Karoline Bjarnesdatter Rypdal

  • Post doc; PhD
  • +47 911 93 598

Personal home page at UiO

Education

  • Philosophiae Doctor (PhD), University of Oslo, Faculty of Medicine 2022
  • Master of Science (MSc), Molecular medicine, Norwegian University of Science of Technology (NTNU) and St Olavs Hospital, 2015
  • Bachelor of Science (BSc), Cell and molecular biology, NTNU, 2013

Work record (selected)

  • Department engineer at Department of Medical Genetics, Oslo University Hospital (OUH), 2015-2017
  • PhD candidate at the Institute for Experimental Medical Research (IEMR), OUS and UiO
  • Post doctoral researcher at the KG. Jebsen Centre for Cardiac Biomarkers, UiO and Oslo Center for Clinical Heart Research (Oslo-CCHR), OUS

Awards, committees, memberships

  • Early Career Investigator Council Member of the International Society of Heart Research (ISHR) European Section
  • Member of the K.G. Jebsen Academy for Young Medical Researchers
  • Young Investigator Award, Runner up, Heart Failure Association (HFA) Winter Meeting, Les Diablerets, Switzerland, 2020
  • Best poster presentation in 2019 and 2022, Annual Norwegian Symposium on Heart Research, Holmenkollen, Oslo, Norway
  • Organization committee member, Nature Masterclass on Scientific Writing, Norwegian PhD School of Heart Research (NORHEART), Stiklestad (2018), Sola (2019) and digital (2021)
  • Organization committee member, Center for Heart Failure Reseach (CHFR) Annual Symposium, 2018, 2019
  • Lecturer, MF9250 - Methods in Cardiac Research, PhD course, NORHEART, UiO, Spring 2019, 2020, 2022, 2023
  • Lecturer,  MED3067 – Translational cardiology: from bench to bedside, Professional Programme in Medicine, UiO, Spring 2023

Research areas

  • Myocardial fibrosis 
  • Extracellular matrix regulation in cardiovascular disease
  • Molecular mechanisms of heart failure
  • Role of ADAMTSL proteins in heart disease
  • Genetic basis of cardiomyopathies
  • Atrial fibrillation
  • Regulation of epicardial adipose tissue in coronary heart disease

Social media

  • Instagram account for dissemination of heart research: @Hjerteforsk
 

Publications 2024

Lunde IG, Rypdal KB, Van Linthout S, Diez J, González A (2024)
Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact
Matrix Biol (in press)
DOI 10.1016/j.matbio.2024.08.008, PubMed 39214156

Rypdal KB, Apte SS, Lunde IG (2024)
Emerging roles for the ADAMTS-like family of matricellular proteins in cardiovascular disease through regulation of the extracellular microenvironment
Mol Biol Rep, 51 (1), 280
DOI 10.1007/s11033-024-09255-5, PubMed 38324186

Publications 2023

Strand ME, Vanhaverbeke M, Henkens MTHM, Sikking MA, Rypdal KB, Braathen B, Almaas VM, Tønnessen T, Christensen G, Heymans S, Lunde IG (2023)
Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease
Biomedicines, 11 (4)
DOI 10.3390/biomedicines11041066, PubMed 37189684

Publications 2022

Andenæs K, Rypdal KB, Palmero S, Tønnessen T, Lunde IG (2022)
The small leucine-rich proteoglycan fibromodulin exerts anti-fibrotic effects in cultured human cardiac fibroblasts
Genet Mol Res, 21 (1), 1-15
DOI 10.4238/gmr19007, PublikaID 434

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599

Publications 2021

Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG (2021)
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
DOI 10.1038/s41598-021-99032-2, PubMed 34611183

Publications 2019

Pope MK, Ratajska A, Johnsen H, Rypdal KB, Sejersted Y, Paus B (2019)
Diagnostics of Hereditary Connective Tissue Disorders by Genetic Next-Generation Sequencing
Genet Test Mol Biomarkers, 23 (11), 783-790
DOI 10.1089/gtmb.2019.0064, PubMed 31638417

Publications 2018

Sitek JC, Kulseth MA, Rypdal KB, Skodje T, Sheng Y, Retterstøl L (2018)
Whole-exome sequencing for diagnosis of hereditary ichthyosis
J Eur Acad Dermatol Venereol, 32 (6), 1022-1027
DOI 10.1111/jdv.14870, PubMed 29444371

Publications 2016

Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, Moshrefi A, Pham K, Stedman W, Liang T, Saghbini M, Dzakula Z, Hastie A, Cao H, Deikus G, Schadt E et al. (2016)
Extensive sequencing of seven human genomes to characterize benchmark reference materials
Sci Data, 3, 160025
DOI 10.1038/sdata.2016.25, PubMed 27271295

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