Solrun Melkorka Maggadottir
- PhD student; MD
HELSE SØR ØST
Education:
2017-to date: PhD student at the Department of Cellular Therapy/Faculty of Medicine University of Oslo, Norway.
2011-2014: Board Certified Allergist and Immunologist, University of Pennsylvania (UPENN), PA, USA.
2008-2011: Board Certified Pediatrician, University of Connecticut, Hartford, CT, USA.
1999-2005: MD, University of Iceland, Reykjavik, Iceland.
Research interests/projects:
Development and clinical implementation of novel immunotherapies
- Translation/transition of pre-clinical data into clinical trials with focus on safety and efficacy
- Therapeutic TCR (T Cell Receptor) discovery, validation and translation into clinical trials
- Therapeutic CAR (Chimeric Antigen Receptor) discovery, validation and translation into clinical trials
- Improvement and advancement of clinical trials in cell-based therapy
Work experience
2017-to date: PhD student, Department of Cellular Therapy, OUS-Radiumhospitalet, Norway
2014-2016: Immunology Specialist MD at the Department of Immunology, LSH University Hospital, Iceland.
2011-2014: Fellowship in Allergy/Immunology, The Children’s Hospital of Philadelphia, PA, USA
2008-2011: Pediatric Internship/Residency, Connecticut Children’s Medical Center, CT, USA
2006-2008: Critical Care/Anesthesiology and Pediatric Resident, LSH University Hospital, Iceland
2005-2006: Rotating Internship in Medicine, Surgery and Pediatrics, Landspitali (LSH) University Hospital, Iceland
Awards
- Oral presentation at AAAAI was selected as one of 9 abstracts from >1000 abstracts to be discussed at one of three press events during the meeting.
- Travel awards from AAAAI: 2011, 2013 and 2014. ACAAI: 2012 and 2013. ESID: 2012 and CIS: 2014.
- “Outstanding intern award” in pediatric residency in Connecticut, 2009.
- “Best research project of the year” in medical school, 2003.
Publications 2024
Long-term use of rituximab increases T cell count in MS patients
Front Immunol, 15, 1412668
DOI 10.3389/fimmu.2024.1412668, PubMed 39086478
Transient TCR-based T cell therapy in a patient with advanced treatment-resistant MSI-high colorectal cancer
Mol Ther, 32 (6), 2021-2029
DOI 10.1016/j.ymthe.2024.04.009, PubMed 38582964
Publications 2023
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
Nat Commun, 14 (1), 3375
DOI 10.1038/s41467-023-39097-x, PubMed 37291203
Publications 2022
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
Front Oncol, 12, 1031232
DOI 10.3389/fonc.2022.1031232, PubMed 36439452
Publications 2020
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol Ther, 29 (3), 1199-1213
DOI 10.1016/j.ymthe.2020.11.019, PubMed 33212301
Publications 2019
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721
Publications 2017
Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency
J Clin Immunol, 37 (6), 592-602
DOI 10.1007/s10875-017-0415-5, PubMed 28755066
Publications 2016
Are genetic tests informative in predicting food allergy?
Curr Opin Allergy Clin Immunol, 16 (3), 257-64
DOI 10.1097/ACI.0000000000000268, PubMed 27070332
Understanding the genetic and epigenetic basis of common variable immunodeficiency disorder through omics approaches
Biochim Biophys Acta, 1860 (11 Pt B), 2656-63
DOI 10.1016/j.bbagen.2016.06.014, PubMed 27316315
Publications 2015
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat Commun, 6, 6804
DOI 10.1038/ncomms7804, PubMed 25891430
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Nat Med, 21 (9), 1018-27
DOI 10.1038/nm.3933, PubMed 26301688
Genetic sharing and heritability of paediatric age of onset autoimmune diseases
Nat Commun, 6, 8442
DOI 10.1038/ncomms9442, PubMed 26450413
Rare variants at 16p11.2 are associated with common variable immunodeficiency
J Allergy Clin Immunol, 135 (6), 1569-77
DOI 10.1016/j.jaci.2014.12.1939, PubMed 25678086
Publications 2014
Resolution of acute IgE-mediated allergy with development of eosinophilic esophagitis triggered by the same food
J Allergy Clin Immunol, 133 (5), 1487-9, 1489.e1
DOI 10.1016/j.jaci.2014.02.004, PubMed 24636092
The intersection of immune deficiency and autoimmunity
Curr Opin Rheumatol, 26 (5), 570-8
DOI 10.1097/BOR.0000000000000091, PubMed 25014038
Publications 2013
The ex vivo induction of human CD103⁺ CD25hi Foxp3⁺ CD4⁺ and CD8⁺ Tregs is IL-2 and TGF-β1 dependent
Scand J Immunol, 77 (2), 125-34
DOI 10.1111/sji.12009, PubMed 23126599
The diverse clinical features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome)
J Allergy Clin Immunol Pract, 1 (6), 589-94
DOI 10.1016/j.jaip.2013.08.003, PubMed 24565705
Publications 2004
Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF-beta1 on CD4+ and CD8+ naïve human T-cells
Int Immunol, 17 (1), 35-44
DOI 10.1093/intimm/dxh183, PubMed 15557315