Johanna Olweus
Position: Professor, MD, PhD
Phone: +47 2278 13 25 / +47 900 54 934

Johanna Olweus graduated medical school in Bergen, Norway, in 1992, and then went further west to work for almost five years as a scientist at Becton Dickinson in San Jose, California. Through inventive use of flow cytometers with ultra high sensitivity, she conducted the first high resolution studies on cytokine receptors on human hematopoietic progenitor cells. This work, performed in collaboration with husband Fridtjof Lund-Johansen, resulted in a series of publications and patents. In 1997, Johanna and Fridtjof found a population of progenitor cells with high levels of the IL-3¥á receptor (CD123) and proved that they were precursors for the cells now known as plasmacytoid dendritic cells (Olweus et al, PNAS 1997). CD123 is now the standard marker for these cells. Johanna defended her PhD in 1998. Since, she had a break in her scientific activities while completing medical internship and taking maternity leaves with three boys. However, in parallel with a residency as an MD in immunology and transfusion medicine (specialist in 2006), she has during the last years built up a research group around studies of antigen presenting cells (see research focus). Two of her PhD students, Espen ¨ªsthagen Kvale and Jakob Dalgaard, have graduated on studies of the role of dendritic cells (DC) in viral immunity (Kvale et al, Blood 2006 and 2007). Together with a brave team of scientists and physicians she has now set out on an ambitious journey to manipulate DCs to tease out cancer targeted T cell to kill leukemia and lymphoma (Str©ªnen et al, Scand J Immunol 2009 and Abrahamsen et al, Leukemia 2010). Johanna was awarded Medinnova¢¥s research award in 2004 for this project, which is part of the Functional Genomics program (FUGE) and the Cancer Programme of the Norwegian Research Council. Johanna became a full time scientist in October 2007, when she joined the Department of Immunology at the Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, as a Scientist. By end of 2008, she was appointed Head of the Department and Professor at the University of Oslo, where she is leader of the research group Antigen Presentation and Immunotherapy.


Author network for Johanna Olweus by COREMINE medical

Publications 2017

Olweus J (2017)
Manufacture of CAR-T cells in the body
Nat Biotechnol, 35 (6), 520-521
PubMed 28591119

Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
PubMed 28476239

Publications 2016

Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2016)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol, 66 (1), 116-122
PubMed 27647428

Mensali N, Ying F, Sheng VO, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J (2016)
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
PubMed 27467957

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN (2016)
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
PubMed 27198675

Taraldsrud E, Aukrust P, Jørgensen S, Lingjærde OC, Olweus J, Myklebust JH, Fevang B (2016)
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
Clin Immunol, 175, 69-74
PubMed 27919819

Publications 2015

Karpanen T, Olweus J (2015)
T-cell receptor gene therapy--ready to go viral?
Mol Oncol, 9 (10), 2019-42
PubMed 26548533

Kolstad A, Olweus J (2015)
"In situ" vaccination for systemic effects in follicular lymphoma
Oncoimmunology, 4 (7), e1014773
PubMed 26140239

Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
PubMed 26257205

Olweus J (2015)
Cancer immunotherapy--Converting immune failure to clinical response
Mol Oncol, 9 (10), 1891-3
PubMed 26563645

Tadesse FG, Mensali N, Fallang LE, Walseng E, Yang W, Olweus J, Wälchli S (2015)
Unpredicted phenotypes of two mutants of the TcR DMF5
J Immunol Methods, 425, 37-44
PubMed 26079729

Walseng E, Wälchli S, Fallang LE, Yang W, Vefferstad A, Areffard A, Olweus J (2015)
Soluble T-cell receptors produced in human cells for targeted delivery
PLoS One, 10 (4), e0119559
PubMed 25875651

Publications 2014

Kolstad A, Kumari S, Walczak M, Madsbu U, Hagtvedt T, Bogsrud TV, Kvalheim G, Holte H, Aurlien E, Delabie J, Tierens A, Olweus J (2014)
Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma
Blood, 125 (1), 82-9
PubMed 25293773

Lossius A, Johansen JN, Vartdal F, Robins H, Jūratė Šaltytė B, Holmøy T, Olweus J (2014)
High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells
Eur J Immunol, 44 (11), 3439-52
PubMed 25103993

Taraldsrud E, Fevang B, Aukrust P, Beiske KH, Fløisand Y, Frøland S, Rollag H, Olweus J (2014)
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin Exp Immunol, 175 (3), 439-48
PubMed 24237110

Publications 2013

Kumari S, Wälchli S, Fallang LE, Yang W, Lund-Johansen F, Schumacher TN, Olweus J (2013)
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Proc Natl Acad Sci U S A, 111 (1), 403-8
PubMed 24344295

Wälchli S, Kumari S, Fallang LE, Sand KM, Yang W, Landsverk OJ, Bakke O, Olweus J, Gregers TF (2013)
Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation
Eur J Immunol, 44 (3), 774-84
PubMed 24293164

Publications 2012

Olweus J, Kolstad A (2012)
[Can the immune system target cancer?]
Tidsskr Nor Laegeforen, 132 (7), 784-5
PubMed 22511078

Publications 2011

Abrahamsen IW, Kjellevoll S, Greve-Isdahl M, Mensali N, Wälchli S, Kumari S, Loland BF, Egeland T, Kolstad A, Olweus J (2011)
T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int J Cancer, 130 (8), 1821-32
PubMed 21630262

Wälchli S, Løset GÅ, Kumari S, Johansen JN, Yang W, Sandlie I, Olweus J (2011)
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
PubMed 22132171

Publications 2010

Abrahamsen IW, Stronen E, Wälchli S, Johansen JN, Kjellevoll S, Kumari S, Komada M, Gaudernack G, Tjonnfjord G, Toebes M, Schumacher TN, Lund-Johansen F, Olweus J (2010)
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
PubMed 20844564

Publications 2009

Rölle A, Olweus J (2009)
Dendritic cells in cytomegalovirus infection: viral evasion and host countermeasures
APMIS, 117 (5-6), 413-26
PubMed 19400865

Stronen E, Abrahamsen IW, Gaudernack G, Wälchli S, Munthe E, Buus S, Johansen FE, Lund-Johansen F, Olweus J (2009)
Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
Scand J Immunol, 69 (4), 319-28
PubMed 19284496

Publications 2007

Villa I, Kvale EO, Lund-Johansen F, Olweus J (2007)
Assay for monitoring in vitro selective depletion strategies in allogeneic stem cell transplantation
Cytotherapy, 9 (6), 600-10
PubMed 17882725

Publications 2006

Kvale EO, Fløisand Y, Lund-Johansen F, Rollag H, Farkas L, Ghanekar S, Brandtzaeg P, Jahnsen FL, Olweus J (2006)
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
PubMed 17158235

Publications 2005

Kvale EØ, Dalgaard J, Lund-Johansen F, Rollag H, Farkas L, Midtvedt K, Jahnsen FL, Brinchmann JE, Olweus J (2005)
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
PubMed 16269620

Publications 1999

Frostad S, Bjerknes R, Hervig T, Nesthus I, Olweus J, Bruserud Ø (1999)
Malignancy: Insulin-like Growth Factor-1 (IGF-1) is a Costimulator of the Expansion of Lineage Committed Cells Derived from Peripheral Blood Mobilized CD34+ Cells in Multiple Myeloma Patients
Hematology, 4 (3), 217-229
PubMed 11399566

Frostad S, Bjerknes R, Hervig T, Nesthus I, Olweus J, Bruserud Ø (1999)
Insulin-like Growth Factor-1 (IGF-1) is a Costimulator of the Expansion of Lineage Committed Cells Derived from Peripheral Blood Mobilized CD34(+) Cells in Multiple Myeloma Patients
Hematology, 4 (3), 217-29
PubMed 27420550

Lund-Johansen F, Houck D, Hoffman R, Davis K, Olweus J (1999)
Primitive human hematopoietic progenitor cells express receptors for granulocyte-macrophage colony-stimulating factor
Exp Hematol, 27 (4), 762-72
PubMed 10210334

Lund-Johansen F, Olweus J (1999)
[Dendritic cells--strong candidates for immunotherapy]
Tidsskr Nor Laegeforen, 119 (17), 2510-4
PubMed 10425906

Publications 1998

Frostad S, Bjerknes R, Abrahamsen JF, Olweus J, Bruserud O (1998)
Insulin-like growth factor-1 (IGF-1) has a costimulatory effect on proliferation of committed progenitors derived from human umbilical cord CD34+ cells
Stem Cells, 16 (5), 334-42
PubMed 9766813

Olweus J (1998)
Early events in human myelopoiesis
APMIS Suppl, 78, 1-36
PubMed 9645190

Publications 1997

Olweus J, BitMansour A, Warnke R, Thompson PA, Carballido J, Picker LJ, Lund-Johansen F (1997)
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin
Proc Natl Acad Sci U S A, 94 (23), 12551-6
PubMed 9356487

Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW (1997)
AC133, a novel marker for human hematopoietic stem and progenitor cells
Blood, 90 (12), 5002-12
PubMed 9389720

Publications 1996

Civin CI, Almeida-Porada G, Lee MJ, Olweus J, Terstappen LW, Zanjani ED (1996)
Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
Blood, 88 (11), 4102-9
PubMed 8943843

Olweus J, Terstappen LW, Thompson PA, Lund-Johansen F (1996)
Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells
Blood, 88 (5), 1594-607
PubMed 8781415

Olweus J, Thompson PA, Lund-Johansen F (1996)
Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1-regulated molecules, CD64 and macrophage colony-stimulating factor receptor
Blood, 88 (10), 3741-54
PubMed 8916938

Publications 1995

Olweus J, Lund-Johansen F, Terstappen LW (1995)
CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells
Blood, 85 (9), 2402-13
PubMed 7537112

Waller EK, Olweus J, Lund-Johansen F, Huang S, Nguyen M, Guo GR, Terstappen L (1995)
The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors
Blood, 85 (9), 2422-35
PubMed 7537114

Publications 1994

Olweus J, Lund-Johansen F, Terstappen LW (1994)
Expression of cell surface markers during differentiation of CD34+, CD38-/lo fetal and adult bone marrow cells
Immunomethods, 5 (3), 179-88
PubMed 7540098

Publications 1993

Lund-Johansen F, Olweus J (1993)
Use of monoclonal antibodies to study hematopoietic cell function
J Hematother, 2 (3), 395-412
PubMed 7922002

Lund-Johansen F, Olweus J, Symington FW, Arli A, Thompson JS, Vilella R, Skubitz K, Horejsi V (1993)
Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens
Eur J Immunol, 23 (11), 2782-91
PubMed 8223854

Olweus J, Lund-Johansen F, Horejsi V (1993)
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells
J Immunol, 151 (2), 707-16
PubMed 8335905

Terstappen LW, Gandour D, Huang S, Lund-Johansen F, Manion K, Nguyen M, Mickaels R, Olweus J, Töpker S (1993)
Assessment of hematopoietic cell differentiation by multidimensional flow cytometry
J Hematother, 2 (3), 431-47
PubMed 7522894

Publications 1992

Lund-Johansen F, Olweus J (1992)
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry
Cytometry, 13 (7), 693-702
PubMed 1451600

Lund-Johansen F, Olweus J, Horejsi V, Skubitz KM, Thompson JS, Vilella R, Symington FW (1992)
Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65)
J Immunol, 148 (10), 3221-9
PubMed 1349618

Publications 1991

Lund-Johansen F, Olweus J, Aarli A, Bjerknes R (1991)
The IgG FcRII and the PI-linked IgG FcRIII trigger cytoplasmic calcium fluxes independently in human granulocytes
Scand J Immunol, 33 (3), 261-6
PubMed 1826373

Westby J, Hexeberg E, Olweus J, Myking OL, Lekven J, Grong K (1991)
Blood flow regulation during acute regional ischemia in feline hearts: importance of postjunctional alpha 1- and alpha 2-adrenoceptors
J Cardiovasc Pharmacol, 18 (4), 487-95
PubMed 1724524

Publications 1990

Lund-Johansen F, Olweus J, Aarli A, Bjerknes R (1990)
Signal transduction in human monocytes and granulocytes through the PI-linked antigen CD14
FEBS Lett, 273 (1-2), 55-8
PubMed 1699812