
Sonia Becharef
- Postodc (visiting); PhD
CNRS & Inserm transfert
Education:
2021-2024: PhD – Physics,” Combined nanoparticle-mediated photothermal therapy to enhance CAR-T cell immunotherapy efficacy in stiff cholangiocarcinoma”, Doctoral School “Physique en Ile de France (PIF)”, Université Paris Cité, Paris, France
2017-2019: MSc – Biology, Health, Ecology, Université Paris Science et Lettre (PSL), Paris, France
2013-2014: BSc – Biotechnology-Genomics, Université Claude Bernard, Lyon 1, France
Professional experience:
2024 – Present: Postdoctoral Researcher, Université Paris Cité, NABI lab, France- Development of thermal approaches (laser and magnetic) using nanoparticles to enhance the efficacy of CAR-T cell therapy in various solid tumor models
2021-2024: PhD student, Université Paris Cité, MSC-Med lab and SARL Nanobactérie, France- Combined nanoparticle-mediated photothermal therapy to enhance CAR-T cell immunotherapy efficacy in stiff cholangiocarcinoma.
20218-2019: Intern in apprenticeship at Sanofi, Vitry-sur-Seine in the “Enabling Technologies Biologicals Research team” - Development of a high-throughput screening test based on the
expression of monoclonal antibodies on the surface of CHO cells, aimed at identifying new therapeutic target.
2017-2018: Intern in Institut Cochin, Paris in the “Functional Pharmacology and Pathophysiology of Membrane Receptors team” - Study of white adipose tissue browning in obesity context: the role of GPR50 in the regulation of thermogenesis.
2015-2017: Laboratory technician, Institut Gustave Roussy, Villejuif - Exploration of the role of gut microbiota in tumor progression and response to immunotherapies.
2013-2014: Intern in apprenticeship at Sanofi, Marcy- L’Etoile - Metagenomic and transcriptomic analysis of NGS data to evaluate the effect of a probiotic treatment on the gut microbiota, comparing profiles of treated and untreated patients.
Research interests/projects:
Thermal therapy to treat cancer — Mechanical modulation of the tumor microenvironment to enhance CAR T-cell therapy efficacy — Nanoparticle-mediated photothermal therapy to modulate the tumor immune microenvironment in cancer.