
Jorrit M. Enserink
- Group leader
- +47 22 78 19 82
Jorrit is involved in all projects
Publications 2025
Improved detection of lipidated Atg8a by immunoblotting in Drosophila melanogaster cells and tissues enables precise investigation of Atg8a flux and its termination
21 (11), 2497-2517
DOI 10.1080/15548627.2025.2508551, PubMed 40426043
Correction for Corrales et al., "Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole"
e0073025 (in press)
DOI 10.1128/spectrum.00730-25, PubMed 41117562
Publications 2024
CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
5 (6), 101572
DOI 10.1016/j.xcrm.2024.101572, PubMed 38754420
Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole
12 (2), e0259423
DOI 10.1128/spectrum.02594-23, PubMed 38230926
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents
275, 116617
DOI 10.1016/j.ejmech.2024.116617, PubMed 38959729
Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data
20 (3), e1011888
DOI 10.1371/journal.pcbi.1011888, PubMed 38446830
Publications 2023
CELLULAR, A Cell Autophagy Imaging Dataset
10 (1), 806
DOI 10.1038/s41597-023-02687-x, PubMed 37973836
Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling
3 (12), 100654
DOI 10.1016/j.crmeth.2023.100654, PubMed 38065095
Standardized assays to monitor drug sensitivity in hematologic cancers
9 (1), 435
DOI 10.1038/s41420-023-01722-5, PubMed 38040674
Robust scoring of selective drug responses for patient-tailored therapy selection
19 (1), 60-82
DOI 10.1038/s41596-023-00903-x, PubMed 37996540
screenwerk: a modular tool for the design and analysis of drug combination screens
39 (1)
DOI 10.1093/bioinformatics/btac840, PubMed 36573326
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
26 (10), 107726
DOI 10.1016/j.isci.2023.107726, PubMed 37720104
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
120 (4), e2210593120
DOI 10.1073/pnas.2210593120, PubMed 36656860
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
14 (1), 115
DOI 10.1038/s41467-022-35624-4, PubMed 36611026
Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
14 (1), 1767
DOI 10.1038/s41467-023-37488-8, PubMed 36997540
Publications 2022
The SUMO stress response in transcriptional regulation: Causal relationships or secondary bystander effects?
44 (7), e2200065
DOI 10.1002/bies.202200065, PubMed 35655365
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries
23 (3)
DOI 10.3390/ijms23031293, PubMed 35163213
Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeast Saccharomyces cerevisiae
3 (1), 101210
DOI 10.1016/j.xpro.2022.101210, PubMed 35265859
Waves of sumoylation support transcription dynamics during adipocyte differentiation
50 (3), 1351-1369
DOI 10.1093/nar/gkac027, PubMed 35100417
Publications 2021
Pharmacologic Control of CAR T Cells
22 (9)
DOI 10.3390/ijms22094320, PubMed 33919245
Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
37 (13), 110186
DOI 10.1016/j.celrep.2021.110186, PubMed 34965431
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096
bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments
22 (6)
DOI 10.1093/bib/bbab251, PubMed 34308471
Publications 2020
Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines
34 (3), 3773-3791
DOI 10.1096/fj.201802061RR, PubMed 31945226
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632
Publications 2019
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast
294 (49), 18784-18795
DOI 10.1074/jbc.RA119.009721, PubMed 31676685
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234
Publications 2018
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271
Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
175 (3), 780-795.e15
DOI 10.1016/j.cell.2018.09.012, PubMed 30318142
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445
Publications 2017
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
1861 (4), 310-319
DOI 10.1016/j.bbagrm.2017.11.001, PubMed 29127063
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
27 (2), 334
DOI 10.1101/gr.218370.116, PubMed 28148563
Anabolic transcription: Secrets of the sumo diet
16 (7), 593-594
DOI 10.1080/15384101.2017.1294945, PubMed 28278057
Regulation of Cellular Processes by SUMO: Understudied Topics
963, 89-97
DOI 10.1007/978-3-319-50044-7_5, PubMed 28197907
Sumo during stress: When transcription takes a pause (comment on DOI.10.1002/bies.201600263)
39 (6)
DOI 10.1002/bies.201700065, PubMed 28464310
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
8 (14), 22606-22615
DOI 10.18632/oncotarget.15146, PubMed 28186983
Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28
7 (6), 1753-1766
DOI 10.1534/g3.117.042317, PubMed 28428242
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
18 (8), 2073-2074
DOI 10.1016/j.celrep.2017.02.020, PubMed 28228270
Publications 2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652
Publications 2015
SUMO-regulated transcription: challenging the dogma
37 (10), 1095-105
DOI 10.1002/bies.201500065, PubMed 26354225
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674
Sumo and the cellular stress response
10, 4
DOI 10.1186/s13008-015-0010-1, PubMed 26101541
Publications 2014
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)
289 (44), 30499-30510
DOI 10.1074/jbc.M114.601658, PubMed 25231979
Metabolic pathways further increase the complexity of cell size control in budding yeast
1 (9), 276-278
DOI 10.15698/mic2014.09.167, PubMed 28362005
Publications 2013
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
5 (4), 1036-46
DOI 10.1016/j.celrep.2013.10.024, PubMed 24239358
Publications 2012
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984
The cell cycle rallies the transcription cycle: Cdc28/Cdk1 is a cell cycle-regulated transcriptional CDK
4 (1), 3-6
DOI 10.4161/trns.22456, PubMed 23131667
Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways
17 (8), 9258-73
DOI 10.3390/molecules17089258, PubMed 22858845
What makes the engine hum: Rad6, a cell cycle supercharger
11 (2), 249-52
DOI 10.4161/cc.11.2.19023, PubMed 22214660
Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae
8 (3), 796-803
DOI 10.1039/c2mb05356j, PubMed 22218487
Publications 2011
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
108 (46), 18748-53
DOI 10.1073/pnas.1115885108, PubMed 22042866
Publications 2010
An overview of Cdk1-controlled targets and processes
5, 11
DOI 10.1186/1747-1028-5-11, PubMed 20465793
Publications 2009
Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
185 (3), 423-37
DOI 10.1083/jcb.200811083, PubMed 19398760
The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants
29 (19), 5226-37
DOI 10.1128/MCB.00894-09, PubMed 19635810
Publications 2006
The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
176 (12), 7361-70
DOI 10.4049/jimmunol.176.12.7361, PubMed 16751380
Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae
175 (5), 729-41
DOI 10.1083/jcb.200605080, PubMed 17130284
An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth
175 (5), 743-53
DOI 10.1083/jcb.200605081, PubMed 17130285
Publications 2004
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
279 (43), 44889-96
DOI 10.1074/jbc.M404599200, PubMed 15302884
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
145 (11), 5177-84
DOI 10.1210/en.2004-0232, PubMed 15284208
Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells
34 (8), 2191-9
DOI 10.1002/eji.200425036, PubMed 15259016
Publications 2003
The role of Rap1 in integrin-mediated cell adhesion
31 (Pt 1), 83-6
DOI 10.1042/bst0310083, PubMed 12546659
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor
160 (4), 487-93
DOI 10.1083/jcb.200209105, PubMed 12578910
Publications 2002
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
4 (11), 901-6
DOI 10.1038/ncb874, PubMed 12402047
Large-scale chromatin organization and the localization of proteins involved in gene expression in human cells
50 (10), 1303-12
DOI 10.1177/002215540205001003, PubMed 12364563
Publications 2000
Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2
185 (2), 269-79
DOI 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L, PubMed 11025449