Stephan Alfons Frye

  • Research scientist; Dr. rer. nat.
  • +47 23079019


Stephan works with transformation in Neisseriaceae.
Academic interests:
- Transformation
- Neisseriaceae


Publications 2022

Avershina E, Frye SA, Ali J, Taxt AM, Ahmad R (2022)
Ultrafast and Cost-Effective Pathogen Identification and Resistance Gene Detection in a Clinical Setting Using Nanopore Flongle Sequencing
Front Microbiol, 13, 822402
DOI 10.3389/fmicb.2022.822402, PubMed 35369431

Fraz MSA, Dahle G, Skaug KM, Jarraud S, Frye S, Bjørnholt JV, Nordøy I (2022)
Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient
Front Med (Lausanne), 9, 1055465
DOI 10.3389/fmed.2022.1055465, PubMed 36405607

Publications 2021

Avershina E, Sharma P, Taxt AM, Singh H, Frye SA, Paul K, Kapil A, Naseer U, Kaur P, Ahmad R (2021)
AMR-Diag: Neural network based genotype-to-phenotype prediction of resistance towards β-lactams in Escherichia coli and Klebsiella pneumoniae
Comput Struct Biotechnol J, 19, 1896-1906
DOI 10.1016/j.csbj.2021.03.027, PubMed 33897984

Publications 2020

Taxt AM, Avershina E, Frye SA, Naseer U, Ahmad R (2020)
Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing
Sci Rep, 10 (1), 7622
DOI 10.1038/s41598-020-64616-x, PubMed 32376847

Publications 2018

Alfsnes K, Frye SA, Eriksson J, Eldholm V, Brynildsrud OB, Bohlin J, Harrison OB, Hood DW, Maiden MCJ, Tønjum T, Ambur OH (2018)
A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis
Microb Genom, 4 (11)
DOI 10.1099/mgen.0.000222, PubMed 30251949

Publications 2017

Frye SA, Beyene GT, Namouchi A, Gómez-Muñoz M, Homberset H, Kalayou S, Riaz T, Tønjum T, Balasingham SV (2017)
The helicase DinG responds to stress due to DNA double strand breaks
PLoS One, 12 (11), e0187900
DOI 10.1371/journal.pone.0187900, PubMed 29121674

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH (2017)
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology (Reading), 163 (7), 1016-1029
DOI 10.1099/mic.0.000489, PubMed 28696187

Publications 2016

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
DOI 10.1371/journal.pone.0164588, PubMed 27736945

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV (2016)
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
DOI 10.1186/s12864-016-3132-1, PubMed 27724857

Publications 2015

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334

Ricanek P, Lunde LK, Frye SA, Støen M, Nygård S, Morth JP, Rydning A, Vatn MH, Amiry-Moghaddam M, Tønjum T (2015)
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
DOI 10.2147/CEG.S70119, PubMed 25624769

Publications 2013

Frye SA, Nilsen M, Tønjum T, Ambur OH (2013)
Dialects of the DNA uptake sequence in Neisseriaceae
PLoS Genet, 9 (4), e1003458
DOI 10.1371/journal.pgen.1003458, PubMed 23637627

Publications 2012

Ambur OH, Frye SA, Nilsen M, Hovland E, Tønjum T (2012)
Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis
PLoS One, 7 (7), e39742
DOI 10.1371/journal.pone.0039742, PubMed 22768309

Ricanek P, Lothe SM, Frye SA, Rydning A, Vatn MH, Tønjum T (2012)
Gut bacterial profile in patients newly diagnosed with treatment-naïve Crohn's disease
Clin Exp Gastroenterol, 5, 173-86
DOI 10.2147/CEG.S33858, PubMed 23049264

Publications 2011

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T (2011)
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation
Microbiology (Reading), 157 (Pt 5), 1329-1342
DOI 10.1099/mic.0.046896-0, PubMed 21330432

Lillenes MS, Espeseth T, Støen M, Lundervold AJ, Frye SA, Rootwelt H, Reinvang I, Tønjum T (2011)
DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span
Mech Ageing Dev, 132 (8-9), 449-58
DOI 10.1016/j.mad.2011.08.002, PubMed 21884718

Publications 2009

Ambur OH, Davidsen T, Frye SA, Balasingham SV, Lagesen K, Rognes T, Tønjum T (2009)
Genome dynamics in major bacterial pathogens
FEMS Microbiol Rev, 33 (3), 453-70
DOI 10.1111/j.1574-6976.2009.00173.x, PubMed 19396949

Balasingham SV, Davidsen T, Szpinda I, Frye SA, Tønjum T (2009)
Molecular diagnostics in tuberculosis: basis and implications for therapy
Mol Diagn Ther, 13 (3), 137-51
DOI 10.1007/BF03256322, PubMed 19650669

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology (Reading), 155 (Pt 3), 852-862
DOI 10.1099/mic.0.022640-0, PubMed 19246756

Tibballs KL, Ambur OH, Alfsnes K, Homberset H, Frye SA, Davidsen T, Tønjum T (2009)
Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair
BMC Microbiol, 9, 7
DOI 10.1186/1471-2180-9-7, PubMed 19134198

Publications 2007

Assalkhou R, Balasingham S, Collins RF, Frye SA, Davidsen T, Benam AV, Bjørås M, Derrick JP, Tønjum T (2007)
The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
Microbiology (Reading), 153 (Pt 5), 1593-1603
DOI 10.1099/mic.0.2006/004200-0, PubMed 17464074

Balasingham SV, Collins RF, Assalkhou R, Homberset H, Frye SA, Derrick JP, Tønjum T (2007)
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
DOI 10.1128/JB.00060-07, PubMed 17526700

Publications 2006

Ambur OH, Frye SA, Tønjum T (2006)
New functional identity for the DNA uptake sequence in transformation and its presence in transcriptional terminators
J Bacteriol, 189 (5), 2077-85
DOI 10.1128/JB.01408-06, PubMed 17194793

Frye SA, Assalkhou R, Collins RF, Ford RC, Petersson C, Derrick JP, Tønjum T (2006)
Topology of the outer-membrane secretin PilQ from Neisseria meningitidis
Microbiology (Reading), 152 (Pt 12), 3751-3764
DOI 10.1099/mic.0.2006/000315-0, PubMed 17159226

Aas FE, Winther-Larsen HC, Wolfgang M, Frye S, Løvold C, Roos N, van Putten JP, Koomey M (2006)
Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions
Mol Microbiol, 63 (1), 69-85
DOI 10.1111/j.1365-2958.2006.05482.x, PubMed 17140412

Publications 2005

Collins RF, Frye SA, Balasingham S, Ford RC, Tønjum T, Derrick JP (2005)
Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ
J Biol Chem, 280 (19), 18923-30
DOI 10.1074/jbc.M411603200, PubMed 15753075

Publications 2004

Collins RF, Frye SA, Kitmitto A, Ford RC, Tønjum T, Derrick JP (2004)
Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution
J Biol Chem, 279 (38), 39750-6
DOI 10.1074/jbc.M405971200, PubMed 15254043

Publications 2002

Aas FE, Wolfgang M, Frye S, Dunham S, Løvold C, Koomey M (2002)
Competence for natural transformation in Neisseria gonorrhoeae: components of DNA binding and uptake linked to type IV pilus expression
Mol Microbiol, 46 (3), 749-60
DOI 10.1046/j.1365-2958.2002.03193.x, PubMed 12410832

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