Bendik S. Winsvold
- Group leader, Senior researcher; PhD
Background
Bendik S Winsvold has a medical degree from Royal College of Surgeons in Ireland (2006), and started specializing in neurology at Oslo University Hospital in 2008. His PhD (2014) was on the genetic basis of migraine, and the relationship between migraine and cardiovascular disease. He has worked as visiting scientist at the department of Human Genetics, Wellcome Trust Sanger Institute (Cambridge, UK) for two years (2011-2012), and at the Broad Institute of MIT and Harvard (Boston, USA) for six months (2014-2015). His main research focus has since been on the genetics of neurological and psychiatric disorders. He organizes the neuropsychiatric arm of a large genetic study (HUNT-MI/All-In) of 70,000 participants in the HUNT Study (https://www.ntnu.edu/huntgenes/research). Former secretary, and active member, of the International Headache Genetics Consortium. Alongside his research activity, he takes a special interest in the follow-up of patients with headache at the department of Neurology.
Research Projects
- HUNT-MI (All-In) (https://www.ntnu.edu/huntgenes/people) (member of advisory group, organizes the Neuropsychiatry arm)
- Genetic and environmental causes of migraine, a large-scale family-based analysis (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=560689&p_parent_id=578614&_ikbLanguageCode=n)
- Genetic risk variants in migraine and cardiovascular disease. The Gene HUNT study (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=324998&p_parent_id=331878&_ikbLanguageCode=n)
- The importance of factors early in life for the development of migraine (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=359603&p_parent_id=385780&_ikbLanguageCode=n)
- Environmental and genetic causes of migraine in children and adolescents (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=940235&p_parent_id=954699&_ikbLanguageCode=n)
- Migraine, obesity and body fat distribution (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=456013&p_parent_id=473370&_ikbLanguageCode=n)
- Headache biomarkers (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=348304&p_parent_id=351133&_ikbLanguageCode=n)
- Familial Hemiplegic Migraine in Norway (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=546944&p_parent_id=566506&_ikbLanguageCode=n)
- Chronification and reversibility in medication-overuse headache (project leader) (https://helseforskning.etikkom.no/prosjekterirek/prosjektregister/prosjekt?p_document_id=546947&p_parent_id=658799&_ikbLanguageCode=n)
Supervision of PhD candidates
- Main supervisor for Sigrid Børte (MD)
- Co-supervisor for Marie Udnesseter Lie (MSc) and Ioannis Kitsos (MD)
Methodology and interests
- Population genetics of neurological and psychiatric disorders. Epigenetics. Epidemiological studies of chronic pain disorders and headache. Organizes the neuropsychiatric arm of the HUNT-MI (All-In) study (https://www.ntnu.edu/huntgenes/research).
Publications
- Lane JM, Jones S, Dashti HS, Wood AR, Aragam KG, van Hees VT, Brumpton B, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman J, Winkelmann J, HUNT All In Sleep, Strand LB, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart J-A, Hveem K, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics 2018 (accepted).
- Åsberg AN, Hagen K, Stovner LJ, Heuch I, Zwart JA, Winsvold BS. Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study. Plos One 2018 Sep 28;13(9):e0203925. doi: 10.1371/journal.pone.0203925.
- Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain I, McGuire D, Tian C [... ] Winsvold BSal. Association studies of up to 1.2 million individuals yield new insights in the genetic etiology of tobacco and alcohol use. Nature Genetics 2018 (accepted)
- Yang Y, Zhao H, Boomsma DI, Ligthart L, Belin AC, Smith GD, Esko T, Freilinger TM, Hansen TF, Ikram MA, Kallela M, Kubisch C, Paraskevi C, Strachan DP, Wessman M; International Headache Genetics Consortium [Winsvold B.S.], van den Maagdenberg AMJM, Terwindt GM, Nyholt DR.Molecular genetic overlap between migraine and major depressive disorder. Eur J Hum Genet 2018 [Epub ahead of print]
- Anttila V., Bulik-Sullivan B., Finucane H.K., Walters R.K., Bras J., Duncan L., Escott-Price V., Falcone G.J., [...] Winsvold B.al. Analysis of shared heritability in common disorders of the brain. Science 2018 Jun 22;360(6395).
- Johnsen M.B, Winsvold B.S., Børte S., Vie G.Å., Pedersen L.M., Storheim K., Skorpen F., Hagen K., Bjørngaard J.H., Åsvold B.O., Zwart J.-A. The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study. Eur J Neurology 2018 (Epub ahead of print).
- Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC) [Winsvold B.S.], Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron 2018 May 16;98(4):743-753.e4.
- Hagen K., Kristoffersen E.S., Winsvold B.S., Stovner L., Zwart J.-A. Remission of chronic headache: an 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008. Cephalalgia 2018 (Epub ahead of print).
- Kambur O., Kaunisto M.A., Winsvold B.S., Wilsgaard T., Stubhaug A., Zwart J.A., Kalso E., Nielsen C.S.. Genetic Variation in P2rx7 and Pain Tolerance. Pain 2018 Feb 20 (Epub ahead of print).
- Hagen K., Åsberg A.N., Stovner L., Linde M., Zwart J.-A., Winsvold B.S., Heuch I. Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008. Cephalalgia 2018 (Epub ahead of print).
- Winsvold B.S., Marvik A., Zwart J.A., Aamodt A.H. Migraine and stroke. Tidsskr Nor Laegeforen. 2018 Feb 19 (Epub ahead of print).
- Winsvold B.S., Bettella F., Witoelar A., Anttila V., Gormley P., Kurth T., Terwindt G.M., Freilinger T.M., Frei O., Shadrin A., Wang Y., Dale A.M., van den Maagdenberg A., Chasman D.I., Nyholt D.R., Palotie A., Andreassen O.A., Zwart J.A., International Headache Genetics C. Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLoS One 2017: Sep 28;12(9):e0185663.
- Børte S., Winsvold B.S., Stensland S.Ø., Småstuen M.C., Zwart J.A. The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. PLoS One 2017:12(4):e0175908.
- Winsvold B.S., Palta P., Eising E., Page C.M., International Headache Genetics C., van den Maagdenberg A.M., Palotie A., Zwart J.A. Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia 2017: doi: 10.1177/0333102417690111 (Epub ahead of print).
- Johnsen M.B., Vie G.A., Winsvold B.S., Bjorngaard J.H., Asvold B.O., Gabrielsen M.E., Pedersen L.M., Hellevik A.I., Langhammer A., Furnes O., Flugsrud G.B., Skorpen F., Romundstad P.R., Storheim K., Nordsletten L., Zwart J.A. The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. Osteoarthritis Cartilage 2017 (Epub ahead of print).
- Gustavsen, M.W., Celius, E.G., Winsvold, B.S., Moen, S.M., Nygaard, G.O., Berg-Hansen, P., Lie, B.A., Zwart, J.-A., Harbo, H.F. Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study. Multiple Sclerosis Journal – Experimental, Translational and Clinical 2016: 10.1177/2055217316682976.
- Gormley P., Winsvold B.S., Nyholt D.R., Kallela M., Chasman D.I., Palotie A. Migraine genetics: from genome-wide association studies to translational insights. Genome Medicine 2016;8:86.
- Gormley P., Anttila V., Winsvold B.S., Palta P., Esko T., Pers T.H., Farh K.H., Cuenca-Leon E., Muona M., Furlotte N.A., Kurth T., Ingason A., McMahon G., Ligthart L., Terwindt G.M., Kallela M., Freilinger T.M., Ran C., Gordon S.G., Stam A.H., Steinberg S., Borck G., Koiranen M., Quaye L., Adams H.H., Lehtimaki T., Sarin A.P., Wedenoja J., Hinds D.A., Buring J.E., Schurks M., Ridker P.M., Hrafnsdottir M.G., Stefansson H., Ring S.M., Hottenga J.J., Penninx B.W., Farkkila M., Artto V., Kaunisto M., Vepsalainen S., Malik R., Heath A.C., Madden P.A., Martin N.G., Montgomery G.W., Kurki M.I., Kals M., Magi R., Parn K., Hamalainen E., Huang H., Byrnes A.E., Franke L., Huang J., Stergiakouli E., Lee P.H., Sandor C., Webber C., Cader Z., Muller-Myhsok B., Schreiber S., Meitinger T., Eriksson J.G., Salomaa V., Heikkila K., Loehrer E., Uitterlinden A.G., Hofman A., van Duijn C.M., Cherkas L., Pedersen L.M., Stubhaug A., Nielsen C.S., Mannikko M., Mihailov E., Milani L., Gobel H., Esserlind A.L., Christensen A.F., Hansen T.F., Werge T., International Headache Genetics C., Kaprio J., Aromaa A.J., Raitakari O., Ikram M.A., Spector T., Jarvelin M.R., Metspalu A., Kubisch C., Strachan D.P., Ferrari M.D., Belin A.C., Dichgans M., Wessman M., van den Maagdenberg A.M., Zwart J.A., Boomsma D.I., Smith G.D., Stefansson K., Eriksson N., Daly M.J., Neale B.M., Olesen J., Chasman D.I., Nyholt D.R., Palotie A. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics 2016;48(8): 856-866.
- Eising E., Huisman S.M., Mahfouz A., Vijfhuizen L.S., Anttila V., Winsvold B.S., Kurth T., Ikram M.A., Freilinger T., Kaprio J., Boomsma D.I., van Duijn C.M., Jarvelin M.R., Zwart J.A., Quaye L., Strachan D.P., Kubisch C., Dichgans M., Davey Smith G., Stefansson K., Palotie A., Chasman D.I., Ferrari M.D., Terwindt G.M., de Vries B., Nyholt D.R., Lelieveldt B.P., van den Maagdenberg A.M., Reinders M.J. Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Human Genetics 2016;135(4):425-439.
- Åsberg A.N., Stovner L., Zwart J.A., Winsvold B.S., Heuch I., Hagen K. Chronic musculoskeletal complaints as a predictor of mortality. The HUNT study. Pain 2016;157:1443-1447.
- Malik R., Winsvold B.S., Auffenberg E., Dichgans M., Freilinger T. The migraine–stroke connection: A genetic perspective. Cephalalgia 2016;36(7):658-668.
- Srinivasan S., Bettella F., Mattingsdal M., Wang Y., Witoelar A., Schork A.J., Thompson W.K., Zuber V., The Schizophrenia Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, Winsvold B.S., Zwart J.A., Collier D.A. Desikan R.S., Melle I., Werge T., Dale A.M., Djurovic S., Andreassen O.A. Genetic markers of human evolution are enriched in schizophrenia.Biological Psychiatry 2015;80(4):284-92.
- Zhao H., Eising E., de Vries B., Anttila V., Winsvold B.S., Kurth T., Stefansson H., Kallela M., Malik R., Stam A.H., Ikram M.A., Ligthart L., Freilinger T., Alexander M., Muller-Myhsok B., Schreiber S., Meitinger T., Aromaa A., Eriksson J.G., Boomsma D.I., van Duijn C.M., Zwart J.-A., Quaye L., Kubisch C., Dichgans M., Wessman M., Stefansson K., Chasman D.I., Palotie A., Martin N.G., Montgomery G.W., Ferrari M.D., Terwindt G.M., van den Maagdenberg A.M.J.M., Nyholt D.R. Gene-based pleiotropy across migraine with aura and migraine without aura. Cephalalgia2016;36(7):648-657.
- Winsvold B.S., Nelson C.P., Malik R., Gormley P., Anttila V., Vander Heiden J., Elliott K.S., Jacobsen L.M., Palta P., Amin N., de Vries B., Hämäläinen E., Freilinger T., Ikram M.A., Kessler T., Koiranen M., Ligthart L., McMahon G., Pedersen L.M., Willenborg C., Won H.-H., Olesen J., Artto V., Assimes T.L., Blankenberg S., Boomsma D.I., Cherkas L., Smith G.D., Epstein S.E., Erdmann J., Ferrari M.D., Göbel H., Hall A.S., Jarvelin M.-R., Kallela M., Kaprio J., Kathiresan S., Lehtimäki T., McPherson R., März W., Nyholt D., O’Donnell C.J., Quaye L., Rader D.J., Raitakari O., Roberts R., Schunkert H., Schürks M., Stewart A.F.R., Terwindt G.M., Thorsteinsdottir U., van den Maagdenberg A.M.J.M, van Duijn C., Wessman M., Kurth T., Kubisch C., Dichgans M., Chasman D.I., Cotsapas C., Zwart J.-A., Samani N.J., Palotie A. for the CARDIoGRAM Consortium and the International Headache Genetics Consortium. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurology: Genetics 2015; 1(1);doi:http://dx.doi.org/10.1212/NXG. 00000000000010.
- Kvalheim S., Sandvik L., Winsvold B., Hagen K., Zwart J.A. (2016) Early menarche and chronic widespread musculoskeletal complaints- Results from the HUNT study.European Journal of Pain 2016: 20(3): 458-464.
- Asberg A.N., Stovner L.J., Zwart J.A., Winsvold B.S., Heuch I., Hagen K. Migraine as a predictor of mortality: The HUNT study. Cephalalgia 2016 36: 351-357.
- Malik R., Freilinger T., Winsvold B.S., Anttila V., Vander Heiden J., Traylor M., de Vries B., Holliday E.G., Terwindt G.M., Sturm J., Bis J.C., Hopewell J.C., Ferrari M.D., Rannikmae K., Wessman M., Kallela M., Kubisch C., Fornage M., Meschia J.F., Lehtimaki T., Sudlow C., Clarke R., Chasman D.I., Mitchell B.D., Maguire J., Kaprio J., Farrall M., Raitakari O.T., Kurth T., Ikram M.A., Reiner A.P., Longstreth W.T., Jr., Rothwell P.M., Strachan D.P., Sharma P., Seshadri S., Quaye L., Cherkas L., Schurks M., Rosand J., Ligthart L., Boncoraglio G.B., Davey Smith G., van Duijn C.M., Stefansson K., Worrall B.B., Nyholt D.R., Markus H.S., van den Maagdenberg A.M., Cotsapas C., Zwart J.A., Palotie A., Dichgans M. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology 2015;84:2132-2145.
- Jacobsen K.K., Nievergelt C.M., Zayats T., Greenwood T.A., Anttila V., Akiskal H.S., Kelsoe J.R., Greenwood T.A., Nievergelt C.M., McKinney R., Shilling P.D., Smith E.N., Schork N.J., Bloss C.S., Nurnberger J.I.J., Edenberg H.J., Foroud T., Koller D.L., Gershon E.S., Badner J.A., Liu C., Scheftner W.A., Lawson W.B., Nwulia E.A., Hipolito M., Potash J., Coryell W., Rice J., Byerley W., McMahon F.J., Berrettini W.H., Zandi P.P., Mahon P.B., McInnis M.G., Zöllner S., Zhang P., Craig D.W., Szelinger S., Barrett T.B., Schulze T.G., Wedenoja J., Kaunisto M.A., Heikkilä K., Kaprio J., Wessman M., Kallela M., Färkkilä M., Artto V., Aromaa A., Eriksson J.G., Winsvold B.S., Zwart J., Gormley P., Palotie A., Kurth T., Rose L.M., Buring J.E., Ridker P.M., Chasman D.I., Bettella F., Steinberg S., Stefansson H., Stefansson K., McMahon G., Davey-Smith G., Malik R., Freilinger T., Wichmann H.E., Dichgans M., Muller-Myhsok B., Meitinger T., de Vries B., Terwindt G., Stam A.H., Frants R.R., Pelzer N., Weller C.M., Zielman R., Ferrari M.D., van den Maagdenberg A.M., Medland S.E., Montgomery G.W., Martin N.G., Nyholt D.R., Todt U., Borck G., Kubisch C., Quaye L., Williams F.M.K., Cherkas L., Koiranen M., Hartikainen A., Pouta A., Jarvelin M., Ikram M.A., van den Ende J., Uitterlinden A.G., Hofman A., Amin N., van Duijn C., Lehtimäki T., Ligthart L., Hottenga J., Vink J.M., Penninx B.W., Boomsma D.I., Schürks M., Jakobsson F., Schoenen J., Heath A.C., Madden P.A.F., Göbel H., Heinze A., Heinze-Kuhn K., Schreiber S., Anttila V., Daly M.J., Alexander M., Raitakari O., Strachan D.P., Haavik J., Fasmer O.B., Kelsoe J.R., Johansson S., Oedegaard K.J. Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. J Affect Disord 2015;10: 453-461.
- Louter M.A.*, Fernandez-Morales J.*, de Vries B., Winsvold B., Anttila V., Fernandez-Cadenas I., Vila-Pueyo M., Sintas C., van Duijn C.M., Cormand B., Álvarez-Sabin J., Montaner J., Ferrari M.D., van den Maagdenberg M.J.M., Palotie A., Zwart J.A., Macaya A., Terwindt G.M., Pozo-Rosich P. Candidate gene association study searching for genetic factors involved in migraine chronification. Cephalalgia 2015;35:500-507.
- Nyholt D.R., Anttila V., Winsvold B.S., Kurth, T., Bettella F., Kallela MN., Malik R., de Vries B., Terwindt G., Ikram M.A., Stam A.H., Ligthart L., Freilinger T., Alexander M., Muller-Myhsok B., Schreiber S., Meitinger T., Aromaa A., Eriksson J.G., Kaprio J., Boomsma D.I., van Duijn C., Raitakari O., Jarvelin M.R., Zwart J.A., Cherkas L., Strachan D.P., Kubisch C., Ferrari M.D., van den Maagdenberg A.M., Dichgans M., Wessman M., Davey Smith G., Stefansson K., Chasman D.I. & Palotie A. Concordance of genetic risk across migraine subgroups: impact on current and future genetic association studies. Cephalalgia 2015;35:489-499.
- Fagernæs C.F., Heuch I., Zwart, J.A., Winsvold B., Linde M, Hagen K. Blood pressure as a risk factor for headache and migraine: A prospective population-based study. European Journal of Neurology 2015;22:156-162, e110-151.
- Chasman D.I., Anttila V., Buring J.E., Ridker P.M., Schurks M. Kurth, T., International Headache Genetics Consortium [including Winsvold, B.S.]. Selectivity in Genetic Association with Sub-classified Migraine in Women. PLoS Genet 2014;10:e1004366.
- Jacobsen L.M., Winsvold, B.S., Romundstad, S., Pripp, A.H., Holmen J., Zwart, J.A. Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway. BMJ Open 2013;3(8);doi:10.1136/bmjopen-2013-003268.
- Anttila, V.*, Winsvold, B.S.*, Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S.E., Todt, U., McArdle, W.L., Quaye, L., Koiranen, M., Ikram, M.A., Lehtimaki, T., Stam, A.H., Ligthart, L., Wedenoja, J., Dunham, I., Neale, B.M., Palta, P., Hamalainen, E., Schurks, M., Rose, L.M., Buring, J.E., Ridker, P.M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D.A., Evans, D.M., Ring, S.M., Farkkila, M., Artto, V., Kaunisto, M.A., Freilinger, T., Schoenen, J., Frants, R.R., Pelzer, N., Weller, C.M., Zielman, R., Heath, A.C., Madden, P.A., Montgomery, G.W., Martin, N.G., Borck, G., Gobel, H., Heinze, A., Heinze-Kuhn, K., Williams, F.M., Hartikainen, A.L., Pouta, A., van den Ende, J., Uitterlinden, A.G., Hofman, A., Amin, N., Hottenga, J.J., Vink, J.M., Heikkila, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H.E., Aromaa, A., Eriksson, J.G., Traynor, B.J., Trabzuni, D., North American Brain Expression Consortium, UK Brain Expression Consortium, Rossin, E., Lage, K., Jacobs, S.B., Gibbs, J.R., Birney, E., Kaprio, J., Penninx, B.W., Boomsma, D.I., van Duijn, C., Raitakari, O., Jarvelin, M.R., Zwart, J.A., Cherkas, L., Strachan, D.P., Kubisch, C., Ferrari, M.D., van den Maagdenberg, A.M., Dichgans, M., Wessman, M., Smith, G.D., Stefansson, K., Daly, M.J., Nyholt, D.R., Chasman, D.I. & Palotie, A. , for the International Headache Genetics Consortium. Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nature Genetics 2013;45(8):912-7.*The authors contributed equally.
- Winsvold B, Sandven I, Hagen K, Linde M, Midthjell K, Zwart J-A. Migraine, headache and development of metabolic syndrome: An 11 year follow-up in the HUNT Study. Pain 2013;154(8):1305-11.
- Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, Pozo-Rosich P, Winsvold B, Nyholt D, van osterhout DPJ, Artto V, Todt U, Hämäläinen E, Fernandez-Morales J, Louter M, Kaunisto M, Schoenen J, Raitakari O, Lehtimäki T, Vila-Pueyo M, Göbel H, Wichmann E, Sintas C, Uitterlinden A, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn C, Kaprio J, Cormand B, Wessman M, Frants R, Meitinger T, Müller-Myhsok B, Zwart JA, Färkkilä M, Macaya A, Ferrari M, Kubisch C, Palotie A, Dichgans M, van den Maagdenberg A for the International Headache Genetics Consortium. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genetics 2012;44(7):777-82.
- Boraska V, Day-Williams A, Franklin C, Elliott K, Panoutsopoulou K, Tachmazidou I, Albrecht E, Bandinelli S, Beilin L, Bochud M, Cadby G, Ernst F, Evans D, Hayward C, Hicks A, Huffman J, Huth C, James A, Klopp N, Kolcic I, Kutalik Z, Lawlor D, Musk A, Pehlic M, Pennell C, Perry J, Peters A, Polasek O, Pourcain B, Ring S, Salvi E, Schipf S, Staessen J, Teumer A, Timpson N, Vitart V, Warrington N, Yaghootkar H, Zemunik T, Zgaga L, An P, Anttila V, Borecki I, Holmen J, Ntalla J, Palotie A, Pietiläinen K, Wedenoja J, Winsvold B, Dedoussis G, Kaprio J, Province M, Zwart JA, Burnier M, Campbell, Cusi D, Davey-Smith G, Frayling T, Gieger C, Palmer L, Pramstaller P, Rudan I, Völzke H, Wichmann HE, Wright A, Zeggini E. Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One 2012;7(3):e31369.
- Winsvold B, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA. Headache, migraine and cardiovascular risk factors. The HUNT study. Eur J Neurol 2011;18(3):504-11.
- Lian A, Karlsen PJ, Winsvold B. A re-evaluation of the phonological similarity effect in adults’ short-term memory of words and nonwords. Memory 2001;9:281-299.
Publications 2024
Relationship between migraine and epilepsy in a large population-based cohort: The HUNT Study
Eur J Neurol, e16496 (in press)
DOI 10.1111/ene.16496, PubMed 39331386
Room for improvement in the follow-up for unilateral headache with autonomic symptoms
Tidsskr Nor Laegeforen, 144 (7)
DOI 10.4045/tidsskr.24.0184, PubMed 38832616
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nat Genet, 56 (5), 792-808
DOI 10.1038/s41588-024-01707-9, PubMed 38637617
Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors
Commun Biol, 7 (1), 646
DOI 10.1038/s42003-024-06299-y, PubMed 38802570
Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia
JAMA Netw Open, 7 (5), e2412824
DOI 10.1001/jamanetworkopen.2024.12824, PubMed 38776079
Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci
medRxiv
DOI 10.1101/2024.03.13.24304161, PubMed 38712091
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
medRxiv
DOI 10.1101/2024.07.03.24309466, PubMed 39006447
Publications 2023
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain
Pain, 164 (8), 1841-1851
DOI 10.1097/j.pain.0000000000002882, PubMed 36943258
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
Stroke, 54 (3), 810-818
DOI 10.1161/STROKEAHA.122.040715, PubMed 36655558
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
medRxiv
DOI 10.1101/2023.08.31.23294915, PubMed 37693460
Cluster headache polygenetic risk and known functional variants of CYP3A4 are not associated with treatment response
Eur J Neurol, 30 (5), 1425-1434
DOI 10.1111/ene.15736, PubMed 36773010
Psychiatric comorbidity in relation to clinical characteristics of epilepsy: A retrospective observational study
Seizure, 110, 136-143
DOI 10.1016/j.seizure.2023.06.011, PubMed 37379699
Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics
medRxiv
DOI 10.1101/2023.08.08.23293761, PubMed 37790435
Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor
Ann Neurol, 94 (4), 713-726
DOI 10.1002/ana.26743, PubMed 37486023
Publications 2022
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Brain, 145 (1), 142-153
DOI 10.1093/brain/awab267, PubMed 34273149
Brain-specific genes contribute to chronic but not to acute back pain
Pain Rep, 7 (5), e1018
DOI 10.1097/PR9.0000000000001018, PubMed 35975136
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Nat Genet, 54 (2), 152-160
DOI 10.1038/s41588-021-00990-0, PubMed 35115687
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
Brain, 145 (3), 1111-1123
DOI 10.1093/brain/awab359, PubMed 34788396
Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC
Front Genet, 12, 757632
DOI 10.3389/fgene.2021.757632, PubMed 35140737
Stroke genetics informs drug discovery and risk prediction across ancestries
Nature, 611 (7934), 115-123
DOI 10.1038/s41586-022-05165-3, PubMed 36180795
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
Nature, 612 (7938), E7
DOI 10.1038/s41586-022-05492-5, PubMed 36376532
Genetic diversity fuels gene discovery for tobacco and alcohol use
Nature, 612 (7941), 720-724
DOI 10.1038/s41586-022-05477-4, PubMed 36477530
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 54 (7), 1062
DOI 10.1038/s41588-022-01126-8, PubMed 35726068
A saturated map of common genetic variants associated with human height
Nature, 610 (7933), 704-712
DOI 10.1038/s41586-022-05275-y, PubMed 36224396
Publications 2021
Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 53 (2), 254
DOI 10.1038/s41588-020-00760-4, PubMed 33353957
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cell, 184 (18), 4784-4818.e17
DOI 10.1016/j.cell.2021.07.038, PubMed 34450027
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cell, 184 (24), 6003-6005
DOI 10.1016/j.cell.2021.11.003, PubMed 34822786
The current state of cluster headache genetics
Headache, 61 (7), 990-991
DOI 10.1111/head.14166, PubMed 34363404
Sex- and age-specific genetic analysis of chronic back pain
Pain, 162 (4), 1176-1187
DOI 10.1097/j.pain.0000000000002100, PubMed 33021770
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Ann Neurol, 90 (2), 203-216
DOI 10.1002/ana.26146, PubMed 34180076
The management and clinical knowledge of headache disorders among general practitioners in Norway: a questionnaire survey
J Headache Pain, 22 (1), 136
DOI 10.1186/s10194-021-01350-3, PubMed 34763647
Acute stroke care during the first phase of COVID-19 pandemic in Norway
Acta Neurol Scand, 143 (4), 349-354
DOI 10.1111/ane.13392, PubMed 33421104
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic
PLoS One, 16 (2), e0246567
DOI 10.1371/journal.pone.0246567, PubMed 33539418
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Nat Genet, 53 (6), 817-829
DOI 10.1038/s41588-021-00857-4, PubMed 34002096
Genome-Wide Association Study Identifies Risk Loci for Cluster Headache
Ann Neurol, 90 (2), 193-202
DOI 10.1002/ana.26150, PubMed 34184781
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
Ann Rheum Dis, 80 (9), 1227-1235
DOI 10.1136/annrheumdis-2020-219624, PubMed 33926923
Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia
Pain, 163 (7), e821-e836
DOI 10.1097/j.pain.0000000000002498, PubMed 34913882
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 53 (9), 1276-1282
DOI 10.1038/s41588-021-00921-z, PubMed 34493870
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 53 (12), 1722
DOI 10.1038/s41588-021-00977-x, PubMed 34773122
Genome-Wide Association Study of 2,093 Cases With Idiopathic Polyneuropathy and 445,256 Controls Identifies First Susceptibility Loci
Front Neurol, 12, 789093
DOI 10.3389/fneur.2021.789093, PubMed 34975738
Publications 2020
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 52 (12), 1303-1313
DOI 10.1038/s41588-020-00725-7, PubMed 33199917
Mitochondrial genome-wide association study of migraine - the HUNT Study
Cephalalgia, 40 (6), 625-634
DOI 10.1177/0333102420906835, PubMed 32056457
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
Osteoarthritis Cartilage, 28 (7), 932-940
DOI 10.1016/j.joca.2020.04.005, PubMed 32360252
Response to Letter to the Editor: 'Comments on the paper presenting prediction models for incident hand OA in the HUNT study'
Osteoarthritis Cartilage, 29 (2), 292-293
DOI 10.1016/j.joca.2020.10.012, PubMed 33279719
Migraine, obesity and body fat distribution - a population-based study
J Headache Pain, 21 (1), 97
DOI 10.1186/s10194-020-01163-w, PubMed 32762643
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study
BMJ Open, 10 (11), e040685
DOI 10.1136/bmjopen-2020-040685, PubMed 33208331
Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway
J Headache Pain, 21 (1), 128
DOI 10.1186/s10194-020-01195-2, PubMed 33121445
Correction to: Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway
J Headache Pain, 21 (1), 132
DOI 10.1186/s10194-020-01199-y, PubMed 33198620
Experiences of telemedicine in neurological out-patient clinics during the COVID-19 pandemic
Ann Clin Transl Neurol, 8 (2), 440-447
DOI 10.1002/acn3.51293, PubMed 33377609
The association between selected genetic variants and individual differences in experimental pain
Scand J Pain, 21 (1), 163-173
DOI 10.1515/sjpain-2020-0091, PubMed 33108341
Publications 2019
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
BMJ, 367, l5654
DOI 10.1136/bmj.l5654, PubMed 31619437
Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
Cephalalgia, 39 (7), 854-862
DOI 10.1177/0333102419828989, PubMed 30714392
The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008
BMC Neurol, 19 (1), 229
DOI 10.1186/s12883-019-1462-8, PubMed 31558164
Migraine polygenic risk score associates with efficacy of migraine-specific drugs
Neurol.-Genet., 5 (6), e364
DOI 10.1212/NXG.0000000000000364
Neurology residents' knowledge of the management of headache
Cephalalgia, 39 (11), 1396-1406
DOI 10.1177/0333102419847973, PubMed 31067081
Prestige of neurological disorders among future neurologists in Norway
Acta Neurol Scand, 139 (6), 555-558
DOI 10.1111/ane.13087, PubMed 30851195
Biological and clinical insights from genetics of insomnia symptoms
Nat Genet, 51 (3), 387-393
DOI 10.1038/s41588-019-0361-7, PubMed 30804566
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Nat Genet, 51 (2), 237-244
DOI 10.1038/s41588-018-0307-5, PubMed 30643251
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Nat Commun, 10 (1), 3503
DOI 10.1038/s41467-019-11456-7, PubMed 31409809
Practical management of headache
Tidsskr. Nor. Laegeforen., 139 (7), 617-620
Practical management of headache
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.18.0837, PubMed 30969051
Publications 2018
Analysis of shared heritability in common disorders of the brain
Science, 360 (6395)
DOI 10.1126/science.aap8757, PubMed 29930110
Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (14), 2026-2034
DOI 10.1177/0333102418769940, PubMed 29629599
Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (13), 1919-1926
DOI 10.1177/0333102418764888, PubMed 29517305
The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study
Eur J Neurol, 25 (9), 1148-e102
DOI 10.1111/ene.13675, PubMed 29747220
Genetic variation in P2RX7 and pain tolerance
Pain, 159 (6), 1064-1073
DOI 10.1097/j.pain.0000000000001188, PubMed 29470314
Migraine and stroke
Tidsskr Nor Laegeforen, 138 (4)
DOI 10.4045/tidsskr.17.0347, PubMed 29460580
Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study
PLoS One, 13 (9), e0203925
DOI 10.1371/journal.pone.0203925, PubMed 30265708
Publications 2017
The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study
PLoS One, 12 (4), e0175908
DOI 10.1371/journal.pone.0175908, PubMed 28410431
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
Osteoarthritis Cartilage, 25 (6), 817-823
DOI 10.1016/j.joca.2016.12.021, PubMed 28049019
Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants
PLoS One, 12 (9), e0185663
DOI 10.1371/journal.pone.0185663, PubMed 28957430
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study
Cephalalgia, 38 (2), 312-322
DOI 10.1177/0333102417690111, PubMed 28103696
Publications 2016
Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas
Hum Genet, 135 (4), 425-439
DOI 10.1007/s00439-016-1638-x, PubMed 26899160
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Nat Genet, 48 (8), 856-66
DOI 10.1038/ng.3598, PubMed 27322543
Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Nat Genet, 48 (10), 1296
DOI 10.1038/ng1016-1296c, PubMed 27681292
Migraine genetics: from genome-wide association studies to translational insights
Genome Med, 8 (1), 86
DOI 10.1186/s13073-016-0346-4, PubMed 27543003
Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study
Mult Scler J Exp Transl Clin, 2, 2055217316682976
DOI 10.1177/2055217316682976, PubMed 28607748
Chronic musculoskeletal complaints as a predictor of mortality-The HUNT study
Pain, 157 (7), 1443-1447
DOI 10.1097/j.pain.0000000000000537, PubMed 26919487
Publications 2015
Early menarche and chronic widespread musculoskeletal complaints--Results from the HUNT study
Eur J Pain, 20 (3), 458-64
DOI 10.1002/ejp.747, PubMed 26132558
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Neurology, 84 (21), 2132-45
DOI 10.1212/WNL.0000000000001606, PubMed 25934857
The migraine-stroke connection: A genetic perspective
Cephalalgia, 36 (7), 658-68
DOI 10.1177/0333102415621055, PubMed 26660850
Genetic Markers of Human Evolution Are Enriched in Schizophrenia
Biol Psychiatry, 80 (4), 284-292
DOI 10.1016/j.biopsych.2015.10.009, PubMed 26681495
Genetic analysis for a shared biological basis between migraine and coronary artery disease
Neurol Genet, 1 (1), e10
DOI 10.1212/NXG.0000000000000010, PubMed 27066539
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups
Cephalalgia, 36 (7), 648-57
DOI 10.1177/0333102415591497, PubMed 26660531
Migraine as a predictor of mortality: The HUNT study
Cephalalgia, 36 (4), 351-7
DOI 10.1177/0333102415593090, PubMed 26115666
Publications 2014
Blood pressure as a risk factor for headache and migraine: a prospective population-based study
Eur J Neurol, 22 (1), 156-62, e10-1
DOI 10.1111/ene.12547, PubMed 25155744
Candidate-gene association study searching for genetic factors involved in migraine chronification
Cephalalgia, 35 (6), 500-7
DOI 10.1177/0333102414547141, PubMed 25169732
Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies
Cephalalgia, 35 (6), 489-99
DOI 10.1177/0333102414547784, PubMed 25179292
Publications 2013
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Nat Genet, 45 (8), 912-917
DOI 10.1038/ng.2676, PubMed 23793025
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
BMJ Open, 3 (8)
DOI 10.1136/bmjopen-2013-003268, PubMed 23943777
Migraine, headache and development of metabolic syndrome: an 11-year follow-up in the Nord-Trøndelag Health Study (HUNT)
Pain, 154 (8), 1305-11
DOI 10.1016/j.pain.2013.04.007, PubMed 23726372
Publications 2012
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
PLoS One, 7 (3), e31369
DOI 10.1371/journal.pone.0031369, PubMed 22479309
Genome-wide association analysis identifies susceptibility loci for migraine without aura
Nat Genet, 44 (7), 777-82
DOI 10.1038/ng.2307, PubMed 22683712
OS046. Genome-wide association scans identify novel maternalsusceptibility loci for preeclampsia
Pregnancy Hypertens, 2 (3), 202
DOI 10.1016/j.preghy.2012.04.047, PubMed 26105260
Publications 2010
Headache, migraine and cardiovascular risk factors: the HUNT study
Eur J Neurol, 18 (3), 504-11
DOI 10.1111/j.1468-1331.2010.03199.x, PubMed 20825470
Publications 2001
A re-evaluation of the phonological similarity effect in adults' short-term memory of words and nonwords
Memory, 9 (4-6), 281-99
DOI 10.1080/09658210143000074, PubMed 11594352
A re-evaluation of the phonological similarity effect in adults' short-term memory of words and nonwords
Memory, 9 (4), 281-299
DOI 10.1080/09658210143000074, PubMed 11747583
Publications 1994
IMPLEMENTATION OF DIGITAL FILTERS FOR REVERBERATION ENHANCEMENT SYSTEMS
NAM '94 - NORDIC ACOUSTICAL MEETING, PROCEEDINGS, 143-148