Publications 2023

Brusletto BS, Hellerud BC, Øvstebø R, Brandtzaeg P (2023)
Neisseria meningitidis accumulate in large organs during meningococcal sepsis
Front Cell Infect Microbiol, 13, 1298360
DOI 10.3389/fcimb.2023.1298360, PubMed 38089821

Cross T, Haug KBF, Brusletto BS, Ommundsen SK, Trøseid AS, Aspelin T, Olstad OK, Aass HCD, Galtung HK, Utheim TP, Jensen JL, Øvstebø R (2023)
Non-Coding RNA in Salivary Extracellular Vesicles: A New Frontier in Sjögren's Syndrome Diagnostics?
Int J Mol Sci, 24 (17)
DOI 10.3390/ijms241713409, PubMed 37686214

Cross T, Øvstebø R, Brusletto BS, Trøseid AS, Olstad OK, Aspelin T, Jackson CJ, Chen X, Utheim TP, Haug KBF (2023)
RNA Profiles of Tear Fluid Extracellular Vesicles in Patients with Dry Eye-Related Symptoms
Int J Mol Sci, 24 (20)
DOI 10.3390/ijms242015390, PubMed 37895069

Rashid A, Brusletto BS, Al-Obeidat F, Toufiq M, Benakatti G, Brierley J, Malik ZA, Hussain Z, Alkhazaimi H, Sharief J, Kadwa R, Sarpal A, Chaussabe D, Malik RA, Quraishi N, Khilnani P, Zaki SA, Nadeem R, Shaikh G, Al-Dubai A, Hafez W, Hussain A (2023)
A TRANSCRIPTOMIC APPRECIATION OF CHILDHOOD MENINGOCOCCAL AND POLYMICROBIAL SEPSIS FROM A PRO-INFLAMMATORY AND TRAJECTORIAL PERSPECTIVE, A ROLE FOR VASCULAR ENDOTHELIAL GROWTH FACTOR A AND B MODULATION?
Shock, 60 (4), 503-516
DOI 10.1097/SHK.0000000000002192, PubMed 37553892

Aas V, Øvstebø R, Brusletto BS, Aspelin T, Trøseid AS, Qureshi S, Eid DSO, Olstad OK, Nyman TA, Haug KBF (2023)
Distinct microRNA and protein profiles of extracellular vesicles secreted from myotubes from morbidly obese donors with type 2 diabetes in response to electrical pulse stimulation
Front Physiol, 14, 1143966
DOI 10.3389/fphys.2023.1143966, PubMed 37064893

Publications 2022

Brusletto BS, Hellerud BC, Olstad OK, Øvstebø R, Brandtzaeg P (2022)
Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model
Front Cell Infect Microbiol, 12, 908204
DOI 10.3389/fcimb.2022.908204, PubMed 36034711

Publications 2021

Bjørnetrø T, Steffensen LA, Vestad B, Brusletto BS, Olstad OK, Trøseid AM, Aass HCD, Haug KBF, Llorente A, Bøe SO, Lång A, Samiappan R, Redalen KR, Øvstebø R, Ree AH (2021)
Uptake of circulating extracellular vesicles from rectal cancer patients and differential responses by human monocyte cultures
FEBS Open Bio, 11 (3), 724-740
DOI 10.1002/2211-5463.13098, PubMed 33512765

Publications 2020

Brusletto BS, Løberg EM, Hellerud BC, Goverud IL, Berg JP, Olstad OK, Gopinathan U, Brandtzaeg P, Øvstebø R (2020)
Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Front Cell Infect Microbiol, 10, 42
DOI 10.3389/fcimb.2020.00042, PubMed 32154187

Publications 2019

Beitland S, Nakstad ER, Berg JP, Trøseid AS, Brusletto BS, Brunborg C, Lundqvist C, Sunde K (2019)
Urine β-2-Microglobulin, Osteopontin, and Trefoil Factor 3 May Early Predict Acute Kidney Injury and Outcome after Cardiac Arrest
Crit Care Res Pract, 2019, 4384796
DOI 10.1155/2019/4384796, PubMed 31205786

Mihret W, Sletbakk Brusletto B, Øvstebø R, Siebke Troseid AM, Norheim G, Merid Y, Kassu A, Abebe W, Ayele S, Silamsaw Asres M, Yamuah L, Aseffa A, Petros B, Caugant DA, Brandtzaeg P (2019)
Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia
Innate Immun, 25 (3), 158-167
DOI 10.1177/1753425918806363, PubMed 30894090

Publications 2017

Brusletto BS, Hellerud BC, Løberg EM, Goverud IL, Vege Å, Berg JP, Brandtzaeg P, Øvstebø R (2017)
Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease
BMC Clin Pathol, 17, 10
DOI 10.1186/s12907-017-0049-9, PubMed 28824331

Gopinathan U, Øvstebø R, Brusletto BS, Olstad OK, Kierulf P, Brandtzaeg P, Berg JP (2017)
Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10
BMC Immunol, 18 (1), 46
DOI 10.1186/s12865-017-0229-5, PubMed 29078758

Publications 2016

Beitland S, Waldum-Grevbo BE, Nakstad ER, Berg JP, Trøseid AS, Brusletto BS, Brunborg C, Andersen GØ, Sunde K (2016)
Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest
Crit Care, 20 (1), 314
DOI 10.1186/s13054-016-1503-2, PubMed 27716377

Opstad TB, Brusletto BS, Arnesen H, Pettersen AÅ, Seljeflot I (2016)
Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease
Immunobiology, 222 (2), 169-175
DOI 10.1016/j.imbio.2016.10.007, PubMed 27765464

Publications 2015

Pasovic L, Eidet JR, Brusletto BS, Lyberg T, Utheim TP (2015)
Effect of Storage Temperature on Key Functions of Cultured Retinal Pigment Epithelial Cells
J Ophthalmol, 2015, 263756
DOI 10.1155/2015/263756, PubMed 26448872

Publications 2014

Gopinathan U, Brusletto BS, Olstad OK, Kierulf P, Berg JP, Brandtzaeg P, Øvstebø R (2014)
IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes
Innate Immun, 21 (4), 429-49
DOI 10.1177/1753425914547743, PubMed 25233959

Vilming Elgaaen B, Olstad OK, Haug KB, Brusletto B, Sandvik L, Staff AC, Gautvik KM, Davidson B (2014)
Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker
BMC Cancer, 14, 80
DOI 10.1186/1471-2407-14-80, PubMed 24512620

Publications 2013

Hellum M, Øvstebø R, Brusletto BS, Berg JP, Brandtzaeg P, Henriksson CE (2013)
Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock
Thromb Res, 133 (3), 507-14
DOI 10.1016/j.thromres.2013.12.031, PubMed 24423888

Jensen K, Brusletto BS, Aass HC, Olstad OK, Kierulf P, Gautvik KM (2013)
Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations
PLoS One, 8 (7), e70721
DOI 10.1371/journal.pone.0070721, PubMed 23936243

Jensen K, Rother MB, Brusletto BS, Olstad OK, Dalsbotten Aass HC, van Zelm MC, Kierulf P, Gautvik KM (2013)
Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output
J Immunol, 191 (3), 1210-9
DOI 10.4049/jimmunol.1203462, PubMed 23825313

Publications 2012

Gopinathan U, Ovstebø R, Olstad OK, Brusletto B, Dalsbotten Aass HC, Kierulf P, Brandtzaeg P, Berg JP (2012)
Global effect of interleukin-10 on the transcriptional profile induced by Neisseria meningitidis in human monocytes
Infect Immun, 80 (11), 4046-54
DOI 10.1128/IAI.00386-12, PubMed 22966040

Publications 2008

Ovstebø R, Olstad OK, Brusletto B, Møller AS, Aase A, Haug KB, Brandtzaeg P, Kierulf P (2008)
Identification of genes particularly sensitive to lipopolysaccharide (LPS) in human monocytes induced by wild-type versus LPS-deficient Neisseria meningitidis strains
Infect Immun, 76 (6), 2685-95
DOI 10.1128/IAI.01625-07, PubMed 18362127

Rojahn A, Brusletto B, Øvstebø R, Haug KB, Kierulf P, Brandtzaeg P (2008)
Does granulocyte colony-stimulating factor ameliorate the proinflammatory response in human meningococcal septic shock?
Crit Care Med, 36 (9), 2583-9
DOI 10.1097/CCM.0b013e3181844399, PubMed 18679115

Publications 2007

Sikkeland LI, Skogstad M, Ovstebø R, Brusletto B, Haug KB, Kongerud J, Eduard W, Kierulf P (2007)
Circulating lipopolysaccharides in the blood from "bioprotein" production workers
Occup Environ Med, 65 (3), 211-4
DOI 10.1136/oem.2007.032938, PubMed 17855504

Publications 2005

Møller AS, Bjerre A, Brusletto B, Joø GB, Brandtzaeg P, Kierulf P (2005)
Chemokine patterns in meningococcal disease
J Infect Dis, 191 (5), 768-75
DOI 10.1086/427514, PubMed 15688294

Ovstebo R, Brandtzaeg P, Brusletto B, Haug KBF, Lande K, Hoiby EA, Kierulf P (2005)
Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease (vol 42, pg 2980, 2004)
J. Clin. Microbiol., 43 (1), 532
DOI 10.1128/JCM.43.1.532.2005

Publications 2004

Bjerre A, Brusletto B, Høiby EA, Kierulf P, Brandtzaeg P (2004)
Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock
Crit Care Med, 32 (2), 433-8
DOI 10.1097/01.CCM.0000104950.52577.97, PubMed 14758160

Brusletto BS (2004)
Måling av transkripsjonsfaktorene NF-kB p50/p65: en sammenligning mellom EMSA- og ELISA-metodikk og applisering på et klinisk materiale (OVITES)
B.S. Brusletto, [Trondheim], 112 bl.
BIBSYS 050413724

Øvstebø R, Brandtzaeg P, Brusletto B, Haug KB, Lande K, Høiby EA, Kierulf P (2004)
Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease
J Clin Microbiol, 42 (7), 2980-7
DOI 10.1128/JCM.42.7.2980-2987.2004, PubMed 15243048

Publications 2003

Bjerre A, Brusletto B, Øvstebø R, Joø GB, Kierulf P, Brandtzaeg P (2003)
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex
J Endotoxin Res, 9 (3), 155-63
DOI 10.1179/096805103125001559, PubMed 12831456

Publications 2002

Bjerre A, Brusletto B, Mollnes TE, Fritzsønn E, Rosenqvist E, Wedege E, Namork E, Kierulf P, Brandtzaeg P (2002)
Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant
J Infect Dis, 185 (2), 220-8
DOI 10.1086/338269, PubMed 11807696

Publications 2001

Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P (2001)
Neisseria meningitidis lipopolysaccharides in human pathology
J Endotoxin Res, 7 (6), 401-20
DOI 10.1177/09680519010070060401, PubMed 11753210

Publications 2000

Bjerre A, Brusletto B, Rosenqvist E, Namork E, Kierulf P, Øvstebø R, Joø GB, Brandtzaeg P (2000)
Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide
J Endotoxin Res, 6 (6), 437-45
DOI 10.1179/096805100101532397, PubMed 11521068

Publications 1991

Daae LN, Kierulf P, Brusletto B, Westheim A, Holme I, Syvertsen JO (1991)
[The effect of doxazosin on blood pressure, lipids, fibrinogen and plasminogen activator inhibitor. A comparative study among smokers and non-smokers with essential hypertension]
Tidsskr Nor Laegeforen, 111 (9), 1102-5
PubMed 1827216

Publications 1990

Brandtzaeg P, Joø GB, Brusletto B, Kierulf P (1990)
Plasminogen activator inhibitor 1 and 2, alpha-2-antiplasmin, plasminogen, and endotoxin levels in systemic meningococcal disease
Thromb Res, 57 (2), 271-8
DOI 10.1016/0049-3848(90)90326-8, PubMed 2315889

Westheim A, Daae LN, Kierulf P, Brusletto B, Holme I, Syvertsen JO (1990)
Selective alpha 1 inhibition with doxazosin in hypertensive smokers and non-smokers: haemodynamic and metabolic effects
J Hypertens Suppl, 8 (5), S41-6
PubMed 1981076