Current projects in my group aim at understanding m6A dependent mechanisms of pluripotent stem cell differentiation, including germ cell lineage induction. We are also investigating how m6A regulation affects cancer progression and refraction to treatment in patients. We apply cutting-edge singe cell resolution quantitative live cell imaging, genetic manipulation and genome-wide single cell sequencing approaches.
N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells
Proc Natl Acad Sci U S A, 118 (51)
Analysis of Cell Lineage Trees by Exact Bayesian Inference Identifies Negative Autoregulation of Nanog in Mouse Embryonic Stem Cells
Cell Syst, 3 (5), 480-490.e13
Software tools for single-cell tracking and quantification of cellular and molecular properties
Nat Biotechnol, 34 (7), 703-6