Publications by Johannes Espolin Roksund Hov
147 publications found
Publications 2024
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Gut dysbiosis and neutrophil extracellular traps in chronic heart failure
Int J Cardiol, 419, 132689 (in press)
DOI 10.1016/j.ijcard.2024.132689, PubMed 39489348 -
Sclerosing cholangitis and inflammatory bowel disease: a paradoxical relationship?
Gut (in press)
DOI 10.1136/gutjnl-2024-332835, PubMed 39025493 -
Tubulin beta 5 is not the target of antineutrophil antibodies in primary sclerosing cholangitis
Clin Exp Immunol, 218 (1), 75-77
DOI 10.1093/cei/uxae053, PubMed 38960384 -
Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 14 (1), 3704
DOI 10.1038/s41598-024-54117-6, PubMed 38355714 -
Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine
Angew Chem Int Ed Engl, 63 (14), e202318579
DOI 10.1002/anie.202318579, PubMed 38235602 -
Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits
Biopreserv Biobank, 22 (4), 363-372
DOI 10.1089/bio.2023.0048, PubMed 38416864 -
Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
Genome Med, 16 (1), 27
DOI 10.1186/s13073-024-01296-6, PubMed 38331891 -
Author Correction: Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Nat Med, 30 (1), 303
DOI 10.1038/s41591-023-02529-8, PubMed 37587221 -
Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV
J Infect Dis, 229 (3), 898-907
DOI 10.1093/infdis/jiad604, PubMed 38195204 -
Gut microbiota diversity is prognostic and associated with benefit from chemo-immunotherapy in metastatic triple-negative breast cancer
Mol Oncol (in press)
DOI 10.1002/1878-0261.13760, PubMed 39545921
Publications 2023
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Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation
J Hepatol, 79 (4), 955-966
DOI 10.1016/j.jhep.2023.05.038, PubMed 37328069 -
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
Nat Commun, 14 (1), 3304
DOI 10.1038/s41467-023-38840-8, PubMed 37280200 -
A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation
Hepatology, 77 (3), 715-728
DOI 10.1002/hep.32773, PubMed 36056902 -
Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC?
Hepatology, 77 (6), E188-E189
DOI 10.1097/HEP.0000000000000340, PubMed 36815351 -
Editorial: dietary interventions to understand and treat primary sclerosing cholangitis-is gluten-free diet a starting point?
Aliment Pharmacol Ther, 57 (2), 265-266
DOI 10.1111/apt.17326, PubMed 36565005 -
[Gut microbiota and intestinal disease –a sober warning]
Tidsskr Nor Laegeforen, 143 (10)
DOI 10.4045/tidsskr.23.0121, PubMed 37376933 -
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
J Clin Immunol, 43 (6), 1229-1240
DOI 10.1007/s10875-023-01475-x, PubMed 36995502 -
Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
Elife, 12
DOI 10.7554/eLife.82785, PubMed 36794912 -
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
Front Cardiovasc Med, 10, 1160030
DOI 10.3389/fcvm.2023.1160030, PubMed 37332580 -
Role of microbiome in autoimmune liver diseases
Hepatology, 80 (4), 965-987
DOI 10.1097/HEP.0000000000000506, PubMed 37369002 -
Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Nat Med, 29 (7), 1738-1749
DOI 10.1038/s41591-023-02407-3, PubMed 37464040 -
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280
Publications 2022
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Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC
Gut, 72 (4), 671-685
DOI 10.1136/gutjnl-2021-326500, PubMed 35705368 -
Phenylacetylglutamine From the Gut Microbiota: A Future Therapeutic Target in Heart Failure?
Circ Heart Fail, 16 (1), e010222
DOI 10.1161/CIRCHEARTFAILURE.122.010222, PubMed 36524473 -
Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis
JHEP Rep, 4 (11), 100561
DOI 10.1016/j.jhepr.2022.100561, PubMed 36176935 -
Novel genes and sex differences in COVID-19 severity
Hum Mol Genet, 31 (22), 3789-3806
DOI 10.1093/hmg/ddac132, PubMed 35708486 -
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Hum Mol Genet, 31 (23), 3945-3966
DOI 10.1093/hmg/ddac158, PubMed 35848942 -
Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation
J Infect Dis, 225 (11), 1948-1954
DOI 10.1093/infdis/jiac018, PubMed 35089326 -
The microbiota and the gut-liver axis in primary sclerosing cholangitis
Nat Rev Gastroenterol Hepatol, 20 (3), 135-154
DOI 10.1038/s41575-022-00690-y, PubMed 36352157 -
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400 -
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction
J Infect Dis, 225 (4), 661-674
DOI 10.1093/infdis/jiaa714, PubMed 33216130 -
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
J Acquir Immune Defic Syndr, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817, PubMed 34878437 -
Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention - a pilot trial
Scand J Clin Lab Invest, 82 (5), 363-370
DOI 10.1080/00365513.2022.2102540, PubMed 35913798 -
Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis
Sci Rep, 12 (1), 22378
DOI 10.1038/s41598-022-26759-x, PubMed 36572703 -
Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens
Am J Pathol, 192 (4), 629-641
DOI 10.1016/j.ajpath.2021.12.008, PubMed 35063408 -
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063
Publications 2021
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Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511, PubMed 34329947 -
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
Clin Transl Gastroenterol, 12 (3), e00315
DOI 10.14309/ctg.0000000000000315, PubMed 33646203 -
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol, 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627, PubMed 33583308 -
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0, PubMed 34611194 -
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J Clin Invest, 131 (23)
DOI 10.1172/JCI152386, PubMed 34597274 -
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
medRxiv
DOI 10.1101/2021.03.07.21252875, PubMed 33758887 -
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
J Hepatol, 75 (3), 634-646
DOI 10.1016/j.jhep.2021.03.029, PubMed 33872692 -
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Nat Metab, 3 (9), 1228-1241
DOI 10.1038/s42255-021-00452-1, PubMed 34552267 -
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J Clin Immunol, 42 (1), 146-157
DOI 10.1007/s10875-021-01146-9, PubMed 34669143 -
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z, PubMed 34078971 -
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk
Sci Rep, 11 (1), 21936
DOI 10.1038/s41598-021-01334-y, PubMed 34754007 -
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Sci Transl Med, 13 (599)
DOI 10.1126/scitranslmed.abb3107, PubMed 34162753
Publications 2020
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Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria
Inflamm Bowel Dis, 26 (12), 1856-1868
DOI 10.1093/ibd/izaa069, PubMed 32304568 -
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393 -
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin Infect Dis, 71 (8), e359-e367
DOI 10.1093/cid/ciz1235, PubMed 31894240 -
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138 -
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798.e0
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530 -
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155 -
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943 -
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485 -
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482 -
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353 -
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489 -
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep, 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178, PubMed 33225252
Publications 2019
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Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Sci Rep, 9 (1), 8450
DOI 10.1038/s41598-019-44762-7, PubMed 31186435 -
Editorial: proton pump inhibition - microbial complications beyond dysbiosis
Aliment Pharmacol Ther, 50 (8), 962-963
DOI 10.1111/apt.15495, PubMed 31591776 -
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J Allergy Clin Immunol, 143 (5), 1969-1971.e11
DOI 10.1016/j.jaci.2019.01.019, PubMed 30707969 -
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568 -
The gut microbial influence on cholestatic liver disease
Liver Int, 39 (7), 1186-1196
DOI 10.1111/liv.14153, PubMed 31125502 -
Alterations of the bile microbiome in primary sclerosing cholangitis
Gut, 69 (4), 665-672
DOI 10.1136/gutjnl-2019-318416, PubMed 31243055 -
Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn's Disease
J Crohns Colitis, 13 (5), 607-614
DOI 10.1093/ecco-jcc/jjy208, PubMed 30541145 -
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail, 6 (3), 557-558
DOI 10.1002/ehf2.12437, PubMed 31034162 -
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Scand J Gastroenterol, 54 (6), 690-699
DOI 10.1080/00365521.2019.1624815, PubMed 31190584 -
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species
Gut, 69 (10), 1890-1892
DOI 10.1136/gutjnl-2019-320008, PubMed 31653787 -
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis
Eur J Clin Invest, 49 (5), e13088
DOI 10.1111/eci.13088, PubMed 30762236 -
Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial
Mult Scler J Exp Transl Clin, 5 (4), 2055217319888767
DOI 10.1177/2055217319888767, PubMed 31798939 -
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
AIDS, 33 (4), 645-653
DOI 10.1097/QAD.0000000000002087, PubMed 30531315 -
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J Heart Lung Transplant, 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003, PubMed 31301965
Publications 2018
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Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
J Acquir Immune Defic Syndr, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693, PubMed 29874201 -
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int, 39 (2), 371-381
DOI 10.1111/liv.13979, PubMed 30269440 -
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8 (1), 6725
DOI 10.1038/s41598-018-25168-3, PubMed 29712976 -
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J Am Coll Cardiol, 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057, PubMed 29519360 -
Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial
ESC Heart Fail, 5 (5), 977-984
DOI 10.1002/ehf2.12332, PubMed 30088346 -
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
PLoS One, 13 (11), e0194904
DOI 10.1371/journal.pone.0194904, PubMed 30427836 -
Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis
Aliment Pharmacol Ther, 48 (2), 179-189
DOI 10.1111/apt.14806, PubMed 29851098 -
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
J Hepatol, 69 (2), 368-377
DOI 10.1016/j.jhep.2018.04.009, PubMed 29709678 -
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver
J Intern Med, 284 (1), 78-91
DOI 10.1111/joim.12750, PubMed 29498764
Publications 2017
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Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025 -
A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
Microbiome, 5 (1), 68
DOI 10.1186/s40168-017-0279-1, PubMed 28683838 -
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887 -
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect Dis, 17 (1), 445
DOI 10.1186/s12879-017-2547-x, PubMed 28645263 -
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657 -
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin Liver Dis, 37 (4), 314-331
DOI 10.1055/s-0037-1608801, PubMed 29272894 -
Intestinal microbiota in primary sclerosing cholangitis
Curr Opin Gastroenterol, 33 (2), 85-92
DOI 10.1097/MOG.0000000000000334, PubMed 28030369 -
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322 -
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur J Clin Nutr, 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43, PubMed 28378853 -
Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lémann Index
Clin Gastroenterol Hepatol, 16 (1), 75-82.e5
DOI 10.1016/j.cgh.2017.06.053, PubMed 28694130 -
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J Card Fail, 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889 -
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979, PubMed 28816579 -
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm Bowel Dis, 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264, PubMed 28902124 -
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472 -
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol, 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134, PubMed 28761687
Publications 2016
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Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int, 37 (3), 458-465
DOI 10.1111/liv.13238, PubMed 27558072 -
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739, PubMed 27406039 -
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597 -
Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by 82Rubidium PET/CT
J Acquir Immune Defic Syndr, 72 (4), e83-5
DOI 10.1097/QAI.0000000000001044, PubMed 27152465 -
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816 -
Response to 'Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis' by Rühlemann et al
Gut, 66 (4), 755-756
DOI 10.1136/gutjnl-2016-312347, PubMed 27340191 -
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol J, 5 (4), 532-541
DOI 10.1177/2050640616663453, PubMed 28588885 -
Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
Gastroenterology, 151 (4), 660-669.e4
DOI 10.1053/j.gastro.2016.06.021, PubMed 27342213 -
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J Hepatol, 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020, PubMed 27720803 -
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-9
DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510 -
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab Syndr Relat Disord, 14 (4), 197-201
DOI 10.1089/met.2015.0120, PubMed 27081744 -
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nat Genet, 48 (11), 1396-1406
DOI 10.1038/ng.3695, PubMed 27723756 -
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int, 36 (9), 1370-7
DOI 10.1111/liv.13092, PubMed 26866350
Publications 2015
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Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-927.e2
DOI 10.1053/j.gastro.2015.01.041, PubMed 25655558 -
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J Hepatol, 63 (5), 1220-8
DOI 10.1016/j.jhep.2015.06.018, PubMed 26119688 -
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Lancet, 387 (10014), 156-67
DOI 10.1016/S0140-6736(15)00465-1, PubMed 26490195 -
Personalised medicine targeting the gut microbiota?
Tidsskr Nor Laegeforen, 135 (7), 624
DOI 10.4045/tidsskr.14.1431, PubMed 25899345 -
Personalized intestinal flora medicine?
Tidsskr. Nor. Laegeforen., 135 (7), 624 -
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804, PubMed 26207384 -
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J Crohns Colitis, 10 (3), 330-7
DOI 10.1093/ecco-jcc/jjv204, PubMed 26526357 -
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
DOI 10.1002/hep.28116, PubMed 26257205 -
Gut microbiota diversity predicts immune status in HIV-1 infection
AIDS, 29 (18), 2409-18
DOI 10.1097/QAD.0000000000000869, PubMed 26355675 -
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
J Acquir Immune Defic Syndr, 70 (4), 329-37
DOI 10.1097/QAI.0000000000000784, PubMed 26258571 -
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-97
DOI 10.1002/hep.27825, PubMed 25833813 -
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol J, 4 (1), 84-91
DOI 10.1177/2050640615581577, PubMed 26966527 -
Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
Clin Gastroenterol Hepatol, 13 (13), 2372-9
DOI 10.1016/j.cgh.2015.07.014, PubMed 26192140 -
Development of a high-resolution NGS-based HLA-typing and analysis pipeline
Nucleic Acids Res, 43 (11), e70
DOI 10.1093/nar/gkv184, PubMed 25753671
Publications 2014
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HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
World J Gastroenterol, 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986, PubMed 24744588 -
PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
J Gastroenterol Hepatol, 29 (7), 1477-84
DOI 10.1111/jgh.12540, PubMed 25273282 -
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int, 34 (10), 1488-95
DOI 10.1111/liv.12492, PubMed 24517468 -
Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486, PubMed 25521205 -
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J Intern Med, 277 (6), 717-26
DOI 10.1111/joim.12328, PubMed 25382824
Publications 2013
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Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis
Clin Gastroenterol Hepatol, 12 (6), 1019-28
DOI 10.1016/j.cgh.2013.09.024, PubMed 24076415 -
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403 -
A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis
PLoS One, 8 (3), e58734
DOI 10.1371/journal.pone.0058734, PubMed 23505555 -
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
DOI 10.1038/ng.2616, PubMed 23603763 -
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J Hepatol, 59 (6), 1278-84
DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938
Publications 2012
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Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342 -
Genetics in primary sclerosing cholangitis
Clin Res Hepatol Gastroenterol, 36 (4), 325-33
DOI 10.1016/j.clinre.2012.02.003, PubMed 22554879
Publications 2011
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TGR5 sequence variation in primary sclerosing cholangitis
Dig Dis, 29 (1), 78-84
DOI 10.1159/000324138, PubMed 21691110 -
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
Hepatology, 53 (6), 1967-76
DOI 10.1002/hep.24299, PubMed 21413052
Publications 2010
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Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403, PubMed 20811628 -
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
J Hepatol, 52 (5), 712-7
DOI 10.1016/j.jhep.2009.11.029, PubMed 20347497 -
Genetics of cholestatic liver disease in 2010
Curr Opin Gastroenterol, 26 (3), 251-8
DOI 10.1097/MOG.0b013e328336807d, PubMed 20042859 -
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
DOI 10.1038/ng.728, PubMed 21151127
Publications 2009
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Agreement of a child's respiratory symptom diary with parental reports and peak expiratory flow
Int J Tuberc Lung Dis, 13 (3), 400-6
PubMed 19275804 -
Genome-wide association analysis in primary sclerosing cholangitis
Gastroenterology, 138 (3), 1102-11
DOI 10.1053/j.gastro.2009.11.046, PubMed 19944697
Publications 2008
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Autoantibodies in primary sclerosing cholangitis
World J Gastroenterol, 14 (24), 3781-91
DOI 10.3748/wjg.14.3781, PubMed 18609700
Publications 2003
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[Wasp allergy vaccination]
Tidsskr Nor Laegeforen, 123 (8), 1075-7
PubMed 12760227