
Yvonne Andersson
- Scientist; PhD
- +47 22 78 17 80
Projects:
- Different aspects examining the immunotoxin MOC31PE immunostimulatory effects, in vivo and ex vivo. New data and submitted data.
- Establishing humanized colorectal cancer models in mice for studying the MOC31PE immunostimulatory effects in vivo.
- Commersialization strategies for the immunotoxin MOC31PE in collaboration with Inven2
- Preparing govermental documentations needed for clinical approval of the immunotoxin BM7PE for metastatic colorectal cancer patients. - Submitted and waiting for reply.
- New anti-angiogenic treatment strategies for pseudomyxoma peritonei in vivo (manuscript)
- Hyperthermia or not is the Q, in chemotherapeutic strategies for peritoneal metastasis from ovarian and colorectal cancer.
- Manuscript on the preclinical data showing the effects of the melanoma spesific immunotoxin 9.2.27PE on chemoresistant melanoma cells.
Publications 2022
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909
Development and initial validation of MedHipPro-Q: a questionnaire assessing medication management of hip fracture patients in different care settings
BMC Health Serv Res, 22 (1), 240
DOI 10.1186/s12913-022-07524-2, PubMed 35193572
Publications 2021
Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale
Cancers (Basel), 13 (11)
DOI 10.3390/cancers13112819, PubMed 34198773
Discharge processes and medicines communication from the patient perspective: A qualitative study at an internal medicines ward in Norway
Health Expect, 24 (3), 892-904
DOI 10.1111/hex.13232, PubMed 33761170
Empowering the patient? Medication communication during hospital discharge: a qualitative study at an internal medicines ward in Norway
BMJ Open, 11 (6), e044850
DOI 10.1136/bmjopen-2020-044850, PubMed 34193483
The observer effect in a hospital setting - Experiences from the observed and the observers
Res Social Adm Pharm, 17 (12), 2136-2144
DOI 10.1016/j.sapharm.2021.07.011, PubMed 34312101
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185
Publications 2020
Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma
Ann Diagn Pathol, 46, 151483
DOI 10.1016/j.anndiagpath.2020.151483, PubMed 32143173
Publications 2019
Immune stimulatory effect of anti-EpCAM immunotoxin - improved overall survival of metastatic colorectal cancer patients
Acta Oncol, 59 (4), 404-409
DOI 10.1080/0284186X.2019.1704864, PubMed 31876430
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol, 47 (1), 134-138
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394
Generic substitution of drugs in hospitals
Tidsskr Nor Laegeforen, 139 (1)
DOI 10.4045/tidsskr.17.0722, PubMed 30644679
Generic change of medicines in hospitals
Tidsskr. Nor. Laegeforen., 139 (1), 36-40
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
Sci Rep, 9 (1), 18021
DOI 10.1038/s41598-019-54226-7, PubMed 31792234
Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics
Front Oncol, 9, 1302
DOI 10.3389/fonc.2019.01302, PubMed 31921617
Publications 2017
MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer
Oncotarget, 8 (37), 61800-61809
DOI 10.18632/oncotarget.18694, PubMed 28977905
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells
Pigment Cell Melanoma Res, 30 (5), 467-476
DOI 10.1111/pcmr.12599, PubMed 28513992
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
DOI 10.1245/s10434-017-5814-6, PubMed 28224367
Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
Exp Mol Pathol, 103 (2), 218-228
DOI 10.1016/j.yexmp.2017.10.001, PubMed 29050853
Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma
Biomark Med, 12 (1), 45-61
DOI 10.2217/bmm-2017-0142, PubMed 29243496
Publications 2015
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
Br J Cancer, 113 (11), 1548-55
DOI 10.1038/bjc.2015.380, PubMed 26554649
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
BMC Cancer, 15, 543
DOI 10.1186/s12885-015-1557-6, PubMed 26205955
Publications 2014
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
J Ovarian Res, 7, 23
DOI 10.1186/1757-2215-7-23, PubMed 24528603
Publications 2013
Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
Int J Cancer, 133 (6), 1497-506
DOI 10.1002/ijc.28158, PubMed 23494569
Publications 2011
Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma
PLoS One, 6 (9), e24012
DOI 10.1371/journal.pone.0024012, PubMed 21915275
Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins
J Immunother, 34 (5), 438-47
DOI 10.1097/CJI.0b013e31821e00ae, PubMed 21577141
Publications 2010
Anti-melanoma activity of the 9.2.27PE immunotoxin in dacarbazine resistant cells
J Immunother, 33 (3), 272-8
DOI 10.1097/CJI.0b013e3181c54991, PubMed 20445347
Immunotoxins: a promising treatment modality for metastatic melanoma?
Ochsner J, 10 (3), 193-9
PubMed 21603377
A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
Cancer Immunol Immunother, 59 (11), 1665-74
DOI 10.1007/s00262-010-0892-3, PubMed 20635083
Publications 2009
The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro
Int J Cancer, 125 (1), 23-33
DOI 10.1002/ijc.24317, PubMed 19350633
Publications 2006
AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death
Mol Cancer Ther, 5 (4), 1050-9
DOI 10.1158/1535-7163.MCT-05-0318, PubMed 16648577
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124
Publications 2005
Lack of proinflammatory effects of free fatty acids on human umbilical cord vein endothelial cells and leukocytes
Acta Obstet Gynecol Scand, 84 (7), 672-8
DOI 10.1111/j.0001-6349.2005.00799.x, PubMed 15954878
Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death
Mol Cancer Ther, 4 (8), 1231-8
DOI 10.1158/1535-7163.MCT-04-0304, PubMed 16093439
Publications 2004
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats
J Mol Cell Cardiol, 36 (3), 393-404
DOI 10.1016/j.yjmcc.2003.12.004, PubMed 15010278
Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin a immunotoxin
Int J Cancer, 112 (3), 475-83
DOI 10.1002/ijc.20371, PubMed 15382075
Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?
Radiother Oncol, 72 (3), 305-10
DOI 10.1016/j.radonc.2004.07.002, PubMed 15450729
Publications 2003
Induction of myocardial biglycan in heart failure in rats--an extracellular matrix component targeted by AT(1) receptor antagonism
Cardiovasc Res, 60 (3), 557-68
DOI 10.1016/j.cardiores.2003.08.017, PubMed 14659801
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes
J Cell Physiol, 196 (1), 113-23
DOI 10.1002/jcp.10282, PubMed 12767047
Publications 1999
Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
Arterioscler Thromb Vasc Biol, 19 (1), 115-21
DOI 10.1161/01.atv.19.1.115, PubMed 9888873
Publications 1997
Guinea pig apolipoprotein C-II: expression in E. coli, functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins
J Lipid Res, 38 (10), 2111-24
PubMed 9374133
Publications 1996
Apolipoprotein CII from chicken (Gallus domesticus). The amino-terminal domain is different from corresponding domains in mammals
J Biol Chem, 271 (51), 33060-6
DOI 10.1074/jbc.271.51.33060, PubMed 8955153
Publications 1991
Rat apolipoprotein C-II lacks the conserved site for proteolytic cleavage of the pro-form
J Lipid Res, 32 (11), 1805-9
PubMed 1770300
Demonstration of apolipoprotein CII in guinea pigs. Functional characteristics, cDNA sequence, and tissue expression
J Biol Chem, 266 (7), 4074-80
PubMed 1999402