Geir Øystein Andersen
- Consultant; MD, PhD
- +47 230 16092
Publications 2024
Novel cardiac extracellular matrix biomarkers in STEMI: Associations with ischemic injury and long-term mortality
PLoS One, 19 (5), e0302732
DOI 10.1371/journal.pone.0302732, PubMed 38739599
Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction
Int J Mol Sci, 25 (16)
DOI 10.3390/ijms25169014, PubMed 39201700
Short- and long-term outcomes of patients with acute myocardial infarction complicated by cardiac arrest: A nationwide cohort study 2013-2022
Eur Heart J Acute Cardiovasc Care (in press)
DOI 10.1093/ehjacc/zuae121, PubMed 39441985
Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size
JACC Adv, 3 (9), 101193
DOI 10.1016/j.jacadv.2024.101193, PubMed 39247678
Effects of mild hypercapnia on myocardial injury after out-of-hospital cardiac arrest. A sub-study of the TAME trial
Resuscitation, 201, 110295
DOI 10.1016/j.resuscitation.2024.110295, PubMed 38936652
Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction
Open Heart, 11 (2)
DOI 10.1136/openhrt-2024-002868, PubMed 39277188
Effect of tocilizumab on endothelial and platelet-derived CXC-chemokines and their association with inflammation and myocardial injury in STEMI patients undergoing primary PCI
Int J Cardiol, 418, 132613 (in press)
DOI 10.1016/j.ijcard.2024.132613, PubMed 39374793
Publications 2023
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest
N Engl J Med, 389 (1), 45-57
DOI 10.1056/NEJMoa2214552, PubMed 37318140
Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial
Resuscitation, 193, 109970
DOI 10.1016/j.resuscitation.2023.109970, PubMed 37716401
Transcranial Doppler during the first week after cardiac arrest and association with 6-month outcomes
Front Neurol, 14, 1222401
DOI 10.3389/fneur.2023.1222401, PubMed 37859655
Outcome prediction in comatose cardiac arrest patients with initial shockable and non-shockable rhythms
Acta Anaesthesiol Scand, 68 (2), 263-273
DOI 10.1111/aas.14337, PubMed 37876138
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
Open Heart, 10 (2)
DOI 10.1136/openhrt-2023-002301, PubMed 37591633
Publications 2022
Comments on-The noradrenaline dosing in the new 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Eur Heart J Cardiovasc Pharmacother, 8 (3), E11
DOI 10.1093/ehjcvp/pvab086, PubMed 34918059
Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair
Adv Sci (Weinh), 10 (5), e2203053
DOI 10.1002/advs.202203053, PubMed 36526599
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
EBioMedicine, 80, 104013
DOI 10.1016/j.ebiom.2022.104013, PubMed 35504178
Complement activation in association with clinical outcomes in ST-elevation myocardial infarction
Am Heart J Plus, 24, 100228
DOI 10.1016/j.ahjo.2022.100228, PubMed 38560636
Changes in health status and health related quality of life from six months to five years in out-of-hospital cardiac arrest survivors - A NORCAST sub study
Resuscitation, 181, 182-189
DOI 10.1016/j.resuscitation.2022.08.019, PubMed 36084805
Publications 2021
Outcome in refractory out-of-hospital cardiac arrest before and after implementation of an ECPR protocol
Resuscitation, 162, 35-42
DOI 10.1016/j.resuscitation.2021.01.038, PubMed 33581226
Reply: Clarification Regarding the Lack of Heart Failure Events in the ASSAIL-MI Trial
J Am Coll Cardiol, 78 (6), 637-638
DOI 10.1016/j.jacc.2021.06.005, PubMed 34353542
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
J Am Coll Cardiol, 77 (15), 1845-1855
DOI 10.1016/j.jacc.2021.02.049, PubMed 33858620
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
Resuscitation, 166, 129-136
DOI 10.1016/j.resuscitation.2021.05.038, PubMed 34126135
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
Mol Immunol, 141, 273-279
DOI 10.1016/j.molimm.2021.11.016, PubMed 34906905
High levels of interleukin-6 are associated with final infarct size and adverse clinical events in patients with STEMI
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001869, PubMed 34933964
Case report: a patient with thyroid storm, refractory cardiogenic shock, and cardiac arrest treated with Lugol's iodine solution and veno-arterial extra corporal membrane oxygenation support
Eur Heart J Case Rep, 5 (2), ytab017
DOI 10.1093/ehjcr/ytab017, PubMed 33569532
Health-related quality of life after out-of-hospital cardiac arrest – a five-year follow-up study
Resuscitation, 162, 372-380
DOI 10.1016/j.resuscitation.2021.01.036, PubMed 33571604
Publications 2020
Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure
PLoS One, 15 (10), e0241333
DOI 10.1371/journal.pone.0241333, PubMed 33119664
Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction
Sci Rep, 10 (1), 5007
DOI 10.1038/s41598-020-61971-7, PubMed 32193509
Late awakening, prognostic factors and long-term outcome in out-of-hospital cardiac arrest - results of the prospective Norwegian Cardio-Respiratory Arrest Study (NORCAST)
Resuscitation, 149, 170-179
DOI 10.1016/j.resuscitation.2019.12.031, PubMed 31926258
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275
Lower ST-elevation myocardial infarction incidence during COVID-19 epidemic in Northern Europe
Scand Cardiovasc J, 54 (6), 358-360
DOI 10.1080/14017431.2020.1820563, PubMed 32945201
Clinical impact of chronic substance abuse in a Norwegian ICU-population
Acta Anaesthesiol Scand, 65 (4), 515-524
DOI 10.1111/aas.13766, PubMed 33340102
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353
Publications 2019
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI)
Open Heart, 6 (2), e001108
DOI 10.1136/openhrt-2019-001108, PubMed 31673391
MR findings of microvascular perfusion in infarcted and remote myocardium early after successful primary PCI (vol 13, e0206723, 2018)
PLoS One, 14 (3), e0213636
DOI 10.1371/journal.pone.0213636
Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study
BMC Cardiovasc Disord, 19 (1), 221
DOI 10.1186/s12872-019-1205-1, PubMed 31615411
Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI
Mediators Inflamm, 2019, 7816491
DOI 10.1155/2019/7816491, PubMed 31772506
Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model
Intensive Care Med Exp, 7 (1), 65
DOI 10.1186/s40635-019-0279-5, PubMed 31802327
IgM antibodies against phosphorylcholine measured early after acute ST-elevation myocardial infarction in relation to atherosclerotic disease burden and long-term clinical outcome
PLoS One, 14 (4), e0215640
DOI 10.1371/journal.pone.0215640, PubMed 31002684
Long-Term Survival after Invasive or Conservative Strategy in Elderly Patients with non-ST-Elevation Myocardial Infarction: A Prospective Cohort Study
Cardiology, 144 (3-4), 79-89
DOI 10.1159/000503442, PubMed 31689705
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008, PubMed 31870625
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410
Publications 2018
Microvascular perfusion in infarcted and remote myocardium after successful primary PCI: angiographic and CMR findings
Eur Radiol, 29 (2), 941-950
DOI 10.1007/s00330-018-5588-7, PubMed 29980929
MR findings of microvascular perfusion in infarcted and remote myocardium early after successful primary PCI
PLoS One, 13 (11), e0206723
DOI 10.1371/journal.pone.0206723, PubMed 30412607
Markers of Thrombin Generation Are Associated With Long-Term Clinical Outcome in Patients With ST-Segment Elevation Myocardial Infarction
Clin Appl Thromb Hemost, 24 (7), 1088-1094
DOI 10.1177/1076029618764847, PubMed 29695176
Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole
Am J Physiol Heart Circ Physiol, 315 (5), H1137-H1147
DOI 10.1152/ajpheart.00208.2018, PubMed 30004809
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
ESC Heart Fail, 5 (3), 292-301
DOI 10.1002/ehf2.12266, PubMed 29424484
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front Immunol, 9, 2035
DOI 10.3389/fimmu.2018.02035, PubMed 30258440
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Int J Cardiol, 268, 187-192
DOI 10.1016/j.ijcard.2018.05.032, PubMed 29853279
Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI
J Am Coll Cardiol, 72 (2), 187-198
DOI 10.1016/j.jacc.2018.04.053, PubMed 29976293
Comparison of three haemodynamic monitoring methods in comatose post cardiac arrest patients
Scand Cardiovasc J, 52 (3), 141-148
DOI 10.1080/14017431.2018.1450992, PubMed 29544369
Publications 2017
Systolic mitral annulus velocity is a sensitive index for changes in left ventricular systolic function during inotropic therapy in patients with acute heart failure
Eur Heart J Acute Cardiovasc Care, 7 (4), 321-329
DOI 10.1177/2048872616687114, PubMed 28045338
Long-term survival in patients with acute myocardial infarction and out-of-hospital cardiac arrest: A prospective cohort study
Resuscitation, 122, 41-47
DOI 10.1016/j.resuscitation.2017.11.047, PubMed 29155294
Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction
Sci Rep, 7 (1), 11945
DOI 10.1038/s41598-017-12372-w, PubMed 28931920
Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function
PLoS One, 12 (3), e0173034
DOI 10.1371/journal.pone.0173034, PubMed 28253327
Publications 2016
Impact of acute kidney injury on patient outcome in out-of-hospital cardiac arrest: a prospective observational study
Acta Anaesthesiol Scand, 60 (8), 1170-81
DOI 10.1111/aas.12753, PubMed 27306254
Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest
Crit Care, 20 (1), 314
DOI 10.1186/s13054-016-1503-2, PubMed 27716377
Monocyte-derived circulating microparticles (CD14+, CD14+/CD11b+ and CD14+/CD142+) are related to long-term prognosis for cardiovascular mortality in STEMI patients
Int J Cardiol, 227, 876-881
DOI 10.1016/j.ijcard.2016.11.302, PubMed 27915085
Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report
J Med Case Rep, 10 (1), 132
DOI 10.1186/s13256-016-0926-3, PubMed 27236329
Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction
J Am Heart Assoc, 5 (6)
DOI 10.1161/JAHA.115.003014, PubMed 27412895
Publications 2015
Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages
Atherosclerosis, 243 (1), 204-10
DOI 10.1016/j.atherosclerosis.2015.09.010, PubMed 26402139
Markers of thrombin generation are associated with myocardial necrosis and left ventricular impairment in patients with ST-elevation myocardial infarction
Thromb J, 13, 31
DOI 10.1186/s12959-015-0061-1, PubMed 26396552
Influence of ischemic postconditioning on myocardial dysfunction measured by speckle tracking echocardiography in patients with ST-elevation myocardial infarction
Int J Cardiol, 187, 459-61
DOI 10.1016/j.ijcard.2015.03.192, PubMed 25846653
Post-Resuscitation ECG for Selection of Patients for Immediate Coronary Angiography in Out-of-Hospital Cardiac Arrest
Circ Cardiovasc Interv, 8 (10)
DOI 10.1161/CIRCINTERVENTIONS.115.002784, PubMed 26453688
The authors reply
Crit Care Med, 43 (3), e98
DOI 10.1097/CCM.0000000000000812, PubMed 25700077
Prediction of outcome after out-of-hospital cardiac arrest already on hospital admission-not reliable enough to be true!
Eur Heart J, 37 (42), 3229-3231
DOI 10.1093/eurheartj/ehv490, PubMed 26516178
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589
Publications 2014
Circulatory shock
N Engl J Med, 370 (6), 583
DOI 10.1056/NEJMc1314999, PubMed 24499234
Association of interleukin 8 and myocardial recovery in patients with ST-elevation myocardial infarction complicated by acute heart failure
PLoS One, 9 (11), e112359
DOI 10.1371/journal.pone.0112359, PubMed 25390695
Effect of ischemic postconditioning on infarct size in patients with ST-elevation myocardial infarction treated by primary PCI results of the POSTEMI (POstconditioning in ST-Elevation Myocardial Infarction) randomized trial
J Am Heart Assoc, 3 (2), e000679
DOI 10.1161/JAHA.113.000679, PubMed 24760962
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
Br J Pharmacol, 171 (23), 5169-81
DOI 10.1111/bph.12647, PubMed 24547784
Bradycardia during therapeutic hypothermia is associated with good neurologic outcome in comatose survivors of out-of-hospital cardiac arrest
Crit Care Med, 42 (11), 2401-8
DOI 10.1097/CCM.0000000000000515, PubMed 25072762
Publications 2013
Levosimendan in acute heart failure following primary percutaneous coronary intervention-treated acute ST-elevation myocardial infarction. Results from the LEAF trial: a randomized, placebo-controlled study
Eur J Heart Fail, 15 (5), 565-72
DOI 10.1093/eurjhf/hfs215, PubMed 23288914
Myocardial salvage is reduced in primary PCI-treated STEMI patients with microvascular obstruction, demonstrated by early and late CMR
PLoS One, 8 (8), e71780
DOI 10.1371/journal.pone.0071780, PubMed 23977143
IL-6 signalling in patients with acute ST-elevation myocardial infarction
Results Immunol, 4, 8-13
DOI 10.1016/j.rinim.2013.11.002, PubMed 24707455
Publications 2012
Increased circulating mitochondrial DNA after myocardial infarction
Int J Cardiol, 158 (1), 132-4
DOI 10.1016/j.ijcard.2012.04.047, PubMed 22578950
Publications 2011
Elevated serum osteoprotegerin levels measured early after acute ST-elevation myocardial infarction predict final infarct size
Heart, 97 (6), 460-5
DOI 10.1136/hrt.2010.206714, PubMed 21270073
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation
Diabetes, 60 (5), 1544-51
DOI 10.2337/db10-1493, PubMed 21464440
Impact of newly diagnosed abnormal glucose regulation on long-term prognosis in low risk patients with ST-elevation myocardial infarction: A follow-up study
BMC Endocr Disord, 11, 14
DOI 10.1186/1472-6823-11-14, PubMed 21801387
Elevated levels of PAI-1 activity and t-PA antigen are associated with newly diagnosed abnormal glucose regulation in patients with ST-elevation myocardial infarction
J Thromb Haemost, 9 (8), 1468-74
DOI 10.1111/j.1538-7836.2011.04377.x, PubMed 21624046
Strong and weak aspects of an established post-resuscitation treatment protocol-A five-year observational study
Resuscitation, 82 (9), 1186-93
DOI 10.1016/j.resuscitation.2011.05.003, PubMed 21636202
Publications 2010
Increased levels of CRP and MCP-1 are associated with previously unknown abnormal glucose regulation in patients with acute STEMI: a cohort study
Cardiovasc Diabetol, 9, 47
DOI 10.1186/1475-2840-9-47, PubMed 20809989
Rationale and design of the POSTEMI (postconditioning in ST-elevation myocardial infarction) study
Cardiology, 116 (2), 103-9
DOI 10.1159/000316965, PubMed 20588018
Publications 2009
Abnormal glucose regulation in patients with acute ST- elevation myocardial infarction-a cohort study on 224 patients
Cardiovasc Diabetol, 8, 6
DOI 10.1186/1475-2840-8-6, PubMed 19183453
Publications 2008
Treatment of acute decompensated heart failure: harmful effects of high doses of loop diuretics?
Cardiology, 113 (1), 9-11
DOI 10.1159/000164148, PubMed 18931491
Publications 2007
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol Pharmacol, 72 (3), 582-91
DOI 10.1124/mol.107.035766, PubMed 17573483
Publications 2006
Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts
Basic Res Cardiol, 101 (6), 471-8
DOI 10.1007/s00395-006-0604-5, PubMed 16783486
Publications 2005
[Cardiogenic shock-- new therapeutic strategies]
Tidsskr Nor Laegeforen, 125 (10), 1318-21
PubMed 15909001
Publications 2004
Ca2+-dependent elevation of inositol 1,4,5-trisphosphate level induced by freezing or homogenization of tissues and cells
Basic Clin Pharmacol Toxicol, 95 (6), 288-94
DOI 10.1111/j.1742-7843.2004.t01-1-pto950507.x, PubMed 15569274
RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
J Mol Cell Cardiol, 38 (1), 145-51
DOI 10.1016/j.yjmcc.2004.10.009, PubMed 15623431
Publications 2003
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter
Am J Physiol Heart Circ Physiol, 286 (4), H1354-60
DOI 10.1152/ajpheart.00549.2003, PubMed 14630635
Publications 2002
Alpha(1)-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation
Am J Physiol Heart Circ Physiol, 283 (4), H1471-80
DOI 10.1152/ajpheart.00232.2002, PubMed 12234799
Publications 2000
Angiotensin II activates a bumetanide sensitive increase in 86RB+ efflux in the rat heart
Res Commun Mol Pathol Pharmacol, 107 (1-2), 89-104
PubMed 11334374
Publications 1998
Alpha1-adrenergic activation of myocardial Na-K-2Cl cotransport involving mitogen-activated protein kinase
Am J Physiol, 275 (2), H641-52
DOI 10.1152/ajpheart.1998.275.2.H641, PubMed 9683454
Publications 1997
Alpha 1-adrenoceptor mediated activation of Na/K/2Cl cotransport and K+ channels in the rat heart involves different receptor subtypes
Res Commun Mol Pathol Pharmacol, 96 (3), 329-40
PubMed 9261892
Receptor subtypes involved in the alpha1-adrenoceptor mediated increase in 86Rb+ efflux from the rat heart
Jpn J Pharmacol, 75 (2), 171-8
DOI 10.1254/jjp.75.171, PubMed 9414032
Publications 1996
Concentration-response relationship of alpha 1-adrenoceptor-stimulated increase of 86Rb+ efflux in rat heart
Pharmacol Toxicol, 79 (4), 169-76
DOI 10.1111/j.1600-0773.1996.tb02084.x, PubMed 8899857
Publications 1995
Life threatening intoxication with sodium valproate
J Toxicol Clin Toxicol, 33 (3), 279-84
DOI 10.3109/15563659509018000, PubMed 7760458