Collaborative projects: 

proPTE – Aim of the study: Carry out and interpret the EEG of patients in the neurointensive care unit. Analyze blood and cerebrospinal fluid (CSF) to find out which damage mechanisms are active in the brain during traumatic head injury. Which cell types are damaged, whether drugs given to counteract epilepsy enter the brain f rom the bloodstream, whether the development of epileptic convulsions or delirium is associated with changes in the CSF and, in the longer term, whether changes in the CSF or blood can predict which patients develop epilepsy as a permanent condition. In this way we hope to understand the mechanisms behind traumatic brain damage and the development of delirium and epilepsy in order to be able to prevent these conditions more effectively than today.

ALL-Star – Aim of the study: To increase the knowledge base on how it goes in the short and long term after treatment of acute lymphoblastic leukemia (ALL) in children. In the ALL-STAR study, we will follow and study health-related variables, psychosocial factors and quality of life in study participants from the Nordic countries (Norway, Sweden, Denmark, Finland, Iceland) and Lithuania, who have all received the same leukemia treatment according to the NOPHO ALL2008 protocol.

Retinoblastom – Aim of the study: Survey the health and quality of life of retinoblastom (RB) survivors in Norway, and explore possible connections with visual and hearing function, disease prevalence, heredity and treatment method. This has not previously been investigated in Norway, and will be able to reveal the challenges and needs of this specific group of childhood cancer survivors. It is very relevant in terms of being able to improve the treatment and follow-up of future RB patients.

MUNE MScanfit study– Aim for the study: Investigate the validity of the new MUNE (motor unit number estimation) method Mscan, as well as investigate the utility of Mscan to monitor progression of ALS. Our research group is pioneered in showing that MScan is a sensitive and reliable method, but the method needs to be tested in multicentre studies using large cohorts, before it can be considered suitable for widespread clinical use.. An international collaborative study as a part of the ESTEEM network, organized by Aarhus University Hospital

NI-study  – Aim of the study: Neurophysiology Index (NI) as an electrophysiological biomarker in ALS patients. To examine whether NI is a sensitive and specific parameter for ALS diagnosis, as well if NI is a sensitive parameter for early detection of motor unit loss in ALS. KNF will perform neurography examinations on the same patients participating in the MUNE project. An international collaborative study as a part of the ESTEEM network, organized by Aarhus University Hospital.

Delta Fatigue – Aim of the study: The aim is to compare the complex fractures randomized to surgery with reversed shoulder prosthesis or non-operative treatment. The study is conducted from 14 major Nordic centers (Norway, Denmark and Finland). Effect measures are primarily various questionnaires and shoulder function tests. KNF is performing nerve conduction studies and electromyography.

NOR-CACTUS – Aim of the study: The main hypothesis of the project is that management of patients with mild to moderate idiopathic CTS by a treatment strategy with initial use of ultrasound-guided corticosteroid injection, scheduled clinical assessment of treatment effect and surgery in case of suboptimal treatment result, provide non-inferior long-term outcomes compared to surgery as first-line treatment, while reducing the incidence of adverse events and the overall need for surgical interventions. Participants are recruiting from Diakonhjemmet and Martine Hansen. KNF is performing nerve conduction studies.