Ragnhild Helseth

  • Senior Cardiologist, Post Doc; MD, PhD
  • +47 971 49 518

Mini CV

Education

  • MD, NTNU, 2011
  • PhD, University of Oslo, 2013-2015
  • Specialist in Internal Medicine (2020) and Cardiology (2021)

Work record

  • Consultant cardiologist, Oslo University Hospital Ullevål (2020 )
  • Resident, Internal Medicine and Cardiology, Drammen Hospital and Oslo University Hospital Ullevål (2013-2020)

Awards, committees, memberships

Awarded national and international awards, including Best Oral Presentation (Eurothrombosis, Barcelona 2018), Best Poster Prize (17th Annual CHFR Symposium on Heart Research, Oslo 2019) and Best Thesis Award (Master Thesis, Medical School Norwegian University of Science and Technology, NTNU 2010). Member of the Norwegian Society of Cardiology (NCS).

Research areas

  • Acute coronary syndrome
  • Diabetes mellitus
  • Innate immunity in cardiometabolic disease 
  • Circulating biomarkers
  • Neutrophil extracellular traps (NETs)
 

Publications 2022

Aukrust SG, Holte KB, Opstad TB, Seljeflot I, Berg TJ, Helseth R (2022)
NETosis in Long-Term Type 1 Diabetes Mellitus and Its Link to Coronary Artery Disease
Front Immunol, 12, 799539
DOI 10.3389/fimmu.2021.799539, PubMed 35069582

Aune SK, Bonnevie-Svendsen M, Nyborg C, Trøseid M, Seljeflot I, Hisdal J, Helseth R (2022)
Gut Leakage and Cardiac Biomarkers after Prolonged Strenuous Exercise
Med Sci Sports Exerc, 54 (9), 1476-1482
DOI 10.1249/MSS.0000000000002948, PubMed 35482788

Bratseth V, Nordeng J, Helseth R, Solheim S, Åkra S, Arnesen H, Chiva-Blanch G, Seljeflot I (2022)
Circulating Microvesicles in Association with the NLRP3 Inflammasome in Coronary Thrombi from STEMI Patients
Biomedicines, 10 (9)
DOI 10.3390/biomedicines10092196, PubMed 36140297

Kluge KE, Langseth MS, Andersen GØ, Halvorsen S, Opstad TB, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2022)
Complement activation in association with clinical outcomes in ST-elevation myocardial infarction
Am Heart J Plus, 24, 100228
DOI 10.1016/j.ahjo.2022.100228, PubMed 38560636

Kluge KE, Seljeflot I, Arnesen H, Jensen T, Halvorsen S, Helseth R (2022)
Coagulation factors XI and XII as possible targets for anticoagulant therapy
Thromb Res, 214, 53-62
DOI 10.1016/j.thromres.2022.04.013, PubMed 35490644

Nordeng J, Schandiz H, Solheim S, Åkra S, Hoffman P, Roald B, Bendz B, Arnesen H, Helseth R, Seljeflot I (2022)
TIMP-1 expression in coronary thrombi associate with myocardial injury in ST-elevation myocardial infarction patients
Coron Artery Dis, 33 (6), 446-455
DOI 10.1097/MCA.0000000000001128, PubMed 35102064

Nordeng J, Solheim S, Åkra S, Schandiz H, Hoffmann P, Roald B, Bendz B, Arnesen H, Helseth R, Seljeflot I (2022)
Gene expression of fibrinolytic markers in coronary thrombi
Thromb J, 20 (1), 23
DOI 10.1186/s12959-022-00383-1, PubMed 35488283

Opstad TB, Nordeng J, Pettersen AR, Åkra S, Bratseth V, Zaidi H, Helseth R, Solheim S, Seljeflot I (2022)
The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome
J Immunol Res, 2022, 2366695
DOI 10.1155/2022/2366695, PubMed 36582742

Publications 2021

Aune SK, Byrkjeland R, Solheim S, Arnesen H, Trøseid M, Awoyemi A, Seljeflot I, Helseth R (2021)
Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training
Diabetol Metab Syndr, 13 (1), 36
DOI 10.1186/s13098-021-00655-2, PubMed 33794977

Aune SK, Cwikiel J, Flaa A, Arnesen H, Solheim S, Awoyemi A, Trøseid M, Seljeflot I, Helseth R (2021)
Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
Cells, 10 (9)
DOI 10.3390/cells10092193, PubMed 34571843

Helseth R, Kleveland O, Ueland T, Wiseth R, Damas JK, Broch K, Michelsen A, Bendz B, Gullestad L, Aukrust P, Seljeflot I (2021)
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001492, PubMed 33972404

Nordeng J, Schandiz H, Solheim S, Åkra S, Hoffman P, Roald B, Bendz B, Arnesen H, Helseth R, Seljeflot I (2021)
The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI
Mediators Inflamm, 2021, 5525917
DOI 10.1155/2021/5525917, PubMed 34135690

Rønning P, Helseth E, Skaansar O, Tverdal C, Andelic N, Bhatnagar R, Melberg M, Skaga NO, Aarhus M, Halvorsen S, Helseth R (2021)
Impact of Preinjury Antithrombotic Therapy on 30-Day Mortality in Older Patients Hospitalized With Traumatic Brain Injury (TBI)
Front Neurol, 12, 650695
DOI 10.3389/fneur.2021.650695, PubMed 34054695

Publications 2020

Kluge KE, Langseth MS, Bratseth V, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Circulating levels of the terminal complement complex are associated with hypercoagulability in patients with stable coronary artery disease
Thromb Res, 196, 106-108
DOI 10.1016/j.thromres.2020.08.023, PubMed 32853976

Kluge KE, Langseth MS, Opstad TB, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
Mediators Inflamm, 2020, 5080743
DOI 10.1155/2020/5080743, PubMed 32308555

Langseth MS, Andersen GØ, Husebye T, Arnesen H, Zucknick M, Solheim S, Eritsland J, Seljeflot I, Opstad TB, Helseth R (2020)
Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure
PLoS One, 15 (10), e0241333
DOI 10.1371/journal.pone.0241333, PubMed 33119664

Langseth MS, Helseth R, Ritschel V, Hansen CH, Andersen GØ, Eritsland J, Halvorsen S, Fagerland MW, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2020)
Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction
Sci Rep, 10 (1), 5007
DOI 10.1038/s41598-020-61971-7, PubMed 32193509

Publications 2019

Helseth R, Knudsen EC, Eritsland J, Opstad TB, Arnesen H, Andersen GØ, Seljeflot I (2019)
Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study
BMC Cardiovasc Disord, 19 (1), 221
DOI 10.1186/s12872-019-1205-1, PubMed 31615411

Helseth R, Shetelig C, Andersen GØ, Langseth MS, Limalanathan S, Opstad TB, Arnesen H, Hoffmann P, Eritsland J, Seljeflot I (2019)
Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI
Mediators Inflamm, 2019, 7816491
DOI 10.1155/2019/7816491, PubMed 31772506

Publications 2018

Langseth MS, Opstad TB, Bratseth V, Solheim S, Arnesen H, Pettersen AÅ, Seljeflot I, Helseth R (2018)
Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease
Eur J Prev Cardiol, 25 (7), 762-769
DOI 10.1177/2047487318760618, PubMed 29473463

Munkhaugen J, Hjelmesæth J, Otterstad JE, Helseth R, Sollid ST, Gjertsen E, Gullestad L, Perk J, Moum T, Husebye E, Dammen T (2018)
Managing patients with prediabetes and type 2 diabetes after coronary events: individual tailoring needed - a cross-sectional study
BMC Cardiovasc Disord, 18 (1), 160
DOI 10.1186/s12872-018-0896-z, PubMed 30075751

Publications 2016

Helseth R (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (10), 945
DOI 10.4045/tidsskr.16.0318, PubMed 27272379

Helseth R, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2016)
The Time Course of Markers of Neutrophil Extracellular Traps in Patients Undergoing Revascularisation for Acute Myocardial Infarction or Stable Angina Pectoris
Mediators Inflamm, 2016, 2182358
DOI 10.1155/2016/2182358, PubMed 28074081

Publications 2015

Helseth R, Opstad T, Solheim S, Lunde K, Arnesen H, Seljeflot I (2015)
The Effect of Intracoronary Stem Cell Injection on Markers of Leukocyte Activation in Acute Myocardial Infarction
Cardiol Res, 6 (1), 209-215
DOI 10.14740/cr375w, PubMed 28197227

Helseth R, Weiss TW, Opstad TB, Siegbahn A, Solheim S, Freynhofer MK, Huber K, Arnesen H, Seljeflot S (2015)
Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction
Thromb Res, 136 (6), 1240-4
DOI 10.1016/j.thromres.2015.10.005, PubMed 26475405

Publications 2014

Helseth R, Ravlo M, Carlsen SM, Vanky EE (2014)
Androgens and hyperemesis gravidarum: a case-control study
Eur J Obstet Gynecol Reprod Biol, 175, 167-71
DOI 10.1016/j.ejogrb.2014.01.007, PubMed 24472692

Helseth R, Salvesen O, Stafne SN, Mørkved S, Salvesen KA, Carlsen SM (2014)
Gestational diabetes mellitus among Nordic Caucasian women: prevalence and risk factors according to WHO and simplified IADPSG criteria
Scand J Clin Lab Invest, 74 (7), 620-8
DOI 10.3109/00365513.2014.928942, PubMed 24980704

Helseth R, Solheim S, Opstad T, Hoffmann P, Arnesen H, Seljeflot I (2014)
The time profile of Pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention
Mediators Inflamm, 2014, 608414
DOI 10.1155/2014/608414, PubMed 24737925

Helseth R, Vanky E, Stridsklev S, Vogt C, Carlsen SM (2014)
Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: data from a randomized controlled study on metformin
Eur J Endocrinol, 170 (5), 769-75
DOI 10.1530/EJE-13-0859, PubMed 24595965

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