Yvonne Andersson
- Scientist; PhD
- +47 22 78 17 80
Projects:
- Different aspects examining the immunotoxin MOC31PE immunostimulatory effects, in vivo and ex vivo. New data and submitted data.
- Establishing humanized colorectal cancer models in mice for studying the MOC31PE immunostimulatory effects in vivo.
- Commersialization strategies for the immunotoxin MOC31PE in collaboration with Inven2
- Preparing govermental documentations needed for clinical approval of the immunotoxin BM7PE for metastatic colorectal cancer patients. - Submitted and waiting for reply.
- New anti-angiogenic treatment strategies for pseudomyxoma peritonei in vivo (manuscript)
- Hyperthermia or not is the Q, in chemotherapeutic strategies for peritoneal metastasis from ovarian and colorectal cancer.
- Manuscript on the preclinical data showing the effects of the melanoma spesific immunotoxin 9.2.27PE on chemoresistant melanoma cells.
Publications 2023
Clinical pharmacist intervention to improve medication safety for hip fracture patients through secondary and primary care settings: a nonrandomised controlled trial
J Orthop Surg Res, 18 (1), 434
DOI 10.1186/s13018-023-03906-2, PubMed 37312222
'The way you talk, do I have a choice?' Patient narratives of medication decision-making during hospitalization
Int J Qual Stud Health Well-being, 18 (1), 2250084
DOI 10.1080/17482631.2023.2250084, PubMed 37615270
Publications 2022
Significant myocardial perfusion defect during stress visible in prone but not in supine imaging
J Nucl Cardiol, 30 (5), 2209-2212
DOI 10.1007/s12350-022-03080-8, PubMed 35978071
Health literacy in medication communication during hospital discharge: a qualitative study at an internal medicines ward in Norway
BMJ Open, 12 (6), e058473
DOI 10.1136/bmjopen-2021-058473, PubMed 35680250
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045
Development and initial validation of MedHipPro-Q: a questionnaire assessing medication management of hip fracture patients in different care settings
BMC Health Serv Res, 22 (1), 240
DOI 10.1186/s12913-022-07524-2, PubMed 35193572
Medication management for patients with hip fracture at a regional hospital and associated primary care units in Norway: a descriptive study based on a survey of clinicians' experience and a review of patient records
BMJ Open, 12 (11), e064868
DOI 10.1136/bmjopen-2022-064868, PubMed 36379642
Publications 2021
Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale
Cancers (Basel), 13 (11)
DOI 10.3390/cancers13112819, PubMed 34198773
Discharge processes and medicines communication from the patient perspective: A qualitative study at an internal medicines ward in Norway
Health Expect, 24 (3), 892-904
DOI 10.1111/hex.13232, PubMed 33761170
Empowering the patient? Medication communication during hospital discharge: a qualitative study at an internal medicines ward in Norway
BMJ Open, 11 (6), e044850
DOI 10.1136/bmjopen-2020-044850, PubMed 34193483
The observer effect in a hospital setting - Experiences from the observed and the observers
Res Social Adm Pharm, 17 (12), 2136-2144
DOI 10.1016/j.sapharm.2021.07.011, PubMed 34312101
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185
Publications 2020
Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma
Ann Diagn Pathol, 46, 151483
DOI 10.1016/j.anndiagpath.2020.151483, PubMed 32143173
Publications 2019
Immune stimulatory effect of anti-EpCAM immunotoxin - improved overall survival of metastatic colorectal cancer patients
Acta Oncol, 59 (4), 404-409
DOI 10.1080/0284186X.2019.1704864, PubMed 31876430
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol, 47 (1), 134-138
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394
[Generic substitution of drugs in hospitals]
Tidsskr Nor Laegeforen, 139 (1)
DOI 10.4045/tidsskr.17.0722, PubMed 30644679
Generic change of medicines in hospitals
Tidsskr. Nor. Laegeforen., 139 (1), 36-40
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
Sci Rep, 9 (1), 18021
DOI 10.1038/s41598-019-54226-7, PubMed 31792234
Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics
Front Oncol, 9, 1302
DOI 10.3389/fonc.2019.01302, PubMed 31921617
Publications 2017
MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer
Oncotarget, 8 (37), 61800-61809
DOI 10.18632/oncotarget.18694, PubMed 28977905
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells
Pigment Cell Melanoma Res, 30 (5), 467-476
DOI 10.1111/pcmr.12599, PubMed 28513992
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
DOI 10.1245/s10434-017-5814-6, PubMed 28224367
Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
Exp Mol Pathol, 103 (2), 218-228
DOI 10.1016/j.yexmp.2017.10.001, PubMed 29050853
Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma
Biomark Med, 12 (1), 45-61
DOI 10.2217/bmm-2017-0142, PubMed 29243496
Publications 2015
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
Br J Cancer, 113 (11), 1548-55
DOI 10.1038/bjc.2015.380, PubMed 26554649
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
BMC Cancer, 15, 543
DOI 10.1186/s12885-015-1557-6, PubMed 26205955
Publications 2014
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
J Ovarian Res, 7, 23
DOI 10.1186/1757-2215-7-23, PubMed 24528603
Publications 2013
Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
Int J Cancer, 133 (6), 1497-506
DOI 10.1002/ijc.28158, PubMed 23494569
Publications 2011
Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma
PLoS One, 6 (9), e24012
DOI 10.1371/journal.pone.0024012, PubMed 21915275
Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins
J Immunother, 34 (5), 438-47
DOI 10.1097/CJI.0b013e31821e00ae, PubMed 21577141
Publications 2010
Anti-melanoma activity of the 9.2.27PE immunotoxin in dacarbazine resistant cells
J Immunother, 33 (3), 272-8
DOI 10.1097/CJI.0b013e3181c54991, PubMed 20445347
Immunotoxins: a promising treatment modality for metastatic melanoma?
Ochsner J, 10 (3), 193-9
PubMed 21603377
A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
Cancer Immunol Immunother, 59 (11), 1665-74
DOI 10.1007/s00262-010-0892-3, PubMed 20635083
Publications 2009
The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro
Int J Cancer, 125 (1), 23-33
DOI 10.1002/ijc.24317, PubMed 19350633
Publications 2006
AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death
Mol Cancer Ther, 5 (4), 1050-9
DOI 10.1158/1535-7163.MCT-05-0318, PubMed 16648577
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124
Publications 2005
Lack of proinflammatory effects of free fatty acids on human umbilical cord vein endothelial cells and leukocytes
Acta Obstet Gynecol Scand, 84 (7), 672-8
DOI 10.1111/j.0001-6349.2005.00799.x, PubMed 15954878
Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death
Mol Cancer Ther, 4 (8), 1231-8
DOI 10.1158/1535-7163.MCT-04-0304, PubMed 16093439
Publications 2004
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats
J Mol Cell Cardiol, 36 (3), 393-404
DOI 10.1016/j.yjmcc.2003.12.004, PubMed 15010278
Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin a immunotoxin
Int J Cancer, 112 (3), 475-83
DOI 10.1002/ijc.20371, PubMed 15382075
Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?
Radiother Oncol, 72 (3), 305-10
DOI 10.1016/j.radonc.2004.07.002, PubMed 15450729
Publications 2003
Induction of myocardial biglycan in heart failure in rats--an extracellular matrix component targeted by AT(1) receptor antagonism
Cardiovasc Res, 60 (3), 557-68
DOI 10.1016/j.cardiores.2003.08.017, PubMed 14659801
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes
J Cell Physiol, 196 (1), 113-23
DOI 10.1002/jcp.10282, PubMed 12767047
Publications 1999
Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
Arterioscler Thromb Vasc Biol, 19 (1), 115-21
DOI 10.1161/01.atv.19.1.115, PubMed 9888873
Publications 1997
Guinea pig apolipoprotein C-II: expression in E. coli, functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins
J Lipid Res, 38 (10), 2111-24
PubMed 9374133
Publications 1996
Apolipoprotein CII from chicken (Gallus domesticus). The amino-terminal domain is different from corresponding domains in mammals
J Biol Chem, 271 (51), 33060-6
DOI 10.1074/jbc.271.51.33060, PubMed 8955153
Publications 1991
Rat apolipoprotein C-II lacks the conserved site for proteolytic cleavage of the pro-form
J Lipid Res, 32 (11), 1805-9
PubMed 1770300
Demonstration of apolipoprotein CII in guinea pigs. Functional characteristics, cDNA sequence, and tissue expression
J Biol Chem, 266 (7), 4074-80
PubMed 1999402