Olav Klingenberg

  • Head of department, Assoc. professor; MD, PhD
  • +47 22 11 94 68

Publications 2023

Bekkenes ME, Fagerland MW, Solberg OG, Aaberge L, Klingenberg O, Norseth J, Rosseland LA (2023)
Reply to: exploring cardiac effects after oxytocin 2.5 IU or carbetocin 100 μg - a randomised controlled trial in women undergoing planned caesarean delivery
Eur J Anaesthesiol, 40 (6), 453-454
DOI 10.1097/EJA.0000000000001841, PubMed 37132304

Vinnes EW, Lillemoen PKS, Klingenberg O, Fjeld B, Iversen PO, Brodwall KM, Bechensteen AG (2023)
[Sickle cell disease – clinical manifestations and diagnostics]
Tidsskr Nor Laegeforen, 143 (3)
DOI 10.4045/tidsskr.22.0353, PubMed 36811424

Publications 2022

Bekkenes ME, Fagerland MW, Solberg OG, Aaberge L, Klingenberg O, Norseth J, Rosseland LA (2022)
Exploring cardiac effects after oxytocin 2.5 IU or carbetocin 100 μg: A randomised controlled trial in women undergoing planned caesarean delivery
Eur J Anaesthesiol, 39 (12), 928-938
DOI 10.1097/EJA.0000000000001763, PubMed 36239406

Fjeld B, Sudmann-Day ÅA, Grimholt RM, Larstorp ACK, Urdal P, Klingenberg O (2022)
Additional value of red blood cell parameters in predicting uncommon α-thalassemia; experience from 10 years of α-globin gene sequencing and copy number variation analysis
Int J Lab Hematol, 45 (2), 250-259
DOI 10.1111/ijlh.14010, PubMed 36567661

Larstorp ACK, Salvador CL, Svensvik BA, Klingenberg O, Distante S (2022)
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C are early biomarkers of acute kidney injury associated with cardiac surgery
Scand J Clin Lab Invest, 82 (5), 410-418
DOI 10.1080/00365513.2022.2114105, PubMed 36036280

Publications 2021

Amundsen EK, Binde C, Christensen EE, Klingenberg O, Kvale D, Holten AR (2021)
Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study
Crit Care Explor, 3 (7), e0490
DOI 10.1097/CCE.0000000000000490, PubMed 34291222

Bekkenes M, Jørgensen MM, Flem Jacobsen A, Wang Fagerland M, Rakstad-Larsen H, Solberg OG, Aaberge L, Klingenberg O, Steinsvik T, Rosseland LA (2021)
A study protocol for the cardiac effects of a single dose of either oxytocin 2.5 IU or carbetocin 100 µg after caesarean delivery: a prospective randomized controlled multi-centre trial in Norway
F1000Res, 10, 973
DOI 10.12688/f1000research.73112.2, PubMed 34745566

Grimholt RM, Fjeld B, Klingenberg O (2021)
Hemoglobinopathy gone astray-three novel forms of α-thalassemia in Norwegian patients characterized by quantitative real-time PCR and DNA sequencing
Scand J Clin Lab Invest, 81 (8), 670-678
DOI 10.1080/00365513.2021.2004218, PubMed 34791962

Hildrum JM, Fjeld B, Risahagen SM, Bernatek BJ, Klingenberg O (2021)
Assessment of Hemoglobin A2 stability at room temperature during 24 or 25 days as measured by high pressure liquid chromatography and capillary electrophoresis
Int J Lab Hematol, 43 (5), e266-e270
DOI 10.1111/ijlh.13555, PubMed 33960673

Martin G, Grimholt RM, Le D, Bechensteen AG, Klingenberg O, Fjeld B, Fourie T, Perrier R, Proven M, Henderson SJ, Roy NBA (2021)
Hb Calgary (HBB: c.194G>T): A Highly Unstable Hemoglobin Variant with a β-Thalassemia Major Phenotype
Hemoglobin, 45 (4), 215-219
DOI 10.1080/03630269.2021.1956947, PubMed 34311670

Publications 2020

Holm AM, Andreassen SL, Christensen VL, Kongerud J, Almås Ø, Auråen H, Henriksen AH, Aaberge IS, Klingenberg O, Rustøen T (2020)
Hypogammaglobulinemia and Risk of Exacerbation and Mortality in Patients with COPD
Int J Chron Obstruct Pulmon Dis, 15, 799-807
DOI 10.2147/COPD.S236656, PubMed 32368026

Publications 2019

Fjeld B, Sudmann-Day AA, Grimholt RM, Klingenberg O (2019)
Can the patient have thalassemia or a hemoglobin variant?
Tidsskr. Nor. Laegeforen., 139 (17), 1679

Fjeld B, Sudmann-Day ÅA, Grimholt RM, Klingenberg O (2019)
[Might the patient have thalassaemia or a haemoglobin variant?]
Tidsskr Nor Laegeforen, 139 (17)
DOI 10.4045/tidsskr.19.0121, PubMed 31746162

Grimholt RM, Fjeld B, Selsås H, Schwettmann L, Klingenberg O (2019)
Hb Aalesund (HBA2: c.400_406delAGCACCG), an Unstable α-Globin Variant Found in a Norwegian Patient Causing Moderate Hemolytic Anemia and Falsely High Hb A1c Using Ion Exchange High Performance Liquid Chromatography
Hemoglobin, 43 (2), 122-125
DOI 10.1080/03630269.2019.1614048, PubMed 31145010

Grimholt RM, Urdal P, Klingenberg O, Piehler AP (2019)
Correction to: Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
BMC Hematol, 19, 13
DOI 10.1186/s12878-019-0144-5, PubMed 31695920

Publications 2018

Grimholt RM, Harteveld CL, Arkesteijn SGJ, Fjeld B, Klingenberg O (2018)
Characterization of Two Deep Intronic Variants on the β-Globin Gene with Inconsistent Interpretations of Clinical Significance
Hemoglobin, 42 (2), 126-128
DOI 10.1080/03630269.2018.1473255, PubMed 30047296

Grimholt RM, Vestli A, Urdal P, Bechensteen AG, Fjeld B, Dalhus B, Klingenberg O (2018)
Hb Oslo [β42(CD1)Phe→Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient
Hemoglobin, 42 (2), 78-83
DOI 10.1080/03630269.2018.1468773, PubMed 30032685

Publications 2017

Klingenberg O (2017)
Hemoglobin amino acids by the numbers
Scand J Clin Lab Invest, 77 (1), 1
DOI 10.1080/00365513.2017.1267428, PubMed 27937007

Klingenberg O, Furuset T, Hestbråten CR, Hallberg MH, Steiro A, Orset IR, Berg JP (2017)
HbA1c analysis by capillary electrophoresis - comparison with chromatography and an immunological method
Scand J Clin Lab Invest, 77 (6), 458-464
DOI 10.1080/00365513.2017.1338747, PubMed 28644050

Lindberg A, Holm AM, Hilberg O, Harju T, Vestbo J, Foronjy R, Harju T, Nurmos NI, Karvonen H, Lappi-Blanco E, Skold M, Lehtonen S, Kaarteenaho R, Backman H, Christensen VL, Rustoen T, Cooper BA, Miaskowski C, Henriksen AH, Bentsen SB, Holm AM, Andersson M, Waatevik M, Johannessen A, Real FG et al. (2017)
VII Scandinavian Copd Research Symposium, Holmenkollen, Oslo 18th-19th November 2016
EUR. CLIN. RESPIR. J., 5 1, 1401867
DOI 10.1080/20018525.2017.1401867

Sagedal S, Sandvik L, Klingenberg O, Sandset PM (2017)
β-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane
Scand J Clin Lab Invest, 77 (8), 679-684
DOI 10.1080/00365513.2017.1397288, PubMed 29117741

Publications 2015

Berntsen NL, Klingenberg O, Juran BD, Benito de Valle M, Lindkvist B, Lazaridis KN, Boberg KM, Karlsen TH, Hov JR (2015)
Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis
Gastroenterology, 148 (5), 924-927.e2
DOI 10.1053/j.gastro.2015.01.041, PubMed 25655558

Sudmann-Day ÅA, Piehler A, Klingenberg O, Urdal P (2015)
Six-day stability of erythrocyte and reticulocyte parameters in-vitro: a comparison of blood samples from healthy, iron-deficient, and thalassemic individuals
Scand J Clin Lab Invest, 75 (3), 247-53
DOI 10.3109/00365513.2014.1000370, PubMed 25608597

Publications 2014

Grimholt RM, Urdal P, Klingenberg O, Piehler AP (2014)
Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
BMC Hematol, 14 (1), 4
DOI 10.1186/2052-1839-14-4, PubMed 24456650

Urdal P, Amundsen EK, Toska K, Klingenberg O (2014)
Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays
Scand J Clin Lab Invest, 74 (7), 575-81
DOI 10.3109/00365513.2014.915426, PubMed 25007050

Publications 2013

Grimholt RM, Sudmann ÅA, Piehler AP, Urdal P, Klingenberg O (2013)
Hb Ullevaal [β78(EF2)Leu→Val; HBB: c.235C>G], a new hemoglobin variant interfering with Hb A1c measurement using a cation exchange high performance liquid chromatography method
Hemoglobin, 38 (2), 130-2
DOI 10.3109/03630269.2013.858640, PubMed 24274186

Publications 2012

Hausken J, Klingenberg O, Mørkrid L, Rollag H, Foss A, Midtvedt K (2012)
Elevated troponin I and NT-proBNP at the time of transplantation may predict a major adverse cardiac event in the early postoperative period after renal transplantation
Transplantation, 94 (2), e15-6
DOI 10.1097/TP.0b013e31825b7633, PubMed 22820562

Publications 2011

Bachmann-Harildstad G, Stenklev NC, Myrvoll E, Jablonski G, Klingenberg O (2011)
β-trace protein as a diagnostic marker for perilymphatic fluid fistula: a prospective controlled pilot study to test a sample collection technique
Otol Neurotol, 32 (1), 7-10
DOI 10.1097/mao.0b013e3181fc74d0, PubMed 21192373

Henriksson CE, Hellum M, Haug KB, Aass HC, Joø GB, Øvstebø R, Trøseid AM, Klingenberg O, Kierulf P (2011)
Anticoagulant effects of an antidiabetic drug on monocytes in vitro
Thromb Res, 128 (5), e100-6
DOI 10.1016/j.thromres.2011.07.007, PubMed 21862110

Sagedal S, Witczak BJ, Osnes K, Hartmann A, Os I, Eikvar L, Klingenberg O, Brosstad F (2011)
A heparin-coated dialysis filter (AN69 ST) does not reduce clotting during hemodialysis when compared to a conventional polysulfone filter (F×8)
Blood Purif, 32 (3), 151-5
DOI 10.1159/000325227, PubMed 21659742

Publications 2007

Jensen T, Kierulf P, Sandset PM, Klingenberg O, Joø GB, Godal HC, Skjønsberg OH (2007)
Fibrinogen and fibrin induce synthesis of proinflammatory cytokines from isolated peripheral blood mononuclear cells
Thromb Haemost, 97 (5), 822-9
DOI 10.1160/th07-01-0039, PubMed 17479194

Knudsen GP, Pedersen J, Klingenberg O, Lygren I, Ørstavik KH (2007)
Increased skewing of X chromosome inactivation with age in both blood and buccal cells
Cytogenet Genome Res, 116 (1-2), 24-8
DOI 10.1159/000097414, PubMed 17268174

Publications 2006

Henriksson CE, Hellum M, Landsverk KS, Klingenberg O, Joø GB, Kierulf P (2006)
Flow cytometry-sorted non-viable endotoxin-treated human monocytes are strongly procoagulant
Thromb Haemost, 96 (1), 29-37
DOI 10.1160/TH06-01-0052, PubMed 16807648

Henriksson CE, Klingenberg O, Hellum M, Landsverk KS, Joø GB, Westvik AB, Kierulf P (2006)
Calcium ionophore-induced de-encryption of tissue factor in monocytes is associated with extensive cell death
Thromb Res, 119 (5), 621-30
DOI 10.1016/j.thromres.2006.05.012, PubMed 16844202

Publications 2005

Henriksson CE, Klingenberg O, Ovstebø R, Joø GB, Westvik AB, Kierulf P (2005)
Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis
Thromb Haemost, 94 (6), 1236-44
DOI 10.1160/TH05-07-0463, PubMed 16411400

Publications 2003

Olsnes S, Klingenberg O, Wiedłocha A (2003)
Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus
Physiol Rev, 83 (1), 163-82
DOI 10.1152/physrev.00021.2002, PubMed 12506129

Publications 2001

Citores L, Khnykin D, Sørensen V, Wesche J, Klingenberg O, Wiedłocha A, Olsnes S (2001)
Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain
J Cell Sci, 114 (Pt 9), 1677-89
DOI 10.1242/jcs.114.9.1677, PubMed 11398757

Publications 2000

Klingenberg O, Wiedlocha A, Rapak A, Khnykin D, Citores L, Olsnes S (2000)
Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus
J Cell Sci, 113 ( Pt 10), 1827-38
DOI 10.1242/jcs.113.10.1827, PubMed 10769213

Klingenberg O, Wiedocha A, Citores L, Olsnes S (2000)
Requirement of phosphatidylinositol 3-kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
J Biol Chem, 275 (16), 11972-80
DOI 10.1074/jbc.275.16.11972, PubMed 10766827

Publications 1999

Klingenberg O (1999)
Translocation of acidic fibroblast growth factor from thecell surface to the cytosol and nucleus
Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital and Norwegian Cancer Society, [Oslo], 1 b. (flere pag.)
BIBSYS 990881717, ISBN 82-7633-124-6

Klingenberg O, Wiedlocha A, Olsnes S (1999)
Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor
J Biol Chem, 274 (25), 18081-6
DOI 10.1074/jbc.274.25.18081, PubMed 10364261

Publications 1998

Klingenberg O, Widlocha A, Rapak A, Muñoz R, Falnes P, Olsnes S (1998)
Inability of the acidic fibroblast growth factor mutant K132E to stimulate DNA synthesis after translocation into cells
J Biol Chem, 273 (18), 11164-72
DOI 10.1074/jbc.273.18.11164, PubMed 9556604

Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S (1998)
Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor
Biochem J, 336 ( Pt 1) (Pt 1), 213-22
DOI 10.1042/bj3360213, PubMed 9806903

Publications 1997

Muñoz R, Klingenberg O, Wiedłocha A, Rapak A, Falnes PO, Olsnes S (1997)
Effect of mutation of cytoplasmic receptor domain and of genistein on transport of acidic fibroblast growth factor into cells
Oncogene, 15 (5), 525-36
DOI 10.1038/sj.onc.1201226, PubMed 9247306

Publications 1996

Klingenberg O, Olsnes S (1996)
Ability of methotrexate to inhibit translocation to the cytosol of dihydrofolate reductase fused to diphtheria toxin
Biochem J, 313 ( Pt 2) (Pt 2), 647-53
DOI 10.1042/bj3130647, PubMed 8573105

Wiedłocha A, Falnes PO, Rapak A, Muñoz R, Klingenberg O, Olsnes S (1996)
Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization
Mol Cell Biol, 16 (1), 270-80
DOI 10.1128/MCB.16.1.270, PubMed 8524304

Publications 1995

Wiedłocha A, Falnes PO, Rapak A, Klingenberg O, Muñoz R, Olsnes S (1995)
Translocation of cytosol of exogenous, CAAX-tagged acidic fibroblast growth factor
J Biol Chem, 270 (51), 30680-5
DOI 10.1074/jbc.270.51.30680, PubMed 8530506

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