Publications

Publications by Nikolai Engedal

55 publications found

Publications 2024

1. Kandathil SA, Akhondi A, Kadletz-Wanke L, Heiduschka G, Engedal N, Brkic FF (2024)
   The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
   J Cancer Res Clin Oncol, 150 (2), 56
   DOI 10.1007/s00432-023-05514-3, PubMed 38291202

Publications 2023

1. Tamargo-Gómez I, Martínez-García GG, Suárez MF, Mayoral P, Bretones G, Astudillo A, Prieto-Lloret J, Sveen C, Fueyo A, Engedal N, López-Otín C, Mariño G (2023)
   Analysis of ATG4C function in vivo
   Autophagy, 19 (11), 2912-2933
   DOI 10.1080/15548627.2023.2234799, PubMed 37459465

Publications 2022

1. Cao S, Wang JR, Ji S, Yang P, Dai Y, Guo S, Montierth MD, Shen JP, Zhao X, Chen J, Lee JJ, Guerrero PA, Spetsieris N, Engedal N, Taavitsainen S, Yu K, Livingstone J, Bhandari V, Hubert SM, Daw NC, Futreal PA, Efstathiou E, Lim B, Viale A, Zhang J et al. (2022)
   Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
   Nat Biotechnol, 40 (11), 1624-1633
   DOI 10.1038/s41587-022-01342-x, PubMed 35697807
2. Engedal N, Proikas-Cezanne T, Albertini MC, Žerovnik E, Lane JD (2022)
   Transautophagy: Research and Translation of Autophagy Knowledge 2020
   Oxid Med Cell Longev, 2022, 9792132
   DOI 10.1155/2022/9792132, PubMed 35340207
3. Engedal N, Sønstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML (2022)
   Measuring Autophagic Cargo Flux with Keima-Based Probes
   Methods Mol Biol, 2445, 99-115
   DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988
4. Nyakas M, Fleten KG, Haugen MH, Engedal N, Sveen C, Farstad IN, Flørenes VA, Prasmickaite L, Mælandsmo GM, Seip K (2022)
   AXL inhibition improves BRAF-targeted treatment in melanoma
   Sci Rep, 12 (1), 5076
   DOI 10.1038/s41598-022-09078-z, PubMed 35332208

Publications 2021

1. Christensen SB, Simonsen HT, Engedal N, Nissen P, Møller JV, Denmeade SR, Isaacs JT (2021)
   From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
   Prog Chem Org Nat Prod, 115, 59-114
   DOI 10.1007/978-3-030-64853-4_2, PubMed 33797641
2. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
   Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
   Autophagy, 17 (1), 1-382
   DOI 10.1080/15548627.2020.1797280, PubMed 33634751
3. Schläfli AM, Tokarchuk I, Parejo S, Jutzi S, Berezowska S, Engedal N, Tschan MP (2021)
   ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
   Sci Rep, 11 (1), 9011
   DOI 10.1038/s41598-021-87966-6, PubMed 33907223
4. Sønstevold T, Engedal N, Torgersen ML (2021)
   Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
   Cells, 10 (12)
   DOI 10.3390/cells10123432, PubMed 34943939
5. Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T et al. (2021)
   Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
   Nat Commun, 12 (1), 5307
   DOI 10.1038/s41467-021-25624-1, PubMed 34489465

Publications 2020

1. Humbert M, Morán M, de la Cruz-Ojeda P, Muntané J, Wiedmer T, Apostolova N, McKenna SL, Velasco G, Balduini W, Eckhart L, Janji B, Sampaio-Marques B, Ludovico P, Žerovnik E, Langer R, Perren A, Engedal N, Tschan MP (2020)
   Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
   Biology (Basel), 9 (3)
   DOI 10.3390/biology9030059, PubMed 32245178
2. Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N (2020)
   Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
   Cell Commun Signal, 18 (1), 12
   DOI 10.1186/s12964-019-0499-z, PubMed 31987044
3. Sønstevold T, Engedal N, Mørch Ý, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2020)
   Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
   J Biomed Nanotechnol, 16 (4), 432-445
   DOI 10.1166/jbn.2020.2906, PubMed 32970976

Publications 2019

1. Engedal N, Luhr M, Szalai P, Seglen PO (2019)
   Measurement of Bulk Autophagy by a Cargo Sequestration Assay
   Methods Mol Biol, 1880, 307-313
   DOI 10.1007/978-1-4939-8873-0_20, PubMed 30610706
2. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
   The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
   J Biol Chem, 294 (20), 8197-8217
   DOI 10.1074/jbc.RA118.002829, PubMed 30926605
3. Szwed M, Sønstevold T, Øverbye A, Engedal N, Grallert B, Mørch Ý, Sulheim E, Iversen TG, Skotland T, Sandvig K, Torgersen ML (2019)
   Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death
   Nanotoxicology, 13 (6), 761-782
   DOI 10.1080/17435390.2019.1576238, PubMed 30760074
4. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
   ESCRT-mediated phagophore sealing during mitophagy
   Autophagy, 16 (5), 826-841
   DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Publications 2018

1. Albertini MC, Proikas-Cezanne T, Engedal N, Žerovnik E, Lane JD (2018)
   Transautophagy: Research and Translation of Autophagy Knowledge
   Oxid Med Cell Longev, 2018, 7504165
   DOI 10.1155/2018/7504165, PubMed 29861835
2. Engedal N, Žerovnik E, Rudov A, Galli F, Olivieri F, Procopio AD, Rippo MR, Monsurrò V, Betti M, Albertini MC (2018)
   From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs
   Oxid Med Cell Longev, 2018, 4968321
   DOI 10.1155/2018/4968321, PubMed 29849898
3. Luhr M, Szalai P, Engedal N (2018)
   The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
   J Vis Exp (137)
   DOI 10.3791/57971, PubMed 30102280
4. Luhr M, Sætre F, Engedal N (2018)
   The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines
   Bio Protoc, 8 (9), e2836
   DOI 10.21769/BioProtoc.2836, PubMed 34286043
5. Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F (2018)
   Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
   Autophagy, 14 (8), 1435-1455
   DOI 10.1080/15548627.2018.1474314, PubMed 29940786
6. Pajares M, Cuadrado A, Engedal N, Jirsova Z, Cahova M (2018)
   The Role of Free Radicals in Autophagy Regulation: Implications for Ageing
   Oxid Med Cell Longev, 2018, 2450748
   DOI 10.1155/2018/2450748, PubMed 29682156
7. Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, Parys JB (2018)
   The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca²⁺-Dependent Manner
   Cells, 7 (12)
   DOI 10.3390/cells7120239, PubMed 30513588
8. Szalai P, Engedal N (2018)
   An Image-based Assay for High-throughput Analysis of Cell Proliferation and Cell Death of Adherent Cells
   Bio Protoc, 8 (9), e2835
   DOI 10.21769/BioProtoc.2835, PubMed 34286042
9. Szalai P, Parys JB, Bultynck G, Christensen SB, Nissen P, Møller JV, Engedal N (2018)
   Nonlinear relationship between ER Ca²⁺ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death
   Cell Calcium, 76, 48-61
   DOI 10.1016/j.ceca.2018.09.005, PubMed 30261424

Publications 2017

1. Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C (2017)
   Rab7b modulates autophagic flux by interacting with Atg4B
   EMBO Rep, 18 (10), 1727-1739
   DOI 10.15252/embr.201744069, PubMed 28835545
2. Sehgal P, Szalai P, Olesen C, Praetorius HA, Nissen P, Christensen SB, Engedal N, Møller JV (2017)
   Inhibition of the sarco/endoplasmic reticulum (ER) Ca²⁺-ATPase by thapsigargin analogs induces cell death via ER Ca²⁺ depletion and the unfolded protein response
   J Biol Chem, 292 (48), 19656-19673
   DOI 10.1074/jbc.M117.796920, PubMed 28972171
3. Vdovikova S, Luhr M, Szalai P, Nygård Skalman L, Francis MK, Lundmark R, Engedal N, Johansson J, Wai SN (2017)
   A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death
   Front Cell Infect Microbiol, 7, 154
   DOI 10.3389/fcimb.2017.00154, PubMed 28516064

Publications 2016

1. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM et al. (2016)
   Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
   Autophagy, 12 (1), 1-222
   DOI 10.1080/15548627.2015.1100356, PubMed 26799652
2. Luhr M, Szalai P, Sætre F, Gerner L, Seglen PO, Engedal N (2016)
   A Simple Cargo Sequestration Assay for Quantitative Measurement of Nonselective Autophagy in Cultured Cells
   Methods Enzymol, 587, 351-364
   DOI 10.1016/bs.mie.2016.09.064, PubMed 28253965

Publications 2015

1. Engedal N, Seglen PO (2015)
   Autophagy of cytoplasmic bulk cargo does not require LC3
   Autophagy, 12 (2), 439-41
   DOI 10.1080/15548627.2015.1076606, PubMed 26237084
2. Saetre F, Hagen LK, Engedal N, Seglen PO (2015)
   Novel steps in the autophagic-lysosomal pathway
   FEBS J, 282 (11), 2202-14
   DOI 10.1111/febs.13268, PubMed 25779646
3. Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
   Macroautophagic cargo sequestration assays
   Methods, 75, 25-36
   DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638
4. Szalai P, Hagen LK, Sætre F, Luhr M, Sponheim M, Øverbye A, Mills IG, Seglen PO, Engedal N (2015)
   Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
   Exp Cell Res, 333 (1), 21-38
   DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710

Publications 2014

1. Engedal N, Mills IG (2014)
   Endosomal signaling and oncogenesis
   Methods Enzymol, 535, 179-200
   DOI 10.1016/B978-0-12-397925-4.00012-2, PubMed 24377925
2. Itkonen HM, Engedal N, Babaie E, Luhr M, Guldvik IJ, Minner S, Hohloch J, Tsourlakis MC, Schlomm T, Mills IG (2014)
   UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation
   Oncogene, 34 (28), 3744-50
   DOI 10.1038/onc.2014.307, PubMed 25241896

Publications 2013

1. Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
   Modulation of intracellular calcium homeostasis blocks autophagosome formation
   Autophagy, 9 (10), 1475-90
   DOI 10.4161/auto.25900, PubMed 23970164
2. Kvalvaag AS, Pust S, Sundet KI, Engedal N, Simm R, Sandvig K (2013)
   The ERM proteins ezrin and moesin regulate retrograde Shiga toxin transport
   Traffic, 14 (7), 839-52
   DOI 10.1111/tra.12077, PubMed 23593995
3. Torgersen ML, Engedal N, Bøe SO, Hokland P, Simonsen A (2013)
   Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
   Blood, 122 (14), 2467-76
   DOI 10.1182/blood-2013-05-500629, PubMed 23970379

Publications 2011

1. Engedal N (2011)
   Immune regulator vitamin A and T cell death
   Vitam Horm, 86, 153-78
   DOI 10.1016/B978-0-12-386960-9.00007-1, PubMed 21419271
2. Engedal N, Skotland T, Torgersen ML, Sandvig K (2011)
   Shiga toxin and its use in targeted cancer therapy and imaging
   Microb Biotechnol, 4 (1), 32-46
   DOI 10.1111/j.1751-7915.2010.00180.x, PubMed 21255370

Publications 2010

1. Sandvig K, Torgersen ML, Engedal N, Skotland T, Iversen TG (2010)
   Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
   FEBS Lett, 584 (12), 2626-34
   DOI 10.1016/j.febslet.2010.04.008, PubMed 20385131
2. Torgersen ML, Engedal N, Bergan J, Sandvig K (2010)
   The Intracellular Journey of Shiga Toxins
   The Open Toxinology Journal, 3, 3-12
   PublikaID 24
3. Torgersen ML, Engedal N, Pedersen AM, Husebye H, Espevik T, Sandvig K (2010)
   Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells
   FEMS Immunol Med Microbiol, 61 (1), 63-75
   DOI 10.1111/j.1574-695X.2010.00749.x, PubMed 21054580

Publications 2008

1. Engedal N, Auberger P, Blomhoff HK (2008)
   Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly
   J Leukoc Biol, 85 (3), 469-80
   DOI 10.1189/jlb.1107790, PubMed 19112091

Publications 2006

1. Engedal N, Gjevik T, Blomhoff R, Blomhoff HK (2006)
   All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3
   J Immunol, 177 (5), 2851-61
   DOI 10.4049/jimmunol.177.5.2851, PubMed 16920920

Publications 2004

1. Engedal N, Ertesvag A, Blomhoff HK (2004)
   Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2
   Int Immunol, 16 (3), 443-53
   DOI 10.1093/intimm/dxh048, PubMed 14978018

Publications 2003

1. Engedal N, Blomhoff HK (2003)
   Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells
   J Biol Chem, 278 (13), 10934-41
   DOI 10.1074/jbc.M211556200, PubMed 12551910

Publications 2002

1. Engedal N, Korkmaz CG, Saatcioglu F (2002)
   C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP
   Oncogene, 21 (7), 1017-27
   DOI 10.1038/sj.onc.1205167, PubMed 11850819
2. Ertesvag A, Engedal N, Naderi S, Blomhoff HK (2002)
   Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion
   J Immunol, 169 (10), 5555-63
   DOI 10.4049/jimmunol.169.10.5555, PubMed 12421932

Publications 2001

1. Engedal N, Saatcioglu F (2001)
   Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features
   Prostate, 46 (4), 289-97
   DOI 10.1002/1097-0045(20010301)46:4<289::aid-pros1035>3.0.co;2-k, PubMed 11241551

Publications 2000

1. Frønsdal K, Engedal N, Saatcioglu F (2000)
   Efficient DNA-mediated gene transfer into prostate cancer cell line LNCaP
   Prostate, 43 (2), 111-7
   DOI 10.1002/(sici)1097-0045(20000501)43:2<111::aid-pros5>3.0.co;2-4, PubMed 10754526

Publications 1998

1. Frønsdal K, Engedal N, Slagsvold T, Saatcioglu F (1998)
   CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1
   J Biol Chem, 273 (48), 31853-9
   DOI 10.1074/jbc.273.48.31853, PubMed 9822653