Translational research projects

Thoracic malignancies (lung cancer and mesothelioma)

  • Improving radiotherapy in lung cancer
  • Combining immunotherapy and radiotherapy (photon/proton)
  • Exploring the immune response to immunotherapy and radiotherapy
    • Circulating immune cells (spectral flow)
    • Cytokines
    • Tumour DNA/RNA sequencing
    • Tumour multiplex immunohistochemistry
    • Gut microbiota
    • T-cell receptor sequencing
  • Circulating tumour DNA (ctDNA)
  • Dual-time FDG-PET analyses
  • Patient-derived cell lines
  • Drug screen for repurposing of targeted therapies
  • Artificial intelligence to predict
    • Immune response based on H&E images
    • Oligometastatic disease based on CT-scans

Real-world data

  • Impact of commonly prescribed non-oncology drugs on immunotherapy outcomes
  • Patient / tumour characteristics, treatments, outcomes and care quality for patients with metastatic non-small cell lung cancer
  • Development of AI methods to define and describe oligometastatic non-small cell lung cancer

Pancreatic cancer 

  • Spatial transcriptomics in PDAC tumors
  • Circulating cell-free DNA in plasma (total DNA and tumor DNA)

Rare cancers

  • Genetic profiling and precision medicine in rare cancers with poor prognosis (the MATRIX-RARE study)
  • Pleural mesothelioma – outcomes, immune responses, molecular profiling (the NIPU study)
 
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