Knut E. A. Lundin
- Professor, consultant; MD, PhD
Publications 2022
Detection of gluten immunogenic peptides and the Celiac Disease Adherence Test to monitor gluten-free diet: a pilot study
Eur. J. Clin. Nutr.
DOI 10.1038/s41430-021-01054-6
Publications 2021
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+T cells
Sci Rep, 11 (1), 9252
DOI 10.1038/s41598-021-86612-5
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv. Sci., 8 (21), 2102778
DOI 10.1002/advs.202102778
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front. Immunol., 12, 639672
DOI 10.3389/fimmu.2021.639672
Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8(+) alpha beta T lymphocytes in untreated celiac disease
Eur. J. Immunol., 51 (6), 1542-1545
DOI 10.1002/eji.202048974
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
Sci. Immunol., 6 (62), eabg4925
DOI 10.1126/sciimmunol.abg4925
COVID-19 and its effects on endothelium in HIV-positive patients in sub-Saharan Africa: Cardiometabolic risk, thrombosis and vascular function (ENDOCOVID STUDY)
BMC Infect. Dis., 21 (1), 719
DOI 10.1186/s12879-021-06426-8
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J. Exp. Med., 218 (2), e20200852
DOI 10.1084/jem.20200852
Medical education in a pandemic era
Tidsskr. Nor. Laegeforen., 141 (12), 1144
Understanding celiac disease monitoring patterns and outcomes after diagnosis: A multinational, retrospective chart review study
World J. Gastroenterol., 27 (20), 2603-2614
DOI 10.3748/wjg.v27.i20.2603
Nutritional quality and costs of gluten-free products: a case-control study of food products on the Norwegian marked
Food Nutr. Res., 65, 6121
DOI 10.29219/fnr.v65.6121
Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning
Front. Immunol., 12, 646163
DOI 10.3389/fimmu.2021.646163
Circulating CD103(+) gamma delta and CD8(+) T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol., 14 (4), 842-851
DOI 10.1038/s41385-021-00385-8
Statement of the Prolamin Working Group on the Determination of Gluten in Fermented Foods Containing Partially Hydrolyzed Gluten
Front. Nutr., 7, 626712
DOI 10.3389/fnut.2020.626712
THE AUTHORS REPLY
N. Engl. J. Med., 385 (16)
A randomized trial of a transglutaminase 2 inhibitor for celiac disease
N. Engl. J. Med., 385 (1), 35-45
DOI 10.1056/NEJMoa2032441
Machine Learning Analysis of Naive B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls
Front. Immunol., 12, 627813
DOI 10.3389/fimmu.2021.627813
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z
IN MEMORIAM Erik Thorsby (1938-2021)
Immunogenetics, 73 (3), 203-205
DOI 10.1007/s00251-021-01218-5
In memoriam: Erik Thorsby (1938-2021)
Scand. J. Immunol., 94 (1), e13055
DOI 10.1111/sji.13055
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge
Adv. Sci., 8 (4), 2003526
DOI 10.1002/advs.202003526
High disease burden in treated celiac patients - a web-based survey
Scand. J. Gastroenterol., 56 (8), 882-888
DOI 10.1080/00365521.2021.1930146
T cell receptor repertoire as a potential diagnostic marker for celiac disease
Clin. Immunol., 222, 108621
DOI 10.1016/j.clim.2020.108621
Publications 2020
Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease
JGH Open, 4 (3), 410-416
DOI 10.1002/jgh3.12266
On the immune response to barley in celiac disease: Biased and public T-cell receptor usage to a barley unique and immunodominant gluten epitope
Eur. J. Immunol., 50 (2), 256-269
DOI 10.1002/eji.201948253
Single-cell TCR sequencing of gut intraepithelial gamma delta T cells reveals a vast and diverse repertoire in celiac disease
Mucosal Immunol., 13 (2), 313-321
DOI 10.1038/s41385-019-0222-9
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739
Experiences of managing a gluten-free diet on multiple levels of society: a qualitative study
BMC Nutr., 6 (1), 65
DOI 10.1186/s40795-020-00390-3
Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials
Biodrugs, 34 (5), 681-694
DOI 10.1007/s40259-020-00438-7
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
Front. Nutr., 7, 29
DOI 10.3389/fnut.2020.00029
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Proc. Natl. Acad. Sci. U. S. A., 117 (6), 3063-3073
DOI 10.1073/pnas.1914308117
Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity
United European Gastroenterol. J., 8 (1), 2050640619874173-118
DOI 10.1177/2050640619874173
Publications 2019
European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders
United European Gastroenterol. J., 7 (5), 583-613
DOI 10.1177/2050640619844125
Distinct phenotype of CD4(+) T cells driving celiac disease identified in multiple autoimmune conditions
Nat. Med., 25 (5), 734-+
DOI 10.1038/s41591-019-0403-9
Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J. Biol. Chem., 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736
Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
Nat. Commun., 10, 628
DOI 10.1038/s41467-019-08489-3
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease
Sci. Adv., 5 (8), eaaw7756
DOI 10.1126/sciadv.aaw7756
No major reduction in bone mineral density after long-term treatment of patients with Celiac Disease
Eur. J. Intern. Med., 68, 23-29
DOI 10.1016/j.ejim.2019.07.024
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-+
DOI 10.1053/j.gastro.2018.12.013
Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease
Proc. Natl. Acad. Sci. U. S. A., 116 (30), 15134-15139
DOI 10.1073/pnas.1901561116
Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort
BMJ-British Medical Journal, 364, l231
DOI 10.1136/bmj.l231
Coeliac disease
Nat. Rev. Dis. Primers, 5, 3
DOI 10.1038/s41572-018-0054-z
Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity
Clin. Nutr. ESPEN, 31, 88-94
DOI 10.1016/j.clnesp.2019.02.012
Transcriptional profiling of human intestinal plasma cells reveals effector functions beyond antibody production
United European Gastroenterol. J., 7 (10), 1399-1407
DOI 10.1177/2050640619862461
A system for students' evaluation of lectures in the medical programme in Oslo
Tidsskr. Nor. Laegeforen., 139 (11), 1056-1060
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease
United European Gastroenterol. J., 7 (10), 2050640619874183-1344
DOI 10.1177/2050640619874183
Publications 2018
Subtherapeutic concentrations of infliximab and adalimumab are associated with increased disease activity in Crohn's disease
Ther. Adv. Gastroenterol., 11, 1756284818759930
DOI 10.1177/1756284818759930
Is Non-Celiac Rice-Starch Sensitivity as Common in Children as Non-Celiac Gluten Sensitivity?
Am. J. Gastroenterol., 113 (8), 1254
DOI 10.1038/s41395-018-0079-7
Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls
Scand. J. Gastroenterol., 53 (10-11), 1212-1216
DOI 10.1080/00365521.2018.1509122
Fatigue as an Extra-Intestinal Manifestation of Celiac Disease: A Systematic Review
Nutrients, 10 (11), 1652
DOI 10.3390/nu10111652
Outcome measures in coeliac disease trials: the Tampere recommendations
Gut, 67 (8), 1410-1424
DOI 10.1136/gutjnl-2017-314853
Disease-driving CD4(+) T cell clonotypes persist for decades in celiac disease
J. Clin. Invest., 128 (6), 2642-2650
DOI 10.1172/JCI98819
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-+
DOI 10.1053/j.gastro.2017.11.006
HLA-DQ: gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461
More Than One Culprit for Nonceliac Gluten/Wheat Sensitivity Reply
Gastroenterology, 155 (1), 228
DOI 10.1053/j.gastro.2018.06.032
Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity
Gastroenterology, 154 (3), 529-+
DOI 10.1053/j.gastro.2017.10.040
Effects of individualized nutrition after allogeneic hematopoietic stem cell transplantation following myeloablative conditioning; a randomized controlled trial
Clin. Nutr. ESPEN, 28, 59-66
DOI 10.1016/j.clnesp.2018.08.002
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
Am. J. Pathol., 188 (7), 1563-1579
DOI 10.1016/j.ajpath.2018.03.017
Publications 2017
Linking Spatial Structure and Community-Level Biotic Interactions through Cooccurrence and Time Series Modeling of the Human Intestinal Microbiota
mSystems, 2 (5), e00086-17
DOI 10.1128/mSystems.00086-17
Targeting Integrin alpha 4 beta 7 in Steroid-Refractory Intestinal Graft-versus-Host Disease
Biol. Blood Marrow Transplant., 23 (1), 172-175
DOI 10.1016/j.bbmt.2016.10.009
Elective courses in medicine studies
Tidsskr. Nor. Laegeforen., 137 (20), 1592-1594
Non-coeliac gluten sensitivity
J. Gastroenterol. Hepatol., 32 1, 86-89
DOI 10.1111/jgh.13705
A TCR alpha framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3 beta interactions
JCI Insight, 2 (17), e95193
DOI 10.1172/jci.insight.95193
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J. Hepatol., 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Reports, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036
Efficacy of infliximab biosimilars in patients with Crohn's disease Reply
Lancet, 390 (10111), 2436
DOI 10.1016/S0140-6736(17)32463-7
Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial
Lancet, 389 (10086), 2304-2316
DOI 10.1016/S0140-6736(17)30068-5
CVID and Celiac Disease
Am. J. Gastroenterol., 112 (2), 393
DOI 10.1038/ajg.2016.551
Early growth in children with coeliac disease: a cohort study
Arch. Dis. Child., 102 (11), 1037-1043
DOI 10.1136/archdischild-2016-312304
High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease
J. Immunol., 199 (2), 782-791
DOI 10.4049/jimmunol.1700169
Wheat challenge in self-reported gluten sensitivity: a comparison of scoring methods
Scand. J. Gastroenterol., 52 (2), 185-192
DOI 10.1080/00365521.2016.1244705
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease
JCI Insight, 2 (17), e93961
DOI 10.1172/jci.insight.93961
Publications 2016
Healthy HLA-DQ2.5(+) Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J. Immunol., 196 (6), 2819-2826
DOI 10.4049/jimmunol.1501152
Long-term mucosal recovery and healing in celiac disease is the rule - not the exception
Scand. J. Gastroenterol., 51 (12), 1439-1446
DOI 10.1080/00365521.2016.1218540
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am. J. Gastroenterol., 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329
Transition from childhood to adulthood in coeliac disease: the Prague consensus report
Gut, 65 (8), 1242-1251
DOI 10.1136/gutjnl-2016-311574
Publications 2015
Four DNA Methylation Biomarkers in Biliary Brush Samples Accurately Identify the Presence of Cholangiocarcinoma
Hepatology, 61 (5), 1651-1659
DOI 10.1002/hep.27707
Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria
Nutrients, 7 (6), 4966-4977
DOI 10.3390/nu7064966
Coeliac disease - from genetic and immunological studies to clinical applications
Scand. J. Gastroenterol., 50 (6), 708-717
DOI 10.3109/00365521.2015.1030766
Coeliac disease and autoimmune disease-genetic overlap and screening
Nat. Rev. Gastroenterol. Hepatol., 12 (9), 507-515
DOI 10.1038/nrgastro.2015.136
Analysis of Celiac Disease Autoreactive Gut Plasma Cells and Their Corresponding Memory Compartment in Peripheral Blood Using High-Throughput Sequencing
J. Immunol., 194 (12), 5703-5712
DOI 10.4049/jimmunol.1402611
Small Bowel, Celiac Disease and Adaptive Immunity
Dig. Dis., 33 (2), 115-121
DOI 10.1159/000369512
Serologic Assay for Diagnosis of Celiac Disease Based on a Patient-Derived Monoclonal Antigliadin Antibody
Gastroenterology, 149 (6), 1530-+
DOI 10.1053/j.gastro.2015.07.008
Non-celiac gluten sensitivity: A work-in-progress entity in the spectrum of wheat-related disorders
Best Pract. Res. Clin. Gastroenterol., 29 (3), 477-491
DOI 10.1016/j.bpg.2015.04.006
Publications 2014
Tetramer-visualized gluten-specific CD4+T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol. J., 2 (4), 268-278
DOI 10.1177/2050640614540154
Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology
Gut, 63 (8), 1210-1228
DOI 10.1136/gutjnl-2013-306578
Non-celiac gluten sensitivity - why worry?
BMC Med., 12, 86
DOI 10.1186/1741-7015-12-86
Advances in coeliac disease
Curr. Opin. Gastroenterol., 30 (2), 154-162
DOI 10.1097/MOG.0000000000000041
Issues associated with the emergence of coeliac disease in the Asia-Pacific region: A working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology
J. Gastroenterol. Hepatol., 29 (4), 666-677
DOI 10.1111/jgh.12514
Biased usage and preferred pairing of alpha- and beta-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease
Int. Immunol., 26 (1), 13-19
DOI 10.1093/intimm/dxt037
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells
Nat. Commun., 5, 4041
DOI 10.1038/ncomms5041
Association Between Maternal Iron Supplementation During Pregnancy and Risk of Celiac Disease in Children
Clin. Gastroenterol. Hepatol., 12 (4), 624-+
DOI 10.1016/j.cgh.2013.09.061
Publications 2013
Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease
Eur. J. Immunol., 43 (10), 2605-2612
DOI 10.1002/eji.201343382
Mucosal Cytokine Response After Short-Term Gluten Challenge in Celiac Disease and Non-Celiac Gluten Sensitivity
Am. J. Gastroenterol., 108 (5), 842-850
DOI 10.1038/ajg.2013.91
Transglutaminase 2-Specific Autoantibodies in Celiac Disease Target Clustered, N-Terminal Epitopes Not Displayed on the Surface of Cells
J. Immunol., 190 (12), 5981-5991
DOI 10.4049/jimmunol.1300183
The Oslo definitions for coeliac disease and related terms
Gut, 62 (1), 43-52
DOI 10.1136/gutjnl-2011-301346
Increased frequency of intestinal CD4(+) T cells reactive with mycobacteria in patients with Crohn's disease
Scand. J. Gastroenterol., 48 (11), 1278-1285
DOI 10.3109/00365521.2013.837952
Publications 2012
Rapid Accumulation of CD14(+)CD11c(+) Dendritic Cells in Gut Mucosa of Celiac Disease after in vivo Gluten Challenge
PLoS One, 7 (3), e33556
DOI 10.1371/journal.pone.0033556
T-Cell Response to Gluten in Patients With HLA-DQ2.2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease
Gastroenterology, 142 (3), 552-561
DOI 10.1053/j.gastro.2011.11.021
Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells
Hum. Immunol., 73 (4), 376-381
DOI 10.1016/j.humimm.2012.01.016
Absence of somatization in non-coeliac gluten sensitivity
Scand. J. Gastroenterol., 47 (7), 770-777
DOI 10.3109/00365521.2012.679685
Video capsule endoscopy in celiac disease: Current clinical practice
J. Dig. Dis., 13 (2), 94-99
DOI 10.1111/j.1751-2980.2011.00561.x
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
Nat. Med., 18 (3), 441-U204
DOI 10.1038/nm.2656
Inflammatory bowel disease in patients with primary sclerosing cholangitis: Clinical characterization in liver transplanted and nontransplanted patients
Inflamm. Bowel Dis., 18 (3), 536-545
DOI 10.1002/ibd.21699
Publications 2011
INSPIRE Study: Does Stress Management Improve the Course of Inflammatory Bowel Disease and Disease-specific Quality of Life in Distressed Patients with Ulcerative Colitis or Crohn's Disease? A Randomized Controlled Trial
Inflamm. Bowel Dis., 17 (9), 1863-1873
DOI 10.1002/ibd.21575
Assessing Possible Celiac Disease by an HLA-DQ2-gliadin Tetramer Test
Am. J. Gastroenterol., 106 (7), 1318-1324
DOI 10.1038/ajg.2011.23
CD62L(neg)CD38(+) Expression on Circulating CD4(+) T Cells Identifies Mucosally Differentiated Cells in Protein Fed Mice and in Human Celiac Disease Patients and Controls
Am. J. Gastroenterol., 106 (6), 1147-1159
DOI 10.1038/ajg.2011.24
Long-Lived Plasma Cells from Human Small Intestine Biopsies Secrete Immunoglobulins for Many Weeks In Vitro
J. Immunol., 187 (6), 2867-2874
DOI 10.4049/jimmunol.1003181
Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease
J. Immunol., 187 (6), 3064-3071
DOI 10.4049/jimmunol.1101526
Publications 2010
Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal Mucosa
J. Immunol., 185 (9), 5377-5383
DOI 10.4049/jimmunol.1001587
Intestinal malabsorption of D-xylose: Comparison of test modalities in patients with celiac disease
Scand. J. Gastroenterol., 45 (11), 1289-1294
DOI 10.3109/00365521.2010.503969
Publications 2009
Isolation of Mycobacterium avium Subspecies paratuberculosis Reactive CD4 T Cells from Intestinal Biopsies of Crohn's Disease Patients
PLoS One, 4 (5), e5641
DOI 10.1371/journal.pone.0005641
Publications 2008
The INSPIRE study: Are different personality traits related to disease-specific quality of life (OBDQ) in distressed patients with ulcerative colitis and Crohn's disease?
Inflamm. Bowel Dis., 14 (5), 680-686
DOI 10.1002/ibd.20367
No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease
Scand. J. Gastroenterol., 43 (2), 161-165
DOI 10.1080/00365520701832822
Publications 2007
Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
Gastroenterology, 132 (7), 2371-2382
DOI 10.1053/j.gastro.2007.04.023
Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
Proc. Natl. Acad. Sci. U. S. A., 104 (8), 2831-2836
DOI 10.1073/pnas.0608610104
Publications 2006
A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
Gastroenterology, 131 (2), 428-438
DOI 10.1053/j.gastro.2006.06.002
HLA-DQ2 and-DQ8 signatures of gluten T cell epitopes in celiac disease
J. Clin. Invest., 116 (8), 2226-2236
DOI 10.1172/JCI27620
Publications 1990
T cell recognition of HLA-DQ molecules
Institute of Transplantation Immunology, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 900878436, ISBN 82-90187-66-1