Publications 2022

Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Troseid M, Reikvam DH (2022)
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
JAIDS, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817

Publications 2021

Awoyemi A, Mayerhofer C, Felix AS, Hov JR, Moscavitch SD, Lappegard KT, Hovland A, Halvorsen S, Halvorsen B, Gregersen I, Svardal A, Berge RK, Hansen SH, Gotz A, Holm K, Aukrust P, Akra S, Seljeflot I, Solheim S, Lorenzo A, Gullestad L, Troseid M, Broch K (2021)
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511

Bossen L, Vesterhus M, Hov JR, Farkkila M, Rosenberg WM, Moller HJ, Boberg KM, Karlsen TH, Gronbaek H (2021)
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
Clin. Transl. Gastroenterol., 12 (3), e00315
DOI 10.14309/ctg.0000000000000315

Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Troseid M, Midttun O, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR (2021)
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand. J. Gastroenterol., 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627

Karlsen TR, Kong XY, Holm S, Quiles-Jimenez A, Dahl TB, Yang K, Sagen EL, Skarpengland T, Ogaard JSD, Holm K, Vestad B, Olsen MB, Aukrust P, Bjoras M, Hov JR, Halvorsen B, Gregersen I (2021)
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0

Kummen M, Thingholm LB, Ruhlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun O, McCann A, Ueland PM, Hoivik ML, Vesterhus M, Troseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR (2021)
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798
DOI 10.1053/j.gastro.2020.12.058

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi MEK, Palom A, Ellinghaus D, Khan A, Martinez-Bueno M, Rolker S, Amitrano S, Tato LR, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernandez-Cadenas I, Holter JC, Banales JM et al. (2021)
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J. Clin. Invest., 131 (23)
DOI 10.1172/JCI152386

Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Hohne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, Garcia-Beccaria M, Gabernet G, Nahnsen S, Mallm JP et al. (2021)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
J. Hepatol., 75 (3), 634-646
DOI 10.1016/j.jhep.2021.03.029

Schneider KM, Candels LS, Hov JR, Myllys M, Hassan R, Schneider CV, Wahlstrom A, Mohs A, Zuhlke S, Liao LJ, Elfers C, Kilic K, Henricsson M, Molinaro A, Hatting M, Zaza A, Drasdo D, Frissen M, Devlin AS, Galvez EJC, Strowig T, Karlsen TH, Hengstler JG, Marschall HU, Ghallab A et al. (2021)
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Nat. Metab., 3 (9), 1228-+
DOI 10.1038/s42255-021-00452-1

Skarpengland T, Macpherson ME, Hov JR, Kong XY, Bohov P, Halvorsen B, Fevang B, Berge RK, Aukrust P, Jorgensen SF (2021)
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J. Clin. Immunol.
DOI 10.1007/s10875-021-01146-9

Skaarud KJ, Hov JR, Hansen SH, Kummen M, Valeur J, Seljeflot I, Bye A, Paulsen V, Lundin KEA, Troseid M, Tjonnfjord GE, Iversen PO (2021)
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2021)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin. Exp. Immunol., 203 (2), 304-314
DOI 10.1111/cei.13541

Vestad B, Nyman TA, Hove-Skovsgaard M, Stensland M, Hoel H, Troseid AMS, Aspelin T, Aass HCD, Puhka M, Hov JR, Nielsen SD, Ovstebo R, Troseid M (2021)
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk
Sci Rep, 11 (1), 21936
DOI 10.1038/s41598-021-01334-y

Vesterhus M, Nielsen MJ, Hov JR, Saffioti F, Manon-Jensen T, Leeming DJ, Moum B, Boberg KM, Pinzani M, Karlsen TH, Karsdal MA, Thorburn D (2021)
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep., 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178

Zimmer CL, von Seth E, Buggert M, Strauss O, Hertwig L, Nguyen S, Wong AYW, Zotter C, Berglin L, Michaelsson J, Hansson MR, Arnelo U, Sparrelid E, Ellis ECS, Soderholm JD, Keita AV, Holm K, Ozenci V, Hov JR, Mold JE, Cornillet M, Ponzetta A, Bergquist A, Bjorkstrom NK (2021)
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Sci. Transl. Med., 13 (599), eabb3107
DOI 10.1126/scitranslmed.abb3107

Publications 2020

Derer S, Brethack AK, Pietsch C, Jendrek ST, Nitzsche T, Bokemeyer A, Hov JR, Schaffler H, Bettenworth D, Grassl GA, Sina C (2020)
Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria
Inflamm. Bowel Dis., 26 (12), 1856-1868
DOI 10.1093/ibd/izaa069

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernandez J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kassens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng TH, Yi XL, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F et al. (2020)
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N. Engl. J. Med., 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283

Fretheim H, Chung BK, Didriksen H, Baekkevold ES, Midtvedt O, Brunborg C, Holm K, Valeur J, Tennoe AH, Garen T, Midtvedt T, Troseid M, Zare H, Lund MB, Hov JR, Lundin KEA, Molberg O, Hoffmann-Vold AM (2020)
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739

Gelpi M, Vestad B, Hansen SH, Holm K, Drivsholm N, Goetz A, Kirkby NS, Lindegaard B, Lebech AM, Hoel H, Michelsen AE, Ueland T, Gerstoft J, Lundgren J, Hov JR, Nielsen SD, Troseid M (2020)
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin. Infect. Dis., 71 (8), E359-E367
DOI 10.1093/cid/ciz1235

Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Troseid M, Vestad B, Skardal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y

Liwinski T, Zenouzi R, John C, Ehlken H, Ruhlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rosch T, Lohse AW, Heeren J, Franke A, Schramm C (2020)
Alterations of the bile microbiome in primary sclerosing cholangitis
Gut, 69 (4), 665-672
DOI 10.1136/gutjnl-2019-318416

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Troseid M, Halvorsen B, Aukrust P, Fevang B, Jorgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front. Immunol., 11, 574500
DOI 10.3389/fimmu.2020.574500

Mayerhofer CCK, Kummen M, Holm K, Broch K, Awoyemi A, Vestad B, Storm-Larsen C, Seljeflot I, Ueland T, Bohov P, Berge RK, Svardal A, Gullestad L, Yndestad A, Aukrust P, Hov JR, Troseid M (2020)
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail., 7 (2), 456-466
DOI 10.1002/ehf2.12596

Ruhlemann MC, Solovjeva MEL, Zenouzi R, Liwinski T, Kummen M, Lieb W, Hov JR, Schramm C, Franke A, Bang C (2020)
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species
Gut, 69 (10), 1890-1892
DOI 10.1136/gutjnl-2019-320008

Sokolova M, Yang K, Hansen SH, Louwe MC, Kummen M, Hov JER, Sjaastad I, Berge RK, Halvorsen B, Aukrust P, Yndestad A, Ranheim T (2020)
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1

Troseid M, Andersen GO, Broch K, Hov JR (2020)
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649

Publications 2019

Dhillon AK, Kremer AE, Kummen M, Boberg KM, Elferink RPO, Karlsen TH, Beuers U, Vesterhus M, Hov JR (2019)
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Sci Rep, 9, 8450
DOI 10.1038/s41598-019-44762-7

Dhillon AK, Kummen M, Troseid M, Akra S, Liaskou E, Moum B, Vesterhus M, Karlsen TH, Seljeflot I, Hov JR (2019)
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int., 39 (2), 371-381
DOI 10.1111/liv.13979

Hov JR (2019)
Editorial: proton pump inhibition - microbial complications beyond dysbiosis
Aliment. Pharmacol. Ther., 50 (8), 962-963
DOI 10.1111/apt.15495

Jorgensen SF, Holm K, Macpherson ME, Storm-Larsen C, Kummen M, Fevang B, Aukrust P, Hov JR (2019)
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J. Allergy Clin. Immunol., 143 (5), 1969-+
DOI 10.1016/j.jaci.2019.01.019

Jorgensen SF, Macpherson ME, Bjornetro T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Troseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9, 167
DOI 10.1038/s41598-018-35367-7

Kummen M, Hov JR (2019)
The gut microbial influence on cholestatic liver disease
Liver Int., 39 (7), 1186-1196
DOI 10.1111/liv.14153

Lunder AK, Bakstad LT, Jahnsen J, Borthne A, Hov JR, Vatn M, Negard A (2019)
Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn's Disease
J. Crohns Colitis, 13 (5), 607-614
DOI 10.1093/ecco-jcc/jjy208

Mayerhofer CCK, Awoyemi A, Hov JR, Troseid M, Broch K (2019)
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail., 6 (3), 557-558
DOI 10.1002/ehf2.12437

Mazzawi T, Hausken T, Hov JR, Valeur J, Sangnes DA, El-Salhy M, Gilja OH, Hatlebakk JG, Lied GA (2019)
Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels
Scand. J. Gastroenterol., 54 (6), 690-699
DOI 10.1080/00365521.2019.1624815

Saffioti F, Roccarina D, Vesterhus M, Hov JR, Rosenberg W, Pinzani M, Pereira SP, Boberg KM, Thorburn D (2019)
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis
Eur. J. Clin. Invest., 49 (5), e13088
DOI 10.1111/eci.13088

Storm-Larsen C, Myhr KM, Farbu E, Midgard R, Nyquist K, Broch L, Berg-Hansen P, Buness A, Holm K, Ueland T, Fallang LE, Burum-Auensen E, Hov JR, Holmoy T (2019)
Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial
Mult. Scler. J. Exp. Transl. Clin., 5 (4)
DOI 10.1177/2055217319888767

Storm-Larsen C, Stiksrud B, Eriksen C, Nowak P, Holm K, Thalme A, Dyrhol-Riise AM, Brix S, Hov JR, Troseid M (2019)
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
Aids, 33 (4), 645-653
DOI 10.1097/QAD.0000000000002087

Troseid M, Mayerhofer CCK, Broch K, Arora S, Svardal A, Hov JR, Andreassen AK, Gude E, Karason K, Dellgren G, Berge RK, Gullestad L, Aukrust P, Ueland T (2019)
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J. Heart Lung Transplant., 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003

Publications 2018

Alberts R, de Vries EMG, Goode EC, Jiang XJ, Sampaziotis F, Rombouts K, Bottcher K, Folseraas T, Weismuller TJ, Mason AL, Wang WW, Alexander G, Alvaro D, Bergquist A, Bjorkstrom NK, Beuers U, Bjornsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouilleres O, Cheung A, Dalekos G, Eaton J et al. (2018)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598

Arnbjerg CJ, Vestad B, Hov JR, Pedersen KK, Jespersen S, Johannesen HH, Holm K, Halvorsen B, Fallentin E, Hansen AE, Lange T, Kjaer A, Troseid M, Fischer BM, Nielsen SD (2018)
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
JAIDS, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693

Hoel H, Hove-Skovsgaard M, Hov JR, Gaardbo JC, Holm K, Kummen M, Rudi K, Nwosu F, Valeur J, Gelpi M, Seljeflot I, Ueland PM, Gerstoft J, Ullum H, Aukrust P, Nielsen SD, Troseid M (2018)
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8, 6725
DOI 10.1038/s41598-018-25168-3

Jahnsen FL, Baekkevold ES, Hov JR, Landsverk OJ (2018)
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol., 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006

Kummen M, Mayerhofer CCK, Vestad B, Broch K, Awoyemi A, Storm-Larsen C, Ueland T, Yndestad A, Hov JR, Troseid M (2018)
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J. Am. Coll. Cardiol., 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057

Lunder AK, Jahnsen J, Bakstad LT, Borthne A, Hov JR, Vatn M, Negard A, IBSEN Study Grp (2018)
Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lemann Index
Clin. Gastroenterol. Hepatol., 16 (1), 75-+
DOI 10.1016/j.cgh.2017.06.053

Mayerhofer CCK, Awoyemi AO, Moscavitch SD, Lappegard KT, Hov JR, Aukrust P, Hovland A, Lorenzo A, Halvorsen S, Seljeflot I, Gullestad L, Troseid M, Broch K (2018)
Design of the GutHearttargeting gut microbiota to treat heart failuretrial: a Phase II, randomized clinical trial
ESC Heart Fail., 5 (5), 978-985
DOI 10.1002/ehf2.12332

Mazzawi T, Lied GA, Sangnes DA, El-Salhy M, Hov JR, Gilja OH, Hatlebakk JG, Hausken T (2018)
The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation
PLoS One, 13 (11), e0194904
DOI 10.1371/journal.pone.0194904

Nielsen MJ, Thorburn D, Leeming DJ, Hov JR, Nygard S, Moum B, Saffioti F, Gilja OH, Boberg KM, Mazza G, Rosjo H, Pinzani M, Karlsen TH, Karsdal MA, Vesterhus M (2018)
Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis
Aliment. Pharmacol. Ther., 48 (2), 179-189
DOI 10.1111/apt.14806

Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P (2018)
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
J. Hepatol., 69 (2), 368-377
DOI 10.1016/j.jhep.2018.04.009

Ruhlemann MC, Degenhardt F, Thingholm LB, Wang J, Skieceviciene J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen FA, Franke A (2018)
Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979

Schmitt C, Lenglet H, Yu A, Delaby C, Benecke A, Lefebvre T, Letteron P, Paradis V, Wahlin S, Sandberg S, Harper P, Sardh E, Sandvik AK, Hov JR, Aarsand AK, Chiche L, Bazille C, Scoazec JY, To-Figueras J, Carrascal M, Abian J, Mirmiran A, Karim Z, Deybach JC, Puy H et al. (2018)
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver
J. Intern. Med., 284 (1), 78-91
DOI 10.1111/joim.12750

Publications 2017

de Muinck EJ, Trosvik P, Gilfillan GD, Hov JR, Sundaram AYM (2017)
A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
Microbiome, 5, 68
DOI 10.1186/s40168-017-0279-1

de Vries EM, Farkkila M, Milkiewicz P, Hov JR, Eksteen B, Thorburn D, Chazouilleres O, Pares A, Nygard S, Gilja OH, Wunsch E, Invernizzi P, Carbone M, Bernuzzi F, Boberg KM, Rosjo H, Rosenberg W, Beuers UH, Ponsioen CY, Karlsen TH, Vesterhus M (2017)
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int., 37 (10), 1554-1561
DOI 10.1111/liv.13402

Haissman JM, Haugaard AK, Ostrowski SR, Berge RK, Hov JR, Troseid M, Nielsen SD (2017)
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect. Dis., 17, 445
DOI 10.1186/s12879-017-2547-x

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouilleres O, Farkkila M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D, Yu L et al. (2017)
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076

Hov JR, Boberg KM, Taraldsrud E, Vesterhus M, Boyadzhieva M, Solberg IC, Schrumpf E, Vatn MH, Lie BA, Molberg O, Karlsen TH (2017)
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int., 37 (3), 458-465
DOI 10.1111/liv.13238

Hov JR, Karlsen TH (2017)
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin. Liver Dis., 37 (4), 314-331
DOI 10.1055/s-0037-1608801

Hov JR, Kummen M (2017)
Intestinal microbiota in primary sclerosing cholangitis
Curr. Opin. Gastroenterol., 33 (2), 85-92
DOI 10.1097/MOG.0000000000000334

Jendrek ST, Gotthardt D, Nitzsche T, Widmann L, Korf T, Michaels MA, Weiss KH, Liaskou E, Vesterhus M, Karlsen TH, Mindorf S, Schemmer P, Bar F, Teegen B, Schroeder T, Ehlers M, Hammers CM, Komorowski L, Lehnert H, Fellermann K, Derer S, Hov JR, Sina C (2017)
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Gut, 66 (1), 137-144
DOI 10.1136/gutjnl-2016-311739

Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MRP, Hopfner T, Jacobs G, Siegert S, Artati A, Kastenmuller G, Romisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nothlings U, Lieb W (2017)
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur. J. Clin. Nutr., 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43

Kummen M, Holm K, Anmarkrud JA, Nygard S, Vesterhus M, Hoivik ML, Troseid M, Marschall HU, Schrumpf E, Moum B, Rosjo H, Aukrust P, Karlsen TH, Hov JR (2017)
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500

Kummen M, Hov JR (2017)
Response to 'Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis' by Ruhlemann et al
Gut, 66 (4), 755-756
DOI 10.1136/gutjnl-2016-312347

Kummen M, Vesterhus M, Troseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR (2017)
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol. J., 5 (4), 532-541
DOI 10.1177/2050640616663453

Mayerhofer CCK, Ueland T, Broch K, Vincent RP, Cross GF, Dahl CP, Aukrust P, Gullestad L, Hov JR, Troseid M (2017)
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J. Card. Fail., 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Backhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2017)
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J. Hepatol., 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020

Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Hoivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR (2017)
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm. Bowel Dis., 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264

Vesterhus M, Holm A, Hov JR, Nygard S, Schrumpf E, Melum E, Thorbjornsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Rosjo H, Moum B, Ponsioen CY, Boberg KM, Farkkila M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J. Hepatol., 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019

Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt O, Lagishetty V, Chang L, Labus JS, Molberg O, Braun J (2017)
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol., 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134

Publications 2016

Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang HL, Kennedy NA, Kupcinskas L et al. (2016)
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Lancet, 387 (10014), 156-167
DOI 10.1016/S0140-6736(15)00465-1

Jorgensen SF, Troseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Hoivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KEA, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol., 9 (6), 1455-1465
DOI 10.1038/mi.2016.18

Kevans D, Tyler AD, Holm K, Jorgensen KK, Vatn MH, Karlsen TH, Kaplan GG, Eksteen B, Gevers D, Hov JR, Silverberg MS (2016)
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis
J. Crohns Colitis, 10 (3), 330-337
DOI 10.1093/ecco-jcc/jjv204

Knudsen A, Christensen TE, Thorsteinsson K, Ghotbi AA, Hasbak P, Lebech AM, Nielsen SD, Hov JR, Berge R, Ripa RS, Kjaer A, Troseid M (2016)
Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by (82)Rubidium PET/CT
JAIDS, 72 (4), e83-e85
DOI 10.1097/QAI.0000000000001044

Liaskou E, Henriksen EKK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2016)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-1619
DOI 10.1002/hep.28116

Lunder AK, Hov JR, Borthne A, Gleditsch J, Johannesen G, Tveit K, Viktil E, Henriksen M, Hovde O, Huppertz-Hauss G, Hoie O, Hoivik ML, Monstad I, Solberg IC, Jahnsen J, Karlsen TH, Moum B, Vatn M, Negard A (2016)
Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease
Gastroenterology, 151 (4), 660-+
DOI 10.1053/j.gastro.2016.06.021

Skagen K, Troseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JER, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-69
DOI 10.1016/j.atherosclerosis.2016.01.033

Troseid M, Hov JR, Nestvold TK, Thoresen H, Berge RK, Svardal A, Lappegard KT (2016)
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab. Syndr. Relat. Disord., 14 (4), 197-201
DOI 10.1089/met.2015.0120

Wang J, Thingholm LB, Skieceviciene J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Ruhlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hubenthal M, Koch M, Schwarz K, Rimbach G, Hubbe P et al. (2016)
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Nature Genet., 48 (11), 1396-1406
DOI 10.1038/ng.3695

Wannhoff A, Folseraas T, Brune M, Rupp C, Friedrich K, Knierim J, Weiss KH, Sauer P, Flechtenmacher C, Schirmacher P, Stremmel W, Hov JR, Gotthardt DN (2016)
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol. J., 4 (1), 84-91
DOI 10.1177/2050640615581577

Zweers SJ, Shiryaev A, Komuta M, Vesterhus M, Hov JR, Perugorria MJ, de Waart DR, Chang JC, Tol S, Velde AAT, de Jonge WJ, Banales JM, Roskams T, Beuers U, Karlsen TH, Jansen PL, Schaap FG (2016)
Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis
Liver Int., 36 (9), 1370-1377
DOI 10.1111/liv.13092

Publications 2015

Berntsen NL, Klingenberg O, Juran BD, de Valle MB, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR (2015)
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-U355
DOI 10.1053/j.gastro.2015.01.041

Carpino G, Cardinale V, Renzi A, Hov JR, Berloco PB, Rossi M, Karlsen TH, Alvaro D, Gaudio E (2015)
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J. Hepatol., 63 (5), 1220-1228
DOI 10.1016/j.jhep.2015.06.018

Hov JER, Troseid M (2015)
Personalized intestinal flora medicine?
Tidsskr. Nor. Laegeforen., 135 (7), 624

Hov JR, Zhong HZ, Qin BC, Anmarkrud JA, Holm K, Franke A, Lie BA, Karlsen TH (2015)
The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study
PLoS One, 10 (7), e0133804
DOI 10.1371/journal.pone.0133804

Nowak P, Troseid M, Avershina E, Barqasho B, Neogi U, Holm K, Hov JR, Noyan K, Vesterbacka J, Svard J, Rudi K, Sonnerborg A (2015)
Gut microbiota diversity predicts immune status in HIV-1 infection
Aids, 29 (18), 2409-2418
DOI 10.1097/QAD.0000000000000869

Stiksrud B, Nowak P, Nwosu FC, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AEA, Sandset PM, Rudi K, Hov JR, Dyrhol-Riise AM, Troseid M (2015)
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
JAIDS, 70 (4), 329-337

Troseid M, Ueland T, Hov JR, Svardal A, Gregersen I, Dahl CP, Aakhus S, Gude E, Bjorndal B, Halvorsen B, Karlsen TH, Aukrust P, Gullestad L, Berge RK, Yndestad A (2015)
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J. Intern. Med., 277 (6), 717-726
DOI 10.1111/joim.12328

Vesterhus M, Hov JR, Holm A, Schrumpf E, Nygard S, Godang K, Andersen IM, Naess S, Thorburn D, Saffioti F, Vatn M, Gilja OH, Lund-Johansen F, Syversveen T, Brabrand K, Pares A, Ponsioen CY, Pinzani M, Farkkila M, Moum B, Ueland T, Rosjo H, Rosenberg W, Boberg KM, Karlsen TH (2015)
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-197
DOI 10.1002/hep.27825

Wannhoff A, Rupp C, Friedrich K, Brune M, Knierim J, Flechtenmacher C, Sauer P, Stremmel W, Hov JR, Schirmacher P, Weiss KH, Gotthardt DN (2015)
Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 13 (13), 2372-2379
DOI 10.1016/j.cgh.2015.07.014

Wittig M, Anmarkrud JA, Kassens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Gorg S, Jacob F, Karlsen TH, Franke A (2015)
Development of a high-resolution NGS-based HLA-typing and analysis pipeline
Nucleic Acids Res., 43 (11), E70-U11
DOI 10.1093/nar/gkv184

Publications 2014

Andersen IM, Tengesdal G, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis
Clin. Gastroenterol. Hepatol., 12 (6), 1019-1028
DOI 10.1016/j.cgh.2013.09.024

Fosby B, Naess S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation vs
World J. Gastroenterol., 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986

Friedrich K, Wannhoff A, Kattner S, Brune M, Hov JR, Weiss KH, Antoni C, Dollinger M, Neumann-Haefelin C, Seufferlein T, Schemmer P, Schirmacher P, Stremmel W, Gotthardt DN (2014)
PNPLA3 in end-stage liver disease: Alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
J. Gastroenterol. Hepatol., 29 (7), 1477-1484
DOI 10.1111/jgh.12540

Naess S, Bjornsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SGE, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int., 34 (10), 1488-1495
DOI 10.1111/liv.12492

Naess S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJP, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
Refinement of the MHC Risk Map in a Scandinavian Primary Sclerosing Cholangitis Population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486

Publications 2013

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismuller TJ, Schramm C, Wittig M, Bergquist A, Bjornsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis and Ulcerative Colitis Identifies Risk Loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-1083
DOI 10.1002/hep.25977

Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PKY, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN (2013)
A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis
PLoS One, 8 (3), e58734
DOI 10.1371/journal.pone.0058734

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismuller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Muller T, Srivastava B, Dalekos G, Nothen MM, Herms S et al. (2013)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nature Genet., 45 (6), 670-+
DOI 10.1038/ng.2616

Wannhoff A, Hov JR, Folseraas T, Rupp C, Friedrich K, Anmarkrud JA, Weiss KH, Sauer P, Schirmacher P, Boberg KM, Stremmel W, Karlsen TH, Gotthardt DN (2013)
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J. Hepatol., 59 (6), 1278-1284
DOI 10.1016/j.jhep.2013.08.005

Publications 2012

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismuller TJ, Gotthard DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Bjornsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J. Hepatol., 57 (2), 366-375
DOI 10.1016/j.jhep.2012.03.031

Naess S, Shiryaev A, Hov JR, Franke A, Karlsen TH (2012)
Genetics in primary sclerosing cholangitis
Clin. Res. Hepatol. Gastroenterol., 36 (4), 325-333
DOI 10.1016/j.clinre.2012.02.003

Publications 2011

Hov JER (2011)
Functional genetics in primary sclerosing cholangitis: studies of the bile acid receptor TGR5 and genes in the HLA complex
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1163, 1 b. (flere pag.)
BIBSYS 114538336, ISBN 978-82-8264-079-4

Hov JR, Keitel V, Schrumpf E, Haussinger D, Karlsen TH (2011)
TGR5 Sequence Variation in Primary Sclerosing Cholangitis
Dig. Dis., 29 (1), 78-84
DOI 10.1159/000324138

Hov JR, Kosmoliaptsis V, Traherne JA, Olsson M, Boberg KM, Bergquist A, Schrumpf E, Bradley JA, Taylor CJ, Lie BA, Trowsdale J, Karlsen TH (2011)
Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis
Hepatology, 53 (6), 1967-1976
DOI 10.1002/hep.24299

Melum E, Franke A, Schramm C, Weismuller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Bjornsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2011)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nature Genet., 43 (1), 17-19
DOI 10.1038/ng.728

Publications 2010

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismuller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403

Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P (2010)
Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C
J. Hepatol., 52 (5), 712-717
DOI 10.1016/j.jhep.2009.11.029

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismuller TJ, Gotthardt D, Rust C, Philipp EER, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2010)
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Gastroenterology, 138 (3), 1102-1111
DOI 10.1053/j.gastro.2009.11.046

Karlsen TH, Hov JR (2010)
Genetics of cholestatic liver disease in 2010
Curr. Opin. Gastroenterol., 26 (3), 251-258
DOI 10.1097/MOG.0b013e328336807d

Publications 2009

Hov JR, Clench-Aas J, Bartonova A, Stavem K (2009)
Agreement of a child's respiratory symptom diary with parental reports and peak expiratory flow
Int. J. Tuberc. Lung Dis., 13 (3), 400-406

Publications 2008

Hov JR, Boberg KM, Karlsen TH (2008)
Autoantibodies in primary sclerosing cholangitis
World J. Gastroenterol., 14 (24), 3781-3791
DOI 10.3748/wjg.14.3781