Selected publications

Kurganovs NJ and Engedal N (2024). To eat or not to eat - a critical review on the role of autophagy in prostate cancer carcinogenesis and prostate cancer therapeutics. Frontiers in Pharmacology, 15:1419806.
doi: 10.3389/fphar.2024.1419806

Engedal N, Sønstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML (2022)
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988

Sønstevold T, Engedal N, Torgersen ML (2021)
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939

Schläfli AM, Tokarchuk I, Parejo S, Jutzi S, Berezowska S, Engedal N*, Tschan MP* (2021)
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
Sci Rep, 11 (1), 9011
DOI 10.1038/s41598-021-87966-6, PubMed 33907223

*shared senior authorship

Humbert M, Morán M, de la Cruz-Ojeda P, Muntané J, Wiedmer T, Apostolova N, McKenna SL, Velasco G, Balduini W, Eckhart L, Janji B, Sampaio-Marques B, Ludovico P, Žerovnik E, Langer R, Perren A, Engedal N, Tschan MP (2020)
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology (Basel), 9 (3)
DOI 10.3390/biology9030059, PubMed 32245178

Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N (2020)**
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Cell Commun Signal, 18 (1), 12
DOI 10.1186/s12964-019-0499-z, PubMed 31987044

**Selected by Editor-in-chief as Feature article on the front of the Journal webpage (March-June 2020).

Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605

Szalai P, Parys JB, Bultynck G, Christensen SB, Nissen P, Møller JV, Engedal N (2018)***
Nonlinear relationship between ER Ca²⁺ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death
Cell Calcium, 76, 48-61
DOI 10.1016/j.ceca.2018.09.005, PubMed 30261424

*** https://f1000.com/prime/734044750#

Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F (2018)
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 14 (8), 1435-1455
DOI 10.1080/15548627.2018.1474314, PubMed 29940786

Luhr M, Szalai P, Engedal N (2018)
The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
J Vis Exp (137)
DOI 10.3791/57971, PubMed 30102280

Szalai P, Engedal N (2018)
An Image-based Assay for High-throughput Analysis of Cell Proliferation and Cell Death of Adherent Cells
Bio-protocol, 8 (9), e2835 DOI 10.21769/BioProtoc.2835, PubMed 34286042

Luhr M, Saetre F, Engedal N (2018)
The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines
Bio-protocol, 8 (9), e2836 DOI 10.21769/BioProtoc.2836, PubMed 34286043

Sehgal P, Szalai P, Ylanko J, Olesen C, Praetorius HA, Nissen P, Andrews DW, Christensen SB, Engedal N****, Møller JV*. Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response. J Biol Chem. 2017 Dec 1; 292(48):19656-19673.DOI:https://doi.org/10.1074/jbc.M117.796920 PubMed 28972171

****shared corresponding author

Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C (2017)
Rab7b modulates autophagic flux by interacting with Atg4B
EMBO Rep, 18 (10), 1727-1739
DOI 10.15252/embr.201744069, PubMed 28835545

Engedal N, Seglen PO (2015)
Autophagy of cytoplasmic bulk cargo does not require LC3
Autophagy, 12 (2), 439-41
DOI 10.1080/15548627.2015.1076606, PubMed 26237084

Szalai P, Hagen LK, Sætre F, Luhr M, Sponheim M, Øverbye A, Mills IG, Seglen PO, Engedal N (2015)
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Exp Cell Res, 333 (1), 21-38
DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710

Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
Macroautophagic cargo sequestration assays
Methods, 75, 25-36
DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638

Torgersen ML, Engedal N, Bøe SO, Hokland P, Simonsen A (2013)
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Blood, 122 (14), 2467-76
DOI 10.1182/blood-2013-05-500629, PubMed 23970379

Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164