Welcome to the home page Mimi Stokke Opdal's group:

Therapeutic Drug Monitoring

Mimi S. Opdal<br>Group leader
Mimi S. Opdal
Group leader

Research aims

Clinical pharmacology is the study of kinetics (absorption, distribution, protein binding, metabolism and excretion) and response of drugs in the human body. A considerable individual variation in both the kinetics and effects/response of the drug is common. A goal in treatment is to achieve optimal drug effects and to avoid harmful side effects. However, the therapeutic window is narrow for many drugs. The effects/side effects of many drugs are concentration dependent, hence it may be useful to measure the total drug concentration in serum/plasma, also called therapeutic drug monitoring (TDM). Gene variants in genes encoding proteins participating in metabolism, transport and drug actions may explain some of the variability in drug response. The research group is working on the optimization of drug therapy using TDM, pharmacogenetic analyses and other outcome measures. The main focus of the group at present is on opioids and antiepileptic drugs. 

Current projects

  • Measurements of methadone and corrected QT-time before and after conversion from R, S-methadone to R-methadone
  • TDM of antiepileptic drugs 

Contact information:
Mimi Stokke Opdal, MD/Ass Professor II, Tel: +47 23036261 E-mail: uxmist@ous-hf.no
Department of Pharmacology, Clinical Pharmacology, Medical Unit, Oslo University Hospital, NO-0424 Oslo, Norway