Publications by Hilde Loge Nilsen

92 publications found

  1. Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen H et al. (2024)
    Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies
    J Gerontol A Biol Sci Med Sci (in press)
    DOI 10.1093/gerona/glae029, PubMed 38289789
  2. Qian S, He H, Xiong X, Ai R, Wang W, Zhu H, Ye Q, Zhou S, Nilsen H, Xie C (2023)
    Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson's disease
    CNS Neurosci Ther (in press)
    DOI 10.1111/cns.14532, PubMed 37990436
  3. Presterud R, Deng WH, Wennerström AB, Burgers T, Gajera B, Mattsson K, Solberg A, Fang EF, Nieminen AI, Stray-Pedersen A, Nilsen H (2023)
    Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia
    Mov Disord, 39 (2), 360-369
    DOI 10.1002/mds.29645, PubMed 37899683
  4. Durfee C, Temiz NA, Levin-Klein R, Argyris PP, Alsøe L, Carracedo S, Alonso de la Vega A, Proehl J, Holzhauer AM, Seeman ZJ, Liu X, Lin YT, Vogel RI, Sotillo R, Nilsen H, Harris RS (2023)
    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
    Cell Rep Med, 4 (10), 101211
    DOI 10.1016/j.xcrm.2023.101211, PubMed 37797615
  5. Prebensen C, Lefol Y, Myhre PL, Lüders T, Jonassen C, Blomfeldt A, Omland T, Nilsen H, Berdal JE (2023)
    Author Correction: Longitudinal whole blood transcriptomic analysis characterizes neutrophil activation and interferon signaling in moderate and severe COVID-19
    Sci Rep, 13 (1), 12691
    DOI 10.1038/s41598-023-39872-2, PubMed 37542160
  6. Kalyanasundaram S, Lefol Y, Gundersen S, Rognes T, Alsøe L, Nilsen HL, Hovig E, Sandve GK, Domanska D (2023)
    hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks
    PLoS One, 18 (7), e0286330
    DOI 10.1371/journal.pone.0286330, PubMed 37467208
  7. Lirussi L, Nilsen HL (2023)
    DNA Glycosylases Define the Outcome of Endogenous Base Modifications
    Int J Mol Sci, 24 (12)
    DOI 10.3390/ijms241210307, PubMed 37373453
  8. Sleiman A, Lalanne K, Vianna F, Perrot Y, Richaud M, SenGupta T, Cardot-Martin M, Pedini P, Picard C, Nilsen H, Galas S, Adam-Guillermin C (2023)
    Targeted Central Nervous System Irradiation with Proton Microbeam Induces Mitochondrial Changes in Caenorhabditis elegans
    Biology (Basel), 12 (6)
    DOI 10.3390/biology12060839, PubMed 37372124
  9. Prebensen C, Lefol Y, Myhre PL, Lüders T, Jonassen C, Blomfeldt A, Omland T, Nilsen H, Berdal JE (2023)
    Longitudinal whole blood transcriptomic analysis characterizes neutrophil activation and interferon signaling in moderate and severe COVID-19
    Sci Rep, 13 (1), 10368
    DOI 10.1038/s41598-023-37606-y, PubMed 37365222
  10. Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nygård S, Nilsen H, Ventura N (2023)
    Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players
    iScience, 26 (4), 106448
    DOI 10.1016/j.isci.2023.106448, PubMed 37020951
  11. Misceo D, Lirussi L, Strømme P, Sumathipala D, Guerin A, Wolf NI, Server A, Stensland M, Dalhus B, Tolun A, Kroes HY, Nyman TA, Nilsen HL, Frengen E (2023)
    A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
    Brain, 146 (8), 3513-3527
    DOI 10.1093/brain/awad086, PubMed 36917474
  12. Lefol Y, Korfage T, Mjelle R, Prebensen C, Lüders T, Müller B, Krokan H, Sarno A, Alsøe L, CONSORTIUM LEMONAID, Berdal JE, Sætrom P, Nilsen H, Domanska D (2023)
    TiSA: TimeSeriesAnalysis-a pipeline for the analysis of longitudinal transcriptomics data
    NAR Genom Bioinform, 5 (1), lqad020
    DOI 10.1093/nargab/lqad020, PubMed 36879899
  13. Durfee C, Temiz NA, Levin-Klein R, Argyris PP, Alsøe L, Carracedo S, de la Vega AA, Proehl J, Holzhauer AM, Seeman ZJ, Lin YT, Vogel RI, Sotillo R, Nilsen H, Harris RS (2023)
    Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
    bioRxiv
    DOI 10.1101/2023.02.24.529970, PubMed 36865194
  14. SenGupta T, Lefol Y, Lirussi L, Suaste V, Luders T, Gupta S, Aman Y, Sharma K, Fang EF, Nilsen H (2022)
    Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
    Aging (Albany NY), 14 (21), 8661-8687
    DOI 10.18632/aging.204375, PubMed 36367773
  15. Carracedo S, Lirussi L, Alsøe L, Segers F, Wang C, Bartosova Z, Bohov P, Tekin NB, Kong XY, Esbensen QY, Chen L, Wennerström A, Kroustallaki P, Ceolotto D, Tönjes A, Berge RK, Bruheim P, Wong G, Böttcher Y, Halvorsen B, Nilsen H (2022)
    SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice
    DNA Repair (Amst), 120, 103410
    DOI 10.1016/j.dnarep.2022.103410, PubMed 36244177
  16. Akbari M, Nilsen HL, Montaldo NP (2022)
    Dynamic features of human mitochondrial DNA maintenance and transcription
    Front Cell Dev Biol, 10, 984245
    DOI 10.3389/fcell.2022.984245, PubMed 36158192
  17. Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H (2022)
    A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
    Nucleic Acids Res, 50 (18), 10449-10468
    DOI 10.1093/nar/gkac807, PubMed 36156150
  18. Høyer H, Busk ØL, Esbensen QY, Røsby O, Hilmarsen HT, Russell MB, Nyman TA, Braathen GJ, Nilsen HL (2022)
    Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation
    BMC Neurol, 22 (1), 299
    DOI 10.1186/s12883-022-02828-6, PubMed 35971119
  19. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 317
    DOI 10.1186/s12967-022-03518-0, PubMed 35841045
  20. Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T (2022)
    C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
    Front Aging, 3, 916118
    DOI 10.3389/fragi.2022.916118, PubMed 35821838
  21. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 225
    DOI 10.1186/s12967-022-03432-5, PubMed 35568909
  22. Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
    A national precision cancer medicine implementation initiative for Norway
    Nat Med, 28 (5), 885-887
    DOI 10.1038/s41591-022-01777-4, PubMed 35513529
  23. Palikaras K, SenGupta T, Nilsen H, Tavernarakis N (2022)
    Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson's disease
    STAR Protoc, 3 (2), 101264
    DOI 10.1016/j.xpro.2022.101264, PubMed 35403008
  24. Vatn SS, Lindstrøm JC, Moen AEF, Brackmann S, Tannæs TM, Olbjørn C, Bergemalm D, Keita ÅV, Gomollon F, Detlie TE, Lüders T, Kalla R, Adams A, Satsangi J, Jahnsen J, Vatn MH, Halfvarson J, Ricanek P, Nilsen H, IBD-CHARACTER consortium (2022)
    Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort
    Clin Exp Gastroenterol, 15, 5-25
    DOI 10.2147/CEG.S343468, PubMed 35185343
  25. Sumathipala D, Strømme P, Fattahi Z, Lüders T, Sheng Y, Kahrizi K, Einarsen IH, Sloan JL, Najmabadi H, van den Heuvel L, Wevers RA, Guerrero-Castillo S, Mørkrid L, Valayannopoulos V, Backe PH, Venditti CP, van Karnebeek CD, Nilsen H, Frengen E, Misceo D (2022)
    ZBTB11 dysfunction: spectrum of brain abnormalities, biochemical signature and cellular consequences
    Brain, 145 (7), 2602-2616
    DOI 10.1093/brain/awac034, PubMed 35104841
  26. Karlsen TR, Olsen MB, Kong XY, Yang K, Quiles-Jiménez A, Kroustallaki P, Holm S, Lines GT, Aukrust P, Skarpengland T, Bjørås M, Dahl TB, Nilsen H, Gregersen I, Halvorsen B (2022)
    NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length
    Biochem Biophys Rep, 29, 101211
    DOI 10.1016/j.bbrep.2022.101211, PubMed 35079641
  27. Alexeeva M, Moen MN, Xu XM, Rasmussen A, Leiros I, Kirpekar F, Klungland A, Alsøe L, Nilsen H, Bjelland S (2021)
    Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
    Front Immunol, 12, 762032
    DOI 10.3389/fimmu.2021.762032, PubMed 35003074
  28. Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA et al. (2022)
    Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
    Nat Biomed Eng, 6 (1), 76-93
    DOI 10.1038/s41551-021-00819-5, PubMed 34992270
  29. SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H (2021)
    Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
    Cell Rep, 36 (10), 109668
    DOI 10.1016/j.celrep.2021.109668, PubMed 34496255
  30. Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Noia JMD (2021)
    Erratum: The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
    NAR Cancer, 3 (1), zcaa045
    DOI 10.1093/narcan/zcaa045, PubMed 34316697
  31. Følling I, Wennerstrøm AB, Eide TJ, Nilsen HL (2021)
    Phaeochromocytomas overexpress insulin transcript and produce insulin
    Endocr Connect, 10 (8), 815-824
    DOI 10.1530/EC-21-0269, PubMed 34170845
  32. Quiles-Jiménez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygård S, Scheffler K, Prins J, Van der Veer E, Øgaard JD, Fløisand Y, Jørgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
    DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
    Atherosclerosis, 324, 123-132
    DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
  33. Gupta S, You P, SenGupta T, Nilsen H, Sharma K (2021)
    Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases
    Biology (Basel), 10 (2)
    DOI 10.3390/biology10020163, PubMed 33669593
  34. Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM (2020)
    The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
    NAR Cancer, 2 (3), zcaa019
    DOI 10.1093/narcan/zcaa019, PubMed 33554121
  35. Bordin DL, Lirussi L, Nilsen H (2021)
    Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation
    DNA Repair (Amst), 99, 103051
    DOI 10.1016/j.dnarep.2021.103051, PubMed 33540225
  36. Lirussi L, Demir Ö, You P, Sarno A, Amaro RE, Nilsen H (2021)
    RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control
    Biomolecules, 11 (1)
    DOI 10.3390/biom11010076, PubMed 33430019
  37. Gilmour BC, Gudmundsrud R, Frank J, Hov A, Lautrup S, Aman Y, Røsjø H, Brenner C, Ziegler M, Tysnes OB, Tzoulis C, Omland T, Søraas A, Holmøy T, Bergersen LH, Storm-Mathisen J, Nilsen H, Fang EF (2020)
    Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
    Mech Ageing Dev, 186, 111208
    DOI 10.1016/j.mad.2020.111208, PubMed 31953124
  38. Aman Y, Frank J, Lautrup SH, Matysek A, Niu Z, Yang G, Shi L, Bergersen LH, Storm-Mathisen J, Rasmussen LJ, Bohr VA, Nilsen H, Fang EF (2019)
    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
    Mech Ageing Dev, 185, 111194
    DOI 10.1016/j.mad.2019.111194, PubMed 31812486
  39. Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE et al. (2019)
    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
    Nat Commun, 10 (1), 5284
    DOI 10.1038/s41467-019-13172-8, PubMed 31754102
  40. Lirussi L, Nilsen H (2019)
    Telomere maintenance: regulating hTERC fate through RNA modifications
    Mol Cell Oncol, 6 (6), e1670489
    DOI 10.1080/23723556.2019.1670489, PubMed 31692866
  41. Serebrenik AA, Starrett GJ, Leenen S, Jarvis MC, Shaban NM, Salamango DJ, Nilsen H, Brown WL, Harris RS (2019)
    The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase
    Proc Natl Acad Sci U S A, 116 (44), 22158-22163
    DOI 10.1073/pnas.1904024116, PubMed 31611371
  42. Zheleva A, Gómez-Orte E, Sáenz-Narciso B, Ezcurra B, Kassahun H, de Toro M, Miranda-Vizuete A, Schnabel R, Nilsen H, Cabello J (2019)
    Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development
    PLoS Genet, 15 (9), e1008338
    DOI 10.1371/journal.pgen.1008338, PubMed 31525188
  43. Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen QY, Götz A, Jobert L, Alsøe L, Sætrom P, Gagos S, Nilsen H (2019)
    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
    Cell Rep, 28 (7), 1690-1702.e10
    DOI 10.1016/j.celrep.2019.07.040, PubMed 31412240
  44. Malt EA, Juhasz K, Frengen A, Wangensteen T, Emilsen NM, Hansen B, Agafonov O, Nilsen HL (2019)
    Neuropsychiatric phenotype in relation to gene variants in the hemizygous allele in 3q29 deletion carriers: A case series
    Mol Genet Genomic Med, 7 (9), e889
    DOI 10.1002/mgg3.889, PubMed 31347308
  45. Lautrup S, Lou G, Aman Y, Nilsen H, Tao J, Fang EF (2019)
    Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease
    Neurochem Int, 129, 104469
    DOI 10.1016/j.neuint.2019.104469, PubMed 31100304
  46. Gómez-Orte E, Sáenz-Narciso B, Zheleva A, Ezcurra B, de Toro M, López R, Gastaca I, Nilsen H, Sacristán MP, Schnabel R, Cabello J (2019)
    Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes
    PLoS Genet, 15 (2), e1007981
    DOI 10.1371/journal.pgen.1007981, PubMed 30807579
  47. Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019)
    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
    Nat Neurosci, 22 (3), 401-412
    DOI 10.1038/s41593-018-0332-9, PubMed 30742114
  48. Nguyen CB, Kumar S, Zucknick M, Kristensen VN, Gjerstad J, Nilsen H, Wyller VB (2018)
    Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome
    Brain Behav Immun, 76, 82-96
    DOI 10.1016/j.bbi.2018.11.008, PubMed 30419269
  49. Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N (2018)
    BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans
    EMBO Rep, 19 (12)
    DOI 10.15252/embr.201845856, PubMed 30366941
  50. Arczewska KD, Stachurska A, Wojewódzka M, Karpińska K, Kruszewski M, Nilsen H, Czarnocka B (2018)
    hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells
    DNA Repair (Amst), 69, 53-62
    DOI 10.1016/j.dnarep.2018.07.006, PubMed 30055508
  51. SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2018)
    Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
    Nat Commun, 9, 16206
    DOI 10.1038/ncomms16206, PubMed 29595188
  52. Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA (2017)
    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
    J Vis Exp (129)
    DOI 10.3791/56301, PubMed 29286376
  53. Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H (2017)
    Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans
    DNA Repair (Amst), 61, 46-55
    DOI 10.1016/j.dnarep.2017.11.009, PubMed 29202295
  54. Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
    TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
    PLoS One, 12 (10), e0185708
    DOI 10.1371/journal.pone.0185708, PubMed 28973009
  55. Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H (2017)
    Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1
    Sci Rep, 7 (1), 7199
    DOI 10.1038/s41598-017-07314-5, PubMed 28775312
  56. Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
    No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
    Sci Rep, 7 (1), 4384
    DOI 10.1038/s41598-017-04472-4, PubMed 28663564
  57. Nguyen CB, Alsøe L, Lindvall JM, Sulheim D, Fagermoen E, Winger A, Kaarbø M, Nilsen H, Wyller VB (2017)
    Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival
    J Transl Med, 15 (1), 102
    DOI 10.1186/s12967-017-1201-0, PubMed 28494812
  58. Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017)
    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
    Sci Rep, 7, 46208
    DOI 10.1038/srep46208, PubMed 28397803
  59. Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF (2017)
    Mitophagy in neurodegeneration and aging
    Neurochem Int, 109, 202-209
    DOI 10.1016/j.neuint.2017.02.007, PubMed 28235551
  60. Croteau DL, Fang EF, Nilsen H, Bohr VA (2017)
    NAD+ in DNA repair and mitochondrial maintenance
    Cell Cycle, 16 (6), 491-492
    DOI 10.1080/15384101.2017.1285631, PubMed 28145802
  61. Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM, Brosh RM, Gorospe M, Bohr VA (2016)
    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
    Proc Natl Acad Sci U S A, 113 (44), 12502-12507
    DOI 10.1073/pnas.1610198113, PubMed 27791127
  62. Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA (2016)
    NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
    Cell Metab, 24 (4), 566-581
    DOI 10.1016/j.cmet.2016.09.004, PubMed 27732836
  63. Wyller VB, Jacobsen K, Dahl MB, Nilsen H, Proske S, Horter T, Brun H (2016)
    Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy
    Int J Cardiol, 221, 376-8
    DOI 10.1016/j.ijcard.2016.06.288, PubMed 27404709
  64. Lirussi L, Antoniali G, D'Ambrosio C, Scaloni A, Nilsen H, Tell G (2016)
    APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation
    Oncotarget, 7 (18), 26293-306
    DOI 10.18632/oncotarget.8477, PubMed 27050370
  65. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
    Autophagy, 12 (1), 1-222
    DOI 10.1080/15548627.2015.1100356, PubMed 26799652
  66. Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J (2015)
    Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype
    PLoS One, 10 (10), e0140883
    DOI 10.1371/journal.pone.0140883, PubMed 26473596
  67. Solberg R, Smith R, Almlöf M, Tewolde E, Nilsen H, Johansen HT (2015)
    Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin
    Biol Chem, 396 (1), 71-80
    DOI 10.1515/hsz-2014-0172, PubMed 25205715
  68. Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA (2014)
    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
    Cell, 157 (4), 882-896
    DOI 10.1016/j.cell.2014.03.026, PubMed 24813611
  69. Kassahun H, Nilsen H (2013)
    Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1
    Worm, 2 (4), e27337
    DOI 10.4161/worm.27337, PubMed 24744987
  70. Jobert L, Nilsen H (2014)
    Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes
    Cell Mol Life Sci, 71 (13), 2451-65
    DOI 10.1007/s00018-014-1562-y, PubMed 24496644
  71. SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2013)
    Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
    Nat Commun, 4, 2674
    DOI 10.1038/ncomms3674, PubMed 24154628
  72. Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H (2013)
    Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1
    Nucleic Acids Res, 41 (10), 5368-81
    DOI 10.1093/nar/gkt225, PubMed 23580547
  73. Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (2012)
    The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
    Mol Cell, 49 (2), 339-45
    DOI 10.1016/j.molcel.2012.11.010, PubMed 23246433
  74. Forthun RB, Sengupta T, Skjeldam HK, Lindvall JM, McCormack E, Gjertsen BT, Nilsen H (2012)
    Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid
    PLoS One, 7 (11), e48992
    DOI 10.1371/journal.pone.0048992, PubMed 23155442
  75. Smith R, Johansen HT, Nilsen H, Haugen MH, Pettersen SJ, Mælandsmo GM, Abrahamson M, Solberg R (2012)
    Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
    Biochimie, 94 (12), 2590-9
    DOI 10.1016/j.biochi.2012.07.026, PubMed 22902879
  76. Tomazella GG, Kassahun H, Nilsen H, Thiede B (2012)
    Quantitative proteome analysis reveals RNA processing factors as modulators of ionizing radiation-induced apoptosis in the C. elegans germline
    J Proteome Res, 11 (8), 4277-88
    DOI 10.1021/pr300386z, PubMed 22757771
  77. Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J, Nilsen H, Vértessy BG, Vellai T (2011)
    Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
    J Cell Sci, 124 (Pt 9), 1510-8
    DOI 10.1242/jcs.080192, PubMed 21502138
  78. Arczewska KD, Baumeier C, Kassahun H, Sengupta T, Bjørås M, Kuśmierek JT, Nilsen H (2010)
    Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability
    DNA Repair (Amst), 10 (2), 176-87
    DOI 10.1016/j.dnarep.2010.10.009, PubMed 21111690
  79. Skjeldam HK, Kassahun H, Fensgård O, SenGupta T, Babaie E, Lindvall JM, Arczewska K, Nilsen H (2010)
    Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents
    DNA Repair (Amst), 9 (8), 861-70
    DOI 10.1016/j.dnarep.2010.04.009, PubMed 20493785
  80. Fensgård Ø, Kassahun H, Bombik I, Rognes T, Lindvall JM, Nilsen H (2010)
    A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways
    Aging (Albany NY), 2 (3), 133-59
    DOI 10.18632/aging.100127, PubMed 20382984
  81. Zakaria C, Kassahun H, Yang X, Labbé JC, Nilsen H, Ramotar D (2009)
    Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability
    DNA Repair (Amst), 9 (2), 169-76
    DOI 10.1016/j.dnarep.2009.11.007, PubMed 20036200
  82. Skjølberg HC, Fensgård O, Nilsen H, Grallert B, Boye E (2009)
    Global transcriptional response after exposure of fission yeast cells to ultraviolet light
    BMC Cell Biol, 10, 87
    DOI 10.1186/1471-2121-10-87, PubMed 20015352
  83. Arczewska KD, Michalickova K, Donaldson IM, Nilsen H (2008)
    The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network
    Crit Rev Oncog, 14 (4), 217-73
    DOI 10.1615/critrevoncog.v14.i4.20, PubMed 19645683
  84. Schmidt F, Strozynski M, Salus SS, Nilsen H, Thiede B (2007)
    Rapid determination of amino acid incorporation by stable isotope labeling with amino acids in cell culture (SILAC)
    Rapid Commun Mass Spectrom, 21 (23), 3919-26
    DOI 10.1002/rcm.3290, PubMed 17979108
  85. Dengg M, Garcia-Muse T, Gill SG, Ashcroft N, Boulton SJ, Nilsen H (2006)
    Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates
    EMBO Rep, 7 (10), 1046-51
    DOI 10.1038/sj.embor.7400782, PubMed 16964178
  86. Andersen S, Ericsson M, Dai HY, Peña-Diaz J, Slupphaug G, Nilsen H, Aarset H, Krokan HE (2005)
    Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice
    DNA Repair (Amst), 4 (12), 1432-41
    DOI 10.1016/j.dnarep.2005.08.004, PubMed 16174566
  87. Nilsen H, An Q, Lindahl T (2005)
    Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice
    Oncogene, 24 (18), 3063-6
    DOI 10.1038/sj.onc.1208480, PubMed 15735713
  88. Andersen S, Heine T, Sneve R, König I, Krokan HE, Epe B, Nilsen H (2004)
    Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts
    Carcinogenesis, 26 (3), 547-55
    DOI 10.1093/carcin/bgh347, PubMed 15564287
  89. Nilsen H, Stamp G, Andersen S, Hrivnak G, Krokan HE, Lindahl T, Barnes DE (2003)
    Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
    Oncogene, 22 (35), 5381-6
    DOI 10.1038/sj.onc.1206860, PubMed 12934097
  90. Nilsen H, Lindahl T, Verreault A (2002)
    DNA base excision repair of uracil residues in reconstituted nucleosome core particles
    EMBO J, 21 (21), 5943-52
    DOI 10.1093/emboj/cdf581, PubMed 12411511
  91. Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS (2002)
    Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    Curr Biol, 12 (20), 1748-55
    DOI 10.1016/s0960-9822(02)01215-0, PubMed 12401169
  92. Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G (2002)
    hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
    J Biol Chem, 277 (42), 39926-36
    DOI 10.1074/jbc.M207107200, PubMed 12161446

 
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