Yngvar Fløisand
- Consultant; PhD
- +47 23 07 24 62
Publications 2024
CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
Cell Rep Med, 5 (6), 101572
DOI 10.1016/j.xcrm.2024.101572, PubMed 38754420
Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial
Nat Med, 30 (8), 2277-2287
DOI 10.1038/s41591-024-03016-4, PubMed 38844797
Allogeneic stem cell transplant recipients surviving at least 2 years without relapse: outcome and risk factors
EJHaem, 5 (1), 117-124
DOI 10.1002/jha2.842, PubMed 38406518
Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry
iScience, 27 (7), 110261
DOI 10.1016/j.isci.2024.110261, PubMed 39021803
CREST-UK: Real-world effectiveness, safety and outpatient delivery of CPX-351 for first-line treatment of newly diagnosed therapy-related AML and AML with myelodysplasia-related changes in the UK
Br J Haematol, 205 (4), 1326-1336
DOI 10.1111/bjh.19622, PubMed 38977430
Bayesian interim analysis for prospective randomized studies: reanalysis of the acute myeloid leukemia HOVON 132 clinical trial
Blood Cancer J, 14 (1), 56
DOI 10.1038/s41408-024-01037-3, PubMed 38538587
Advantages of a genomic DNA-based NGS assay for detection of mutant NPM1 measurable residual disease in AML
Blood Adv (in press)
DOI 10.1182/bloodadvances.2024014490, PubMed 39637308
Publications 2023
Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling
Cell Rep Methods, 3 (12), 100654
DOI 10.1016/j.crmeth.2023.100654, PubMed 38065095
WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy
Leukemia, 37 (9), 1842-1849
DOI 10.1038/s41375-023-01980-3, PubMed 37507426
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Nat Commun, 14 (1), 115
DOI 10.1038/s41467-022-35624-4, PubMed 36611026
Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Nat Commun, 14 (1), 1767
DOI 10.1038/s41467-023-37488-8, PubMed 36997540
Allogeneic stem cell transplantation in adults 2015-21
Tidsskr Nor Laegeforen, 143 (4)
DOI 10.4045/tidsskr.22.0521, PubMed 36919291
Publications 2022
Patient age and donor HLA matching can stratify allogeneic hematopoietic cell transplantation patients into prognostic groups
Eur J Haematol, 109 (6), 672-679
DOI 10.1111/ejh.13850, PubMed 36028979
Worked to the bone: antibody-based conditioning as the future of transplant biology
J Hematol Oncol, 15 (1), 65
DOI 10.1186/s13045-022-01284-6, PubMed 35590415
Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia
J Clin Oncol, 41 (4), 756-765
DOI 10.1200/JCO.22.00715, PubMed 36315929
COVID-19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta-analysis
EJHaem, 3 (3), 862-872
DOI 10.1002/jha2.465, PubMed 35941880
Publications 2021
Addition of Anti-thymocyte Globulin in Allogeneic Stem Cell Transplantation With Peripheral Stem Cells From Matched Unrelated Donors Improves Graft-Versus-Host Disease and Relapse Free Survival
Clin Lymphoma Myeloma Leuk, 21 (9), 598-605
DOI 10.1016/j.clml.2021.05.003, PubMed 34158268
Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy
Stem Cell Rev Rep, 17 (1), 63-70
DOI 10.1007/s12015-020-10004-x, PubMed 32696426
A phase 2a randomized clinical trial of intravenous vedolizumab for the treatment of steroid-refractory intestinal acute graft-versus-host disease
Bone Marrow Transplant, 56 (10), 2477-2488
DOI 10.1038/s41409-021-01356-0, PubMed 34108672
Recent Progress in Interferon Therapy for Myeloid Malignancies
Front Oncol, 11, 769628
DOI 10.3389/fonc.2021.769628, PubMed 34778087
A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT
J Clin Immunol, 42 (2), 404-420
DOI 10.1007/s10875-021-01189-y, PubMed 34893945
Addition of lenalidomide to intensive treatment in younger and middle-aged adults with newly diagnosed AML: the HOVON-SAKK-132 trial
Blood Adv, 5 (4), 1110-1121
DOI 10.1182/bloodadvances.2020003855, PubMed 33616652
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
Superior Graft-versus-Host Disease-Free Relapse-Free Survival in Matched Unrelated Donor Hematopoietic Stem Cell Transplantation with Anti-Thymocyte Globulin (ATG) Compared to Matched Related Donor without ATG
Transplant Cell Ther, 27 (7), 621.e1-621.e3
DOI 10.1016/j.jtct.2021.03.019, PubMed 33895156
Publications 2020
Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Haematologica, 105 (6), 1507-1516
DOI 10.3324/haematol.2019.243410, PubMed 32241850
A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance
JACC Case Rep, 2 (5), 785-789
DOI 10.1016/j.jaccas.2020.02.024, PubMed 34317348
Decreasing early mortality in acute myeloid leukaemia in Sweden 1997-2014: improving performance status is a major contributing factor
Br J Haematol, 188 (1), 187-191
DOI 10.1111/bjh.16265, PubMed 31863470
HLA-DPB1 mismatch reduce relapse and improve survival in T-cell replete unrelated donor allogeneic stem cell transplantation
Bone Marrow Transplant, 55 (8), 1658-1661
DOI 10.1038/s41409-020-0827-3, PubMed 32054997
The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors
Clin Hematol Int, 2 (2), 74-81
DOI 10.2991/chi.d.200221.001, PubMed 34595446
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
Bone Marrow Transplant, 55 (6), 1114-1125
DOI 10.1038/s41409-020-0803-y, PubMed 31996792
Correction: Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
Bone Marrow Transplant, 55 (6), 1213
DOI 10.1038/s41409-020-0835-3, PubMed 32144364
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632
Publications 2019
Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
Cancers (Basel), 11 (8)
DOI 10.3390/cancers11081088, PubMed 31370273
Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
Biol Blood Marrow Transplant, 25 (9), 1875-1883
DOI 10.1016/j.bbmt.2019.05.007, PubMed 31085303
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood
J Immunol, 203 (6), 1571-1578
DOI 10.4049/jimmunol.1900047, PubMed 31413105
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, 104 (5), e229
DOI 10.3324/haematol.2019.220533, PubMed 31040234
Publications 2018
Anti-α4β7 integrin monoclonal antibody (vedolizumab) for the treatment of steroid-resistant severe intestinal acute graft-versus-host disease
Bone Marrow Transplant, 54 (7), 987-993
DOI 10.1038/s41409-018-0364-5, PubMed 30356163
Cost-utility of allogeneic hematopoietic stem cell transplantation in Norway
Bone Marrow Transplant, 53 (5), 657-660
DOI 10.1038/s41409-018-0091-y, PubMed 29358600
Safety and Effectiveness of Vedolizumab in Patients with Steroid-Refractory Gastrointestinal Acute Graft-versus-Host Disease: A Retrospective Record Review
Biol Blood Marrow Transplant, 25 (4), 720-727
DOI 10.1016/j.bbmt.2018.11.013, PubMed 30468919
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
FASEB J, 32 (9), 5063-5077
DOI 10.1096/fj.201701544R, PubMed 29913558
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Haematologica, Online ahead of print (in press) (Retracted)
DOI 10.3324/haematol.2018.189399, PubMed 29748445
Publications 2017
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
Medicine (Baltimore), 96 (11), e6338
DOI 10.1097/MD.0000000000006338, PubMed 28296762
What is the outcome in patients with acute leukaemia who survive severe acute graft-versus-host disease?
J Intern Med, 283 (2), 166-177
DOI 10.1111/joim.12695, PubMed 29027756
Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation
Neuroradiology, 59 (2), 105-126
DOI 10.1007/s00234-017-1804-4, PubMed 28255902
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice
Leukemia, 31 (10), 2114-2121
DOI 10.1038/leu.2017.69, PubMed 28232741
Publications 2016
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
Rheumatology (Oxford), 55 (7), 1337-9
DOI 10.1093/rheumatology/kew040, PubMed 27105662
Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease
Biol Blood Marrow Transplant, 23 (1), 172-175
DOI 10.1016/j.bbmt.2016.10.009, PubMed 27777142
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia
Leukemia, 31 (2), 301-309
DOI 10.1038/leu.2016.222, PubMed 27499136
Benzylpenicillin plus an aminoglycoside versus meropenem in neutropenic lymphoma and leukaemia patients with a suspected bacterial infection: a randomized, controlled trial
Clin Microbiol Infect, 23 (3), 179-187
DOI 10.1016/j.cmi.2016.10.019, PubMed 27793737
Publications 2015
Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning
Ther Drug Monit, 37 (4), 493-500
DOI 10.1097/FTD.0000000000000180, PubMed 25565670
Hemophagocytic lymphohistiocytosis in leprosy
Lepr Rev, 86 (4), 403-6
PubMed 26964439
Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries
Pediatr Blood Cancer, 63 (1), 83-92
DOI 10.1002/pbc.25713, PubMed 26281822
Publications 2014
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
DOI 10.4045/tidsskr.13.1415, PubMed 25178233
Eltrombopag in Good's Syndrome
Case Rep Hematol, 2014, 172139
DOI 10.1155/2014/172139, PubMed 25389501
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin Exp Immunol, 175 (3), 439-48
DOI 10.1111/cei.12239, PubMed 24237110
Publications 2013
Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage
PLoS One, 8 (5), e62994
DOI 10.1371/journal.pone.0062994, PubMed 23671648
Malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin
Case Rep Hematol, 2013, 934781
DOI 10.1155/2013/934781, PubMed 24455338
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: unresolved questions
Transplantation, 96 (4), e21-2
DOI 10.1097/TP.0b013e31829df2c0, PubMed 23958883
Publications 2012
Relationship between clinical and BK virological response in patients with late hemorrhagic cystitis treated with cidofovir: a retrospective study from the European Group for Blood and Marrow Transplantation
Bone Marrow Transplant, 48 (6), 809-13
DOI 10.1038/bmt.2012.247, PubMed 23222380
Ultra-short course sirolimus contributes to effective GVHD prophylaxis after reduced-intensity allogeneic hematopoietic cell transplantation
Bone Marrow Transplant, 47 (12), 1552-7
DOI 10.1038/bmt.2012.63, PubMed 22522568
[Invasive fungal infection]
Tidsskr Nor Laegeforen, 132 (23-24), 2618
DOI 10.4045/tidsskr.12.0603, PubMed 23338093
Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT
Bone Marrow Transplant, 48 (5), 703-7
DOI 10.1038/bmt.2012.197, PubMed 23064037
Publications 2011
Richter syndrome presenting as a solitary cerebellar tumor during first-line treatment for chronic lymphocytic leukemia
Leuk Lymphoma, 52 (10), 2007-9
DOI 10.3109/10428194.2011.580480, PubMed 21663503
Effect of three-dimensional culture and incubator gas concentration on phenotype and differentiation capability of human mesenchymal stem cells
J Cell Biochem, 112 (2), 684-93
DOI 10.1002/jcb.22978, PubMed 21268090
Publications 2010
Studies on dendritic cell ontogeny, differentiation and function
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 959, 1 b. (flere pag.)
BIBSYS 101339860, ISBN 978-82-8072-361-1
Recent advances in hematopoietic stem cell transplantation and perspectives of RNAi applications
Methods Mol Biol, 629, 507-23
DOI 10.1007/978-1-60761-657-3_30, PubMed 20387168
Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation
Scand J Immunol, 71 (4), 267-74
DOI 10.1111/j.1365-3083.2010.02378.x, PubMed 20384870
Mesenchymal stem cell-mediated T cell suppression occurs through secreted galectins
Int J Oncol, 38 (2), 385-90
DOI 10.3892/ijo.2010.869, PubMed 21165555
[Survival in adults with acute lymphoblastic leukaemia]
Tidsskr Nor Laegeforen, 130 (17), 1710-3
DOI 10.4045/tidsskr.09.1293, PubMed 20835280
Publications 2009
Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication
Clin Exp Immunol, 157 (3), 400-7
DOI 10.1111/j.1365-2249.2009.03976.x, PubMed 19664149
NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation
J Leukoc Biol, 85 (6), 939-46
DOI 10.1189/jlb.1008650, PubMed 19244164
Age and stress related phenotypical changes in bone marrow CD34+ cells
Scand J Clin Lab Invest, 69 (1), 79-84
DOI 10.1080/00365510802419447, PubMed 18836945
Publications 2008
[Allogeneic stem cell transplantation in adults with acute lymphoblastic leukaemia]
Tidsskr Nor Laegeforen, 128 (22), 2563-6
PubMed 19023351
[Survival in adults with acute myelogenous leukemia]
Tidsskr Nor Laegeforen, 128 (10), 1164-7
PubMed 18480864
Publications 2007
[Non-myeloablative allogeneic stem cell transplantation]
Tidsskr Nor Laegeforen, 127 (6), 721-4
PubMed 17363982
High expression of CD7 on CD34+ cells is not linked to deletion of derivative chromosome 9 or lack of dendritic cells in chronic myeloid leukaemia
Scand J Clin Lab Invest, 68 (2), 93-8
DOI 10.1080/00365510701558477, PubMed 17852828
Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands
Immunology, 123 (2), 263-71
DOI 10.1111/j.1365-2567.2007.02695.x, PubMed 17725606
TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1-type response
Eur J Immunol, 37 (10), 2834-46
DOI 10.1002/eji.200737112, PubMed 17853407
Publications 2006
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
DOI 10.1182/blood-2006-06-031484, PubMed 17158235
Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage
J Mol Biol, 364 (5), 945-54
DOI 10.1016/j.jmb.2006.09.054, PubMed 17049554
Publications 2004
[Treatment of T-cell prolymphocytic leukemia with monoclonal anti- CD52 antibody (alemtuzumab]
Tidsskr Nor Laegeforen, 124 (6), 768-70
PubMed 15039804