Publications 2024

Dagenborg VJ, Brudvik KW, Lund-Andersen C, Torgunrud A, Lund-Iversen M, Flatmark K, Larsen SG, Yaqub S (2024)
Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy and Liver Resection is a Treatment Option for Patients With Peritoneal and Liver Metastases From Colorectal Cancer
Ann Surg, 280 (5), 745-752
DOI 10.1097/SLA.0000000000006492, PubMed 39185557

Grønvold LAB, Mjørud Forsmo H, Pfeffer F, Norderval S, Sjo O, Brunborg C, Brudvik KW, Thomas Seeberg L (2024)
Aggregated 1-year complication rates and health-related quality of life after reconstructive surgery for rectal cancer with or without diverting stoma (Norwegian Stoma Trial): a protocol for national multicentre, open-label, prospective cohort study
BJS Open, 8 (1)
DOI 10.1093/bjsopen/zrae010, PubMed 38386703

Publications 2023

Sahakyan MA, Brudvik KW, Angelsen JH, Dille-Amdam RG, Sandvik OM, Edwin B, Nymo LS, Lassen K (2023)
Preoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Study
World J Surg, 47 (9), 2213-2220
DOI 10.1007/s00268-023-07035-z, PubMed 37140610

Vega EA, Newhook TE, Mellado S, Ruzzenente A, Okuno M, De Bellis M, Panettieri E, Ahmad MU, Merlo I, Rojas J, De Rose AM, Nishino H, Sinnamon AJ, Donadon M, Hauger MS, Guevara OA, Munoz C, Denbo JW, Chun YS, Tran Cao HS, Sanchez Claria R, Tzeng CD, De Aretxabala X, Vivanco M, Brudvik KW et al. (2023)
Benchmarks and Geographic Differences in Gallbladder Cancer Surgery: An International Multicenter Study
Ann Surg Oncol, 30 (8), 4904-4911
DOI 10.1245/s10434-023-13531-2, PubMed 37149547

Publications 2022

Sahakyan MA, Aghayan DL, Edwin B, Alikhanov R, Britskaia N, Brudvik KW, D'Hondt M, De Meyere C, Efanov M, Fretland ÅA, Hoff R, Ismail W, Ivanecz A, Kazaryan AM, Lassen K, Magdalenić T, Parmentier I, Røsok BI, Villanger O, Yaqub S (2022)
Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study
Scand J Gastroenterol, 58 (5), 489-496
DOI 10.1080/00365521.2022.2143724, PubMed 36373379

Publications 2021

Berg KCG, Brunsell TH, Sveen A, Alagaratnam S, Bjørnslett M, Hektoen M, Brudvik KW, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA (2021)
Genomic and prognostic heterogeneity among RAS/BRAF^V600E /TP53 co-mutated resectable colorectal liver metastases
Mol Oncol, 15 (4), 830-845
DOI 10.1002/1878-0261.12885, PubMed 33325154

Dueland S, Yaqub S, Syversveen T, Carling U, Hagness M, Brudvik KW, Line PD (2021)
Survival Outcomes After Portal Vein Embolization and Liver Resection Compared With Liver Transplant for Patients With Extensive Colorectal Cancer Liver Metastases
JAMA Surg, 156 (6), 550-557
DOI 10.1001/jamasurg.2021.0267, PubMed 33787838

Moosavi SH, Eide PW, Eilertsen IA, Brunsell TH, Berg KCG, Røsok BI, Brudvik KW, Bjørnbeth BA, Guren MG, Nesbakken A, Lothe RA, Sveen A (2021)
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
Genome Med, 13 (1), 143
DOI 10.1186/s13073-021-00956-1, PubMed 34470666

Publications 2020

Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
Clin Cancer Res, 26 (15), 4107-4119
DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813

Publications 2019

Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, Song J, Li L, Dagenborg VJ, Fretland ÅA, Røsok B, De Rose AM, Ardito F, Edwin B, Panettieri E, Larocca LM, Yamashita S, Conrad C, Aloia TA, Poston GJ, Bjørnbeth BA, Vauthey JN (2019)
RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases
Ann Surg, 269 (1), 120-126
DOI 10.1097/SLA.0000000000002319, PubMed 28549012

Brudvik KW, Shindoh J (2019)
Limitations of molecular biomarkers in patients with resectable colorectal liver metastases
Chin Clin Oncol, 8 (5), 48
DOI 10.21037/cco.2019.08.02, PubMed 31500431

Brudvik KW, Yaqub S, Kemsley E, Coolsen MME, Dejong CHC, Wigmore SJ, Lassen K (2019)
Survey of the attitudes of hepatopancreatobiliary surgeons in northern Europe to resection of choledochal cysts in asymptomatic Western adults
BJS Open, 3 (6), 785-792
DOI 10.1002/bjs5.50208, PubMed 31832585

Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
Eur J Surg Oncol, 45 (12), 2340-2346
DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075

Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
Clin Colorectal Cancer, 19 (1), e26-e47
DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351

Lillemoe HA, Brudvik KW, Vauthey JN (2019)
Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review
Semin Liver Dis, 39 (3), 395-402
DOI 10.1055/s-0039-1685517, PubMed 31100757

Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
HPB (Oxford), 21 (8), 1017-1023
DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198

Schulz A, Joelsen-Hatlehol ES, Brudvik KW, Aasand KK, Hanekamp B, Viktil E, Johansen CK, Dormagen JB (2019)
Preoperative detection of colorectal liver metastases: DWI alone or combined with MDCT is no substitute for Gd-EOB-DTPA-enhanced MRI
Acta Radiol, 61 (3), 302-311
DOI 10.1177/0284185119864000, PubMed 31335157

Publications 2018

Brudvik KW, Røsok B, Naresh U, Yaqub S, Fretland ÅA, Labori KJ, Edwin B, Bjørnbeth BA (2018)
Survival after resection of colorectal liver metastases in octogenarians and sexagenarians compared to their respective age-matched national population
Hepatobiliary Surg Nutr, 7 (4), 234-241
DOI 10.21037/hbsn.2017.09.03, PubMed 30221151

Brudvik KW, Søreide K (2018)
Association between the lymph node ratio and hepatic tumor burden: importance for resectable colorectal liver metastases?
Hepatobiliary Surg Nutr, 7 (3), 206-208
DOI 10.21037/hbsn.2018.03.02, PubMed 30046575

Kleive D, Sahakyan M, Søreide K, Brudvik KW, Line PD, Gladhaug IP, Labori KJ (2018)
Risk for hemorrhage after pancreatoduodenectomy with venous resection
Langenbecks Arch Surg, 403 (8), 949-957
DOI 10.1007/s00423-018-1721-y, PubMed 30397778

Lassen K, Nymo LS, Olsen F, Brudvik KW, Fretland ÅA, Søreide K (2018)
Contemporary practice and short-term outcomes after liver resections in a complete national cohort
Langenbecks Arch Surg, 404 (1), 11-19
DOI 10.1007/s00423-018-1737-3, PubMed 30519886

Yamashita S, Brudvik KW, Kopetz SE, Maru D, Clarke CN, Passot G, Conrad C, Chun YS, Aloia TA, Vauthey JN (2018)
Embryonic Origin of Primary Colon Cancer Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colon Cancer Liver Metastases
Ann Surg, 267 (3), 514-520
DOI 10.1097/SLA.0000000000002087, PubMed 28002060

Publications 2017

Bendvold B, Refsum A, Schjøth-Iversen L, Bringedal K, Husby A, Brudvik KW (2017)
Unplanned readmission and outpatient examination 90-days after acute appendectomy in adults
Am J Surg, 216 (2), 217-221
DOI 10.1016/j.amjsurg.2017.07.020, PubMed 28760356

Brudvik KW, Vauthey JN (2017)
Surgery: KRAS mutations and hepatic recurrence after treatment of colorectal liver metastases
Nat Rev Gastroenterol Hepatol, 14 (11), 638-639
DOI 10.1038/nrgastro.2017.129, PubMed 28930294

Jones RP, Brudvik KW, Franklin JM, Poston GJ (2017)
Precision surgery for colorectal liver metastases: Opportunities and challenges of omics-based decision making
Eur J Surg Oncol, 43 (5), 875-883
DOI 10.1016/j.ejso.2017.02.014, PubMed 28302330

Labori KJ, Brudvik KW (2017)
Follow-up After Surgery for Pancreatic Ductal Adenocarcinoma: Steps Toward an International Consensus
Pancreas, 46 (1), e2-e3
DOI 10.1097/MPA.0000000000000689, PubMed 27977631

Labori KJ, Guren MG, Brudvik KW, Røsok BI, Waage A, Nesbakken A, Larsen S, Dueland S, Edwin B, Bjørnbeth BA (2017)
Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival
Colorectal Dis, 19 (8), 731-738
DOI 10.1111/codi.13622, PubMed 28181384

Schjøth-Iversen L, Refsum A, Brudvik KW (2017)
Factors associated with hernia recurrence after laparoscopic total extraperitoneal repair for inguinal hernia: a 2-year prospective cohort study
Hernia, 21 (5), 729-735
DOI 10.1007/s10029-017-1634-7, PubMed 28752424

Seeberg LT, Brunborg C, Waage A, Hugenschmidt H, Renolen A, Stav I, Bjørnbeth BA, Borgen E, Naume B, Brudvik KW, Wiedswang G (2017)
Survival Impact of Primary Tumor Lymph Node Status and Circulating Tumor Cells in Patients with Colorectal Liver Metastases
Ann Surg Oncol, 24 (8), 2113-2121
DOI 10.1245/s10434-017-5818-2, PubMed 28258416

Publications 2016

Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
Aspirin As Secondary Prevention in Patients With Colorectal Cancer: An Unselected Population-Based Study
J Clin Oncol, 34 (21), 2501-8
DOI 10.1200/JCO.2015.65.3519, PubMed 27247217

Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
Reply to M. Løberg et al
J Clin Oncol, 35 (5), 569-571
DOI 10.1200/JCO.2016.70.8263, PubMed 29236616

Barkhatov L, Fretland ÅA, Kazaryan AM, Røsok BI, Brudvik KW, Waage A, Bjørnbeth BA, Sahakyan MA, Edwin B (2016)
Validation of clinical risk scores for laparoscopic liver resections of colorectal liver metastases: A 10-year observed follow-up study
J Surg Oncol, 114 (6), 757-763
DOI 10.1002/jso.24391, PubMed 27471127

Brudvik KW, Mise Y, Chung MH, Chun YS, Kopetz SE, Passot G, Conrad C, Maru DM, Aloia TA, Vauthey JN (2016)
RAS Mutation Predicts Positive Resection Margins and Narrower Resection Margins in Patients Undergoing Resection of Colorectal Liver Metastases
Ann Surg Oncol, 23 (8), 2635-43
DOI 10.1245/s10434-016-5187-2, PubMed 27016292

Brudvik KW, Passot G, Vauthey JN (2016)
Colorectal Liver Metastases: A Changing Treatment Landscape
J Oncol Pract, 12 (1), 40-1
DOI 10.1200/JOP.2015.009746, PubMed 26759465

Brudvik KW, Vauthey JN (2016)
Re "Comparison of techniques for volumetric analysis of the future liver remnant: implications for major hepatic resections"
HPB (Oxford), 18 (6), 557
DOI 10.1016/j.hpb.2016.02.008, PubMed 27317961

Denbo JW, Yamashita S, Passot G, Egger M, Chun YS, Kopetz SE, Maru D, Brudvik KW, Wei SH, Conrad C, Vauthey JN, Aloia TA (2016)
RAS Mutation Is Associated with Decreased Survival in Patients Undergoing Repeat Hepatectomy for Colorectal Liver Metastases
J Gastrointest Surg, 21 (1), 68-77
DOI 10.1007/s11605-016-3189-9, PubMed 27334313

Mise Y, Aloia TA, Brudvik KW, Schwarz L, Vauthey JN, Conrad C (2016)
Parenchymal-sparing Hepatectomy in Colorectal Liver Metastasis Improves Salvageability and Survival
Ann Surg, 263 (1), 146-52
DOI 10.1097/SLA.0000000000001194, PubMed 25775068

Mise Y, Day RW, Vauthey JN, Brudvik KW, Schwarz L, Prakash L, Parker NH, Katz MH, Conrad C, Lee JE, Fleming JB, Aloia TA (2016)
After Pancreatectomy, the “90 Days from Surgery” Definition Is Superior to the “30 Days from Discharge” Definition for Capture of Clinically Relevant Readmissions
J Gastrointest Surg, 20 (1), 77-84; discussion 84
DOI 10.1007/s11605-015-2984-z, PubMed 26493976

Mise Y, Passot G, Wang X, Chen HC, Wei S, Brudvik KW, Aloia TA, Conrad C, Huang SY, Vauthey JN (2016)
A Nomogram to Predict Hypertrophy of Liver Segments 2 and 3 After Right Portal Vein Embolization
J Gastrointest Surg, 20 (7), 1317-23
DOI 10.1007/s11605-016-3145-8, PubMed 27073080

Passot G, Chun YS, Kopetz SE, Zorzi D, Brudvik KW, Kim BJ, Conrad C, Aloia TA, Vauthey JN (2016)
Predictors of Safety and Efficacy of 2-Stage Hepatectomy for Bilateral Colorectal Liver Metastases
J Am Coll Surg, 223 (1), 99-108
DOI 10.1016/j.jamcollsurg.2015.12.057, PubMed 26968325

Passot G, Denbo JW, Yamashita S, Kopetz SE, Chun YS, Maru D, Overman MJ, Brudvik KW, Conrad C, Aloia TA, Vauthey JN (2016)
Is hepatectomy justified for patients with RAS mutant colorectal liver metastases? An analysis of 524 patients undergoing curative liver resection
Surgery, 161 (2), 332-340
DOI 10.1016/j.surg.2016.07.032, PubMed 27592215

Passot G, Vaudoyer D, Messager M, Brudvik KW, Kim BJ, Mariette C, Glehen O (2016)
Is Extended Lymphadenectomy Needed for Elderly Patients With Gastric Adenocarcinoma?
Ann Surg Oncol, 23 (8), 2391-7
DOI 10.1245/s10434-016-5260-x, PubMed 27169773

Publications 2015

Brudvik KW, Kopetz SE, Li L, Conrad C, Aloia TA, Vauthey JN (2015)
Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases
Br J Surg, 102 (10), 1175-83
DOI 10.1002/bjs.9870, PubMed 26206254

Brudvik KW, Mise Y, Conrad C, Zimmitti G, Aloia TA, Vauthey JN (2015)
Definition of Readmission in 3,041 Patients Undergoing Hepatectomy
J Am Coll Surg, 221 (1), 38-46
DOI 10.1016/j.jamcollsurg.2015.01.063, PubMed 26047760

Brudvik KW, Patel SH, Roland CL, Conrad C, Torres KE, Hunt KK, Cormier JN, Feig BW, Aloia TA, Vauthey JN (2015)
Survival After Resection of Gastrointestinal Stromal Tumor and Sarcoma Liver Metastases in 146 Patients
J Gastrointest Surg, 19 (8), 1476-83
DOI 10.1007/s11605-015-2845-9, PubMed 26001368

Brudvik KW, Seeberg LT, Hugenschmidt H, Renolen A, Schirmer CB, Brunborg C, Bjørnbeth BA, Borgen E, Naume B, Waage A, Wiedswang G (2015)
Detection of Circulating Tumor Cells at Surgery and at Follow-Up Assessment to Predict Survival After Two-Stage Liver Resection of Colorectal Liver Metastases
Ann Surg Oncol, 22 (12), 4029-37
DOI 10.1245/s10434-015-4482-7, PubMed 25801354

Brudvik KW, Vauthey JN (2015)
Peeling-off technique or bile duct resection of tumor thrombus in hepatocellular carcinoma: does future liver-directed treatment justify less extensive surgery?
Ann Surg, 261 (5), e126
DOI 10.1097/SLA.0000000000001210, PubMed 25775077

Day RW, Brudvik KW, Vauthey JN, Conrad C, Gottumukkala V, Chun YS, Katz MH, Fleming JB, Lee JE, Aloia TA (2015)
Advances in hepatectomy technique: Toward zero transfusions in the modern era of liver surgery
Surgery, 159 (3), 793-801
DOI 10.1016/j.surg.2015.10.006, PubMed 26584854

Seeberg LT, Waage A, Brunborg C, Hugenschmidt H, Renolen A, Stav I, Bjørnbeth BA, Brudvik KW, Borgen EF, Naume B, Wiedswang G (2015)
Circulating tumor cells in patients with colorectal liver metastasis predict impaired survival
Ann Surg, 261 (1), 164-71
DOI 10.1097/SLA.0000000000000580, PubMed 24509211

Publications 2014

Mise Y, Kopetz S, Mehran RJ, Aloia TA, Conrad C, Brudvik KW, Taggart MW, Vauthey JN (2014)
Is complete liver resection without resection of synchronous lung metastases justified?
Ann Surg Oncol, 22 (5), 1585-92
DOI 10.1245/s10434-014-4207-3, PubMed 25373535

Publications 2013

Brudvik KW, Bains SJ, Seeberg LT, Labori KJ, Waage A, Taskén K, Aandahl EM, Bjørnbeth BA (2013)
Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience
HPB Surg, 2013, 727095
DOI 10.1155/2013/727095, PubMed 23840074

Publications 2012

Brudvik KW, Taskén K (2012)
Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states
Br J Pharmacol, 166 (2), 411-9
DOI 10.1111/j.1476-5381.2011.01800.x, PubMed 22141738

Hagness M, Henjum K, Landskron J, Brudvik KW, Bjørnbeth BA, Foss A, Taskén K, Aandahl EM (2012)
Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells
J Immunol, 188 (11), 5459-66
DOI 10.4049/jimmunol.1101367, PubMed 22539784

Publications 2011

Brudvik KW, Henjum K, Aandahl EM, Bjørnbeth BA, Taskén K (2011)
Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
Cancer Immunol Immunother, 61 (7), 1045-53
DOI 10.1007/s00262-011-1174-4, PubMed 22159472

Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011)
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice
Mol Cancer, 10, 149
DOI 10.1186/1476-4598-10-149, PubMed 22168384