Hilde Loge Nilsen

  • Professor; PhD
  • +47 932 46 618
 

Publications 2022

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045

Karlsen TR, Olsen MB, Kong XY, Yang K, Quiles-Jiménez A, Kroustallaki P, Holm S, Lines GT, Aukrust P, Skarpengland T, Bjørås M, Dahl TB, Nilsen H, Gregersen I, Halvorsen B (2022)
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length
Biochem Biophys Rep, 29, 101211
DOI 10.1016/j.bbrep.2022.101211, PubMed 35079641

Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T (2022)
C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
Front Aging, 3, 916118
DOI 10.3389/fragi.2022.916118, PubMed 35821838

Palikaras K, SenGupta T, Nilsen H, Tavernarakis N (2022)
Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson's disease
STAR Protoc, 3 (2), 101264
DOI 10.1016/j.xpro.2022.101264, PubMed 35403008

Sumathipala D, Strømme P, Fattahi Z, Lüders T, Sheng Y, Kahrizi K, Einarsen IH, Sloan JL, Najmabadi H, van den Heuvel L, Wevers RA, Guerrero-Castillo S, Mørkrid L, Valayannopoulos V, Backe PH, Venditti CP, van Karnebeek CD, Nilsen H, Frengen E, Misceo D (2022)
ZBTB11 dysfunction: spectrum of brain abnormalities, biochemical signature and cellular consequences
Brain, 145 (7), 2602-2616
DOI 10.1093/brain/awac034, PubMed 35104841

Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529

Vatn SS, Lindstrøm JC, Moen AEF, Brackmann S, Tannæs TM, Olbjørn C, Bergemalm D, Keita ÅV, Gomollon F, Detlie TE, Lüders T, Kalla R, Adams A, Satsangi J, Jahnsen J, Vatn MH, Halfvarson J, Ricanek P, Nilsen H, IBD-CHARACTER consortium (2022)
Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort
Clin Exp Gastroenterol, 15, 5-25
DOI 10.2147/CEG.S343468, PubMed 35185343

Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA et al. (2022)
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
Nat Biomed Eng, 6 (1), 76-93
DOI 10.1038/s41551-021-00819-5, PubMed 34992270

Publications 2021

Alexeeva M, Moen MN, Xu XM, Rasmussen A, Leiros I, Kirpekar F, Klungland A, Alsøe L, Nilsen H, Bjelland S (2021)
Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification
Front Immunol, 12, 762032
DOI 10.3389/fimmu.2021.762032, PubMed 35003074

Bordin DL, Lirussi L, Nilsen H (2021)
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation
DNA Repair (Amst), 99, 103051
DOI 10.1016/j.dnarep.2021.103051, PubMed 33540225

Følling I, Wennerstrøm AB, Eide TJ, Nilsen HL (2021)
Phaeochromocytomas overexpress insulin transcript and produce insulin
Endocr Connect, 10 (8), 815-824
DOI 10.1530/EC-21-0269, PubMed 34170845

Gupta S, You P, SenGupta T, Nilsen H, Sharma K (2021)
Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases
Biology (Basel), 10 (2)
DOI 10.3390/biology10020163, PubMed 33669593

Lirussi L, Demir Ö, You P, Sarno A, Amaro RE, Nilsen H (2021)
RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control
Biomolecules, 11 (1)
DOI 10.3390/biom11010076, PubMed 33430019

Quiles-Jiménez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygård S, Scheffler K, Prins J, Van der Veer E, Øgaard JD, Fløisand Y, Jørgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552

Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Noia JMD (2021)
Erratum: The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
NAR Cancer, 3 (1), zcaa045
DOI 10.1093/narcan/zcaa045, PubMed 34316697

SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H (2021)
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
Cell Rep, 36 (10), 109668
DOI 10.1016/j.celrep.2021.109668, PubMed 34496255

Publications 2020

Gilmour BC, Gudmundsrud R, Frank J, Hov A, Lautrup S, Aman Y, Røsjø H, Brenner C, Ziegler M, Tysnes OB, Tzoulis C, Omland T, Søraas A, Holmøy T, Bergersen LH, Storm-Mathisen J, Nilsen H, Fang EF (2020)
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Mech Ageing Dev, 186, 111208
DOI 10.1016/j.mad.2020.111208, PubMed 31953124

Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM (2020)
The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
NAR Cancer, 2 (3), zcaa019
DOI 10.1093/narcan/zcaa019, PubMed 33554121

Publications 2019

Aman Y, Frank J, Lautrup SH, Matysek A, Niu Z, Yang G, Shi L, Bergersen LH, Storm-Mathisen J, Rasmussen LJ, Bohr VA, Nilsen H, Fang EF (2019)
The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Mech Ageing Dev, 185, 111194
DOI 10.1016/j.mad.2019.111194, PubMed 31812486

Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE et al. (2019)
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Nat Commun, 10 (1), 5284
DOI 10.1038/s41467-019-13172-8, PubMed 31754102

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Nat Neurosci, 22 (3), 401-412
DOI 10.1038/s41593-018-0332-9, PubMed 30742114

Gómez-Orte E, Sáenz-Narciso B, Zheleva A, Ezcurra B, de Toro M, López R, Gastaca I, Nilsen H, Sacristán MP, Schnabel R, Cabello J (2019)
Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes
PLoS Genet, 15 (2), e1007981
DOI 10.1371/journal.pgen.1007981, PubMed 30807579

Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen QY, Götz A, Jobert L, Alsøe L, Sætrom P, Gagos S, Nilsen H (2019)
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
Cell Rep, 28 (7), 1690-1702.e10
DOI 10.1016/j.celrep.2019.07.040, PubMed 31412240

Lautrup S, Lou G, Aman Y, Nilsen H, Tao J, Fang EF (2019)
Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease
Neurochem Int, 129, 104469
DOI 10.1016/j.neuint.2019.104469, PubMed 31100304

Lirussi L, Nilsen H (2019)
Telomere maintenance: regulating hTERC fate through RNA modifications
Mol Cell Oncol, 6 (6), e1670489
DOI 10.1080/23723556.2019.1670489, PubMed 31692866

Malt EA, Juhasz K, Frengen A, Wangensteen T, Emilsen NM, Hansen B, Agafonov O, Nilsen HL (2019)
Neuropsychiatric phenotype in relation to gene variants in the hemizygous allele in 3q29 deletion carriers: A case series
Mol Genet Genomic Med, 7 (9), e889
DOI 10.1002/mgg3.889, PubMed 31347308

Serebrenik AA, Starrett GJ, Leenen S, Jarvis MC, Shaban NM, Salamango DJ, Nilsen H, Brown WL, Harris RS (2019)
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase
Proc Natl Acad Sci U S A, 116 (44), 22158-22163
DOI 10.1073/pnas.1904024116, PubMed 31611371

Zheleva A, Gómez-Orte E, Sáenz-Narciso B, Ezcurra B, Kassahun H, de Toro M, Miranda-Vizuete A, Schnabel R, Nilsen H, Cabello J (2019)
Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development
PLoS Genet, 15 (9), e1008338
DOI 10.1371/journal.pgen.1008338, PubMed 31525188

Publications 2018

Arczewska KD, Stachurska A, Wojewódzka M, Karpińska K, Kruszewski M, Nilsen H, Czarnocka B (2018)
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells
DNA Repair (Amst), 69, 53-62
DOI 10.1016/j.dnarep.2018.07.006, PubMed 30055508

Nguyen CB, Kumar S, Zucknick M, Kristensen VN, Gjerstad J, Nilsen H, Wyller VB (2018)
Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome
Brain Behav Immun, 76, 82-96
DOI 10.1016/j.bbi.2018.11.008, PubMed 30419269

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2018)
Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 9, 16206
DOI 10.1038/ncomms16206, PubMed 29595188

Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N (2018)
BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans
EMBO Rep, 19 (12)
DOI 10.15252/embr.201845856, PubMed 30366941

Publications 2017

Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H (2017)
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1
Sci Rep, 7 (1), 7199
DOI 10.1038/s41598-017-07314-5, PubMed 28775312

Croteau DL, Fang EF, Nilsen H, Bohr VA (2017)
NAD+ in DNA repair and mitochondrial maintenance
Cell Cycle, 16 (6), 491-492
DOI 10.1080/15384101.2017.1285631, PubMed 28145802

Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA (2017)
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
J Vis Exp (129)
DOI 10.3791/56301, PubMed 29286376

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG (2017)
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Sci Rep, 7, 46208
DOI 10.1038/srep46208, PubMed 28397803

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF (2017)
Mitophagy in neurodegeneration and aging
Neurochem Int, 109, 202-209
DOI 10.1016/j.neuint.2017.02.007, PubMed 28235551

Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK (2017)
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009

Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H (2017)
Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans
DNA Repair (Amst), 61, 46-55
DOI 10.1016/j.dnarep.2017.11.009, PubMed 29202295

Nguyen CB, Alsøe L, Lindvall JM, Sulheim D, Fagermoen E, Winger A, Kaarbø M, Nilsen H, Wyller VB (2017)
Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival
J Transl Med, 15 (1), 102
DOI 10.1186/s12967-017-1201-0, PubMed 28494812

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564

Publications 2016

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA (2016)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Cell Metab, 24 (4), 566-581
DOI 10.1016/j.cmet.2016.09.004, PubMed 27732836

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652

Lirussi L, Antoniali G, D'Ambrosio C, Scaloni A, Nilsen H, Tell G (2016)
APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation
Oncotarget, 7 (18), 26293-306
DOI 10.18632/oncotarget.8477, PubMed 27050370

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM, Brosh RM, Gorospe M, Bohr VA (2016)
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
Proc Natl Acad Sci U S A, 113 (44), 12502-12507
DOI 10.1073/pnas.1610198113, PubMed 27791127

Wyller VB, Jacobsen K, Dahl MB, Nilsen H, Proske S, Horter T, Brun H (2016)
Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy
Int J Cardiol, 221, 376-8
DOI 10.1016/j.ijcard.2016.06.288, PubMed 27404709

Publications 2015

Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J (2015)
Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype
PLoS One, 10 (10), e0140883
DOI 10.1371/journal.pone.0140883, PubMed 26473596

Solberg R, Smith R, Almlöf M, Tewolde E, Nilsen H, Johansen HT (2015)
Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin
Biol Chem, 396 (1), 71-80
DOI 10.1515/hsz-2014-0172, PubMed 25205715

Publications 2014

Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA (2014)
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
Cell, 157 (4), 882-896
DOI 10.1016/j.cell.2014.03.026, PubMed 24813611

Jobert L, Nilsen H (2014)
Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes
Cell Mol Life Sci, 71 (13), 2451-65
DOI 10.1007/s00018-014-1562-y, PubMed 24496644

Publications 2013

Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H (2013)
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1
Nucleic Acids Res, 41 (10), 5368-81
DOI 10.1093/nar/gkt225, PubMed 23580547

Kassahun H, Nilsen H (2013)
Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1
Worm, 2 (4), e27337
DOI 10.4161/worm.27337, PubMed 24744987

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H (2013)
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
Nat Commun, 4, 2674
DOI 10.1038/ncomms3674, PubMed 24154628

Publications 2012

Forthun RB, Sengupta T, Skjeldam HK, Lindvall JM, McCormack E, Gjertsen BT, Nilsen H (2012)
Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid
PLoS One, 7 (11), e48992
DOI 10.1371/journal.pone.0048992, PubMed 23155442

Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (2012)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
Mol Cell, 49 (2), 339-45
DOI 10.1016/j.molcel.2012.11.010, PubMed 23246433

Smith R, Johansen HT, Nilsen H, Haugen MH, Pettersen SJ, Mælandsmo GM, Abrahamson M, Solberg R (2012)
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
Biochimie, 94 (12), 2590-9
DOI 10.1016/j.biochi.2012.07.026, PubMed 22902879

Tomazella GG, Kassahun H, Nilsen H, Thiede B (2012)
Quantitative proteome analysis reveals RNA processing factors as modulators of ionizing radiation-induced apoptosis in the C. elegans germline
J Proteome Res, 11 (8), 4277-88
DOI 10.1021/pr300386z, PubMed 22757771

Publications 2011

Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J, Nilsen H, Vértessy BG, Vellai T (2011)
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
J Cell Sci, 124 (Pt 9), 1510-8
DOI 10.1242/jcs.080192, PubMed 21502138

Publications 2010

Arczewska KD, Baumeier C, Kassahun H, Sengupta T, Bjørås M, Kuśmierek JT, Nilsen H (2010)
Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability
DNA Repair (Amst), 10 (2), 176-87
DOI 10.1016/j.dnarep.2010.10.009, PubMed 21111690

Fensgård Ø, Kassahun H, Bombik I, Rognes T, Lindvall JM, Nilsen H (2010)
A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways
Aging (Albany NY), 2 (3), 133-59
DOI 10.18632/aging.100127, PubMed 20382984

Skjeldam HK, Kassahun H, Fensgård O, SenGupta T, Babaie E, Lindvall JM, Arczewska K, Nilsen H (2010)
Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents
DNA Repair (Amst), 9 (8), 861-70
DOI 10.1016/j.dnarep.2010.04.009, PubMed 20493785

Publications 2009

Skjølberg HC, Fensgård O, Nilsen H, Grallert B, Boye E (2009)
Global transcriptional response after exposure of fission yeast cells to ultraviolet light
BMC Cell Biol, 10, 87
DOI 10.1186/1471-2121-10-87, PubMed 20015352

Zakaria C, Kassahun H, Yang X, Labbé JC, Nilsen H, Ramotar D (2009)
Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability
DNA Repair (Amst), 9 (2), 169-76
DOI 10.1016/j.dnarep.2009.11.007, PubMed 20036200

Publications 2008

Arczewska KD, Michalickova K, Donaldson IM, Nilsen H (2008)
The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network
Crit Rev Oncog, 14 (4), 217-73
DOI 10.1615/critrevoncog.v14.i4.20, PubMed 19645683

Publications 2007

Schmidt F, Strozynski M, Salus SS, Nilsen H, Thiede B (2007)
Rapid determination of amino acid incorporation by stable isotope labeling with amino acids in cell culture (SILAC)
Rapid Commun Mass Spectrom, 21 (23), 3919-26
DOI 10.1002/rcm.3290, PubMed 17979108

Publications 2006

Dengg M, Garcia-Muse T, Gill SG, Ashcroft N, Boulton SJ, Nilsen H (2006)
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates
EMBO Rep, 7 (10), 1046-51
DOI 10.1038/sj.embor.7400782, PubMed 16964178

Publications 2005

Andersen S, Ericsson M, Dai HY, Peña-Diaz J, Slupphaug G, Nilsen H, Aarset H, Krokan HE (2005)
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice
DNA Repair (Amst), 4 (12), 1432-41
DOI 10.1016/j.dnarep.2005.08.004, PubMed 16174566

Nilsen H, An Q, Lindahl T (2005)
Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice
Oncogene, 24 (18), 3063-6
DOI 10.1038/sj.onc.1208480, PubMed 15735713

Publications 2004

Andersen S, Heine T, Sneve R, König I, Krokan HE, Epe B, Nilsen H (2004)
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts
Carcinogenesis, 26 (3), 547-55
DOI 10.1093/carcin/bgh347, PubMed 15564287

Publications 2003

Nilsen H, Stamp G, Andersen S, Hrivnak G, Krokan HE, Lindahl T, Barnes DE (2003)
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
Oncogene, 22 (35), 5381-6
DOI 10.1038/sj.onc.1206860, PubMed 12934097

Publications 2002

Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G (2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
J Biol Chem, 277 (42), 39926-36
DOI 10.1074/jbc.M207107200, PubMed 12161446

Nilsen H, Lindahl T, Verreault A (2002)
DNA base excision repair of uracil residues in reconstituted nucleosome core particles
EMBO J, 21 (21), 5943-52
DOI 10.1093/emboj/cdf581, PubMed 12411511

Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS (2002)
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
Curr Biol, 12 (20), 1748-55
DOI 10.1016/s0960-9822(02)01215-0, PubMed 12401169

Publications 1999

Haug T, Skorpen F, Otterlei M, Steinsbekk K, Nilsen H, Skjelbred CF, Bharati S, Kavli B, Standal R, Slupphaug G (1999)
Human uracil-DNA glycosylase: gene structure, regulation, and structural basis for catalysis
Kluwer Academic, [Dordrecht], S. 221-236
BIBSYS 000229466

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