Metabolite biomarkers for treatment failure

Although radical prostatectomy normally is administered with curative intent, 20-30% of men experience prostate cancer recurrence following surgery. Adjuvant therapy has been shown to be beneficial in terms of recurrence-free, metastasis-free, and overall survival, but is associated with more comorbidities than PSA-monitoring alone. Thus, novel prognostic biomarkers capable of distinguishing non-recurrent from recurrent prostate cancers will improve  prostate cancer care.

Tissue and clinicopathological data from men radically operated for PCa at Oslo University Hospital and St. Olavs Hospital are being metabolically fingerprinted using High Resolution Magic Angle Spinning  1H Magnetic Resonance Spectroscopy (1H HR-MAS MRS). We investigate the association between metabolite levels and development of recurrence.

Importantly, the translational potential of ex vivo MRS to in vivo MRS imaging (MRSI) may be exploited preoperatively for risk prediction. Together, an enhanced diagnostic and prognostic accuracy through performing MRS and MRSI on prostate cancer patients can help uro-oncologists consider tailored adjuvant therapy and/or closer monitoring of high-risk patients, as well as possibly prevent over-treatment of patients with low-risk disease.

Publications:

Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence, British Journal of Cancer (2017)

Project members: Braadland, P.R (OUS), Giskeødegård, G. (NTNU) Sandsmark, E.(NTNU), Bertilsson, H. (NTNU/St.Olavs), Euceda, L.G. (NTNU), Hansen, A.F. (NTNU), Katz, B.(OUS), Svindland, A.(OUS), Grytli, H.H, (OUS), Berge, V. (OUS) Eri, L.M. (OUS/UIO), Nygård, S. (OUS), Bathen T.F. (NTNU), Taskén, K.A. (OUS/UIO), Tessem M.B. (NTNU).

 

 
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