Breder S, Wang B, Villard C, Båve A, Lindström-Älgå L, Eide E, Engesæter LK, Reims HM, Grzyb K, Aabakken L, Melum E, Line PD, Wiencke K, Folseraas T, Bergquist A(2026) Liver transplantation in primary sclerosing cholangitis with hepatobiliary neoplasia: survival outcomes and impact of diagnostic uncertainty Scand J Gastroenterol, 1-12(in press) DOI 10.1080/00365521.2026.2709611, PubMed 42549941
Brynjulfsen LRV, ElAbd H, Øgaard J, Jördens MS, Bozward AG, Kearns D, Jiang X, Folseraas T, Trivedi PJ, Oo YH, Franke A, Karlsen TH, Melum E, Chung BK(2026) Intrahepatic T cell analysis reveals Th17 and MAIT17 enrichment in primary sclerosing cholangitis JHEP Rep, 8(9), 101857 DOI 10.1016/j.jhepr.2026.101857, PubMed 42002038
Braadland PR, Ali AH, Puchas P, Juran BD, Atkinson EJ, Schlicht EM, Bianchi JK, McCauley BM, Tjønnfjord SKV, Helgadottir H, Ueland PM, Ulvik A, Sauer P, Folseraas T, Karlsen TH, Vesterhus M, Dill MT, Lazaridis KN, Hov JR(2026) Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis J Hepatol, 85(2), 227-237 DOI 10.1016/j.jhep.2026.03.048, PubMed 42002000
Han Y, Byun J, VanLith CJ, Cooley MA, Shaw VR, Hatia RI, Ahmed FY, Giama NH, Ali HM, Campbell NA, Hassan M, Andersen JB, Ankoma-Sey V, Banales JM, Bujanda L, Bathe OF, Bekaii-Saab TS, Borad MJ, Björkström NK, Chan CHF, Cleary SP, Cornillet M, Folseraas T, Galle PR, Genkinger JM, MacInnis RJ, Gores GJ, Goyal L, Houlston RS, Ilyas SIet al.(2026) Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses Hepatology(in press) DOI 10.1097/HEP.0000000000001699, PubMed 41627892
Izquierdo-Sanchez L, Narbaiza J, Martin-Robles J, Lamarca A, Klümpen HJ, La Casta A, Valsan A, Roessler S, Braconi C, da Fonseca LG, Dopazo C, Juliebø AT, Mauro E, Buettner S, Balderramo D, Ponz-Sarvise M, Ferrer JD, Zieniewicz K, Utpatel K, Sparchez Z, Brustia R, Peck-Radosavljevic M, De Sario G, Gómez-Gavara C, Carrilho FJ, Tesini G, Nair P, Gutierrez E, Zonderhuis BM, Koerkamp BGet al.(2026) Chronic liver disease is associated with earlier-stage cholangiocarcinoma diagnosis and improved prognosis: Findings from the GLOBAL-BTC registry J Hepatol(in press) DOI 10.1016/j.jhep.2026.08.020, PubMed 42637053
Juliebø AT, Folseraas T, Karlsen TH, Boberg KM, International PSC Study Group (IPSCSG)(2026) Differences in immunosuppressive strategies for primary sclerosing cholangitis after liver transplantation J Hepatol, 84(5), e157-e159 DOI 10.1016/j.jhep.2026.02.009, PubMed 41722732
Lapitz A, Grimsrud MM, Catanzaro E, Rodrigues PM, Hov JR, Azkargorta M, Val B, Vesterhus M, Grzyb K, Reims HM, Elortza F, Izquierdo-Sánchez L, Perugorria MJ, Bujanda L, Aabakken L, Paulsen V, Karlsen TH, Banales JM, Folseraas T(2026) Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis JHEP Rep, 102003(in press) DOI 10.1016/j.jhepr.2026.102003, PubMed 42628796
Molinaro A, Braadland PR, Carpino G, Carreras A, Nikolaidis M, Hanzely P, Beck KR, Ali AH, Bossen L, Frank A, Lundqvist A, Juran BD, Overi D, Geng L, Amundsen-Isaksen E, Reims HM, Björk I, Grzyb K, Abildgaard A, Folseraas T, Cornillet M, Helgadóttir H, McCauley BM, Cristoferi L, Carbone M, Cardinale V, Høivik ML, Engesæter LK, Tjønnfjord SKV, McCann Aet al.(2026) Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling Nat Metab(in press) DOI 10.1038/s42255-026-01600-1, PubMed 42698000
Vedeld HM, Breder S, Pharo H, Brodal HP, Adolfsen EM, Brandt-Winge S, von Seth E, Grimsrud MM, Yaqub S, Karlsen TH, Grzyb K, Paulsen V, Färkkilä MA, Bergquist A, Aabakken L, Boberg KM, Folseraas T, Lind GE(2026) Accurate detection of cholangiocarcinoma in primary sclerosing cholangitis using DNA methylation biomarkers in bile and plasma JHEP Rep, 8(8), 101876 DOI 10.1016/j.jhepr.2026.101876, PubMed 42067191
Publications 2025
Banales JM, Rodrigues PM, Affò S, Andersen JB, Aspichueta P, Boulter L, Bridgewater J, Calvisi DF, Cardenas A, Cardinale V, Carpino G, Coulouarn C, Dopazo C, Edeline J, Fabris L, Folseraas T, Forner A, Goeppert B, Heikenwalder M, Kendall TJ, Khan SA, Klümpen HJ, Koerkamp BG, Lamarca A, Lindsey S, Lleo A, Luedde T, Macias RIR, Morement H, Nault JCet al.(2025) Cholangiocarcinoma 2026: status quo, unmet needs and priorities Nat Rev Gastroenterol Hepatol, 23(1), 65-96 DOI 10.1038/s41575-025-01153-w, PubMed 41372578
Breder S, Villard C, Eide E, Wang B, Engesæter LK, Reims HM, Hov JR, Melum E, Aabakken L, Line PD, Lømo J, Grzyb K, Wiencke K, Bergquist A, Folseraas T(2025) A retrospective evaluation of preemptive liver transplantation for bile duct dysplasia in primary sclerosing cholangitis: Balancing risks and benefits JHEP Rep, 7(12), 101598 DOI 10.1016/j.jhepr.2025.101598, PubMed 41321929
Del Zompo F, Crouchet E, Ostyn T, Nehme Z, Messé M, Jühling F, Désert R, Vieira AT, Moehlin J, Nakib D, Andrews T, Perciani C, Chung S, Bader GD, McGilvray I, Caime C, Scaravaglio M, Carbone M, Invernizzi P, Yaqub S, Folseraas T, Karlsen TH, Shankar G, Primeaux M, Dhawan P, Banales JM, Roehlen N, Iacone R, Teixeira G, Heikenwälder Met al.(2025) Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis J Hepatol, 83(6), 1305-1319 DOI 10.1016/j.jhep.2025.08.005, PubMed 40846184
ElAbd H, Pesesky M, Innocenti G, Chung BK, Mahdy AKH, Kriukova V, Kulsvehagen L, Strobbe D, Stühler C, Mayr G, May DH, Prinzensteiner M, Steiert TA, Tran F, Hadjihannas MV, Günther R, Rosati E, Mucha S, Lieb W, Ziemann M, Dempfle A, Braun F, Folseraas T, Hov JR, Melum E, Bacher P, Sterneck M, Weismüller TJ, Lenzen H, Bokemeyer Bet al.(2025) T and B cell responses against Epstein-Barr virus in primary sclerosing cholangitis Nat Med, 31(7), 2306-2316 DOI 10.1038/s41591-025-03692-w, PubMed 40500415
Fossdal G, Braadland P, Hov JR, Husebye ES, Folseraas T, Ueland PM, Ulvik A, Karlsen TH, Berge RK, Vesterhus M(2025) Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis Scand J Gastroenterol, 60(2), 165-173 DOI 10.1080/00365521.2024.2447521, PubMed 39764583
Holmer M, Ingre M, Färkkilä M, Ponsioen C, Mol B, Schramm C, Folseraas T, Wiencke K, Cazzagon N, Catanzaro E, Molinaro A, Nilsson E, Vessby J, Kechagias S, Nyhlin N, Werner M, Bergquist A(2025) Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study Hepatology, 83(1), 21-29 DOI 10.1097/HEP.0000000000001351, PubMed 40238209
Holmer M, Ingre M, Färkkilä M, Ponsioen C, Mol B, Schramm C, Folseraas T, Wiencke K, Cazzagon N, Catanzaro E, Molinaro A, Nilsson E, Vessby J, Kechagias S, Nyhlin N, Werner M, Bergquist A(2025) Reply: Competing risk and surveillance thresholds for HCC in patients with PSC Hepatology, 83(4), E123-E124 DOI 10.1097/HEP.0000000000001651, PubMed 41405465
Mol B, van Nieuwamerongen M, van Munster KN, Färkkilä M, Folseraas T, Tjønnfjord SKV, Hov JR, Boberg K, Vesterhus M, Jørgensen KK, Bergquist A, Goet JC, de Vries AC, van der Meer AJP, Weersma RK, Inderson A, Bogaards JA, Ponsioen CY, IPSCR study group(2025) Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC JHEP Rep, 8(3), 101700 DOI 10.1016/j.jhepr.2025.101700, PubMed 41757378
Singh Y, Eaton JE, Venkatesh SK, Welle CL, Smith B, Faghani S, Vesterhus M, Karlsen TH, Jorgensen KK, Folseraas T, Petrovic K, Negard A, Bjoerk I, Abildgaard A, Gulamhusein AF, Jhaveri K, Gores GJ, Ilyas SI, Taner T, Heimbach JK, Diwan TS, LaRusso NF, Lazaridis KN, Erickson BJ(2025) Deep learning analysis of MRI accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis Hepatology, 83(1), 30-39 DOI 10.1097/HEP.0000000000001314, PubMed 40112296
Yaqub S, Busund S, Smedman TM, Syversveen T, Khan A, Solheim JM, Folseraas T, Wiencke K, Lassen K, Dueland S, Line PD(2025) Liver transplantation for locally advanced non-resectable intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: early results from the TESLA trial Br J Surg, 112(3) DOI 10.1093/bjs/znaf054, PubMed 40099404
Publications 2024
Grimsrud MM, Forster M, Goeppert B, Hemmrich-Stanisak G, Sax I, Grzyb K, Braadland PR, Charbel A, Metzger C, Albrecht T, Steiert TA, Schlesner M, Manns MP, Vogel A, Yaqub S, Karlsen TH, Schirmacher P, Boberg KM, Franke A, Roessler S, Folseraas T(2024) Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis Hepatol Commun, 8(7) DOI 10.1097/HC9.0000000000000461, PubMed 38967597
Poch T, Bahn J, Casar C, Krause J, Evangelakos I, Gilladi H, Kunzmann LK, Laschtowitz A, Iuso N, Schäfer AM, Liebig LA, Steinmann S, Sebode M, Folseraas T, Engesæter LK, Karlsen TH, Franke A, Hubner N, Schlein C, Galun E, Huber S, Lohse AW, Gagliani N, Schwinge D, Schramm C(2024) Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis Cell Rep Med, 5(7), 101620 DOI 10.1016/j.xcrm.2024.101620, PubMed 38901430
van Keulen AM, Buettner S, Olthof PB, Klümpen HJ, Erdmann JI, Izquierdo-Sanchez L, Banales JM, Goeppert B, Roessler S, Zieniewicz K, Lamarca A, Valle JW, La Casta A, Hoogwater FJH, Donadon M, Scheiter A, Marzioni M, Adeva J, Kiudeliene E, Fernández JMU, Vidili G, Mocan T, Fabris L, Krawczyk M, Folseraas T, Dopazo C, Detry O, Voiosu T, Scripcariu V, Biancaniello Fet al.(2024) Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease Ann Surg Oncol, 31(10), 6495-6503 DOI 10.1245/s10434-024-15582-5, PubMed 38896226
Publications 2023
Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR(2023) Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation J Hepatol, 79(4), 955-966 DOI 10.1016/j.jhep.2023.05.038, PubMed 37328069
De Muynck K, Heyerick L, De Ponti FF, Vanderborght B, Meese T, Van Campenhout S, Baudonck L, Gijbels E, Rodrigues PM, Banales JM, Vesterhuus M, Folseraas T, Scott CL, Vinken M, Van der Linden M, Hoorens A, Van Dorpe J, Lefere S, Geerts A, Van Nieuwerburgh F, Verhelst X, Van Vlierberghe H, Devisscher L(2023) Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis Hepatology, 79(2), 269-288 DOI 10.1097/HEP.0000000000000557, PubMed 37535809
Grant CW, Juran BD, Ali AH, Schlicht EM, Bianchi JK, Hu X, Liang Y, Jarrell Z, Liu KH, Go YM, Jones DP, Walker DI, Miller GW, Folseraas T, Karlsen TH, LaRusso NF, Gores GJ, Athreya AP, Lazaridis KN(2023) Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis Exposome, 3(1), osac011 DOI 10.1093/exposome/osac011, PubMed 36687160
Han Y, Byun J, Zhu C, Sun R, Roh JY, Cordell HJ, Lee HS, Shaw VR, Kang SW, Razjouyan J, Cooley MA, Hassan MM, Siminovitch KA, Folseraas T, Ellinghaus D, Bergquist A, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN, International PSC Study Group, McGlynn KA, Roberts LR, Amos CI(2023) Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis Nat Commun, 14(1), 1069 DOI 10.1038/s41467-023-36678-8, PubMed 36828809
Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JBet al.(2023) Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma J Hepatol, 79(1), 93-108 DOI 10.1016/j.jhep.2023.02.027, PubMed 36868481
Mikalsen IM, Breder S, Medhus AW, Folseraas T, Aabakken L, Ånonsen KV(2023) ERCP for the initial management of malignant biliary obstruction - real world data on 596 procedures Scand J Gastroenterol, 59(3), 369-377 DOI 10.1080/00365521.2023.2282375, PubMed 37994406
Steiert TA, Parra G, Gut M, Arnold N, Trotta JR, Tonda R, Moussy A, Gerber Z, Abuja PM, Zatloukal K, Röcken C, Folseraas T, Grimsrud MM, Vogel A, Goeppert B, Roessler S, Hinz S, Schafmayer C, Rosenstiel P, Deleuze JF, Gut IG, Franke A, Forster M(2023) A critical spotlight on the paradigms of FFPE-DNA sequencing Nucleic Acids Res, 51(14), 7143-7162 DOI 10.1093/nar/gkad519, PubMed 37351572
Wacker EM, Uellendahl-Werth F, Bej S, Wolkenhauer O, Vesterhus M, Lieb W, Franke A, Karlsen TH, Folseraas T, Ellinghaus D(2023) Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis JHEP Rep, 6(2), 100988 DOI 10.1016/j.jhepr.2023.100988, PubMed 38304234
Yaqub S, Bjørk I, Sugulle M, Folseraas T(2023) Biopsy helpful in diagnosing a liver mass in pregnancy: focal nodular hyperplasia Lancet, 402(10403), e10 DOI 10.1016/S0140-6736(23)01606-9, PubMed 37633669
Publications 2022
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti Aet al.(2022) Detailed stratified GWAS analysis for severe COVID-19 in four European populations Hum Mol Genet, 31(23), 3945-3966 DOI 10.1093/hmg/ddac158, PubMed 35848942
Eliasson J, Lo B, Schramm C, Chazouilleres O, Folseraas T, Beuers U, Ytting H(2022) Survey uncovering variations in the management of primary sclerosing cholangitis across Europe JHEP Rep, 4(11), 100553 DOI 10.1016/j.jhepr.2022.100553, PubMed 36164416
Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert Ket al.(2022) Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry J Hepatol, 76(5), 1109-1121 DOI 10.1016/j.jhep.2021.12.010, PubMed 35167909
Lei L, Bruneau A, El Mourabit H, Guégan J, Folseraas T, Lemoinne S, Karlsen TH, Hoareau B, Morichon R, Gonzalez-Sanchez E, Goumard C, Ratziu V, Charbord P, Gautheron J, Tacke F, Jaffredo T, Cadoret A, Housset C(2022) Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis Hepatology, 76(5), 1360-1375 DOI 10.1002/hep.32456, PubMed 35278227
Nooijen LE, Banales JM, de Boer MT, Braconi C, Folseraas T, Forner A, Holowko W, Hoogwater FJH, Klümpen HJ, Groot Koerkamp B, Lamarca A, La Casta A, López-López F, Izquierdo-Sánchez L, Scheiter A, Utpatel K, Swijnenburg RJ, Kazemier G, Erdmann JI, ENSCCA Group(2022) Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry Cancers (Basel), 14(10) DOI 10.3390/cancers14102389, PubMed 35625993
Singh Y, Jons WA, Eaton JE, Vesterhus M, Karlsen T, Bjoerk I, Abildgaard A, Jorgensen KK, Folseraas T, Little D, Gulamhusein AF, Petrovic K, Negard A, Conte GM, Sobek JD, Jagtap J, Venkatesh SK, Gores GJ, LaRusso NF, Lazaridis KN, Erickson BJ(2022) Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis Eur Radiol Exp, 6(1), 58 DOI 10.1186/s41747-022-00312-x, PubMed 36396865
Uellendahl-Werth F, Maj C, Borisov O, Juzenas S, Wacker EM, Jørgensen IF, Steiert TA, Bej S, Krawitz P, Hoffmann P, Schramm C, Wolkenhauer O, Banasik K, Brunak S, Schreiber S, Karlsen TH, Degenhardt F, Nöthen M, Franke A, Folseraas T, Ellinghaus D(2022) Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease Commun Biol, 5(1), 80 DOI 10.1038/s42003-022-03031-6, PubMed 35058554
Yu J, Refsum E, Helsingen LM, Folseraas T, Ploner A, Wieszczy P, Barua I, Jodal HC, Melum E, Løberg M, Blom J, Bretthauer M, Adami HO, Kalager M, Ye W(2022) Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study United European Gastroenterol J, 10(2), 212-224 DOI 10.1002/ueg2.12204, PubMed 35107865
Publications 2021
Aune D, Sen A, Norat T, Riboli E, Folseraas T(2021) Primary sclerosing cholangitis and the risk of cancer, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of cohort studies Sci Rep, 11(1), 10646 DOI 10.1038/s41598-021-90175-w, PubMed 34017024
Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Trøseid M, Midttun Ø, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR(2021) Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis Scand J Gastroenterol, 56(4), 443-452 DOI 10.1080/00365521.2021.1880627, PubMed 33583308
Fossdal G, Mjelle AB, Wiencke K, Bjørk I, Gilja OH, Folseraas T, Karlsen TH, Rosenberg W, Giil LM, Vesterhus M(2021) Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF JHEP Rep, 3(5), 100328 DOI 10.1016/j.jhepr.2021.100328, PubMed 34485881
Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RI, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW(2021) REPLY Hepatology, 74(4), 2319-2321 DOI 10.1002/hep.31904, PubMed 33998692
Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW(2021) REPLY Hepatology, 74(2), 1129-1131 DOI 10.1002/hep.31740, PubMed 33550618
Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW(2021) Letter to the Editor: Does Multiple Intrahepatic Cholangiocarcinoma Worsen Prognosis as "M1" Stage? REPLY Hepatology, 74(2), 1129-1131 DOI 10.1002/hep.31740
Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RIR, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW, Group: on behalf of the European Network for the Study of Cholangiocarcinoma (ENS-CCA)(2021) Liver Metastases of Intrahepatic Cholangiocarcinoma: Implications for an Updated Staging System Hepatology, 73(6), 2311-2325 DOI 10.1002/hep.31598, PubMed 33073396
Mousa OY, Juran BD, McCauley BM, Vesterhus MN, Folseraas T, Turgeon CT, Ali AH, Schlicht EM, Atkinson EJ, Hu C, Harnois D, Carey EJ, Gossard AA, Oglesbee D, Eaton JE, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN(2021) Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation Hepatology, 74(1), 281-295 DOI 10.1002/hep.31652, PubMed 33226645
Vedeld HM, Grimsrud MM, Andresen K, Pharo HD, von Seth E, Karlsen TH, Honne H, Paulsen V, Färkkilä MA, Bergquist A, Jeanmougin M, Aabakken L, Boberg KM, Folseraas T, Lind GE(2021) Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile Hepatology, 75(1), 59-73 DOI 10.1002/hep.32125, PubMed 34435693
Vesterhus M, Wiencke K, Haukeland JW, Frigstad SO, Karlsen LN, Jørgensen KK, Folseraas T(2021) [Diagnosis and treatment of autoimmune hepatitis] Tidsskr Nor Laegeforen, 141(10) DOI 10.4045/tidsskr.20.1045, PubMed 34182737
Publications 2020
Goeppert B, Folseraas T, Roessler S, Kloor M, Volckmar AL, Endris V, Buchhalter I, Stenzinger A, Grzyb K, Grimsrud MM, Gornicka B, von Seth E, Reynolds GM, Franke A, Gotthardt DN, Mehrabi A, Cheung A, Verheij J, Arola J, Mäkisalo H, Eide TJ, Weidemann S, Cheville JC, Mazza G, Hirschfield GM, Ponsioen CY, Bergquist A, Milkiewicz P, Lazaridis KN, Schramm Cet al.(2020) Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities Hepatology, 72(4), 1253-1266 DOI 10.1002/hep.31110, PubMed 31925805
Severe Covid-19 GWAS Group, Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo Aet al.(2020) Genomewide Association Study of Severe Covid-19 with Respiratory Failure N Engl J Med, 383(16), 1522-1534 DOI 10.1056/NEJMoa2020283, PubMed 32558485
Vedeld HM, Folseraas T, Lind GE(2020) Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers JHEP Rep, 2(5), 100143 DOI 10.1016/j.jhepr.2020.100143, PubMed 32939446
Publications 2019
Carpino G, Cardinale V, Folseraas T, Overi D, Grzyb K, Costantini D, Berloco PB, Di Matteo S, Karlsen TH, Alvaro D, Gaudio E(2019) Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis Hepatology, 69(2), 622-638 DOI 10.1002/hep.30210, PubMed 30102768
Grimsrud MM, Folseraas T(2019) Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis Liver Int, 39(12), 2230-2237 DOI 10.1111/liv.14180, PubMed 31216595
Publications 2018
Thorgersen EB, Melum E, Folseraas T, Larsen SG, Line PD(2018) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report World J Surg Oncol, 16(1), 180 DOI 10.1186/s12957-018-1482-7, PubMed 30185175
Publications 2017
Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani Aet al.(2017) Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis Gut, 67(8), 1517-1524 DOI 10.1136/gutjnl-2016-313598, PubMed 28779025
Carpino G, Cardinale V, Folseraas T, Overi D, Floreani A, Franchitto A, Onori P, Cazzagon N, Berloco PB, Karlsen TH, Alvaro D, Gaudio E(2017) Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis Am J Pathol, 188(3), 627-639 DOI 10.1016/j.ajpath.2017.11.010, PubMed 29248458
Chung BK, Karlsen TH, Folseraas T(2017) Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma Biochim Biophys Acta Mol Basis Dis, 1864(4 Pt B), 1390-1400 DOI 10.1016/j.bbadis.2017.08.020, PubMed 28844951
Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D, Yu L, Bowlus CL, Franke A, Lie BA, Karlsen TH(2017) HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry HLA, 90(4), 228-233 DOI 10.1111/tan.13076, PubMed 28695657
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D(2016) Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) Nat Rev Gastroenterol Hepatol, 13(5), 261-80 DOI 10.1038/nrgastro.2016.51, PubMed 27095655
Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, Franke L, Pers TH, Weersma RK, Collij V, D'Amato M, Halfvarson J, Jensen AB, Lieb W, Degenhardt F, Forstner AJ, Hofmann A, International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC)et al.(2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci Nat Genet, 48(5), 510-8 DOI 10.1038/ng.3528, PubMed 26974007
Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F, Teufel A, Laudes M, Lieb W, Jacobs G, Beuers Uet al.(2016) Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease Nat Genet, 49(2), 269-273 DOI 10.1038/ng.3745, PubMed 27992413
Publications 2015
Folseraas T, Boberg KM(2015) Cancer Risk and Surveillance in Primary Sclerosing Cholangitis Clin Liver Dis, 20(1), 79-98 DOI 10.1016/j.cld.2015.08.014, PubMed 26593292
Folseraas T, Liaskou E, Anderson CA, Karlsen TH(2015) Genetics in PSC: what do the "risk genes" teach us? Clin Rev Allergy Immunol, 48(2-3), 154-64 DOI 10.1007/s12016-014-8417-z, PubMed 24736995
Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, Videm V, Folseraas T, Atschekzei F, Elder JT, Nair RP, Winkelmann J, Gieger C, Nöthen MM, Büning C, Brand S, Sullivan KE, Orange JS, Fevang B, Schreiber S, Lieb Wet al.(2015) Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells Nat Commun, 6, 6804 DOI 10.1038/ncomms7804, PubMed 25891430
Wannhoff A, Folseraas T, Brune M, Rupp C, Friedrich K, Knierim J, Weiss KH, Sauer P, Flechtenmacher C, Schirmacher P, Stremmel W, Hov JR, Gotthardt DN(2015) A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis United European Gastroenterol J, 4(1), 84-91 DOI 10.1177/2050640615581577, PubMed 26966527
Publications 2014
Rupp C, Friedrich K, Folseraas T, Wannhoff A, Bode KA, Weiss KH, Schirmacher P, Sauer P, Stremmel W, Gotthardt DN(2014) Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis Aliment Pharmacol Ther, 39(8), 873-82 DOI 10.1111/apt.12663, PubMed 24612312
Publications 2013
Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK, Wijmenga C, Ponsioen CY, Mathew CG, Rutgeerts P, Vermeire Set al.(2013) Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4 Hepatology, 58(3), 1074-83 DOI 10.1002/hep.25977, PubMed 22821403
Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJet al.(2013) Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis Nat Genet, 45(6), 670-5 DOI 10.1038/ng.2616, PubMed 23603763
Wannhoff A, Hov JR, Folseraas T, Rupp C, Friedrich K, Anmarkrud JA, Weiss KH, Sauer P, Schirmacher P, Boberg KM, Stremmel W, Karlsen TH, Gotthardt DN(2013) FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis J Hepatol, 59(6), 1278-84 DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938
Publications 2012
Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE, Bergquist A, Ryu E, Ponsioen CY, Runz H, Sterneck Met al.(2012) Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci J Hepatol, 57(2), 366-75 DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342
Publications 2011
Folseraas T, Karlsen TH(2011) To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis? Liver Int, 31(6), 751-4 DOI 10.1111/j.1478-3231.2011.02471.x, PubMed 21645205
Folseraas T, Melum E, Franke A, Karlsen TH(2011) Genetics in primary sclerosing cholangitis Best Pract Res Clin Gastroenterol, 25(6), 713-26 DOI 10.1016/j.bpg.2011.09.010, PubMed 22117637
Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F, Vermeire S, Henckaerts L, Wijmenga C, Ponsioen CY, Schreiber Set al.(2011) Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9 Hepatology, 53(6), 1977-85 DOI 10.1002/hep.24307, PubMed 21425313
Molinaro A, Braadland PR, Carpino G, Carreras A, Nikolaidis M, Hanzely P, Beck KR, Ali AH, Bossen L, Frank A, Lundqvist A, Juran BD, Overi D, Geng L, Amundsen-Isaksen E, Reims HM, Björk I, Grzyb K, Abildgaard A, Folseraas T, Cornillet M, Helgadóttir H, McCauley BM, Cristoferi L, Carbone M, Cardinale V, Høivik ML, Engesæter LK, Tjønnfjord SKV, McCann Aet al.(2026) Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling Nat Metab(in press) DOI 10.1038/s42255-026-01600-1, PubMed 42698000
Izquierdo-Sanchez L, Narbaiza J, Martin-Robles J, Lamarca A, Klümpen HJ, La Casta A, Valsan A, Roessler S, Braconi C, da Fonseca LG, Dopazo C, Juliebø AT, Mauro E, Buettner S, Balderramo D, Ponz-Sarvise M, Ferrer JD, Zieniewicz K, Utpatel K, Sparchez Z, Brustia R, Peck-Radosavljevic M, De Sario G, Gómez-Gavara C, Carrilho FJ, Tesini G, Nair P, Gutierrez E, Zonderhuis BM, Koerkamp BGet al.(2026) Chronic liver disease is associated with earlier-stage cholangiocarcinoma diagnosis and improved prognosis: Findings from the GLOBAL-BTC registry J Hepatol(in press) DOI 10.1016/j.jhep.2026.08.020, PubMed 42637053
Lapitz A, Grimsrud MM, Catanzaro E, Rodrigues PM, Hov JR, Azkargorta M, Val B, Vesterhus M, Grzyb K, Reims HM, Elortza F, Izquierdo-Sánchez L, Perugorria MJ, Bujanda L, Aabakken L, Paulsen V, Karlsen TH, Banales JM, Folseraas T(2026) Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis JHEP Rep, 102003(in press) DOI 10.1016/j.jhepr.2026.102003, PubMed 42628796
