tuning the Antigen Density Requirement for CAR T-cell Activity
Cancer Discov., 10 (5), 702-723
DOI 10.1158/2159-8290.CD-19-0945 -
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
Blood, 136 (10), 1134-1143
DOI 10.1182/blood.2020006965 -
Natural killer cell immunotypes related to COVID-19 disease severity
Sci. Immunol., 5 (50), eabd6832
DOI 10.1126/sciimmunol.abd6832 -
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nat. Commun., 11 (1), 147
DOI 10.1038/s41467-019-13837-4 -
Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy (vol 68, pg 1235, 2019)
Cancer Immunol. Immunother., 69 (1), 159-161
DOI 10.1007/s00262-019-02409-6 -
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Cell Calcium, 92, 102289
DOI 10.1016/j.ceca.2020.102289 -
Deciphering Natural Killer Cell Homeostasis
Front. Immunol., 11, 812
DOI 10.3389/fimmu.2020.00812 -
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry
Cytom. Part A, 97 (8), 832-844
DOI 10.1002/cyto.a.23960 -
Microbial sensing by haematopoietic stem and progenitor cells: Vigilance against infections and immune education of myeloid cells
Scand. J. Immunol., 92 (5), e12957
DOI 10.1111/sji.12957 -
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7 -
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia
Scand. J. Immunol., 92 (5), e12931
DOI 10.1111/sji.12931 -
Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
BMC Immunol., 21 (1), 43
DOI 10.1186/s12865-020-00373-w -
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv., 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325 -
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
Cell Stem Cell, 27 (2), 224-+
DOI 10.1016/j.stem.2020.05.008
Publications 2019
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Induction of neoantigen-reactive T cells from healthy donors
Nat. Protoc., 14 (6), 1926-1943
DOI 10.1038/s41596-019-0170-6 -
Resident memory CD8 T cells persist for years in human small intestine
J. Exp. Med., 216 (10), 2412-2426
DOI 10.1084/jem.20190414 -
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discov., 24 (3), 398-413
DOI 10.1177/2472555218816276 -
The PI3K p110 delta Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J. Immunol., 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703 -
Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Gastroenterology, 157 (4), 1067-+
DOI 10.1053/j.gastro.2019.06.023 -
Hierarchical Normalized Completely Random Measures for Robust Graphical Modeling
Bayesian Anal., 14 (4), 1271-1301
DOI 10.1214/19-BA1153 -
Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
Front. Immunol., 10, 2085
DOI 10.3389/fimmu.2019.02085 -
Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency
J. Allergy Clin. Immunol.-Pract., 7 (6), 1970-+
DOI 10.1016/j.jaip.2019.02.038 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat. Commun., 10, 514
DOI 10.1038/s41467-019-08384-x -
Expanding the Clinical Cytometry Toolbox-Receptor Occupancy by Mass Cytometry
Cytom. Part A, 95 (10), 1046-1048
DOI 10.1002/cyto.a.23784 -
Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response
Cytom. Part A, 95A (4), 442-449
DOI 10.1002/cyto.a.23737 -
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J. Immunol., 202 (3), 736-746
DOI 10.4049/jimmunol.1801146 -
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol. Res., 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351 -
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv., 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678 -
Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination
OncoImmunology, 8 (4), e1565236
DOI 10.1080/2162402X.2019.1565236 -
NK cells specifically TCR-dressed to kill cancer cells
EBioMedicine, 40, 106-117
DOI 10.1016/j.ebiom.2019.01.031 -
Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity
OncoImmunology, 8 (3), e1558663
DOI 10.1080/2162402X.2018.1558663 -
Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy
Cancer Immunol. Immunother., 68 (8), 1235-1243
DOI 10.1007/s00262-019-02356-2 -
Finding Neo (antigens, that is)
Blood, 134 (2), 108-109
DOI 10.1182/blood.2019001334 -
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Reports, 29 (8), 2284-+
DOI 10.1016/j.celrep.2019.10.058 -
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Semin. Immunopathol., 41 (1), 59-68
DOI 10.1007/s00281-018-0721-x -
Phage Display Libraries: From Binders to Targeted Drug Delivery and Human Therapeutics
Mol. Biotechnol., 61 (4), 286-303
DOI 10.1007/s12033-019-00156-8 -
Releasing the Immune System Brakes Using siRNAs Enhances Cancer Immunotherapy
Cancers, 11 (2), 176
DOI 10.3390/cancers11020176 -
Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
Cancers, 11 (8), 1088
DOI 10.3390/cancers11081088 -
Off-label uses of drugs for depression
Eur. J. Pharmacol., 865, 172732
DOI 10.1016/j.ejphar.2019.172732 -
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J. Immunol., 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660 -
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
Haematologica, 104 (10), E460-E464
DOI 10.3324/haematol.2018.209080 -
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4(+) recovery
Aids, 33 (7), 1117-1129
DOI 10.1097/QAD.0000000000002173 -
FOXK1 and FOXK2 regulate aerobic glycolysis
Nature, 566 (7743), 279-+
DOI 10.1038/s41586-019-0900-5 -
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat. Commun., 10, 5499
DOI 10.1038/s41467-019-13329-5 -
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
npj Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8 -
Genomes captured during tumour spread
Nature, 575 (7781), 60-61
DOI 10.1038/d41586-019-03123-0
Publications 2018
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Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis
JNCI-J. Natl. Cancer Inst., 110 (6), djy018-567
DOI 10.1093/jnci/djy018 -
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Clin. Cancer Res., 24 (8), 1834-1844
DOI 10.1158/1078-0432.CCR-17-3196 -
Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
Cytokine Growth Factor Rev., 44, 1-10
DOI 10.1016/j.cytogfr.2018.10.005 -
Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
Biochem. J., 475, 455-476
DOI 10.1042/BCJ20170529 -
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Adv. Radiat. Oncol., 3 (2), 130-138
DOI 10.1016/j.adro.2017.12.007 -
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8, 17651
DOI 10.1038/s41598-018-36121-9 -
The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy
Br. J. Haematol., 183 (2), 225-234
DOI 10.1111/bjh.15518 -
Human c-SRC kinase (CSK) overexpression makes T cells dummy
Cancer Immunol. Immunother., 67 (4), 525-536
DOI 10.1007/s00262-017-2105-9 -
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin. Cancer Res., 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337 -
Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency
J. Allergy Clin. Immunol., 141 (6), 2303-2306
DOI 10.1016/j.jaci.2018.02.007 -
Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens
Blood, 132 (22), 2401-2405
DOI 10.1182/blood-2018-05-851154 -
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol. Res., 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207 -
Epidermal growth factor receptor (EGFR) density may not be the only determinant for the efficacy of EGFR-targeted photoimmunotherapy in human head and neck cancer cell lines
Lasers Surg. Med., 50 (5), 513-522
DOI 10.1002/lsm.22930 -
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells
Mol. Biol. Cell, 29 (12), 1487-1501
DOI 10.1091/mbc.E17-09-0538 -
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects
J. Allergy Clin. Immunol., 142 (6), 1932-1946
DOI 10.1016/j.jaci.2018.02.055 -
T-cell cross-reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors
Scand. J. Immunol., 87 (3), e12643
DOI 10.1111/sji.12643 -
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
Faseb J., 32 (9), 5063-5077
DOI 10.1096/fj.201701544R -
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
Am. J. Pathol., 188 (7), 1563-1579
DOI 10.1016/j.ajpath.2018.03.017 -
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J. Hematol. Oncol., 11, 23
DOI 10.1186/s13045-018-0561-0 -
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8, 5307
DOI 10.1038/s41598-018-23563-4
Publications 2017
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Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
J. Virol., 91 (9), e00010
DOI 10.1128/JVI.00010-17 -
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-beta receptor type I ALK5
PLoS One, 12 (5), e0177188
DOI 10.1371/journal.pone.0177188 -
Dissecting the interaction between transglutaminase 2 and fibronectin
Amino Acids, 49 (3), 489-500
DOI 10.1007/s00726-016-2296-y -
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr. Pharm. Design, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936 -
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J. Hepatol., 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002 -
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int., 37 (3), 458-465
DOI 10.1111/liv.13238 -
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
OncoImmunology, 6 (4), e1302631
DOI 10.1080/2162402X.2017.1302631 -
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
Sci Rep, 7, 4916
DOI 10.1038/s41598-017-04982-1 -
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
Front. Immunol., 8, 1718
DOI 10.3389/fimmu.2017.01718 -
Fishing therapeutic T-cell receptors in healthy donor blood, is safety predictable?
Transl. Cancer Res., 6 3, S622-S624
DOI 10.21037/tcr.2017.05.25 -
Phase I/IIa clinical trial of a novel hTERT peptide vaccine in men with metastatic hormone-naive prostate cancer
Cancer Immunol. Immunother., 66 (7), 891-901
DOI 10.1007/s00262-017-1994-y -
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Cancer Immunol. Res., 5 (8), 654-665
DOI 10.1158/2326-6066.CIR-16-0296 -
Natural killer cell-mediated immunosurveillance of human cancer
Semin. Immunol., 31, 20-29
DOI 10.1016/j.smim.2017.08.002 -
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Immunogenetics, 69 (8-9), 547-556
DOI 10.1007/s00251-017-1011-9 -
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling
Blood, 129 (6), 759-770
DOI 10.1182/blood-2016-05-718494 -
Manufacture of CAR-T cells in the body
Nat. Biotechnol., 35 (6), 520-521
DOI 10.1038/nbt.3898 -
Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Arthritis Res. Ther., 19, 284
DOI 10.1186/s13075-017-1494-7 -
New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies
J. Clin. Oncol., 35 (15), 1668-+
DOI 10.1200/JCO.2016.70.7901 -
Improved method for cannula fixation for long-term intracerebral brain infusion
J. Neurosci. Methods, 290, 145-150
DOI 10.1016/j.jneumeth.2017.07.026 -
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
Sci Rep, 7, 39710
DOI 10.1038/srep39710 -
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
Clin. Immunol., 175, 69-74
DOI 10.1016/j.clim.2016.11.014 -
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J. Autoimmun., 81, 110-119
DOI 10.1016/j.jaut.2017.04.004 -
CD56(bright) NK cells exhibit potent antitumor responses following IL-15 priming
J. Clin. Invest., 127 (11), 4042-4058
DOI 10.1172/JCI90387 -
A TCR-based Chimeric Antigen Receptor
Sci Rep, 7, 10713
DOI 10.1038/s41598-017-11126-y -
Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations
Cytom. Part B-Clin. Cytom., 92 (1), 79-87
DOI 10.1002/cyto.b.21498
Publications 2016
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Enhancing Antitumor Immune Responses by Optimized Combinations of Cell-penetrating Peptide-based Vaccines and Adjuvants
Mol. Ther., 24 (9), 1675-1685
DOI 10.1038/mt.2016.134 -
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J. Immunol., 196 (3), 1400-1411
DOI 10.4049/jimmunol.1501434 -
The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era
Br. J. Haematol., 175 (1), 102-114
DOI 10.1111/bjh.14201 -
Cancer immunotherapy: from the lab to clinical applications-Potential impact on cancer centres' organisation
eCancerMedicalScience, 10, 691
DOI 10.3332/ecancer.2016.691 -
Profiling networks of distinct immune-cells in tumors
BMC Bioinformatics, 17, 263
DOI 10.1186/s12859-016-1141-3 -
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Clin. Transl. Immunol., 5, e109
DOI 10.1038/cti.2016.65 -
Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis
Immunology, 149 (1), 62-73
DOI 10.1111/imm.12629 -
Class I HLA haplotypes form two schools that educate NK cells in different ways
Sci. Immunol., 1 (3), eaag1672
DOI 10.1126/sciimmunol.aag1672 -
Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells
OncoImmunology, 5 (1), e1039763
DOI 10.1080/2162402X.2015.1039763 -
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy
OncoImmunology, 5 (12), e1249090
DOI 10.1080/2162402X.2016.1249090 -
Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells
OncoImmunology, 5 (11), e1232237
DOI 10.1080/2162402X.2016.1232237 -
Cognate HLA absence in trans diminishes human NK cell education
J. Clin. Invest., 126 (10), 3772-3782
DOI 10.1172/JCI86923 -
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-1619
DOI 10.1002/hep.28116 -
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Cell Reports, 15 (5), 1088-1099
DOI 10.1016/j.celrep.2016.04.005 -
Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response
Cancer Res., 76 (23), 6864-6876
DOI 10.1158/0008-5472.CAN-16-1219 -
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
OncoImmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199 -
Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth
Oncotarget, 7 (46), 75940-75953
DOI 10.18632/oncotarget.12445 -
Incidence of Data Duplications in a Randomly Selected Pool of Life Science Publications
Sci. Eng. Ethics, 22 (2), 487-496
DOI 10.1007/s11948-015-9668-7 -
Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine
Case Rep. Med., 2016, 9639585
DOI 10.1155/2016/9639585 -
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-1341
DOI 10.1126/science.aaf2288 -
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem. Biol., 11 (1), 251-262
DOI 10.1021/acschembio.5b00734 -
VOLIN and KJONTwo novel hyperdiploid myeloma cell lines
Gene Chromosomes Cancer, 55 (11), 890-901
DOI 10.1002/gcc.22388 -
Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies
J. Allergy Clin. Immunol.-Pract., 4 (6), 1089-1100
DOI 10.1016/j.jaip.2016.08.004 -
PI3-kinase mutation linked to insulin and growth factor resistance in vivo
J. Clin. Invest., 126 (4), 1401-1412
DOI 10.1172/JCI84005 -
Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency
Cancer Res., 76 (15), 4347-4358
DOI 10.1158/0008-5472.CAN-16-0008 -
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with beta-catenin-dependent and beta-catenin-independent signaling pathways
Oncotarget, 7 (29), 46187-46202
DOI 10.18632/oncotarget.10070
Publications 2015
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Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model
Gene Ther., 22 (5), 391-403
DOI 10.1038/gt.2015.4 -
Polyclonal expansion of NKG2C(+) NK cells in TAP-deficient patients
Front. Immunol., 6, 507
DOI 10.3389/fimmu.2015.00507 -
Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma
Histopathology, 67 (1), 62-69
DOI 10.1111/his.12624 -
Content of Endothelial Progenitor Cells in Autologous Stem Cell Grafts Predict Survival after Transplantation for Multiple Myeloma
Biol. Blood Marrow Transplant., 21 (5), 840-847
DOI 10.1016/j.bbmt.2014.12.027 -
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Front. Pharmacol., 6, 192
DOI 10.3389/fphar.2015.00192 -
Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells
J. Immunol., 194 (9), 4518-4527
DOI 10.4049/jimmunol.1401972 -
Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma
Leuk. Lymphoma, 56 (6), 1742-1749
DOI 10.3109/10428194.2014.970550 -
Microchip-Based Single-Cell Imaging Reveals That CD56(dim) CD57(-)KIR(-)NKG2A(+) NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56(dim)CD57(-)KIR(-)NKG2A(-) NK Cells
J. Immunol., 195 (7), 3374-3381
DOI 10.4049/jimmunol.1500171 -
Newtonian cell interactions shape natural killer cell education
Immunol. Rev., 267 (1), 197-213
DOI 10.1111/imr.12325 -
Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination
Cancer Immunol. Immunother., 64 (12), 1609-1621
DOI 10.1007/s00262-015-1766-5 -
T-cell receptor gene therapy - ready to go-viral?
Mol. Oncol., 9 (10), 2019-2042
DOI 10.1016/j.molonc.2015.10.006 -
Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma
Blood, 125 (1), 82-89
DOI 10.1182/blood-2014-07-592162 -
"In situ" vaccination for systemic effects in follicular lymphoma
OncoImmunology, 4 (7), e1014773
DOI 10.1080/2162402X.2015.1014773 -
Harnessing adaptive natural killer cells in cancer immunotherapy
Mol. Oncol., 9 (10), 1904-1917
DOI 10.1016/j.molonc.2015.10.001 -
Effects of HDV infection and pegylated interferon a treatment on the natural killer cell compartment in chronically infected individuals
Gut, 64 (3), 469-482
DOI 10.1136/gutjnl-2014-306767 -
Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell
Haematologica, 100 (10), E415-E418
DOI 10.3324/haematol.2015.126656 -
Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells
Human Vaccines Immunother., 11 (11), 2664-2673
DOI 10.1080/21645515.2015.1056952 -
The targeting of human and mouse B lymphocytes by dasatinib
Exp. Hematol., 43 (5), 352-363
DOI 10.1016/j.exphem.2015.01.008 -
Cancer immunotherapy - Converting immune failure to clinical response
Mol. Oncol., 9 (10), 1891-1893
DOI 10.1016/j.molonc.2015.10.017 -
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells
J. Immunol., 195 (4), 1364-1367
DOI 10.4049/jimmunol.1500904 -
New distinct compartments in the G(2) phase of the cell cycle defined by the levels of gamma H2AX
Cell Cycle, 14 (20), 3261-3269
DOI 10.1080/15384101.2015.1087617 -
Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial
Haematologica, 100 (2), 238-245
DOI 10.3324/haematol.2014.113472 -
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Immunity, 42 (3), 443-456
DOI 10.1016/j.immuni.2015.02.008 -
Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells
Mol.Ther.-Methods Clin. Dev., 2, 15043
DOI 10.1038/mtm.2015.43 -
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
Biol. Blood Marrow Transplant., 21 (9), 1589-1596
DOI 10.1016/j.bbmt.2015.05.002 -
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Oncotarget, 6 (33), 34178-34190
DOI 10.18632/oncotarget.6213 -
Unpredicted phenotypes of two mutants of the TcR DMF5
J. Immunol. Methods, 425, 37-44
DOI 10.1016/j.jim.2015.06.006 -
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation
Bone Marrow Transplant., 50 (9), 1217-1223
DOI 10.1038/bmt.2015.123 -
Soluble T-Cell Receptors Produced in Human Cells for Targeted Delivery
PLoS One, 10 (4), e0119559
DOI 10.1371/journal.pone.0119559
Publications 2014
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Role for early-differentiated natural killer cells in infectious mononucleosis
Blood, 124 (16), 2533-2543
DOI 10.1182/blood-2014-01-553024 -
Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
Age, 36 (2), 571-582
DOI 10.1007/s11357-013-9587-y -
A Gene Panel, Including LRP12, Is Frequently Hypermethylated in Major Types of B-Cell Lymphoma
PLoS One, 9 (9), e104249
DOI 10.1371/journal.pone.0104249 -
Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
Epigenetics, 9 (3), 428-436
DOI 10.4161/epi.27554 -
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Eur. J. Immunol., 44 (7), 2192-2196
DOI 10.1002/eji.201444464 -
High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era
Leuk. Lymphoma, 55 (10), 2319-2327
DOI 10.3109/10428194.2013.871632 -
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma
Blood, 123 (7), 1051-1054
DOI 10.1182/blood-2013-07-512392 -
Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma
Int. J. Cancer, 134 (1), 102-113
DOI 10.1002/ijc.28338 -
Low Incidence of Hyperfibrinolysis and Thromboembolism in 195 Primary Liver Transplantations Transfused with Solvent/Detergent-Treated Plasma
Clin. Med. Res., 12 (1-2), 27-32
DOI 10.3121/cmr.2013.1168 -
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Proc. Natl. Acad. Sci. U. S. A., 111 (1), 403-408
DOI 10.1073/pnas.1306549111 -
High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8(+) T cells
Eur. J. Immunol., 44 (11), 3439-3452
DOI 10.1002/eji.201444662 -
Exosome-Derived miRNAs and Cellular miRNAs Activate Innate Immunity
J. Innate Immun., 6 (1), 105-110
DOI 10.1159/000351460 -
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
Blood, 124 (5), 812-821
DOI 10.1182/blood-2013-11-536888 -
Loss of signalling via G alpha 13 in germinal centre B-cell-derived lymphoma
Nature, 516 (7530), 254-+
DOI 10.1038/nature13765 -
Expression of B-Cell Surface Antigens in Subpopulations of Exosomes Released From B-Cell Lymphoma Cells
Clin. Ther., 36 (6), 847-862
DOI 10.1016/j.clinthera.2014.05.010 -
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Blood, 123 (8), 1214-1217
DOI 10.1182/blood-2013-11-536433 -
Engineering better immunotherapies via RNA interference
Human Vaccines Immunother., 10 (11), 3165-3174
DOI 10.4161/hv.29754 -
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin. Exp. Immunol., 175 (3), 439-448
DOI 10.1111/cei.12239 -
Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy
Leuk. Lymphoma, 55 (2), 288-295
DOI 10.3109/10428194.2013.802778 -
Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation
Eur. J. Immunol., 44 (3), 774-784
DOI 10.1002/eji.201343671 -
Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms
Cancer Discov., 4 (4), 480-493
DOI 10.1158/2159-8290.CD-13-0915
Publications 2013
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Signaling pathways in lymphoma: pathogenesis and therapeutic targets
Future Oncol., 9 (10), 1549-1571
DOI 10.2217/fon.13.113 -
Identification of Highly Methylated Genes across Various Types of B-Cell Non-Hodgkin Lymphoma
PLoS One, 8 (11), e79602
DOI 10.1371/journal.pone.0079602 -
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Blood, 121 (14), 2678-2688
DOI 10.1182/blood-2012-10-459545 -
Influence of KIR gene copy number on natural killer cell education
Blood, 121 (23), 4703-4707
DOI 10.1182/blood-2012-10-461442 -
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Blood, 122 (18), 3165-3168
DOI 10.1182/blood-2013-04-496893 -
Non-allergic, mastocytosis-associated rhinitis
Clin. Exp. Allergy, 43 (4), 406-412
DOI 10.1111/cea.12053 -
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome
Eur. J. Haematol., 91 (4), 332-338
DOI 10.1111/ejh.12171 -
BiP Negatively Affects Ricin Transport
Toxins, 5 (5), 969-982
DOI 10.3390/toxins5050969 -
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
Blood, 121 (8), 1367-1376
DOI 10.1182/blood-2012-04-421826 -
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett., 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026 -
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients
Int. J. Oncol., 43 (1), 280-288
DOI 10.3892/ijo.2013.1922 -
A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells
Faseb J., 27 (8), 3272-3283
DOI 10.1096/fj.12-224758 -
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Front. Immunol., 4, 65
DOI 10.3389/fimmu.2013.00065 -
Classification of human natural killer cells based on migration behavior and cytotoxic response
Blood, 121 (8), 1326-1334
DOI 10.1182/blood-2012-06-439851 -
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
Cancer Immunol. Immunother., 62 (9), 1499-1509
DOI 10.1007/s00262-013-1453-3 -
Identification and Characterization of Cells with Cancer Stem Cell Properties in Human Primary Lung Cancer Cell Lines
PLoS One, 8 (3), e57020
DOI 10.1371/journal.pone.0057020 -
In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines
Exp. Hematol. Oncol., 2, 16
DOI 10.1186/2162-3619-2-16 -
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk. Lymphoma, 54 (10), 2205-2214
DOI 10.3109/10428194.2013.774392 -
Inhibition of Stromal PlGF Suppresses the Growth of Prostate Cancer Xenografts
Int. J. Mol. Sci., 14 (9), 17958-17971
DOI 10.3390/ijms140917958
Publications 2012
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T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int. J. Cancer, 130 (8), 1821-1832
DOI 10.1002/ijc.26209 -
Polyelectrolyte multilayer capsules with quantum dots for biomedical applications
Colloid Surf. B-Biointerfaces, 90, 211-216
DOI 10.1016/j.colsurfb.2011.10.028 -
SARA is dispensable for functional TGF-beta signaling
FEBS Lett., 586 (19), 3367-3372
DOI 10.1016/j.febslet.2012.07.027 -
Interferon Regulatory Factor-8 Is Important for Histone Deacetylase Inhibitor-Mediated Antitumor Activity
PLoS One, 7 (9), e45422
DOI 10.1371/journal.pone.0045422 -
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Blood, 120 (17), 3455-3465
DOI 10.1182/blood-2012-03-416867 -
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma
BMC Cancer, 12, 478
DOI 10.1186/1471-2407-12-478 -
Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients
Br. J. Haematol., 159 (5), 604-608
DOI 10.1111/bjh.12073 -
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC
Leukemia, 26 (5), 1073-1080
DOI 10.1038/leu.2011.263 -
Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma
PLoS One, 7 (10), e46117
DOI 10.1371/journal.pone.0046117 -
Widespread CD4(+) T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
OncoImmunology, 1 (5), 670-686
DOI 10.4161/onci.20426 -
Leishmania donovani: Immunostimulatory Cellular Responses of Membrane and Soluble Protein Fractions of Splenic Amastigotes in Cured Patient and Hamsters
PLoS One, 7 (1), e30746
DOI 10.1371/journal.pone.0030746 -
Toward a prime-boost regime for NK cells?
Blood, 120 (24), 4663-4664
DOI 10.1182/blood-2012-09-457184 -
Spotlight on NKG2C and the human NK-cell response to CMV infection
Eur. J. Immunol., 42 (12), 3141-3145
DOI 10.1002/eji.201243050 -
Galectin-1 and-3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-gamma production
J. Leukoc. Biol., 91 (3), 461-467
DOI 10.1189/jlb.0711361 -
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591 -
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett., 586 (20), 3575-3581
DOI 10.1016/j.febslet.2012.08.022 -
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Nature, 490 (7418), 116-120
DOI 10.1038/nature11378 -
Efficient siRNA Targeted Delivery into Cancer Cells by Gastrin-Releasing Peptides
Bioconjugate Chem., 23 (5), 1040-1049
DOI 10.1021/bc300050j -
Selective killing of cancer cells by peptide-targeted delivery of an anti-microbial peptide
Biochem. Pharmacol., 84 (9), 1123-1132
DOI 10.1016/j.bcp.2012.08.002 -
B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes
Int. J. Cancer, 130 (10), 2282-2290
DOI 10.1002/ijc.26238 -
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times
Br. J. Haematol., 156 (2), 225-233
DOI 10.1111/j.1365-2141.2011.08942.x -
Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
Leuk. Lymphoma, 53 (10), 1934-1944
DOI 10.3109/10428194.2012.682307
Publications 2011
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Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
Blood, 118 (5), 1350-1358
DOI 10.1182/blood-2011-03-345272 -
Transiently redirected T cells for adoptive transfer
Cytotherapy, 13 (5), 629-640
DOI 10.3109/14653249.2010.542461 -
Telomerase Peptide Vaccination in NSCLC: A Phase II Trial in Stage III Patients Vaccinated after Chemoradiotherapy and an 8-Year Update on a Phase I/II Trial
Clin. Cancer Res., 17 (21), 6847-6857
DOI 10.1158/1078-0432.CCR-11-1385 -
Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4(+) T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer
Scand. J. Immunol., 73 (6), 527-530
DOI 10.1111/j.1365-3083.2011.02558.x -
High dose chemotherapy with autologous stem cell support for patients with histologically transformed B-cell non-Hodgkin lymphomas. A Norwegian multi centre phase II study
Br. J. Haematol., 152 (5), 600-610
DOI 10.1111/j.1365-2141.2010.08519.x -
Vaccination of patients with cutaneous melanoma with telomerase-specific peptides
Cancer Immunol. Immunother., 60 (11), 1553-1564
DOI 10.1007/s00262-011-1061-z -
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7
Eur. J. Immunol., 41 (11), 3135-3145
DOI 10.1002/eji.201141558 -
Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy
Eur. J. Haematol., 87 (6), 494-502
DOI 10.1111/j.1600-0609.2011.01681.x -
Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Clin. Cancer Res., 17 (13), 4568-4580
DOI 10.1158/1078-0432.CCR-11-0184 -
LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome
Haematol-Hematol. J., 96 (7), 980-986
DOI 10.3324/haematol.2011.040568 -
Oncogenically active MYD88 mutations in human lymphoma
Nature, 470 (7332), 115-U133
DOI 10.1038/nature09671 -
New Insights into Mesenchymal Stromal Cell-Mediated T-Cell Suppression Through Galectins
Scand. J. Immunol., 73 (2), 79-84
DOI 10.1111/j.1365-3083.2010.02491.x -
Mesenchymal stem cell-mediated T cell suppression occurs through secreted galectins
Int. J. Oncol., 38 (2), 385-390
DOI 10.3892/ijo.2010.869 -
hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
Cancer Immunol. Immunother., 60 (6), 809-818
DOI 10.1007/s00262-011-0991-9 -
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother. Oncol., 101 (1), 24-27
DOI 10.1016/j.radonc.2011.05.060 -
The Mild Inflammatory Response in Febrile Neutropenic Lymphoma Patients with Low Risk of Complications is More Pronounced in Patients Receiving Tobramycin Once Daily Compared with Three Times Daily
Scand. J. Immunol., 74 (6), 632-639
DOI 10.1111/j.1365-3083.2011.02618.x -
A Practical Approach to T-Cell Receptor Cloning and Expression
PLoS One, 6 (11), e27930
DOI 10.1371/journal.pone.0027930
Publications 2010
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Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma
Int. J. Cancer, 126 (6), 1339-1352
DOI 10.1002/ijc.24859 -
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-1909
DOI 10.1038/leu.2010.186 -
TGF-beta-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK
BMC Immunol., 11, 57
DOI 10.1186/1471-2172-11-57 -
Light-Induced Gene Expression Using Messenger RNA Molecules
Oligonucleotides, 20 (1), 1-6
DOI 10.1089/oli.2009.0209 -
Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma
Cell, 142 (5), 699-713
DOI 10.1016/j.cell.2010.07.044 -
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
Nature, 463 (7277), 88-U97
DOI 10.1038/nature08638 -
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-1497
DOI 10.1182/blood-2010-03-272278 -
Cell Wall Anchoring of the 37-Kilodalton Oncofetal Antigen by Lactobacillus plantarum for Mucosal Cancer Vaccine Delivery
Appl. Environ. Microbiol., 76 (21), 7359-7362
DOI 10.1128/AEM.01031-10 -
A combined immunostimulatory and immunoinhibitory short interference RNA reduces hypercoagulability in a rat model of acute promyelocytic leukaemia
Thromb. Haemost., 104 (2), 350-354
DOI 10.1160/TH09-12-0816 -
Ex vivo expansion protocol for human tumor specific T cells for adoptive T cell therapy
J. Immunol. Methods, 355 (1-2), 52-60
DOI 10.1016/j.jim.2010.02.004 -
Cooperative Epigenetic Modulation by Cancer Amplicon Genes
Cancer Cell, 18 (6), 590-605
DOI 10.1016/j.ccr.2010.11.013 -
Long-Term Muscular Outcome and Predisposing and Prognostic Factors in Juvenile Dermatomyositis: A Case-Control Study
Arthritis Care Res., 62 (8), 1103-1111
DOI 10.1002/acr.20203 -
Recent advances in small interfering RNA sensing by the immune system
New Biotech., 27 (3), 236-242
DOI 10.1016/j.nbt.2010.02.015 -
Evidence for the Involvement of Galectin-3 in Mesenchymal Stem Cell Suppression of Allogeneic T-Cell Proliferation
Scand. J. Immunol., 71 (4), 267-274
DOI 10.1111/j.1365-3083.2010.02378.x -
Formation of Biocompatible Nanocapsules with Emulsion Core and Pegylated Shell by Polyelectrolyte Multi layer Adsorption
Langmuir, 26 (15), 12592-12597
DOI 10.1021/la102061s -
Splice variants of Enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy
Cardiovasc. Res., 86 (3), 374-382
DOI 10.1093/cvr/cvq023
Publications 2009
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Improving the efficacy of cancer immunotherapy
Eur. J. Cancer, 45 (8), 1424-1431
DOI 10.1016/j.ejca.2008.12.017 -
Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells
Cancer Res., 69 (14), 5901-5907
DOI 10.1158/0008-5472.CAN-08-4816 -
Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase
Immunology, 128 (1), e837-e848
DOI 10.1111/j.1365-2567.2009.03093.x -
Identification of Cancer Stem-like Side Population Cells in Ovarian Cancer Cell Line OVCAR-3
Ultrastruct. Pathol., 33 (4), PII 914188460-181
DOI 10.1080/01913120903086072 -
Evidence for the involvement of FAM110C protein in cell spreading and migration
Cell. Signal., 21 (12), 1866-1873
DOI 10.1016/j.cellsig.2009.08.001 -
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by T-reg depletion
Blood, 114 (16), 3431-3438
DOI 10.1182/blood-2009-05-223958 -
c-Met signaling promotes IL-6-induced myeloma cell proliferation
Eur. J. Haematol., 82 (4), 277-287
DOI 10.1111/j.1600-0609.2009.01212.x -
Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells
Transl. Oncol., 2 (4), 242-246
DOI 10.1593/tlo.09154 -
Cancer vaccination with telomerase peptide GV1001
Expert Opin. Investig. Drugs, 18 (5), 687-694
DOI 10.1517/13543780902897631 -
Unconventional cytokine profiles and development of T cell memory in long-term survivors after cancer vaccination
Cancer Immunol. Immunother., 58 (10), 1609-1626
DOI 10.1007/s00262-009-0670-2 -
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells
Exp. Hematol., 37 (2), 225-233
DOI 10.1016/j.exphem.2008.10.007 -
Array-based DNA methylation profiling in follicular lymphoma
Leukemia, 23 (10), 1858-1866
DOI 10.1038/leu.2009.114 -
Dendritic cells in cytomegalovirus infection: viral evasion and host countermeasures
APMIS, 117 (5-6), 413-426
DOI 10.1111/j.1600-0463.2009.02449.x -
Does our Current Understanding of Immune Tolerance, Autoimmunity, and Immunosuppressive Mechanisms Facilitate the Design of Efficient Cancer Vaccines?
Scand. J. Immunol., 70 (6), 516-525
DOI 10.1111/j.1365-3083.2009.02326.x -
Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs
Int. J. Mol. Med., 23 (1), 33-39
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NOD2/CARD15 on bone marrow CD34+hematopoietic cells mediates induction of cytokines and cell differentiation
J. Leukoc. Biol., 85 (6), 939-946
DOI 10.1189/jlb.1008650 -
SNX4 in Complex with Clathrin and Dynein: Implications for Endosome Movement
PLoS One, 4 (6), e5935
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beta-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol., 11 (5), 796-807
DOI 10.1111/j.1462-5822.2009.01292.x -
Dendritic Cells Engineered to Express Defined Allo-HLA Peptide Complexes Induce Antigen-specific Cytotoxic T Cells Efficiently Killing Tumour Cells
Scand. J. Immunol., 69 (4), 319-328
DOI 10.1111/j.1365-3083.2008.02223.x -
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell. Signal., 21 (7), 1161-1168
DOI 10.1016/j.cellsig.2009.03.005
Publications 2008
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Host CD147 blockade by small interfering RNAs suppresses growth of human colon cancer xenografts
Front. Biosci., 13, 5571-5579 -
Identification of prostate cancer antigens by automated high-throughput filter immunoscreening
J. Immunol. Methods, 330 (1-2), 12-23
DOI 10.1016/j.jim.2007.10.011 -
The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling
Oncogene, 27 (39), 5182-5194
DOI 10.1038/onc.2008.157 -
Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGF beta/BMP-6 and TIEG1 in chemotherapy escape
Int. J. Cancer, 123 (12), 2759-2766
DOI 10.1002/ijc.23833 -
Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands
Immunology, 123 (2), 263-271
DOI 10.1111/j.1365-2567.2007.02695.x -
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell. Signal., 20 (6), 1169-1178
DOI 10.1016/j.cellsig.2008.02.007 -
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
Science, 319 (5870), 1676-1679
DOI 10.1126/science.1153629 -
Stromal Gene Signatures in Large-B-Cell Lymphomas
N. Engl. J. Med., 359 (22), 2313-2323
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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
Proc. Natl. Acad. Sci. U. S. A., 105 (36), 13520-13525
DOI 10.1073/pnas.0804295105 -
The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival
Blood, 112 (8), 3126-3129
DOI 10.1182/blood-2008-05-154013 -
Mucosal vaccination with phage-displayed tumour antigens identified through proteomics-based strategy inhibits the growth and metastasis of 4T1 breast adenocarcinoma
Int. J. Oncol., 32 (1), 241-247 -
Does the understanding of immune activation by RNA predict the design of safe siRNAs?
Front. Biosci., 13, 4379-4392
DOI 10.2741/3011 -
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol. Cell. Biol., 28 (12), 4129-4141
DOI 10.1128/MCB.02117-07 -
Vector-based delivery of siRNAs: In vitro and in vivo challenges
Front. Biosci., 13, 3488-3493 -
Treatment with autologous bone marrow mononuclear cells in patients with critical lower limb ischaemia. A pilot study
Scand. J. Surg., 97 (1), 56-62
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Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes
Oncogene, 27 (19), 2763-2771
DOI 10.1038/sj.onc.1210937
Publications 2007
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Expression of S100A4 by, a variety of cell types present in the tumor microenvironment of human breast cancer
Int. J. Cancer, 121 (7), 1433-1444
DOI 10.1002/ijc.22850 -
Gene expression analysis in blood cells in response to unmodified and 2 '-modified siRNAs reveals TLR-dependent and independent effects
J. Mol. Biol., 365 (1), 90-108
DOI 10.1016/j.jmb.2006.09.034 -
Design of bifunctional siRNAs: Combining immunostimulation and gene-silencing in one single siRNA molecule
Biochem. Biophys. Res. Commun., 352 (3), 642-649
DOI 10.1016/j.bbrc.2006.11.059 -
Characterization of early stages of human B cell development by gene expression profiling
J. Immunol., 179 (6), 3662-3671
DOI 10.4049/jimmunol.179.6.3662 -
A full scale comparative study of methods for generation of functional Dendritic cells for use as cancer vaccines
BMC Cancer, 7, 119
DOI 10.1186/1471-2407-7-119 -
MRNA transfection of DC in the immature or mature state: comparable in vitro priming of Th and cytotoxic T lymphocytes against DC electroporated with tumor cell line-derived mRNA
Cytotherapy, 9 (6), 587-592
DOI 10.1080/14653240701466354 -
T cell responses in melanoma patients after vaccination with tumor-mRNA transfected dendritic cells
Cancer Immunol. Immunother., 56 (5), 659-675
DOI 10.1007/s00262-006-0222-y -
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
J. Exp. Med., 204 (3), 633-643
DOI 10.1084/jem.20062041 -
Wnt3A activates canonical Wnt signalling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B-ALL cell lines
Br. J. Haematol., 136 (3), 400-413
DOI 10.1111/j.1365-2141.2006.06442.x -
RNA interference and innate immunity
Adv. Drug Deliv. Rev., 59 (2-3), 153-163
DOI 10.1016/j.addr.2007.03.006 -
TLR agonists induce the differentiation of human bone marrow CD34(+) progenitors into CD11c(+) CD80/86(+) DC capable of inducing a Th1-type response
Eur. J. Immunol., 37 (10), 2834-2846
DOI 10.1002/eji.200737112 -
Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs
Biochem. Biophys. Res. Commun., 361 (1), 122-126
DOI 10.1016/j.bbrc.2007.06.177 -
Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells
Eur. J. Immunol., 37 (10), 2937-2948
DOI 10.1002/eji.200636759 -
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
Blood, 109 (11), 4599-4606
DOI 10.1182/blood-2006-08-039859 -
Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway
Cancer Res., 67 (3), 1038-1045
DOI 10.1158/0008-5472.CAN-06-2295 -
Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations
J. Cancer Res. Clin. Oncol., 133 (7), 455-470
DOI 10.1007/s00432-006-0188-3
Publications 2006
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Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model
J. Neurosurg., 104 (1), 109-117
DOI 10.3171/jns.2006.104.1.109 -
Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
Br. J. Cancer, 95 (11), 1474-1482
DOI 10.1038/sj.bjc.6603437 -
Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer
Cancer Immunol. Immunother., 55 (12), 1553-1564
DOI 10.1007/s00262-006-0145-7 -
Molecular diagnosis of Burkitt's lymphoma
N. Engl. J. Med., 354 (23), 2431-2442
DOI 10.1056/NEJMoa055759 -
Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis
BMC Immunol., 7, 13
DOI 10.1186/1471-2172-7-13 -
Transcriptional targeting of small interfering RNAs into cancer cells
Biochem. Biophys. Res. Commun., 350 (4), 854-859
DOI 10.1016/j.bbrc.2006.09.127 -
Induction of hypoxia-inducible factor-1 alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy
Cancer Lett., 244 (2), 182-189
DOI 10.1016/j.canlet.2005.12.010 -
BMP-6 inhibits human bone marrow B lymphopoiesis - Upregulation of Id1 and Id3
Exp. Hematol., 34 (1), 72-81
DOI 10.1016/j.exphem.2005.09.010 -
Immuno-gene therapy of cancer with tumour-mRNA transfected dendritic cells
Cancer Immunol. Immunother., 55 (11), 1432-1442
DOI 10.1007/s00262-006-0161-7 -
Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA
Cancer Gene Ther., 13 (10), 905-918
DOI 10.1038/sj.cgt.7700961 -
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
N. Engl. J. Med., 355 (12), 1199-1209
DOI 10.1056/NEJMoa055706 -
Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
BMC Mol. Biol., 7, 26
DOI 10.1186/1471-2199-7-26 -
RNAi therapy - Antibodies guide the way
Gene Ther., 13 (3), 194-195
DOI 10.1038/sj.gt.3302634 -
RNA interference below the immune radar
Nat. Biotechnol., 24 (5), 521-522
DOI 10.1038/nbt0506-521 -
Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2 '-hydroxyl uridines in immune responses
Eur. J. Immunol., 36 (5), 1222-1230
DOI 10.1002/eji.200535708 -
Innate sensing of self and non-self RNAs by Toll-like receptors
Trends Mol. Med, 12 (4), 167-176
DOI 10.1016/j.molmed.2006.02.004 -
Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+progenitor cells along the myeloid lineage
J. Mol. Biol., 364 (5), 945-954
DOI 10.1016/j.jmb.2006.09.054 -
Molecular basis for the immunostimulatory potency of small interfering RNAs
J. Biomed. Biotechnol., 23429
DOI 10.1155/JBB/2006/23429 -
RNA interference
J. Biomed. Biotechnol., 89018
DOI 10.1155/JBB/2006/89018 -
PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells
Br. J. Haematol., 135 (1), 117-128
DOI 10.1111/j.1365-2141.2006.06252.x
Publications 2005
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Targeting PBR by hexaminolevulinate-mediated photodynamic therapy induces apoptosis through translocation of apoptosis-inducing factor in human leukemia cells
Cancer Res., 65 (23), 11051-11060
DOI 10.1158/0008-5472.CAN-05-0510 -
Evaluation of dendritic cells loaded with apoptotic cancer cells or expressing tumour mRNA as potential cancer vaccines against leukemia
BMC Cancer, 5, 20
DOI 10.1186/1471-2407-5-20 -
Preclinical evaluation of autologous dendritic cells transfected with mRNA or loaded with apoptotic cells for immunotherapy of high-risk neuroblastoma
Cancer Gene Ther., 12 (8), 699-707
DOI 10.1038/sj.cgt.7700820 -
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
BMC Immunol., 6, 9
DOI 10.1186/1471-2172-6-9 -
Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination
Cancer Gene Ther., 12 (6), 579-591
DOI 10.1038/sj.cgt.7700837 -
Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients
Br. J. Cancer, 93 (7), 749-756
DOI 10.1038/sj.bjc.6602761 -
Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization
Oncogene, 24 (7), 1159-1173
DOI 10.1038/sj.onc.1208267 -
Systematic search for natural antisense transcripts in eukaryotes - (Review)
Int. J. Mol. Med., 15 (2), 197-203 -
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
J. Mol. Biol., 348 (5), 1079-1090
DOI 10.1016/j.jmb.2005.03.013 -
Ribozymes, DNAzymes and small interfering RNAs as therapeutics
Curr. Drug Targets, 6 (6), 647-653
DOI 10.2174/1389450054863653 -
PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: Identification of PU.1 putative binding sites in the BCL-6 promotor
J. Pathol., 206 (3), 312-319
DOI 10.1002/path.1777 -
CD10(+) stromal cells form B-lymphocyte maturation niches in the human bone marrow
J. Pathol., 205 (3), 311-317
DOI 10.1002/path.1705
Publications 2004
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Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
Cancer Res., 64 (15), 5378-5384
DOI 10.1158/0008-5472.CAN-04-0961 -
Resolving the evolutionary paradox of genetic instability: a cost-benefit analysis of DNA repair in changing environments
FEBS Lett., 563 (1-3), 7-12
DOI 10.1016/S0014-5793(04)00282-0 -
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-2582
DOI 10.1002/pmic.200300768 -
Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display
Cancer Immunol. Immunother., 53 (5), 431-438
DOI 10.1007/s00262-003-0458-8 -
NY-ESO-1 protein expression and humoral immune responses in prostate cancer
Prostate, 59 (4), 440-447
DOI 10.1002/pros.20025 -
Repetitive 5-aminolevulinic acid mediated photodynamic therapy of rat glioma
P SOC PHOTO-OPT INS, 5312, 405-414
DOI 10.1117/12.527395 -
Analysis of the autoantibody repertoire in Burkitt's lymphoma patients: frequent response against the transcription factor ATF-2
Cancer Immunol. Immunother., 53 (12), 1119-1126
DOI 10.1007/s00262-004-0558-0 -
Experimental attempt to introduce a vaccine therapy by using DC-developed from CD34+cells
NATO SCI SER I LIFE, 361, 134 -
Identification of genes differentially expressed in breast cancer cell line SKBR3: Potential identification of new prognostic biomarkers
Int. J. Mol. Med., 14 (2), 217-222 -
Adapting email functionality for mobile terminals
LECT NOTES COMPUT SC, 3283, 199-206 -
Development of a clinical grade procedure for generation of mRNA transfected dendritic cells from purified frozen CD34+blood progenitor cells
Int. J. Immunopathol. Pharmacol., 17 (3), 255-263
DOI 10.1177/039463200401700305 -
Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells
Biochem. Biophys. Res. Commun., 324 (1), 218-223
DOI 10.1016/j.bbrc.2004.09.030 -
Systematic identification of sense-antisense transcripts in mammalian cells
Nat. Biotechnol., 22 (1), 104-108
DOI 10.1038/nbt925 -
Therapeutic siRNAs
Trends Pharmacol. Sci., 25 (1), 22-28
DOI 10.1016/j.tips.2003.11.006 -
Therapeutic potential of small interfering RNAs
Drug Future, 29 (7), 741-750
DOI 10.1358/dof.2004.029.07.854171 -
Profiling microRNA expression using sensitive cDNA probes and filter arrays
Biotechniques, 37 (4), 574-+
DOI 10.2144/04374ST01
Publications 2003
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Approach to analysis of single nucleotide polymorphisms by automated constant denaturant capillary electrophoresis
Mutat. Res.-Fundam. Mol. Mech. Mutagen., 526 (1-2), 75-83
DOI 10.1016/S0027-5107(03)00033-2 -
Direct identification of all oncogenic mutants in KRAS exon 1 by cycling temperature capillary electrophoresis
Electrophoresis, 24 (1-2), 63-69
DOI 10.1002/elps.200390032 -
Evaluation of denaturing conditions in analysis of DNA variants applied to multi-capillary electrophoresis instruments
J. Sep. Sci., 26 (12-13), 1163-1168
DOI 10.1002/jssc.200301521 -
Probing the specificity of human myeloma proteins with a random peptide phage library
Scand. J. Immunol., 57 (6), 583-590
DOI 10.1046/j.1365-3083.2003.01254.x -
HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes
J. Mol. Med., 81 (1), 43-50
DOI 10.1007/s00109-002-0390-y -
A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines
Scand. J. Immunol., 58 (5), 578-586
DOI 10.1046/j.1365-3083.2003.01333.x -
Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
Anticancer Res., 23 (3B), 2201-2216 -
Selective targeting of cancer cells using synthetic peptides
Drug Resist. Update, 6 (6), 363-371
DOI 10.1016/j.drup.2003.11.002 -
Generation of an effective anti-tumor immunity after immunization with xenogeneic antigens
Eur. J. Immunol., 33 (1), 38-45
DOI 10.1002/immu.200390005 -
Cationic liposome-mediated delivery of siRNAs in adult mice
Biochem. Biophys. Res. Commun., 312 (4), 1220-1225
DOI 10.1016/j.bbrc.2003.11.057 -
Gene silencing by systemic delivery of synthetic siRNAs in adult mice
J. Mol. Biol., 327 (4), 761-766
DOI 10.1016/S0022-2836(03)00181-5 -
A survey of therapeutic hemapheresis in Norway year 2000
Transfus. Apher. Sci., 28 (2), 135-141
DOI 10.1016/S1473-0502(03)00004-1 -
The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters
Biochem. Biophys. Res. Commun., 306 (3), 718-724
DOI 10.1016/S0006-291X(03)01030-1
Publications 2002
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Melting gel techniques in single nucleotide polymorphism and mutation detection: From theory to automation
J. Sep. Sci., 25 (10-11), 637-647
DOI 10.1002/1615-9314(20020701)25:10/11<637::AID-JSSC637>3.0.CO;2-L -
Mutation detection in KRAS exon 1 by constant denaturant capillary electrophoresis in 96 parallel capillaries
Anal. Biochem., 304 (2), 200-205
DOI 10.1006/abio.2002.5629 -
Population screening of single-nucleotide polymorphisms exemplified by analysis of 8000 alleles
J. Biomol. Screen, 7 (6), 501-506
DOI 10.1177/1087057102238623 -
Independent prognostic significance of Her-2 oncoprotein expression in pNO prostate cancer undergoing curative radiotherapy
Int. J. Cancer, 99 (1), 100-105
DOI 10.1002/ijc.10286 -
Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth
Blood, 99 (11), 4147-4153
DOI 10.1182/blood.V99.11.4147 -
Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes
Biochem. Biophys. Res. Commun., 297 (4), PII S0006-291X(02)02228-3-917
DOI 10.1016/S0006-291X(02)02228-3 -
Gene silencing in mammalian cells by preformed small RNA duplexes
Biochem. Biophys. Res. Commun., 295 (3), PII S0006-291X(02)00736-2-748
DOI 10.1016/S0006-291X(02)00736-2 -
Forebrain-specific promoter/enhancer D6 derived from the mouse Dach1 gene controls expression in neural stem cells
Neuroscience, 112 (4), PII S0306-4522(02)00053-2-966
DOI 10.1016/S0306-4522(02)00053-2 -
Effect of vaccination with mutant KRAS peptides on rat colon carcinogenesis induced by azoxymethane
Anticancer Res., 22 (1A), 171-175 -
mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT)
J. Immunol. Methods, 259 (1-2), 191-203
DOI 10.1016/S0022-1759(01)00506-3 -
Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells
Faseb J., 16 (14), 256-+
DOI 10.1096/fj.02-0280fje -
How does autoimmunity cause tumor regression? A potential mechanism involving cross-reaction through epitope mimicry
Mol. Med., 8 (3), 115-119
DOI 10.1007/BF03402004 -
Combination of endostatin and a protein kinase C alpha DNA enzyme improves the survival of rats with malignant glioma
Neoplasia, 4 (6), 474-479
DOI 10.1038/sj.neo.7900271 -
The mouse enhancer element D6 directs Cre recombinase activity in the neocortex and the hippocampus
Mech. Dev., 110 (1-2), 179-182
DOI 10.1016/S0925-4773(01)00597-4 -
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
BMC Bioinformatics, 3, 36
DOI 10.1186/1471-2105-3-36
Publications 2001
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Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study
Br. J. Cancer, 85 (5), 692-696
DOI 10.1054/bjoc.2001.1964 -
Automated constant denaturant capillary electrophoresis applied for detection of KRAS exon 1 mutations
Biotechniques, 30 (5), 972-975 -
Mutation analysis of TP53 exons 5-8 by automated constant denaturant capillary electrophoresis
Tumor Biol., 22 (5), 323-327
DOI 10.1159/000050634 -
High-dose therapy in patients with Hodgkin's disease: the use of selected CD34(+) cells is as safe as unmanipulated peripheral blood progenitor cells
Bone Marrow Transplant., 28 (9), 849-857
DOI 10.1038/sj.bmt.1703244 -
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
Int. J. Cancer, 92 (3), 441-450
DOI 10.1002/ijc.1205 -
Antigen-specific IgG antibodies in stage IV long-time survival breast cancer patients
Mol. Med., 7 (4), 230-239
DOI 10.1007/BF03401842 -
Identification of immunogenic antigens using a phage-displayed cDNA library from an invasive ductal breast carcinoma tumour
Int. J. Oncol., 19 (6), 1303-1309 -
Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant
Exp. Dermatol., 10 (3), 161-167
DOI 10.1034/j.1600-0625.2001.010003161.x -
DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
Am. J. Physiol.-Heart Circul. Physiol., 281 (5), H2211-H2217
DOI 10.1152/ajpheart.2001.281.5.H2211 -
Evidence for the involvement of G(i2) in activation of extracellular signal-regulated kinases in hepatocytes
BMC Cell Biol., 2, art. no.-13
DOI 10.1186/1471-2121-2-13 -
A signal sequence trap based on cell enrichment using Anti-CD19 antibody coated magnetic beads
Scand. J. Immunol., 54 (3), 280-284
DOI 10.1046/j.1365-3083.2001.00925.x -
Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer
Proc. Natl. Acad. Sci. U. S. A., 98 (23), 13255-13260
DOI 10.1073/pnas.231326898 -
A TGF beta RII frameshift-mutation-derived CTL epitope recognised by HLA-A2-restricted CD8(+) T cells
Cancer Immunol. Immunother., 50 (9), 469-476
DOI 10.1007/s002620100222 -
An anti-leukemic single chain Fv antibody selected from a synthetic human phage antibody library
Biochem. Biophys. Res. Commun., 280 (2), 548-552
DOI 10.1006/bbrc.2000.4158 -
Profiling the immune response in patients with breast cancer by phage-displayed cDNA libraries
Eur. J. Immunol., 31 (3), 716-725
DOI 10.1002/1521-4141(200103)31:3<716::AID-IMMU716>3.0.CO;2-9
Publications 2000
-
Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer
Br. J. Cancer, 83 (6), 743-749
DOI 10.1054/bjoc.2000.1365 -
Probing antinuclear antibody specificities by peptide phage display libraries
Clin. Exp. Rheumatol., 18 (4), 465-472 -
Differential expression of Bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells
Stem Cells, 18 (4), 261-272
DOI 10.1634/stemcells.18-4-261 -
Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6
FEBS Lett., 466 (1), 169-174
DOI 10.1016/S0014-5793(99)01793-7 -
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow
Blood, 95 (2), 510-518
DOI 10.1182/blood.V95.2.510 -
Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells
J. Bone Miner. Res., 15 (12), 2402-2412
DOI 10.1359/jbmr.2000.15.12.2402 -
The C1orf9 gene encodes a putative transmembrane member of a novel protein family
Biochem. Biophys. Res. Commun., 267 (3), 855-862
DOI 10.1006/bbrc.1999.2016 -
Profiling the immune responses in patient sera with peptide and cDNA display libraries (Review)
Int. J. Mol. Med., 6 (2), 123-128 -
Design of nuclease resistant protein kinase C alpha DNA enzymes with potential therapeutic application
J. Mol. Biol., 296 (3), 937-947
DOI 10.1006/jmbi.2000.3491 -
Therapeutic RNA and DNA enzymes
Biochem. Pharmacol., 60 (8), 1023-1026
DOI 10.1016/S0006-2952(00)00395-6