
Stephen J. Ryan
- PhD student
Doctoral Student at University of Oslo and Neurologist in training.
Stephen J. Ryan is PhD student in the TenCRAOS trial.
Publications 2018
Chronic inflammatory demyelinating polyneuropathy: considerations for diagnosis, management, and population health
Am J Manag Care, 24 (17 Suppl), S371-S379
PubMed 30312032
Publications 2014
Herpes zoster ophthalmicus following onabotulinumtoxinA administration for chronic migraine: a case report and literature review
Cephalalgia, 35 (5), 443-8
DOI 10.1177/0333102414544974, PubMed 25135654
Publications 2013
Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells
Invest Ophthalmol Vis Sci, 54 (4), 2787-98
DOI 10.1167/iovs.12-11571, PubMed 23532520
Publications 2012
Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction
Free Radic Biol Med, 53 (5), 1111-22
DOI 10.1016/j.freeradbiomed.2012.06.042, PubMed 22781655
Interview with Stephen J. Ryan, MD, by George B. Bartley, MD
Arch Ophthalmol, 130 (5), 650-1
DOI 10.1001/archophthalmol.2012.125, PubMed 22652853
Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux
PLoS One, 7 (3), e33420
DOI 10.1371/journal.pone.0033420, PubMed 22442691
Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9
Angiogenesis, 15 (2), 213-27
DOI 10.1007/s10456-012-9254-4, PubMed 22392094
Publications 2011
Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII
Invest Ophthalmol Vis Sci, 52 (8), 5068-78
DOI 10.1167/iovs.11-7191, PubMed 21571675
With looming budget cuts, vision research advocacy is vital
Optom Vis Sci, 88 (4), 454-5
DOI 10.1097/OPX.0b013e3182170c76, PubMed 21430501
Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram
Phys Med Biol, 56 (10), 3015-32
DOI 10.1088/0031-9155/56/10/008, PubMed 21508444
Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration
FASEB J, 25 (7), 2221-33
DOI 10.1096/fj.10-178350, PubMed 21411747
Publications 2010
αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells
PLoS One, 5 (10), e12578
DOI 10.1371/journal.pone.0012578, PubMed 20949024
Neutrophils compromise retinal pigment epithelial barrier integrity
J Biomed Biotechnol, 2010, 289360
DOI 10.1155/2010/289360, PubMed 20204129
Publications 2009
Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro
Invest Ophthalmol Vis Sci, 51 (1), 543-52
DOI 10.1167/iovs.09-3475, PubMed 19696168
alphaB-crystallin regulation of angiogenesis by modulation of VEGF
Blood, 115 (16), 3398-406
DOI 10.1182/blood-2009-01-197095, PubMed 20023214
Regulated secretion of complement factor H by RPE and its role in RPE migration
Graefes Arch Clin Exp Ophthalmol, 247 (5), 651-9
DOI 10.1007/s00417-009-1049-y, PubMed 19214553
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells
Nat Protoc, 4 (5), 662-73
DOI 10.1038/nprot.2009.33, PubMed 19373231
Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration
Aging (Albany NY), 2 (1), 28-42
DOI 10.18632/aging.100111, PubMed 20228934
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration
J Biol Chem, 284 (14), 9529-39
DOI 10.1074/jbc.M809393200, PubMed 19158083
Publications 2008
Connective tissue growth factor as a mediator of intraocular fibrosis
Invest Ophthalmol Vis Sci, 49 (9), 4078-88
DOI 10.1167/iovs.07-1302, PubMed 18450591
Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells
Graefes Arch Clin Exp Ophthalmol, 246 (5), 677-83
DOI 10.1007/s00417-008-0770-2, PubMed 18278507
Regulation of thioredoxin by ceramide in retinal pigment epithelial cells
Exp Eye Res, 88 (3), 410-7
DOI 10.1016/j.exer.2008.10.009, PubMed 18996115
N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice
Invest Ophthalmol Vis Sci, 49 (3), 1210-20
DOI 10.1167/iovs.07-0667, PubMed 18326751
Publications 2007
In vivo models of proliferative vitreoretinopathy
Nat Protoc, 2 (1), 67-77
DOI 10.1038/nprot.2007.4, PubMed 17401340
Publications 2006
Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor
Exp Eye Res, 83 (1), 212-22
DOI 10.1016/j.exer.2005.12.007, PubMed 16563380
Thrombospondin-1 expression in RPE and choroidal neovascular membranes
Yan Ke Xue Bao, 22 (4), 265-74
PubMed 17378161
MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes
Retina, 26 (4), 454-61
DOI 10.1097/01.iae.0000238549.74626.33, PubMed 16603966
Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells
Biochem Biophys Res Commun, 346 (4), 1200-6
DOI 10.1016/j.bbrc.2006.06.021, PubMed 16793007
Characterization of brimonidine transport in retinal pigment epithelium
Invest Ophthalmol Vis Sci, 47 (1), 287-94
DOI 10.1167/iovs.05-0189, PubMed 16384975
Publications 2005
Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
Lab Invest, 85 (6), 721-33
DOI 10.1038/labinvest.3700277, PubMed 15856049
Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells
J Neuroimmunol, 171 (1-2), 45-56
DOI 10.1016/j.jneuroim.2005.09.018, PubMed 16288810
Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization
Invest Ophthalmol Vis Sci, 46 (12), 4772-9
DOI 10.1167/iovs.05-0502, PubMed 16303978
Inhibitory effects of verapamil isomers on the proliferation of choroidal endothelial cells
Graefes Arch Clin Exp Ophthalmol, 244 (3), 376-81
DOI 10.1007/s00417-004-1104-7, PubMed 16088412
A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion
BMC Ophthalmol, 5, 16
DOI 10.1186/1471-2415-5-16, PubMed 15987521
Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells
Curr Eye Res, 30 (2), 103-13
DOI 10.1080/02713680490894595, PubMed 15814468
Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion
Invest Ophthalmol Vis Sci, 46 (11), 4311-9
DOI 10.1167/iovs.05-0353, PubMed 16249513
Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes
Am J Ophthalmol, 140 (6), 1044-1050
DOI 10.1016/j.ajo.2005.07.021, PubMed 16376649
National and international patient networks: standardization of phenotype and genotype definitions
Retina, 25 (8 Suppl), S68
DOI 10.1097/00006982-200512001-00032, PubMed 16374345
Governmental, university, pharmaceutical, and foundation partnerships to advance translational research in retinal disease
Retina, 25 (8 Suppl), S82
DOI 10.1097/00006982-200512001-00039, PubMed 16374353
Protection from oxidative stress by methionine sulfoxide reductases in RPE cells
Biochem Biophys Res Commun, 334 (1), 245-53
DOI 10.1016/j.bbrc.2005.06.081, PubMed 15993845
Neutrophils promote experimental choroidal neovascularization
Mol Vis, 11, 414-24
PubMed 15988410
Publications 2004
Mouse strain-dependent heterogeneity of resting limbal vasculature
Invest Ophthalmol Vis Sci, 45 (2), 441-7
DOI 10.1167/iovs.03-0869, PubMed 14744883
Hepatocyte growth factor and its role in the pathogenesis of retinal detachment
Invest Ophthalmol Vis Sci, 45 (1), 323-9
DOI 10.1167/iovs.03-0355, PubMed 14691191
Publications 2002
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis
Am J Pathol, 161 (4), 1429-37
DOI 10.1016/S0002-9440(10)64418-5, PubMed 12368215
Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor
Invest Ophthalmol Vis Sci, 43 (8), 2782-90
PubMed 12147616
Translational research in ophthalmology
Arch Ophthalmol, 120 (3), 389-90
DOI 10.1001/archopht.120.3.389, PubMed 11879146