Publications from OUS - Dept. of Microbiology, Nilsen - Genome Instability in Ageing and Disease

33 publications found

Publications 2025

  1. Dragland JS, Liu G, Nilsen HL, Böttcher Y, Wang J (2025)
    EpiMapper: A new tool for analyzing high-throughput sequencing from CUT&Tag
    Comput Biol Med, 186, 109692
    DOI 10.1016/j.compbiomed.2025.109692, PubMed 39832438
  2. Lautrup S, Zhang SQ, Funayama S, Lirussi L, Visnovska T, Cheung HH, Niere M, Tian Y, Nilsen HL, Selbæk G, Saarela J, Maezawa Y, Yokote K, Nilsson P, Chan WY, Kato H, Ziegler M, Bohr VA, Fang EF (2025)
    Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation
    Aging (Albany NY), null (in press)
    DOI 10.18632/aging.206236, PubMed 40179319
  3. Song L, Kostas M, Laerdahl JK, Skálová M, Janská T, Juzeniene A, Ræstad S, Krivokapic A, Kalantzopoulos GN, Soltes J, Vlk M, Kozempel J, Hassfjell S, Wesche J (2025)
    Preparation and Characterization of an Engineered FGF1 Conjugated to 161Tb for Targeting of FGFRs
    ACS Omega, 10 (6), 5730-5743
    DOI 10.1021/acsomega.4c09179, PubMed 39989790
  4. Yarar N, Martens M, Rognes T, Lavender J, Dirven H, Audouze K, Wojewodzic MW (2025)
    AOP-networkFinder-a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki
    Bioinform Adv, 5 (1), vbaf007
    DOI 10.1093/bioadv/vbaf007, PubMed 39968376

Publications 2024

  1. Bordin DL, Grooms K, Montaldo NP, Fordyce Martin SL, Sætrom P, Samson LD, Bjørås M, van Loon B (2024)
    Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory
    DNA Repair (Amst), 135, 103632
    DOI 10.1016/j.dnarep.2024.103632, PubMed 38280242
  2. Istvan P, Birkeland E, Avershina E, Kværner AS, Bemanian V, Pardini B, Tarallo S, de Vos WM, Rognes T, Berstad P, Rounge TB (2024)
    Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
    Nat Commun, 15 (1), 1791
    DOI 10.1038/s41467-024-46033-0, PubMed 38424056
  3. Lång E, Lång A, Blicher P, Rognes T, Dommersnes PG, Bøe SO (2024)
    Topology-guided polar ordering of collective cell migration
    Sci Adv, 10 (16), eadk4825
    DOI 10.1126/sciadv.adk4825, PubMed 38630812
  4. Neurauter CG, Pannone M, Sousa MML, Wang W, Kuśnierczyk A, Luna L, Sætrom P, Scheffler K, Bjørås M (2024)
    Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells
    Free Radic Biol Med, 213, 470-487
    DOI 10.1016/j.freeradbiomed.2024.01.037, PubMed 38301978
  5. Ree AH, Høye E, Esbensen Y, Beitnes AR, Negård A, Bernklev L, Tetlie LK, Fretland ÅA, Hamre HM, Kersten C, Hofsli E, Guren MG, Sorbye H, Nilsen HL, Flatmark K, Meltzer S (2024)
    Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade
    Oncoimmunology, 13 (1), 2372886
    DOI 10.1080/2162402X.2024.2372886, PubMed 38952672
  6. Turconi G, Alam F, SenGupta T, Pirnes-Karhu S, Olfat S, Schmidt MS, Mätlik K, Montaño-Rodriguez A, Heiskanen V, Garton D, Piepponen PT, Brenner C, Holmberg CI, Nilsen H, Pirinen E, Andressoo JO (2024)
    Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease
    Heliyon, 10 (14), e34355
    DOI 10.1016/j.heliyon.2024.e34355, PubMed 39108921
  7. Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen H et al. (2024)
    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
    J Gerontol A Biol Sci Med Sci, 79 (4)
    DOI 10.1093/gerona/glae029, PubMed 38289789
  8. Yang M, Kaarbø M, Myhre V, Reims HM, Karlsen TH, Wang J, Rognes T, Halvorsen B, Fevang B, Lundin KEA, Aukrust P, Bjørås M, Jørgensen SF (2024)
    Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
    J Clin Immunol, 44 (6), 133
    DOI 10.1007/s10875-024-01726-5, PubMed 38780872

Publications 2023

  1. Durfee C, Temiz NA, Levin-Klein R, Argyris PP, Alsøe L, Carracedo S, Alonso de la Vega A, Proehl J, Holzhauer AM, Seeman ZJ, Liu X, Lin YT, Vogel RI, Sotillo R, Nilsen H, Harris RS (2023)
    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
    Cell Rep Med, 4 (10), 101211
    DOI 10.1016/j.xcrm.2023.101211, PubMed 37797615
  2. Kalyanasundaram S, Lefol Y, Gundersen S, Rognes T, Alsøe L, Nilsen HL, Hovig E, Sandve GK, Domanska D (2023)
    hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks
    PLoS One, 18 (7), e0286330
    DOI 10.1371/journal.pone.0286330, PubMed 37467208
  3. Lefol Y, Korfage T, Mjelle R, Prebensen C, Lüders T, Müller B, Krokan H, Sarno A, Alsøe L, CONSORTIUM LEMONAID, Berdal JE, Sætrom P, Nilsen H, Domanska D (2023)
    TiSA: TimeSeriesAnalysis-a pipeline for the analysis of longitudinal transcriptomics data
    NAR Genom Bioinform, 5 (1), lqad020
    DOI 10.1093/nargab/lqad020, PubMed 36879899
  4. Lirussi L, Nilsen HL (2023)
    DNA Glycosylases Define the Outcome of Endogenous Base Modifications
    Int J Mol Sci, 24 (12)
    DOI 10.3390/ijms241210307, PubMed 37373453
  5. Misceo D, Lirussi L, Strømme P, Sumathipala D, Guerin A, Wolf NI, Server A, Stensland M, Dalhus B, Tolun A, Kroes HY, Nyman TA, Nilsen HL, Frengen E (2023)
    A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
    Brain, 146 (8), 3513-3527
    DOI 10.1093/brain/awad086, PubMed 36917474
  6. Presterud R, Deng WH, Wennerström AB, Burgers T, Gajera B, Mattsson K, Solberg A, Fang EF, Nieminen AI, Stray-Pedersen A, Nilsen H (2023)
    Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia
    Mov Disord, 39 (2), 360-369
    DOI 10.1002/mds.29645, PubMed 37899683
  7. Qian S, He H, Xiong X, Ai R, Wang W, Zhu H, Ye Q, Zhou S, Nilsen H, Xie C (2023)
    Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson's disease
    CNS Neurosci Ther, 30 (4), e14532
    DOI 10.1111/cns.14532, PubMed 37990436
  8. Radenkovic S, Laerdahl JK, Backe PH, Morava E (2023)
    The role of PGM1isoform 2 in PGM1-CDG: One step closer to genotype-phenotype correlation?
    J Inherit Metab Dis, 46 (2), 159-160
    DOI 10.1002/jimd.12601, PubMed 36843136
  9. Rumbavicius I, Rounge TB, Rognes T (2023)
    HoCoRT: host contamination removal tool
    BMC Bioinformatics, 24 (1), 371
    DOI 10.1186/s12859-023-05492-w, PubMed 37784008
  10. Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nygård S, Nilsen H, Ventura N (2023)
    Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players
    iScience, 26 (4), 106448
    DOI 10.1016/j.isci.2023.106448, PubMed 37020951
  11. Sleiman A, Lalanne K, Vianna F, Perrot Y, Richaud M, SenGupta T, Cardot-Martin M, Pedini P, Picard C, Nilsen H, Galas S, Adam-Guillermin C (2023)
    Targeted Central Nervous System Irradiation with Proton Microbeam Induces Mitochondrial Changes in Caenorhabditis elegans
    Biology (Basel), 12 (6)
    DOI 10.3390/biology12060839, PubMed 37372124
  12. Strøm TB, Asprusten E, Laerdahl JK, Øygard I, Hussain MM, Bogsrud MP, Leren TP (2023)
    Missense mutation Q384K in the APOB gene affecting the large lipid transfer module of apoB reduces the secretion of apoB-100 in the liver without reducing the secretion of apoB-48 in the intestine
    J Clin Lipidol, 17 (6), 800-807
    DOI 10.1016/j.jacl.2023.08.009, PubMed 37718180
  13. Ølnes ÅS, Teigen M, Laerdahl JK, Leren TP, Strøm TB, Bjune K (2023)
    Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
    PLoS One, 18 (12), e0294764
    DOI 10.1371/journal.pone.0294764, PubMed 38039300

Publications 2022

  1. Akbari M, Nilsen HL, Montaldo NP (2022)
    Dynamic features of human mitochondrial DNA maintenance and transcription
    Front Cell Dev Biol, 10, 984245
    DOI 10.3389/fcell.2022.984245, PubMed 36158192
  2. Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H (2022)
    SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice
    DNA Repair (Amst), 120, 103410
    DOI 10.1016/j.dnarep.2022.103410, PubMed 36244177
  3. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 225
    DOI 10.1186/s12967-022-03432-5, PubMed 35568909
  4. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 317
    DOI 10.1186/s12967-022-03518-0, PubMed 35841045
  5. Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H (2022)
    A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
    Nucleic Acids Res, 50 (18), 10449-10468
    DOI 10.1093/nar/gkac807, PubMed 36156150
  6. Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T (2022)
    C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
    Front Aging, 3, 916118
    DOI 10.3389/fragi.2022.916118, PubMed 35821838
  7. SenGupta T, Lefol Y, Lirussi L, Suaste V, Luders T, Gupta S, Aman Y, Sharma K, Fang EF, Nilsen H (2022)
    Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
    Aging (Albany NY), 14 (21), 8661-8687
    DOI 10.18632/aging.204375, PubMed 36367773
  8. Whyte CE, Singh K, Burton OT, Aloulou M, Kouser L, Veiga RV, Dashwood A, Okkenhaug H, Benadda S, Moudra A, Bricard O, Lienart S, Bielefeld P, Roca CP, Naranjo-Galindo FJ, Lombard-Vadnais F, Junius S, Bending D, Ono M, Hochepied T, Halim TYF, Schlenner S, Lesage S, Dooley J, Liston A (2022)
    Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits
    J Exp Med, 219 (8)
    DOI 10.1084/jem.2021239107142022c, PubMed 35878878

 
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