Human c-SRC kinase (CSK) overexpression makes T cells dummy
Patient safety upon immunotherapy treatment is a challenge that still need to be adressed.
In this publication we report how by affecting c-SRC kinase we can make T-cells "dummy": effector cells are still able to recognize and bind to the target but unable to carry on with their activation. This mechanism could potentially open the way for a safe-lock system permitting to reduce off-target toxicity.
Image from: Ellen Tenstad/Science Shaped