| Johanna Olweus | |
| Position: | Professor |
| Phone: | +47 2278 13 25 / +47 900 54 934 |
| Email: | |
Johanna Olweus graduated medical school in Bergen, Norway, in 1992, and then went further west to work for almost five years as a scientist at Becton Dickinson in San Jose, California. Through inventive use of flow cytometers with ultra high sensitivity, she conducted the first high resolution studies on cytokine receptors on human hematopoietic progenitor cells. This work, performed in collaboration with husband Fridtjof Lund-Johansen, resulted in a series of publications and patents. In 1997, Johanna and Fridtjof found a population of progenitor cells with high levels of the IL-3¥á receptor (CD123) and proved that they were precursors for the cells now known as plasmacytoid dendritic cells (Olweus et al, PNAS 1997). CD123 is now the standard marker for these cells. Johanna defended her PhD in 1998. Since, she had a break in her scientific activities while completing medical internship and taking maternity leaves with three boys. However, in parallel with a residency as an MD in immunology and transfusion medicine (specialist in 2006), she has during the last years built up a research group around studies of antigen presenting cells (see research focus). Two of her PhD students, Espen ¨ªsthagen Kvale and Jakob Dalgaard, have graduated on studies of the role of dendritic cells (DC) in viral immunity (Kvale et al, Blood 2006 and 2007). Together with a brave team of scientists and physicians she has now set out on an ambitious journey to manipulate DCs to tease out cancer targeted T cell to kill leukemia and lymphoma (Str©ªnen et al, Scand J Immunol 2009 and Abrahamsen et al, Leukemia 2010). Johanna was awarded Medinnova¢¥s research award in 2004 for this project, which is part of the Functional Genomics program (FUGE) and the Cancer Programme of the Norwegian Research Council. Johanna became a full time scientist in October 2007, when she joined the Department of Immunology at the Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, as a Scientist. By end of 2008, she was appointed Head of the Department and Professor at the University of Oslo, where she is leader of the research group Antigen Presentation and Immunotherapy.
Author network for Johanna Olweus by COREMINE medical
Publications 2012
T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int J Cancer, 130 (8), 1821-32
PubMed 21630262
[In Process Citation]
Tidsskr Nor Laegeforen, 132 (7), 784-5
PubMed 22511078
Publications 2011
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
PubMed 22132171
Publications 2010
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
PubMed 20844564
Publications 2009
Dendritic cells in cytomegalovirus infection: viral evasion and host countermeasures
APMIS, 117 (5-6), 413-26
PubMed 19400865
Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
Scand J Immunol, 69 (4), 319-28
PubMed 19284496
Publications 2007
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
PubMed 17158235
Assay for monitoring in vitro selective depletion strategies in allogeneic stem cell transplantation
Cytotherapy, 9 (6), 600-10
PubMed 17882725
Publications 2006
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
PubMed 16269620
Publications 1999
Malignancy: Insulin-like Growth Factor-1 (IGF-1) is a Costimulator of the Expansion of Lineage Committed Cells Derived from Peripheral Blood Mobilized CD34+ Cells in Multiple Myeloma Patients
Hematology, 4 (3), 217-229
PubMed 11399566
Primitive human hematopoietic progenitor cells express receptors for granulocyte-macrophage colony-stimulating factor
Exp Hematol, 27 (4), 762-72
PubMed 10210334
[Dendritic cells--strong candidates for immunotherapy]
Tidsskr Nor Laegeforen, 119 (17), 2510-4
PubMed 10425906
Publications 1998
Insulin-like growth factor-1 (IGF-1) has a costimulatory effect on proliferation of committed progenitors derived from human umbilical cord CD34+ cells
Stem Cells, 16 (5), 334-42
PubMed 9766813
Early events in human myelopoiesis
APMIS Suppl, 78, 1-36
PubMed 9645190
Publications 1997
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin
Proc Natl Acad Sci U S A, 94 (23), 12551-6
PubMed 9356487
AC133, a novel marker for human hematopoietic stem and progenitor cells
Blood, 90 (12), 5002-12
PubMed 9389720
Publications 1996
Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
Blood, 88 (11), 4102-9
PubMed 8943843
Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells
Blood, 88 (5), 1594-607
PubMed 8781415
Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1-regulated molecules, CD64 and macrophage colony-stimulating factor receptor
Blood, 88 (10), 3741-54
PubMed 8916938
Publications 1995
CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells
Blood, 85 (9), 2402-13
PubMed 7537112
The >common stem cell> hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors
Blood, 85 (9), 2422-35
PubMed 7537114
Publications 1994
Expression of cell surface markers during differentiation of CD34+, CD38-/lo fetal and adult bone marrow cells
Immunomethods, 5 (3), 179-88
PubMed 7540098
Publications 1993
Use of monoclonal antibodies to study hematopoietic cell function
J Hematother, 2 (3), 395-412
PubMed 7922002
Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens
Eur J Immunol, 23 (11), 2782-91
PubMed 8223854
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells
J Immunol, 151 (2), 707-16
PubMed 8335905
Assessment of hematopoietic cell differentiation by multidimensional flow cytometry
J Hematother, 2 (3), 431-47
PubMed 7522894
Publications 1992
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry
Cytometry, 13 (7), 693-702
PubMed 1451600
Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65)
J Immunol, 148 (10), 3221-9
PubMed 1349618
Publications 1991
The IgG FcRII and the PI-linked IgG FcRIII trigger cytoplasmic calcium fluxes independently in human granulocytes
Scand J Immunol, 33 (3), 261-6
PubMed 1826373
Blood flow regulation during acute regional ischemia in feline hearts: importance of postjunctional alpha 1- and alpha 2-adrenoceptors
J Cardiovasc Pharmacol, 18 (4), 487-95
PubMed 1724524
Publications 1990
Signal transduction in human monocytes and granulocytes through the PI-linked antigen CD14
FEBS Lett, 273 (1-2), 55-8
PubMed 1699812
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