Clinical heart research with translational aspects focusing on patients with acute ST-elevation myocardial infarction (STEMI) or cardiac arrest admitted to the cardiac intensive care unit (CICU).
To explore in detail the pathogenesis of acute coronary syndromes ((ACS) including STEMI) and ischemia-reperfusion injury with focus on how systemic and local inflammation may potentially contribute to plaque destabilization and myocardial damage.
Interventional studies targeting ischemia/reperfusion injury aiming to reduce infarct size
Treatment of acute heart failure and cardiogenic shock complicating STEMI
Prognostication, monitoring and treatment of patients with out-of- hospital cardiac arrest in order to improve survival and neurological prognosis
Obtain new mechanistic insights on the importance of residual inflammation on patients with ACS, open the way for novel treatment and prevention options
Wimmer H, Stensønes SH, Benth JŠ, Lundqvist C, Andersen GØ, Draegni T, Sunde K, Nakstad ER(2023) Outcome prediction in comatose cardiac arrest patients with initial shockable and non-shockable rhythms Acta Anaesthesiol Scand(in press) DOI 10.1111/aas.14337, PubMed 37876138
Reichenbach A, Alteheld L, Henriksen J, Nakstad ER, Andersen GØ, Sunde K, Šaltytė Benth J, Lundqvist C(2023) Transcranial Doppler during the first week after cardiac arrest and association with 6-month outcomes Front Neurol, 14, 1222401 DOI 10.3389/fneur.2023.1222401, PubMed 37859655
Melberg MB, Flaa A, Andersen GØ, Sunde K, Bellomo R, Eastwood G, Olasveengen TM, Qvigstad E(2023) Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial Resuscitation, 109970(in press) DOI 10.1016/j.resuscitation.2023.109970, PubMed 37716401