Stephen J. Ryan

  • PhD student

Doctoral Student at University of Oslo and Neurologist in training.

Stephen J. Ryan is PhD student in the TenCRAOS trial.

 

Publications 2018

Ryan M, Ryan SJ (2018)
Chronic inflammatory demyelinating polyneuropathy: considerations for diagnosis, management, and population health
Am J Manag Care, 24 (17 Suppl), S371-S379
PubMed 30312032

Publications 2014

Gadient PM, Smith JH, Ryan SJ (2014)
Herpes zoster ophthalmicus following onabotulinumtoxinA administration for chronic migraine: a case report and literature review
Cephalalgia, 35 (5), 443-8
DOI 10.1177/0333102414544974, PubMed 25135654

Publications 2013

Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton DR (2013)
Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells
Invest Ophthalmol Vis Sci, 54 (4), 2787-98
DOI 10.1167/iovs.12-11571, PubMed 23532520

Publications 2012

Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR (2012)
Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction
Free Radic Biol Med, 53 (5), 1111-22
DOI 10.1016/j.freeradbiomed.2012.06.042, PubMed 22781655

Ryan SJ (2012)
Interview with Stephen J. Ryan, MD, by George B. Bartley, MD
Arch Ophthalmol, 130 (5), 650-1
DOI 10.1001/archophthalmol.2012.125, PubMed 22652853

Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton DR (2012)
Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux
PLoS One, 7 (3), e33420
DOI 10.1371/journal.pone.0033420, PubMed 22442691

Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton DR (2012)
Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9
Angiogenesis, 15 (2), 213-27
DOI 10.1007/s10456-012-9254-4, PubMed 22392094

Publications 2011

Khankan R, Oliver N, He S, Ryan SJ, Hinton DR (2011)
Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII
Invest Ophthalmol Vis Sci, 52 (8), 5068-78
DOI 10.1167/iovs.11-7191, PubMed 21571675

Ryan SJ (2011)
With looming budget cuts, vision research advocacy is vital
Optom Vis Sci, 88 (4), 454-5
DOI 10.1097/OPX.0b013e3182170c76, PubMed 21430501

Shang Y, Cheng R, Dong L, Ryan SJ, Saha SP, Yu G (2011)
Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram
Phys Med Biol, 56 (10), 3015-32
DOI 10.1088/0031-9155/56/10/008, PubMed 21508444

Xu J, Zhu D, He S, Spee C, Ryan SJ, Hinton DR (2011)
Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration
FASEB J, 25 (7), 2221-33
DOI 10.1096/fj.10-178350, PubMed 21411747

Publications 2010

Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR (2010)
αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells
PLoS One, 5 (10), e12578
DOI 10.1371/journal.pone.0012578, PubMed 20949024

Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton DR (2010)
Neutrophils compromise retinal pigment epithelial barrier integrity
J Biomed Biotechnol, 2010, 289360
DOI 10.1155/2010/289360, PubMed 20204129

Publications 2009

He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton DR (2009)
Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro
Invest Ophthalmol Vis Sci, 51 (1), 543-52
DOI 10.1167/iovs.09-3475, PubMed 19696168

Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR (2009)
alphaB-crystallin regulation of angiogenesis by modulation of VEGF
Blood, 115 (16), 3398-406
DOI 10.1182/blood-2009-01-197095, PubMed 20023214

Kim YH, He S, Kase S, Kitamura M, Ryan SJ, Hinton DR (2009)
Regulated secretion of complement factor H by RPE and its role in RPE migration
Graefes Arch Clin Exp Ophthalmol, 247 (5), 651-9
DOI 10.1007/s00417-009-1049-y, PubMed 19214553

Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR (2009)
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells
Nat Protoc, 4 (5), 662-73
DOI 10.1038/nprot.2009.33, PubMed 19373231

Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton DR (2009)
Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration
Aging (Albany NY), 2 (1), 28-42
DOI 10.18632/aging.100111, PubMed 20228934

Zhu D, Wu J, Spee C, Ryan SJ, Hinton DR (2009)
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration
J Biol Chem, 284 (14), 9529-39
DOI 10.1074/jbc.M809393200, PubMed 19158083

Publications 2008

He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR (2008)
Connective tissue growth factor as a mediator of intraocular fibrosis
Invest Ophthalmol Vis Sci, 49 (9), 4078-88
DOI 10.1167/iovs.07-1302, PubMed 18450591

He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR (2008)
Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells
Graefes Arch Clin Exp Ophthalmol, 246 (5), 677-83
DOI 10.1007/s00417-008-0770-2, PubMed 18278507

Sreekumar PG, Ding Y, Ryan SJ, Kannan R, Hinton DR (2008)
Regulation of thioredoxin by ceramide in retinal pigment epithelial cells
Exp Eye Res, 88 (3), 410-7
DOI 10.1016/j.exer.2008.10.009, PubMed 18996115

Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR (2008)
N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice
Invest Ophthalmol Vis Sci, 49 (3), 1210-20
DOI 10.1167/iovs.07-0667, PubMed 18326751

Publications 2007

Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton DR (2007)
In vivo models of proliferative vitreoretinopathy
Nat Protoc, 2 (1), 67-77
DOI 10.1038/nprot.2007.4, PubMed 17401340

Publications 2006

Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR (2006)
Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor
Exp Eye Res, 83 (1), 212-22
DOI 10.1016/j.exer.2005.12.007, PubMed 16563380

He S, Incardona F, Jin M, Ryan SJ, Hinton DR (2006)
Thrombospondin-1 expression in RPE and choroidal neovascular membranes
Yan Ke Xue Bao, 22 (4), 265-74
PubMed 17378161

Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR (2006)
MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes
Retina, 26 (4), 454-61
DOI 10.1097/01.iae.0000238549.74626.33, PubMed 16603966

Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR (2006)
Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells
Biochem Biophys Res Commun, 346 (4), 1200-6
DOI 10.1016/j.bbrc.2006.06.021, PubMed 16793007

Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR (2006)
Characterization of brimonidine transport in retinal pigment epithelium
Invest Ophthalmol Vis Sci, 47 (1), 287-94
DOI 10.1167/iovs.05-0189, PubMed 16384975

Publications 2005

Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR (2005)
Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
Lab Invest, 85 (6), 721-33
DOI 10.1038/labinvest.3700277, PubMed 15856049

Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR (2005)
Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells
J Neuroimmunol, 171 (1-2), 45-56
DOI 10.1016/j.jneuroim.2005.09.018, PubMed 16288810

He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton DR (2005)
Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization
Invest Ophthalmol Vis Sci, 46 (12), 4772-9
DOI 10.1167/iovs.05-0502, PubMed 16303978

Hoffmann S, Balthasar S, Friedrichs U, Ehren M, Ryan SJ, Wiedemann P (2005)
Inhibitory effects of verapamil isomers on the proliferation of choroidal endothelial cells
Graefes Arch Clin Exp Ophthalmol, 244 (3), 376-81
DOI 10.1007/s00417-004-1104-7, PubMed 16088412

Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton DR (2005)
A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion
BMC Ophthalmol, 5, 16
DOI 10.1186/1471-2415-5-16, PubMed 15987521

Hoffmann S, He S, Jin ML, Masiero L, Wiedemann P, Ryan SJ, Kohn EC (2005)
Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells
Curr Eye Res, 30 (2), 103-13
DOI 10.1080/02713680490894595, PubMed 15814468

Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR (2005)
Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion
Invest Ophthalmol Vis Sci, 46 (11), 4311-9
DOI 10.1167/iovs.05-0353, PubMed 16249513

Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton DR (2005)
Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes
Am J Ophthalmol, 140 (6), 1044-1050
DOI 10.1016/j.ajo.2005.07.021, PubMed 16376649

Ryan SJ (2005)
National and international patient networks: standardization of phenotype and genotype definitions
Retina, 25 (8 Suppl), S68
DOI 10.1097/00006982-200512001-00032, PubMed 16374345

Ryan SJ (2005)
Governmental, university, pharmaceutical, and foundation partnerships to advance translational research in retinal disease
Retina, 25 (8 Suppl), S82
DOI 10.1097/00006982-200512001-00039, PubMed 16374353

Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton DR (2005)
Protection from oxidative stress by methionine sulfoxide reductases in RPE cells
Biochem Biophys Res Commun, 334 (1), 245-53
DOI 10.1016/j.bbrc.2005.06.081, PubMed 15993845

Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton DR (2005)
Neutrophils promote experimental choroidal neovascularization
Mol Vis, 11, 414-24
PubMed 15988410

Publications 2004

Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton DR (2004)
Mouse strain-dependent heterogeneity of resting limbal vasculature
Invest Ophthalmol Vis Sci, 45 (2), 441-7
DOI 10.1167/iovs.03-0869, PubMed 14744883

Jin M, Chen Y, He S, Ryan SJ, Hinton DR (2004)
Hepatocyte growth factor and its role in the pathogenesis of retinal detachment
Invest Ophthalmol Vis Sci, 45 (1), 323-9
DOI 10.1167/iovs.03-0355, PubMed 14691191

Publications 2002

Hangai M, Kitaya N, Xu J, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC (2002)
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis
Am J Pathol, 161 (4), 1429-37
DOI 10.1016/S0002-9440(10)64418-5, PubMed 12368215

Jin M, Barron E, He S, Ryan SJ, Hinton DR (2002)
Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor
Invest Ophthalmol Vis Sci, 43 (8), 2782-90
PubMed 12147616

Ryan SJ, Hinton DR, Ogden TE, Rao N (2002)
Translational research in ophthalmology
Arch Ophthalmol, 120 (3), 389-90
DOI 10.1001/archopht.120.3.389, PubMed 11879146

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