The ASAC study, Scandinavian multicentre, placebo-controlled, randomized trial, initiated by our group, investigating the role of aspirin as adjuvant after surgery for colorectal liver metastases, is still recruiting patients and has now 300 of 800 patients included (www.asac.no). The trial is funded by Research Council of Norway, Norwegian Cancer Society, and KLINBEFORSK.
EXCALIBUR study; single centre, un-blinded, three-armed randomized trial for patients with high load of colorectal liver metastases, treated with 1)liver transplantation 2)liver resection 3)hepatic artery infusion of chemotherapy. The trial is approved by the Ethical committee and Norwegian Medicinal Agency and will to be initiated in 2021 (www.excaliburstudy.com).
Precision Medicine in Early Diagnostics and Therapy of Biliary Tract Cancer; is a collaborative project between several groups, led by Sheraz Yaqub, started December 2020.
TESLA trial: Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a prospective exploratory trial; this is a collaborative study between several groups at OUH-KIT treating patients with cholangiocarcinoma
CAMINO study: Investigate the value of MRI in assessing CRC liver mets compared to CT scan, and if MRI affects the surgical decision.
Rangelova E, Stoop TF, van Ramshorst TME, Ali M, van Bodegraven EA, Javed AA, Hashimoto D, Steyerberg E, Banerjee A, Jain A, Sauvanet A, Serrablo A, Giani A, Giardino A, Zerbi A, Arshad A, Wijma AG, Coratti A, Zironda A, Socratous A, Rojas A, Halimi A, Ejaz A, Oba A, Patel BYet al.(2025) The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study Ann Oncol(in press) DOI 10.1016/j.annonc.2024.12.015, PubMed 39814200
Braadland PR, Farnes I, Kure EH, Yaqub S, McCann A, Ueland PM, Labori KJ, Hov JR(2024) Indole 3-acetate and response to therapy in borderline resectable or locally advanced pancreatic cancer Front Oncol, 14, 1488749 DOI 10.3389/fonc.2024.1488749, PubMed 39759130
Høye E, Kanduri C, Torgunrud A, Lorenz S, Edwin B, Larsen SG, Fretland ÅA, Dagenborg VJ, Flatmark K, Lund-Andersen C(2025) Enrichment of Cancer-Associated Fibroblasts, Macrophages, and Up-Regulated TNF-α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis Cancer Med, 14(1), e70521 DOI 10.1002/cam4.70521, PubMed 39739693