Johannes Espolin Roksund Hov
- Group leader, Professor; MD, PhD
Current positions
- Senior consultant, Section for Gastroenterology, Department of Transplantation Medicine, Division for Cancer medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet
- Professor II (gastroenterology), Institute of Clinical Medicine, University of Oslo
- Group leader, Genomics and metagenomics in inflammatory disorders at Norwegian PSC Research Center and Research Institute of Internal Medicine.
Research interests
Primary sclerosing cholangitis, gut microbiota in inflammatory diseases, genetics, gene-environment interactions, autoimmunity
Previous positions
- Fellow, Section for Gastroenterology, Department of Transplantation Medicine, Division for Cancer medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet (50%, 2011-2018)
- 2015-2019 Senior scientist, Norwegian PSC research center, Oslo University Hospital Rikshospitalet / University of Oslo (50%)
- 2011-2015 Postdoctoral researcher, Norwegian PSC research center, Oslo University Hospital Rikshospitalet / University of Oslo (50%)
Education
- MD, University of Oslo, 2003
- PhD, University of Oslo, 2011: "Functional genetics in primary sclerosing cholangitis: Studies of the bile acid receptor TGR5 and genes in the HLA complex"
Publications 2022
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
JAIDS, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817
Publications 2021
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
Clin. Transl. Gastroenterol., 12 (3), e00315
DOI 10.14309/ctg.0000000000000315
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand. J. Gastroenterol., 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798
DOI 10.1053/j.gastro.2020.12.058
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J. Clin. Invest., 131 (23)
DOI 10.1172/JCI152386
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
J. Hepatol., 75 (3), 634-646
DOI 10.1016/j.jhep.2021.03.029
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Nat. Metab., 3 (9), 1228-+
DOI 10.1038/s42255-021-00452-1
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J. Clin. Immunol.
DOI 10.1007/s10875-021-01146-9
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin. Exp. Immunol., 203 (2), 304-314
DOI 10.1111/cei.13541
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk
Sci Rep, 11 (1), 21936
DOI 10.1038/s41598-021-01334-y
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep., 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Sci. Transl. Med., 13 (599), eabb3107
DOI 10.1126/scitranslmed.abb3107
Publications 2020
Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria
Inflamm. Bowel Dis., 26 (12), 1856-1868
DOI 10.1093/ibd/izaa069
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N. Engl. J. Med., 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin. Infect. Dis., 71 (8), E359-E367
DOI 10.1093/cid/ciz1235
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y
Alterations of the bile microbiome in primary sclerosing cholangitis
Gut, 69 (4), 665-672
DOI 10.1136/gutjnl-2019-318416
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front. Immunol., 11, 574500
DOI 10.3389/fimmu.2020.574500
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail., 7 (2), 456-466
DOI 10.1002/ehf2.12596
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species
Gut, 69 (10), 1890-1892
DOI 10.1136/gutjnl-2019-320008
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649
Publications 2019
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Sci Rep, 9, 8450
DOI 10.1038/s41598-019-44762-7
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int., 39 (2), 371-381
DOI 10.1111/liv.13979
Editorial: proton pump inhibition - microbial complications beyond dysbiosis
Aliment. Pharmacol. Ther., 50 (8), 962-963
DOI 10.1111/apt.15495
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J. Allergy Clin. Immunol., 143 (5), 1969-+
DOI 10.1016/j.jaci.2019.01.019
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9, 167
DOI 10.1038/s41598-018-35367-7
The gut microbial influence on cholestatic liver disease
Liver Int., 39 (7), 1186-1196
DOI 10.1111/liv.14153
Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn's Disease
J. Crohns Colitis, 13 (5), 607-614
DOI 10.1093/ecco-jcc/jjy208
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail., 6 (3), 557-558
DOI 10.1002/ehf2.12437
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Scand. J. Gastroenterol., 54 (6), 690-699
DOI 10.1080/00365521.2019.1624815
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis
Eur. J. Clin. Invest., 49 (5), e13088
DOI 10.1111/eci.13088
Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial
Mult. Scler. J. Exp. Transl. Clin., 5 (4)
DOI 10.1177/2055217319888767
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
Aids, 33 (4), 645-653
DOI 10.1097/QAD.0000000000002087
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J. Heart Lung Transplant., 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003
Publications 2018
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
JAIDS, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8, 6725
DOI 10.1038/s41598-018-25168-3
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol., 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J. Am. Coll. Cardiol., 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057
Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lemann Index
Clin. Gastroenterol. Hepatol., 16 (1), 75-+
DOI 10.1016/j.cgh.2017.06.053
Design of the GutHearttargeting gut microbiota to treat heart failuretrial: a Phase II, randomized clinical trial
ESC Heart Fail., 5 (5), 978-985
DOI 10.1002/ehf2.12332
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
PLoS One, 13 (11), e0194904
DOI 10.1371/journal.pone.0194904
Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis
Aliment. Pharmacol. Ther., 48 (2), 179-189
DOI 10.1111/apt.14806
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
J. Hepatol., 69 (2), 368-377
DOI 10.1016/j.jhep.2018.04.009
Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver
J. Intern. Med., 284 (1), 78-91
DOI 10.1111/joim.12750
Publications 2017
A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
Microbiome, 5, 68
DOI 10.1186/s40168-017-0279-1
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int., 37 (10), 1554-1561
DOI 10.1111/liv.13402
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect. Dis., 17, 445
DOI 10.1186/s12879-017-2547-x
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int., 37 (3), 458-465
DOI 10.1111/liv.13238
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin. Liver Dis., 37 (4), 314-331
DOI 10.1055/s-0037-1608801
Intestinal microbiota in primary sclerosing cholangitis
Curr. Opin. Gastroenterol., 33 (2), 85-92
DOI 10.1097/MOG.0000000000000334
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur. J. Clin. Nutr., 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500
Response to 'Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis' by Ruhlemann et al
Gut, 66 (4), 755-756
DOI 10.1136/gutjnl-2016-312347
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol. J., 5 (4), 532-541
DOI 10.1177/2050640616663453
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J. Card. Fail., 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J. Hepatol., 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm. Bowel Dis., 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J. Hepatol., 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol., 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134
Publications 2016
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Lancet, 387 (10014), 156-167
DOI 10.1016/S0140-6736(15)00465-1
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol., 9 (6), 1455-1465
DOI 10.1038/mi.2016.18
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J. Crohns Colitis, 10 (3), 330-337
DOI 10.1093/ecco-jcc/jjv204
Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by (82)Rubidium PET/CT
JAIDS, 72 (4), e83-e85
DOI 10.1097/QAI.0000000000001044
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-1619
DOI 10.1002/hep.28116
Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
Gastroenterology, 151 (4), 660-+
DOI 10.1053/j.gastro.2016.06.021
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-69
DOI 10.1016/j.atherosclerosis.2016.01.033
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab. Syndr. Relat. Disord., 14 (4), 197-201
DOI 10.1089/met.2015.0120
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nature Genet., 48 (11), 1396-1406
DOI 10.1038/ng.3695
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol. J., 4 (1), 84-91
DOI 10.1177/2050640615581577
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int., 36 (9), 1370-1377
DOI 10.1111/liv.13092
Publications 2015
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-U355
DOI 10.1053/j.gastro.2015.01.041
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J. Hepatol., 63 (5), 1220-1228
DOI 10.1016/j.jhep.2015.06.018
Personalized intestinal flora medicine?
Tidsskr. Nor. Laegeforen., 135 (7), 624
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804
Gut microbiota diversity predicts immune status in HIV-1 infection
Aids, 29 (18), 2409-2418
DOI 10.1097/QAD.0000000000000869
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
JAIDS, 70 (4), 329-337
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J. Intern. Med., 277 (6), 717-726
DOI 10.1111/joim.12328
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-197
DOI 10.1002/hep.27825
Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 13 (13), 2372-2379
DOI 10.1016/j.cgh.2015.07.014
Development of a high-resolution NGS-based HLA-typing and analysis pipeline
Nucleic Acids Res., 43 (11), E70-U11
DOI 10.1093/nar/gkv184
Publications 2014
Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 12 (6), 1019-1028
DOI 10.1016/j.cgh.2013.09.024
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation vs
World J. Gastroenterol., 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986
PNPLA3 in end-stage liver disease: Alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
J. Gastroenterol. Hepatol., 29 (7), 1477-1484
DOI 10.1111/jgh.12540
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int., 34 (10), 1488-1495
DOI 10.1111/liv.12492
Refinement of the MHC Risk Map in a Scandinavian Primary Sclerosing Cholangitis Population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486
Publications 2013
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis and Ulcerative Colitis Identifies Risk Loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-1083
DOI 10.1002/hep.25977
A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis
PLoS One, 8 (3), e58734
DOI 10.1371/journal.pone.0058734
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nature Genet., 45 (6), 670-+
DOI 10.1038/ng.2616
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J. Hepatol., 59 (6), 1278-1284
DOI 10.1016/j.jhep.2013.08.005
Publications 2012
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J. Hepatol., 57 (2), 366-375
DOI 10.1016/j.jhep.2012.03.031
Genetics in primary sclerosing cholangitis
Clin. Res. Hepatol. Gastroenterol., 36 (4), 325-333
DOI 10.1016/j.clinre.2012.02.003
Publications 2011
Functional genetics in primary sclerosing cholangitis: studies of the bile acid receptor TGR5 and genes in the HLA complex
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1163, 1 b. (flere pag.)
BIBSYS 114538336, ISBN 978-82-8264-079-4
TGR5 Sequence Variation in Primary Sclerosing Cholangitis
Dig. Dis., 29 (1), 78-84
DOI 10.1159/000324138
Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
Hepatology, 53 (6), 1967-1976
DOI 10.1002/hep.24299
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nature Genet., 43 (1), 17-19
DOI 10.1038/ng.728
Publications 2010
Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403
Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C
J. Hepatol., 52 (5), 712-717
DOI 10.1016/j.jhep.2009.11.029
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Gastroenterology, 138 (3), 1102-1111
DOI 10.1053/j.gastro.2009.11.046
Genetics of cholestatic liver disease in 2010
Curr. Opin. Gastroenterol., 26 (3), 251-258
DOI 10.1097/MOG.0b013e328336807d
Publications 2009
Agreement of a child's respiratory symptom diary with parental reports and peak expiratory flow
Int. J. Tuberc. Lung Dis., 13 (3), 400-406
Publications 2008
Autoantibodies in primary sclerosing cholangitis
World J. Gastroenterol., 14 (24), 3781-3791
DOI 10.3748/wjg.14.3781