Clinical heart research with translational aspects focusing on patients with acute ST-elevation myocardial infarction (STEMI) or cardiac arrest admitted to the cardiac intensive care unit (CICU).
Primary objectives:
To explore in detail the pathogenesis of acute coronary syndromes ((ACS) including STEMI) and ischemia-reperfusion injury with focus on how systemic and local inflammation may potentially contribute to plaque destabilization and myocardial damage.
Interventional studies targeting ischemia/reperfusion injury aiming to reduce infarct size
Treatment of acute heart failure and cardiogenic shock complicating STEMI
Prognostication, monitoring and treatment of patients with out-of- hospital cardiac arrest in order to improve survival and neurological prognosis
Obtain new mechanistic insights on the importance of residual inflammation on patients with ACS, open the way for novel treatment and prevention options
Baumann Melberg M, Flaa A, Øystein Andersen G, Sunde K, Bellomo R, Eastwood G, Mariero Olasveengen T, Qvigstad E(2024) Effects of mild hypercapnia on myocardial injury after out-of-hospital cardiac arrest. A sub-study of the TAME trial Resuscitation, 110295(in press) DOI 10.1016/j.resuscitation.2024.110295, PubMed 38936652
Andrup S, Andersen GØ, Hoffmann P, Eritsland J, Seljeflot I, Halvorsen S, Vistnes M(2024) Novel cardiac extracellular matrix biomarkers in STEMI: Associations with ischemic injury and long-term mortality PLoS One, 19(5), e0302732 DOI 10.1371/journal.pone.0302732, PubMed 38739599
Kluge KE, Langseth MS, Andersen GØ, Halvorsen S, Opstad TB, Arnesen H, Tønnessen T, Seljeflot I, Helseth R(2022) Complement activation in association with clinical outcomes in ST-elevation myocardial infarction Am Heart J Plus, 24, 100228 DOI 10.1016/j.ahjo.2022.100228, PubMed 38560636