Petter Brandtzæg

  • Professor Emeritus

Publications 2023

Brusletto BS, Hellerud BC, Øvstebø R, Brandtzaeg P (2023)
Neisseria meningitidis accumulate in large organs during meningococcal sepsis
Front Cell Infect Microbiol, 13, 1298360
DOI 10.3389/fcimb.2023.1298360, PubMed 38089821

Publications 2022

Brusletto BS, Hellerud BC, Olstad OK, Øvstebø R, Brandtzaeg P (2022)
Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model
Front Cell Infect Microbiol, 12, 908204
DOI 10.3389/fcimb.2022.908204, PubMed 36034711

Publications 2020

Brusletto BS, Løberg EM, Hellerud BC, Goverud IL, Berg JP, Olstad OK, Gopinathan U, Brandtzaeg P, Øvstebø R (2020)
Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Front Cell Infect Microbiol, 10, 42
DOI 10.3389/fcimb.2020.00042, PubMed 32154187

Publications 2019

Mihret W, Sletbakk Brusletto B, Øvstebø R, Siebke Troseid AM, Norheim G, Merid Y, Kassu A, Abebe W, Ayele S, Silamsaw Asres M, Yamuah L, Aseffa A, Petros B, Caugant DA, Brandtzaeg P (2019)
Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia
Innate Immun, 25 (3), 158-167
DOI 10.1177/1753425918806363, PubMed 30894090

Publications 2018

Gopinathan U, Redalen KR, Trøseid AM, Kierulf P, Brandtzaeg P, Ree AH, Berg JP, Øvstebø R (2018)
Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis
PLoS One, 13 (1), e0181912
DOI 10.1371/journal.pone.0181912, PubMed 29357362

Knudsen PK, Brandtzaeg P, Høiby EA, Bohlin J, Samuelsen Ø, Steinbakk M, Abrahamsen TG, Müller F, Gammelsrud KW (2018)
Correction: Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting
PLoS One, 13 (2), e0193439
DOI 10.1371/journal.pone.0193439, PubMed 29466441

Aass HCD, Hellum M, Trøseid AS, Brandtzaeg P, Berg JP, Øvstebø R, Henriksson CE (2018)
Whole-blood incubation with the Neisseria meningitidis lpxL1 mutant induces less pro-inflammatory cytokines than the wild type, and IL-10 reduces the MyD88-dependent cytokines
Innate Immun, 24 (2), 101-111
DOI 10.1177/1753425917749299, PubMed 29313733

Publications 2017

Brusletto BS, Hellerud BC, Løberg EM, Goverud IL, Vege Å, Berg JP, Brandtzaeg P, Øvstebø R (2017)
Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease
BMC Clin Pathol, 17, 10
DOI 10.1186/s12907-017-0049-9, PubMed 28824331

Gopinathan U, Øvstebø R, Brusletto BS, Olstad OK, Kierulf P, Brandtzaeg P, Berg JP (2017)
Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10
BMC Immunol, 18 (1), 46
DOI 10.1186/s12865-017-0229-5, PubMed 29078758

Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE (2017)
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
J Intensive Care, 5, 21
DOI 10.1186/s40560-017-0217-0, PubMed 28261486

Knudsen PK, Brandtzaeg P, Høiby EA, Bohlin J, Samuelsen Ø, Steinbakk M, Abrahamsen TG, Müller F, Gammelsrud KW (2017)
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting
PLoS One, 12 (11), e0187618
DOI 10.1371/journal.pone.0187618, PubMed 29112974

Publications 2016

Hellum M, Trøseid AS, Berg JP, Brandtzaeg P, Øvstebø R, Henriksson CE (2016)
The Neisseria meningitidis lpxL1 mutant induces less tissue factor expression and activity in primary human monocytes and monocyte-derived microvesicles than the wild type meningococcus
Innate Immun, 23 (2), 196-205
DOI 10.1177/1753425916684201, PubMed 28024455

Publications 2015

Hellerud BC, Olstad OK, Nielsen EW, Trøseid AM, Skadberg Ø, Thorgersen EB, Vege Å, Mollnes TE, Brandtzæg P (2015)
Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock
Shock, 44 (5), 458-69
DOI 10.1097/SHK.0000000000000441, PubMed 26473439

Publications 2014

Gopinathan U, Brusletto BS, Olstad OK, Kierulf P, Berg JP, Brandtzaeg P, Øvstebø R (2014)
IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes
Innate Immun, 21 (4), 429-49
DOI 10.1177/1753425914547743, PubMed 25233959

Publications 2013

Hellum M, Øvstebø R, Brusletto BS, Berg JP, Brandtzaeg P, Henriksson CE (2013)
Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock
Thromb Res, 133 (3), 507-14
DOI 10.1016/j.thromres.2013.12.031, PubMed 24423888

Øvstebø R, Hellum M, Aass HC, Trøseid AM, Brandtzaeg P, Mollnes TE, Henriksson CE (2013)
Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis-exposed whole blood
Innate Immun, 20 (5), 552-60
DOI 10.1177/1753425913502099, PubMed 24051102

Publications 2012

Brandtzaeg P, van Deuren M (2012)
Classification and pathogenesis of meningococcal infections
Methods Mol Biol, 799, 21-35
DOI 10.1007/978-1-61779-346-2_2, PubMed 21993637

Gammelsrud KW, Lindstad BL, Gaustad P, Ingebretsen A, Høiby EA, Brandtzaeg P, Sandven P (2012)
Multilocus sequence typing of serial Candida albicans isolates from children with cancer, children with cystic fibrosis and healthy controls
Med Mycol, 50 (6), 619-26
DOI 10.3109/13693786.2012.675088, PubMed 22524637

Gopinathan U, Ovstebø R, Olstad OK, Brusletto B, Dalsbotten Aass HC, Kierulf P, Brandtzaeg P, Berg JP (2012)
Global effect of interleukin-10 on the transcriptional profile induced by Neisseria meningitidis in human monocytes
Infect Immun, 80 (11), 4046-54
DOI 10.1128/IAI.00386-12, PubMed 22966040

Hellum M, Øvstebø R, Trøseid AM, Berg JP, Brandtzaeg P, Henriksson CE (2012)
Microparticle-associated tissue factor activity measured with the Zymuphen MP-TF kit and the calibrated automated thrombogram assay
Blood Coagul Fibrinolysis, 23 (6), 520-6
DOI 10.1097/MBC.0b013e328354a256, PubMed 22732249

Kvakkestad KM, Gammelsrud KW, Brandtzaeg P, Høiby EA (2012)
Unchanged antibiotic susceptibility in Escherichia coli and Pseudomonas aeruginosa after long-term in vitro exposure to antineoplastic drugs
Chemotherapy, 58 (2), 118-22
DOI 10.1159/000337058, PubMed 22507969

Publications 2011

Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE (2011)
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood
Mol Immunol, 48 (15-16), 2159-69
DOI 10.1016/j.molimm.2011.07.011, PubMed 21839519

Gammelsrud KW, Sandven P, Høiby EA, Sandvik L, Brandtzaeg P, Gaustad P (2011)
Colonization by Candida in children with cancer, children with cystic fibrosis, and healthy controls
Clin Microbiol Infect, 17 (12), 1875-81
DOI 10.1111/j.1469-0691.2011.03528.x, PubMed 21745258

Rasmussen I, Wallace S, Mengshoel AT, Høiby EA, Brandtzæg P (2011)
Diphtheria outbreak in Norway: lessons learned
Scand J Infect Dis, 43 (11-12), 986-9
DOI 10.3109/00365548.2011.600326, PubMed 21867473

Øvstebø R, Aass HC, Haug KB, Trøseid AM, Gopinathan U, Kierulf P, Berg JP, Brandtzaeg P, Henriksson CE (2011)
LPS from Neisseria meningitidis is crucial for inducing monocyte- and microparticle-associated tissue factor activity but not for tissue factor expression
Innate Immun, 18 (4), 580-91
DOI 10.1177/1753425911428230, PubMed 22180561

Publications 2010

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tønnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
DOI 10.1097/CCM.0b013e3181de8c94, PubMed 20400898

Krogh K, Surén P, Mengshoel AT, Brandtzæg P (2010)
Tuberculosis among children in Oslo, Norway, from 1998 to 2009
Scand J Infect Dis, 42 (11-12), 866-72
DOI 10.3109/00365548.2010.508461, PubMed 20735328

Publications 2009

Hellerud BC, Aase A, Herstad TK, Naess LM, Kristiansen LH, Trøseid AM, Harboe M, Lappegård KT, Brandtzaeg P, Høiby EA, Mollnes TE (2009)
Critical roles of complement and antibodies in host defense mechanisms against Neisseria meningitidis as revealed by human complement genetic deficiencies
Infect Immun, 78 (2), 802-9
DOI 10.1128/IAI.01044-09, PubMed 19933829

Kristiansen BE, Brandtzaeg P, Bjorvatn B, Solberg CO (2009)
[The meningococcal vaccine trial 1988-91]
Tidsskr Nor Laegeforen, 129 (3), 192-4
DOI 10.4045/tidsskr.09.33173, PubMed 19180164

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tønnessen TI, Brandtzaeg P, Mollnes TE (2009)
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
DOI 10.1097/SHK.0b013e31819c37be, PubMed 19174740

Publications 2008

Hellerud BC, Stenvik J, Espevik T, Lambris JD, Mollnes TE, Brandtzaeg P (2008)
Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation
Infect Immun, 76 (9), 4183-9
DOI 10.1128/IAI.00195-08, PubMed 18591229

Ovstebø R, Olstad OK, Brusletto B, Møller AS, Aase A, Haug KB, Brandtzaeg P, Kierulf P (2008)
Identification of genes particularly sensitive to lipopolysaccharide (LPS) in human monocytes induced by wild-type versus LPS-deficient Neisseria meningitidis strains
Infect Immun, 76 (6), 2685-95
DOI 10.1128/IAI.01625-07, PubMed 18362127

Rojahn A, Brusletto B, Øvstebø R, Haug KB, Kierulf P, Brandtzaeg P (2008)
Does granulocyte colony-stimulating factor ameliorate the proinflammatory response in human meningococcal septic shock?
Crit Care Med, 36 (9), 2583-9
DOI 10.1097/CCM.0b013e3181844399, PubMed 18679115

Publications 2007

Stephens DS, Greenwood B, Brandtzaeg P (2007)
Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
Lancet, 369 (9580), 2196-2210
DOI 10.1016/S0140-6736(07)61016-2, PubMed 17604802

Publications 2005

Brandtzaeg P (2005)
[Recently discovered virus--known symptoms]
Tidsskr Nor Laegeforen, 125 (20), 2756
PubMed 16244672

Brandtzaeg P, van Deuren M (2005)
Meningococcal infections at the start of the 21st century
Adv Pediatr, 52, 129-62
DOI 10.1016/j.yapd.2005.03.005, PubMed 16124339

Møller AS, Bjerre A, Brusletto B, Joø GB, Brandtzaeg P, Kierulf P (2005)
Chemokine patterns in meningococcal disease
J Infect Dis, 191 (5), 768-75
DOI 10.1086/427514, PubMed 15688294

van Deuren M, Brandtzaeg P (2005)
Myocardial dysfunction in meningococcal septic shock: no clear answer yet
Crit Care Med, 33 (8), 1884-6
DOI 10.1097/01.ccm.0000174482.51523.96, PubMed 16096482

Publications 2004

Bjerre A, Brusletto B, Høiby EA, Kierulf P, Brandtzaeg P (2004)
Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock
Crit Care Med, 32 (2), 433-8
DOI 10.1097/01.CCM.0000104950.52577.97, PubMed 14758160

Brandtzaeg P (2004)
[Activated protein C in sepsis]
Tidsskr Nor Laegeforen, 124 (6), 766
PubMed 15039802

Sprong T, Møller AS, Bjerre A, Wedege E, Kierulf P, van der Meer JW, Brandtzaeg P, van Deuren M, Mollnes TE (2004)
Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide
Infect Immun, 72 (6), 3344-9
DOI 10.1128/IAI.72.6.3344-3349.2004, PubMed 15155639

Øvstebø R, Brandtzaeg P, Brusletto B, Haug KB, Lande K, Høiby EA, Kierulf P (2004)
Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease
J Clin Microbiol, 42 (7), 2980-7
DOI 10.1128/JCM.42.7.2980-2987.2004, PubMed 15243048

Publications 2003

Bjerre A, Brusletto B, Øvstebø R, Joø GB, Kierulf P, Brandtzaeg P (2003)
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex
J Endotoxin Res, 9 (3), 155-63
DOI 10.1179/096805103125001559, PubMed 12831456

Brandtzaeg P (2003)
Host response to Neisseria meningitidis lacking lipopolysaccharides
Expert Rev Anti Infect Ther, 1 (4), 589-96
DOI 10.1586/14787210.1.4.589, PubMed 15482156

Sprong T, Brandtzaeg P, Fung M, Pharo AM, Høiby EA, Michaelsen TE, Aase A, van der Meer JW, van Deuren M, Mollnes TE (2003)
Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis
Blood, 102 (10), 3702-10
DOI 10.1182/blood-2003-03-0703, PubMed 12881318

Publications 2002

Bjerre A, Brusletto B, Mollnes TE, Fritzsønn E, Rosenqvist E, Wedege E, Namork E, Kierulf P, Brandtzaeg P (2002)
Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant
J Infect Dis, 185 (2), 220-8
DOI 10.1086/338269, PubMed 11807696

Brandtzaeg P, van Deuren M (2002)
Current concepts in the role of the host response in Neisseria meningitidis septic shock
Curr Opin Infect Dis, 15 (3), 247-52
DOI 10.1097/00001432-200206000-00006, PubMed 12015458

Iversen N, Brandtzaeg P, Sandset PM, Kierulf P, Abildgaard U (2002)
TFPI fractions in plasma from patients with systemic meningococcal disease
Thromb Res, 108 (5-6), 347-53
DOI 10.1016/s0049-3848(03)00065-3, PubMed 12676197

Namork E, Brandtzaeg P (2002)
Fatal meningococcal septicaemia with "blebbing" meningococcus
Lancet, 360 (9347), 1741
DOI 10.1016/S0140-6736(02)11721-1, PubMed 12480427

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