Publications from OUS - Dept. of Microbiology, Nilsen - Genome Instability in Ageing and Disease

36 publications found

  1. Song L, Kostas M, Laerdahl JK, Skálová M, Janská T, Juzeniene A, Ræstad S, Krivokapic A, Kalantzopoulos GN, Soltes J, Vlk M, Kozempel J, Hassfjell S, Wesche J (2025)
    Preparation and Characterization of an Engineered FGF1 Conjugated to 161Tb for Targeting of FGFRs
    ACS Omega, 10 (6), 5730-5743
    DOI 10.1021/acsomega.4c09179, PubMed 39989790
  2. Yarar N, Martens M, Rognes T, Lavender J, Dirven H, Audouze K, Wojewodzic MW (2025)
    AOP-networkFinder-a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki
    Bioinform Adv, 5 (1), vbaf007
    DOI 10.1093/bioadv/vbaf007, PubMed 39968376
  3. Dragland JS, Liu G, Nilsen HL, Böttcher Y, Wang J (2025)
    EpiMapper: A new tool for analyzing high-throughput sequencing from CUT&Tag
    Comput Biol Med, 186, 109692
    DOI 10.1016/j.compbiomed.2025.109692, PubMed 39832438
  4. Turconi G, Alam F, SenGupta T, Pirnes-Karhu S, Olfat S, Schmidt MS, Mätlik K, Montaño-Rodriguez A, Heiskanen V, Garton D, Piepponen PT, Brenner C, Holmberg CI, Nilsen H, Pirinen E, Andressoo JO (2024)
    Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease
    Heliyon, 10 (14), e34355
    DOI 10.1016/j.heliyon.2024.e34355, PubMed 39108921
  5. Ree AH, Høye E, Esbensen Y, Beitnes AR, Negård A, Bernklev L, Tetlie LK, Fretland ÅA, Hamre HM, Kersten C, Hofsli E, Guren MG, Sorbye H, Nilsen HL, Flatmark K, Meltzer S (2024)
    Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade
    Oncoimmunology, 13 (1), 2372886
    DOI 10.1080/2162402X.2024.2372886, PubMed 38952672
  6. Yang M, Kaarbø M, Myhre V, Reims HM, Karlsen TH, Wang J, Rognes T, Halvorsen B, Fevang B, Lundin KEA, Aukrust P, Bjørås M, Jørgensen SF (2024)
    Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
    J Clin Immunol, 44 (6), 133
    DOI 10.1007/s10875-024-01726-5, PubMed 38780872
  7. Lång E, Lång A, Blicher P, Rognes T, Dommersnes PG, Bøe SO (2024)
    Topology-guided polar ordering of collective cell migration
    Sci Adv, 10 (16), eadk4825
    DOI 10.1126/sciadv.adk4825, PubMed 38630812
  8. Istvan P, Birkeland E, Avershina E, Kværner AS, Bemanian V, Pardini B, Tarallo S, de Vos WM, Rognes T, Berstad P, Rounge TB (2024)
    Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study
    Nat Commun, 15 (1), 1791
    DOI 10.1038/s41467-024-46033-0, PubMed 38424056
  9. Neurauter CG, Pannone M, Sousa MML, Wang W, Kuśnierczyk A, Luna L, Sætrom P, Scheffler K, Bjørås M (2024)
    Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells
    Free Radic Biol Med, 213, 470-487
    DOI 10.1016/j.freeradbiomed.2024.01.037, PubMed 38301978
  10. Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen H et al. (2024)
    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
    J Gerontol A Biol Sci Med Sci, 79 (4)
    DOI 10.1093/gerona/glae029, PubMed 38289789
  11. Bordin DL, Grooms K, Montaldo NP, Fordyce Martin SL, Sætrom P, Samson LD, Bjørås M, van Loon B (2024)
    Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory
    DNA Repair (Amst), 135, 103632
    DOI 10.1016/j.dnarep.2024.103632, PubMed 38280242
  12. Ølnes ÅS, Teigen M, Laerdahl JK, Leren TP, Strøm TB, Bjune K (2023)
    Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
    PLoS One, 18 (12), e0294764
    DOI 10.1371/journal.pone.0294764, PubMed 38039300
  13. Qian S, He H, Xiong X, Ai R, Wang W, Zhu H, Ye Q, Zhou S, Nilsen H, Xie C (2023)
    Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson's disease
    CNS Neurosci Ther, 30 (4), e14532
    DOI 10.1111/cns.14532, PubMed 37990436
  14. Presterud R, Deng WH, Wennerström AB, Burgers T, Gajera B, Mattsson K, Solberg A, Fang EF, Nieminen AI, Stray-Pedersen A, Nilsen H (2023)
    Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia
    Mov Disord, 39 (2), 360-369
    DOI 10.1002/mds.29645, PubMed 37899683
  15. Durfee C, Temiz NA, Levin-Klein R, Argyris PP, Alsøe L, Carracedo S, Alonso de la Vega A, Proehl J, Holzhauer AM, Seeman ZJ, Liu X, Lin YT, Vogel RI, Sotillo R, Nilsen H, Harris RS (2023)
    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
    Cell Rep Med, 4 (10), 101211
    DOI 10.1016/j.xcrm.2023.101211, PubMed 37797615
  16. Rumbavicius I, Rounge TB, Rognes T (2023)
    HoCoRT: host contamination removal tool
    BMC Bioinformatics, 24 (1), 371
    DOI 10.1186/s12859-023-05492-w, PubMed 37784008
  17. Strøm TB, Asprusten E, Laerdahl JK, Øygard I, Hussain MM, Bogsrud MP, Leren TP (2023)
    Missense mutation Q384K in the APOB gene affecting the large lipid transfer module of apoB reduces the secretion of apoB-100 in the liver without reducing the secretion of apoB-48 in the intestine
    J Clin Lipidol, 17 (6), 800-807
    DOI 10.1016/j.jacl.2023.08.009, PubMed 37718180
  18. Kalyanasundaram S, Lefol Y, Gundersen S, Rognes T, Alsøe L, Nilsen HL, Hovig E, Sandve GK, Domanska D (2023)
    hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks
    PLoS One, 18 (7), e0286330
    DOI 10.1371/journal.pone.0286330, PubMed 37467208
  19. Lirussi L, Nilsen HL (2023)
    DNA Glycosylases Define the Outcome of Endogenous Base Modifications
    Int J Mol Sci, 24 (12)
    DOI 10.3390/ijms241210307, PubMed 37373453
  20. Sleiman A, Lalanne K, Vianna F, Perrot Y, Richaud M, SenGupta T, Cardot-Martin M, Pedini P, Picard C, Nilsen H, Galas S, Adam-Guillermin C (2023)
    Targeted Central Nervous System Irradiation with Proton Microbeam Induces Mitochondrial Changes in Caenorhabditis elegans
    Biology (Basel), 12 (6)
    DOI 10.3390/biology12060839, PubMed 37372124
  21. Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nygård S, Nilsen H, Ventura N (2023)
    Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players
    iScience, 26 (4), 106448
    DOI 10.1016/j.isci.2023.106448, PubMed 37020951
  22. Misceo D, Lirussi L, Strømme P, Sumathipala D, Guerin A, Wolf NI, Server A, Stensland M, Dalhus B, Tolun A, Kroes HY, Nyman TA, Nilsen HL, Frengen E (2023)
    A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
    Brain, 146 (8), 3513-3527
    DOI 10.1093/brain/awad086, PubMed 36917474
  23. Lefol Y, Korfage T, Mjelle R, Prebensen C, Lüders T, Müller B, Krokan H, Sarno A, Alsøe L, CONSORTIUM LEMONAID, Berdal JE, Sætrom P, Nilsen H, Domanska D (2023)
    TiSA: TimeSeriesAnalysis-a pipeline for the analysis of longitudinal transcriptomics data
    NAR Genom Bioinform, 5 (1), lqad020
    DOI 10.1093/nargab/lqad020, PubMed 36879899
  24. Radenkovic S, Laerdahl JK, Backe PH, Morava E (2023)
    The role of PGM1isoform 2 in PGM1-CDG: One step closer to genotype-phenotype correlation?
    J Inherit Metab Dis, 46 (2), 159-160
    DOI 10.1002/jimd.12601, PubMed 36843136
  25. SenGupta T, Lefol Y, Lirussi L, Suaste V, Luders T, Gupta S, Aman Y, Sharma K, Fang EF, Nilsen H (2022)
    Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
    Aging (Albany NY), 14 (21), 8661-8687
    DOI 10.18632/aging.204375, PubMed 36367773
  26. Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H (2022)
    SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice
    DNA Repair (Amst), 120, 103410
    DOI 10.1016/j.dnarep.2022.103410, PubMed 36244177
  27. Akbari M, Nilsen HL, Montaldo NP (2022)
    Dynamic features of human mitochondrial DNA maintenance and transcription
    Front Cell Dev Biol, 10, 984245
    DOI 10.3389/fcell.2022.984245, PubMed 36158192
  28. Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H (2022)
    A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
    Nucleic Acids Res, 50 (18), 10449-10468
    DOI 10.1093/nar/gkac807, PubMed 36156150
  29. Whyte CE, Singh K, Burton OT, Aloulou M, Kouser L, Veiga RV, Dashwood A, Okkenhaug H, Benadda S, Moudra A, Bricard O, Lienart S, Bielefeld P, Roca CP, Naranjo-Galindo FJ, Lombard-Vadnais F, Junius S, Bending D, Ono M, Hochepied T, Halim TYF, Schlenner S, Lesage S, Dooley J, Liston A (2022)
    Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits
    J Exp Med, 219 (8)
    DOI 10.1084/jem.2021239107142022c, PubMed 35878878
  30. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 317
    DOI 10.1186/s12967-022-03518-0, PubMed 35841045
  31. Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T (2022)
    C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
    Front Aging, 3, 916118
    DOI 10.3389/fragi.2022.916118, PubMed 35821838
  32. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 225
    DOI 10.1186/s12967-022-03432-5, PubMed 35568909
  33. Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G (2013)
    SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
    Mol Biol Cell, 25 (4), 532-47
    DOI 10.1091/mbc.E13-05-0286, PubMed 24356447
  34. Antoniali G, Lirussi L, Poletto M, Tell G (2013)
    Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example
    Antioxid Redox Signal, 20 (4), 621-39
    DOI 10.1089/ars.2013.5491, PubMed 23879289
  35. Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A (2013)
    Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases
    Antioxid Redox Signal, 20 (2), 217-35
    DOI 10.1089/ars.2012.5051, PubMed 23641861
  36. Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G (2013)
    Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)
    Biochem J, 452 (3), 545-57
    DOI 10.1042/BJ20121277, PubMed 23544830

 
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