Publications 2024

Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB (2024)
Supplementation with selenium and coenzyme Q₁₀ in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life
BMC Med, 22 (1), 191
DOI 10.1186/s12916-024-03411-1, PubMed 38714999

Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, Alexander J (2024)
Selenoprotein P increases upon selenium and coenzyme Q₁₀ supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality
Free Radic Biol Med, 222, 403-413
DOI 10.1016/j.freeradbiomed.2024.06.027, PubMed 38960007

Publications 2023

Alehagen U, Alexander J, Aaseth JO, Larsson A, Svensson E, Opstad TB (2023)
Effects of an Intervention with Selenium and Coenzyme Q₁₀ on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
Cells, 12 (13)
DOI 10.3390/cells12131773, PubMed 37443807

Opstad TB, Alexander J, Aaseth J, Larsson A, Seljeflot I, Alehagen U (2023)
Increased SIRT1 Concentration Following Four Years of Selenium and Q₁₀ Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up-Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Antioxidants (Basel), 12 (3)
DOI 10.3390/antiox12030759, PubMed 36979007

Opstad TB, Papotti B, Åkra S, Hansen CH, Braathen B, Tønnessen T, Solheim S, Seljeflot I (2023)
Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
J Transl Med, 21 (1), 644
DOI 10.1186/s12967-023-04518-4, PubMed 37730614

Papotti B, Opstad TB, Åkra S, Tønnessen T, Braathen B, Hansen CH, Arnesen H, Solheim S, Seljeflot I, Ronda N (2023)
Macrophage polarization markers in subcutaneous, pericardial, and epicardial adipose tissue are altered in patients with coronary heart disease
Front Cardiovasc Med, 10, 1055069
DOI 10.3389/fcvm.2023.1055069, PubMed 36937936

Aaseth JO, Alehagen U, Opstad TB, Alexander J (2023)
Vitamin K and Calcium Chelation in Vascular Health
Biomedicines, 11 (12)
DOI 10.3390/biomedicines11123154, PubMed 38137375

Publications 2022

Aukrust SG, Holte KB, Opstad TB, Seljeflot I, Berg TJ, Helseth R (2022)
NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease
Front Immunol, 12, 799539
DOI 10.3389/fimmu.2021.799539, PubMed 35069582

Kluge KE, Langseth MS, Andersen GØ, Halvorsen S, Opstad TB, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2022)
Complement activation in association with clinical outcomes in ST-elevation myocardial infarction
Am Heart J Plus, 24, 100228
DOI 10.1016/j.ahjo.2022.100228, PubMed 38560636

Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U (2022)
Selenium and Coenzyme Q₁₀ Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Nutrients, 14 (16)
DOI 10.3390/nu14163346, PubMed 36014852

Opstad TB, Farup PG, Rootwelt H, Aaseth JO (2022)
Changes in circulating sirtuin 1 after bariatric surgery
Nutr Metab Cardiovasc Dis, 32 (12), 2858-2864
DOI 10.1016/j.numecd.2022.09.009, PubMed 36404480

Opstad TB, Nordeng J, Pettersen AR, Åkra S, Bratseth V, Zaidi H, Helseth R, Solheim S, Seljeflot I (2022)
The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome
J Immunol Res, 2022, 2366695
DOI 10.1155/2022/2366695, PubMed 36582742

Opstad TB, Solheim S, Pettersen AR, Kalstad AA, Arnesen H, Seljeflot I (2022)
TERT and TET2 Genetic Variants Affect Leukocyte Telomere Length and Clinical Outcome in Coronary Artery Disease Patients-A Possible Link to Clonal Hematopoiesis
Biomedicines, 10 (8)
DOI 10.3390/biomedicines10082027, PubMed 36009574

Warlo EMK, Bratseth V, Pettersen AR, Holme PA, Arnesen H, Seljeflot I, Opstad TB (2022)
Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events
Clin Appl Thromb Hemost, 28, 10760296221141893
DOI 10.1177/10760296221141893, PubMed 36474435

Zaidi H, Aksnes T, Åkra S, Eggesbø HB, Byrkjeland R, Seljeflot I, Opstad TB (2022)
Abdominal Adipose Tissue Associates With Adiponectin and TNFα in Middle-Aged Healthy Men
Front Endocrinol (Lausanne), 13, 874977
DOI 10.3389/fendo.2022.874977, PubMed 35872989

Publications 2021

Alehagen U, Opstad TB, Alexander J, Larsson A, Aaseth J (2021)
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Biomolecules, 11 (10)
DOI 10.3390/biom11101478, PubMed 34680111

Kalstad AA, Myhre PL, Laake K, Opstad TB, Tveit A, Solheim S, Arnesen H, Seljeflot I (2021)
Biomarkers of ageing and cardiac remodeling are associated with atrial fibrillation
Scand Cardiovasc J, 55 (4), 213-219
DOI 10.1080/14017431.2021.1889653, PubMed 33650449

Opstad TB, Sundfør T, Tonstad S, Seljeflot I (2021)
Effect of intermittent and continuous caloric restriction on Sirtuin1 concentration depends on sex and body mass index
Nutr Metab Cardiovasc Dis, 31 (6), 1871-1878
DOI 10.1016/j.numecd.2021.03.005, PubMed 33975734

Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2021)
Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease
Adipocyte, 10 (1), 612-620
DOI 10.1080/21623945.2021.1996699, PubMed 34779349

Publications 2020

Kluge KE, Langseth MS, Opstad TB, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
Mediators Inflamm, 2020, 5080743
DOI 10.1155/2020/5080743, PubMed 32308555

Langseth MS, Andersen GØ, Husebye T, Arnesen H, Zucknick M, Solheim S, Eritsland J, Seljeflot I, Opstad TB, Helseth R (2020)
Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure
PLoS One, 15 (10), e0241333
DOI 10.1371/journal.pone.0241333, PubMed 33119664

Langseth MS, Helseth R, Ritschel V, Hansen CH, Andersen GØ, Eritsland J, Halvorsen S, Fagerland MW, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2020)
Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction
Sci Rep, 10 (1), 5007
DOI 10.1038/s41598-020-61971-7, PubMed 32193509

Opstad TB, Berg TJ, Holte KB, Arnesen H, Solheim S, Seljeflot I (2020)
Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long-term survivors of type 1 diabetes: A Dialong substudy
J Diabetes Investig, 12 (7), 1183-1192
DOI 10.1111/jdi.13470, PubMed 33249778

Opstad TB, Kalstad AA, Holte KB, Berg TJ, Solheim S, Arnesen H, Seljeflot I (2020)
Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease
Rejuvenation Res, 23 (4), 324-332
DOI 10.1089/rej.2019.2258, PubMed 31805818

Åkra S, Aksnes TA, Flaa A, Eggesbø HB, Opstad TB, Njerve IU, Seljeflot I (2020)
Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men
Sci Rep, 10 (1), 14055
DOI 10.1038/s41598-020-71109-4, PubMed 32820223

Publications 2019

Helseth R, Knudsen EC, Eritsland J, Opstad TB, Arnesen H, Andersen GØ, Seljeflot I (2019)
Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study
BMC Cardiovasc Disord, 19 (1), 221
DOI 10.1186/s12872-019-1205-1, PubMed 31615411

Helseth R, Shetelig C, Andersen GØ, Langseth MS, Limalanathan S, Opstad TB, Arnesen H, Hoffmann P, Eritsland J, Seljeflot I (2019)
Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI
Mediators Inflamm, 2019, 7816491
DOI 10.1155/2019/7816491, PubMed 31772506

Kalstad AA, Tveit S, Myhre PL, Laake K, Opstad TB, Tveit A, Schmidt EB, Solheim S, Arnesen H, Seljeflot I (2019)
Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients
BMC Geriatr, 19 (1), 376
DOI 10.1186/s12877-019-1383-9, PubMed 31881852

Opstad TB, Kalstad AA, Pettersen AÅ, Arnesen H, Seljeflot I (2019)
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease
Exp Gerontol, 119, 53-60
DOI 10.1016/j.exger.2019.01.020, PubMed 30684534

Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2019)
Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial
Diab Vasc Dis Res, 16 (4), 360-368
DOI 10.1177/1479164119836922, PubMed 30939905

Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2019)
Effects of exercise training on markers of adipose tissue remodeling in patients with coronary artery disease and type 2 diabetes mellitus: sub study of the randomized controlled EXCADI trial
Diabetol Metab Syndr, 11, 109
DOI 10.1186/s13098-019-0508-9, PubMed 31890043

Publications 2018

Langseth MS, Opstad TB, Bratseth V, Solheim S, Arnesen H, Pettersen AÅ, Seljeflot I, Helseth R (2018)
Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease
Eur J Prev Cardiol, 25 (7), 762-769
DOI 10.1177/2047487318760618, PubMed 29473463

Åkra S, Aksnes TA, Flaa A, Eggesbø HB, Opstad TB, Njerve IU, Seljeflot I (2018)
Interleukin-18 and the NLR family pyrin domain containing-3 inflammasome in adipose tissue are strongly associated with glucometabolic variables in a cohort of middle-aged men
Diab Vasc Dis Res, 15 (5), 458-464
DOI 10.1177/1479164118785307, PubMed 29972041

Publications 2017

Opstad TB, Seljeflot I, Bøhmer E, Arnesen H, Halvorsen S (2017)
MMP-9 and Its Regulators TIMP-1 and EMMPRIN in Patients with Acute ST-Elevation Myocardial Infarction: A NORDISTEMI Substudy
Cardiology, 139 (1), 17-24
DOI 10.1159/000481684, PubMed 29141241

Publications 2016

Helseth R, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2016)
The Time Course of Markers of Neutrophil Extracellular Traps in Patients Undergoing Revascularisation for Acute Myocardial Infarction or Stable Angina Pectoris
Mediators Inflamm, 2016, 2182358
DOI 10.1155/2016/2182358, PubMed 28074081

Opstad TB, Arnesen H, Pettersen AÅ, Seljeflot I (2016)
Combined Elevated Levels of the Proinflammatory Cytokines IL-18 and IL-12 Are Associated with Clinical Events in Patients with Coronary Artery Disease: An Observational Study
Metab Syndr Relat Disord, 14 (5), 242-8
DOI 10.1089/met.2015.0130, PubMed 27058587

Opstad TB, Brusletto BS, Arnesen H, Pettersen AÅ, Seljeflot I (2016)
Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease
Immunobiology, 222 (2), 169-175
DOI 10.1016/j.imbio.2016.10.007, PubMed 27765464

Publications 2015

Helseth R, Opstad T, Solheim S, Lunde K, Arnesen H, Seljeflot I (2015)
The Effect of Intracoronary Stem Cell Injection on Markers of Leukocyte Activation in Acute Myocardial Infarction
Cardiol Res, 6 (1), 209-215
DOI 10.14740/cr375w, PubMed 28197227

Helseth R, Weiss TW, Opstad TB, Siegbahn A, Solheim S, Freynhofer MK, Huber K, Arnesen H, Seljeflot S (2015)
Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction
Thromb Res, 136 (6), 1240-4
DOI 10.1016/j.thromres.2015.10.005, PubMed 26475405

Publications 2014

Furenes EB, Opstad TB, Solheim S, Lunde K, Arnesen H, Seljeflot I (2014)
The influence of autologous bone marrow stem cell transplantation on matrix metalloproteinases in patients treated for acute ST-elevation myocardial infarction
Mediators Inflamm, 2014, 385901
DOI 10.1155/2014/385901, PubMed 25294955

Helseth R, Seljeflot I, Opstad T, Solheim S, Freynhofer M, Arnesen H, Huber K, Weiss T (2014)
Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction
Thromb Res, 135 (2), 329-33
DOI 10.1016/j.thromres.2014.11.028, PubMed 25496999

Helseth R, Solheim S, Opstad T, Hoffmann P, Arnesen H, Seljeflot I (2014)
The time profile of Pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention
Mediators Inflamm, 2014, 608414
DOI 10.1155/2014/608414, PubMed 24737925

Opstad TB, Arnesen H, Pettersen AÅ, Seljeflot I (2014)
The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinical events in patients with coronary artery disease
PLoS One, 9 (9), e106816
DOI 10.1371/journal.pone.0106816, PubMed 25191702

Publications 2013

Opstad TB, Pettersen AÅ, Arnesen H, Seljeflot I (2013)
The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in coronary artery disease patients
PLoS One, 8 (9), e74498
DOI 10.1371/journal.pone.0074498, PubMed 24040261

Publications 2012

Bratseth V, Pettersen AÅ, Opstad TB, Arnesen H, Seljeflot I (2012)
Markers of hypercoagulability in CAD patients. Effects of single aspirin and clopidogrel treatment
Thromb J, 10 (1), 12
DOI 10.1186/1477-9560-10-12, PubMed 22883224

Njerve IU, Pettersen AÅ, Opstad TB, Arnesen H, Seljeflot I (2012)
Fractalkine and its receptor (CX3CR1) in patients with stable coronary artery disease and diabetes mellitus
Metab Syndr Relat Disord, 10 (6), 400-6
DOI 10.1089/met.2012.0052, PubMed 22897138

Pettersen AÅ, Arnesen H, Opstad TB, Bratseth V, Seljeflot I (2012)
Markers of endothelial and platelet activation are associated with high on-aspirin platelet reactivity in patients with stable coronary artery disease
Thromb Res, 130 (3), 424-8
DOI 10.1016/j.thromres.2012.06.016, PubMed 22795340

Publications 2011

Opstad TB, Pettersen AÅ, Arnesen H, Seljeflot I (2011)
Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study
Cardiovasc Diabetol, 10, 110
DOI 10.1186/1475-2840-10-110, PubMed 22141572

Opstad TB, Pettersen AA, Weiss TW, Akra S, Øvstebø R, Arnesen H, Seljeflot I (2011)
Genetic variation, gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease
Clin Chim Acta, 413 (1-2), 113-20
DOI 10.1016/j.cca.2011.09.004, PubMed 21963461

Pettersen AA, Arnesen H, Opstad TB, Seljeflot I (2011)
The influence of CYP 2C19*2 polymorphism on platelet function testing during single antiplatelet treatment with clopidogrel
Thromb J, 9, 4
DOI 10.1186/1477-9560-9-4, PubMed 21426546

Publications 2010

Opstad TB, Eilertsen AL, Høibraaten E, Skretting G, Sandset PM (2010)
Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy
Blood Coagul Fibrinolysis, 21 (6), 516-21
DOI 10.1097/MBC.0b013e32833a06cd, PubMed 20453636

Opstad TB, Pettersen AA, Bratseth V, Arnesen H, Seljeflot I (2010)
The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable coronary artery disease
Pathophysiol Haemost Thromb, 37 (2-4), 98-103
DOI 10.1159/000327491, PubMed 21555871

Opstad TB, Pettersen AA, Weiss T, Arnesen H, Seljeflot I (2010)
Gender differences of polymorphisms in the TF and TFPI genes, as related to phenotypes in patients with coronary heart disease and type-2 diabetes
Thromb J, 8, 7
DOI 10.1186/1477-9560-8-7, PubMed 20444258

Publications 2006

Dahm A, Rosendaal FR, Andersen TO, Sandset PM (2006)
Tissue factor pathway inhibitor anticoagulant activity: risk for venous thrombosis and effect of hormonal state
Br J Haematol, 132 (3), 333-8
DOI 10.1111/j.1365-2141.2005.05876.x, PubMed 16409298

Eilertsen AL, Qvigstad E, Andersen TO, Sandvik L, Sandset PM (2006)
Conventional-dose hormone therapy (HT) and tibolone, but not low-dose HT and raloxifene, increase markers of activated coagulation
Maturitas, 55 (3), 278-87
DOI 10.1016/j.maturitas.2006.04.012, PubMed 16713143

Eilertsen AL, Sandvik L, Mowinckel MC, Andersen TO, Qvigstad E, Sandset PM (2006)
Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis
Thromb Res, 120 (3), 371-9
DOI 10.1016/j.thromres.2006.10.013, PubMed 17156824

Publications 2005

Dahm AE, Andersen TO, Rosendaal F, Sandset PM (2005)
A novel anticoagulant activity assay of tissue factor pathway inhibitor I (TFPI)
J Thromb Haemost, 3 (4), 651-8
DOI 10.1111/j.1538-7836.2005.01237.x, PubMed 15842349

Eilertsen AL, Høibraaten E, Os I, Andersen TO, Sandvik L, Sandset PM (2005)
The effects of oral and transdermal hormone replacement therapy on C-reactive protein levels and other inflammatory markers in women with high risk of thrombosis
Maturitas, 52 (2), 111-8
DOI 10.1016/j.maturitas.2005.01.004, PubMed 16186073

Publications 2001

Bendz B, Sevre K, Andersen TO, Sandset PM (2001)
Low molecular weight heparin prevents activation of coagulation in a hypobaric environment
Blood Coagul Fibrinolysis, 12 (5), 371-4
DOI 10.1097/00001721-200107000-00006, PubMed 11505080

Publications 2000

Bendz B, Andersen TO, Sandset PM (2000)
A new sensitive chromogenic substrate assay of tissue factor pathway inhibitor type 1
Thromb Res, 97 (6), 463-72
DOI 10.1016/s0049-3848(99)00183-8, PubMed 10704656

Bendz B, Andersen TO, Sandset PM (2000)
Dose-dependent release of endogenous tissue factor pathway inhibitor by different low molecular weight heparins
Blood Coagul Fibrinolysis, 11 (4), 343-8
DOI 10.1097/00001721-200006000-00005, PubMed 10847421

Bendz B, Rostrup M, Sevre K, Andersen TO, Sandset PM (2000)
Association between acute hypobaric hypoxia and activation of coagulation in human beings
Lancet, 356 (9242), 1657-8
DOI 10.1016/S0140-6736(00)03165-2, PubMed 11089830

Hoibraaten E, Os I, Seljeflot I, Andersen TO, Hofstad A, Sandset PM (2000)
The effects of hormone replacement therapy on hemostatic variables in women with angiographically verified coronary artery disease: results from the estrogen in women with atherosclerosis study
Thromb Res, 98 (1), 19-27
DOI 10.1016/s0049-3848(99)00233-9, PubMed 10706930

Publications 1999

Bendz B, Hansen JB, Andersen TO, Ostergaard P, Sandset PM (1999)
Partial depletion of tissue factor pathway inhibitor during subcutaneous administration of unfractionated heparin, but not with two low molecular weight heparins
Br J Haematol, 107 (4), 756-62
DOI 10.1046/j.1365-2141.1999.01791.x, PubMed 10606880

Publications 1990

Smith P, Arnesen H, Opstad T, Kierulf P (1990)
Warfarin has no negative impact on fibrinolysis
Thromb Res, 58 (6), 653-6
DOI 10.1016/0049-3848(90)90311-y, PubMed 2201102

Smith P, Seljeflot I, Opstad T (1990)
Withdrawal of chronic beta-adrenoceptorblockade: effects on haemodynamics, blood lipids and haemostatic variables
Eur J Clin Pharmacol, 39 (1), 81-2
DOI 10.1007/BF02657064, PubMed 1980463

Publications 1989

Smith P, Arnesen H, Opstad T, Dahl KH, Eritsland J (1989)
Influence of highly concentrated n-3 fatty acids on serum lipids and hemostatic variables in survivors of myocardial infarction receiving either oral anticoagulants or matching placebo
Thromb Res, 53 (5), 467-74
DOI 10.1016/0049-3848(89)90201-6, PubMed 2660319

Publications 1988

Smith P, Arnesen H, Dahl KH, Nilsen DW, Opstad T, Andersen P (1988)
A comparative study of venous occlusion and DDAVP stimulated fibrinolysis in normolipidemic subjects
Thromb Res, 52 (6), 655-60
DOI 10.1016/0049-3848(88)90138-7, PubMed 3148209