Mutant fractions in 3D Links to Plotly graphs

The mutant fraction of mtDNA distributed in 3-dimensions in 8 different macroscopic samples. Several microtome slices are taken from each tissue sample and subjected to laser capture microdissection. From each 12-micrometer section, 96 LCMD samples are collected and subjected to CTCE.

One orange "bead" (wildtype) in combination with the black circle (mutant) represents mutant fraction in one LCMD spot.

Bubble size legend

Mutation analysis by CTCE

Microtome slices and pictures, testicular cancer

Testicular cancer

Histogram of marker 1 and 2

Hepatocellular Carcinoma

Histogram, distribution of wildtype fraction within each LCMD spot

Breast cancer

Liver metastasis

Bladder cancer

Primary tumor

Lymph node

Histogram, comparison of mutant fraction of the two markers

Colon cancer

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