Publications
Publications by Mouldy Sioud
210 publications found
Publications 2024
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Exploring the Impact of mRNA Modifications on Translation Efficiency and Immune Tolerance to Self-Antigens
Vaccines (Basel), 12 (6)
DOI 10.3390/vaccines12060624, PubMed 38932353
Publications 2023
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How the initial discovery of modified RNA enabled evasion of innate immune responses and facilitated the development of RNA therapeutics
Scand J Immunol, 98 (1), e13282
DOI 10.1111/sji.13282, PubMed 37132451 -
Antibody Surface Profiling Identifies Glycoforms in Multiple Myeloma as Targets for Immunotherapy: From Antibody Derivatives to Mimetic Peptides for Killing Tumor Cells
Cancers (Basel), 15 (7)
DOI 10.3390/cancers15071934, PubMed 37046595 -
Precision Killing of M2 Macrophages with Phage-Displayed Peptide-Photosensitizer Conjugates
Cancers (Basel), 15 (7)
DOI 10.3390/cancers15072009, PubMed 37046671 -
Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting
Int J Mol Sci, 24 (8)
DOI 10.3390/ijms24087493, PubMed 37108657
Publications 2022
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Structural Requirements for the Binding of a Peptide to Prohibitins on the Cell Surface of Monocytes/Macrophages
Int J Mol Sci, 23 (8)
DOI 10.3390/ijms23084282, PubMed 35457098
Publications 2021
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RNA Interference: Story and Mechanisms
Methods Mol Biol, 2282, 1-15
DOI 10.1007/978-1-0716-1298-9_1, PubMed 33928566 -
Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy
EBioMedicine, 67, 103351
DOI 10.1016/j.ebiom.2021.103351, PubMed 33965875 -
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133356, PubMed 34283089 -
Correction: Sioud et al. Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models. Cancers 2021, 13, 3356
Cancers (Basel), 13 (21)
DOI 10.3390/cancers13215513, PubMed 34771754
Publications 2020
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Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351 -
Harnessing the Antiviral-Type Responses Induced by Immunostimulatory siRNAs for Cancer Immunotherapy
Methods Mol Biol, 2115, 281-287
DOI 10.1007/978-1-0716-0290-4_16, PubMed 32006407 -
Exploring 5'-Biotinylation of the Sense Strand to Improve siRNA Specificity and Potency
Methods Mol Biol, 2115, 163-170
DOI 10.1007/978-1-0716-0290-4_9, PubMed 32006400 -
RNA and CRISPR Interferences: Past, Present, and Future Perspectives
Methods Mol Biol, 2115, 1-22
DOI 10.1007/978-1-0716-0290-4_1, PubMed 32006392 -
Optimized siRNA Delivery into Primary Immune Cells Using Electroporation
Methods Mol Biol, 2115, 119-131
DOI 10.1007/978-1-0716-0290-4_7, PubMed 32006398 -
Unleashing the Therapeutic Potential of Dendritic and T Cell Therapies Using RNA Interference
Methods Mol Biol, 2115, 259-280
DOI 10.1007/978-1-0716-0290-4_15, PubMed 32006406 -
Microbial sensing by haematopoietic stem and progenitor cells: Vigilance against infections and immune education of myeloid cells
Scand J Immunol, 92 (5), e12957
DOI 10.1111/sji.12957, PubMed 32767789 -
Improving Dendritic Cell Cancer Vaccine Potency Using RNA Interference
Methods Mol Biol, 2115, 249-258
DOI 10.1007/978-1-0716-0290-4_14, PubMed 32006405 -
Next Generation of Adoptive T Cell Therapy Using CRISPR/Cas9 Technology: Universal or Boosted?
Methods Mol Biol, 2115, 407-417
DOI 10.1007/978-1-0716-0290-4_22, PubMed 32006413
Publications 2019
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Releasing the Immune System Brakes Using siRNAs Enhances Cancer Immunotherapy
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020176, PubMed 30717461 -
Phage Display Libraries: From Binders to Targeted Drug Delivery and Human Therapeutics
Mol Biotechnol, 61 (4), 286-303
DOI 10.1007/s12033-019-00156-8, PubMed 30729435 -
Targeted Killing of Monocytes/Macrophages and Myeloid Leukemia Cells with Pro-Apoptotic Peptides
Cancers (Basel), 11 (8)
DOI 10.3390/cancers11081088, PubMed 31370273
Publications 2018
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Epidermal growth factor receptor (EGFR) density may not be the only determinant for the efficacy of EGFR-targeted photoimmunotherapy in human head and neck cancer cell lines
Lasers Surg Med, 50 (5), 513-522
DOI 10.1002/lsm.22930, PubMed 29777587 -
T-cell cross-reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors
Scand J Immunol, 87 (3)
DOI 10.1111/sji.12643, PubMed 29381830 -
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
FASEB J, 32 (9), 5063-5077
DOI 10.1096/fj.201701544R, PubMed 29913558
Publications 2016
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Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth
Oncotarget, 7 (46), 75940-75953
DOI 10.18632/oncotarget.12445, PubMed 27713158 -
Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine
Case Rep Med, 2016, 9639585
DOI 10.1155/2016/9639585, PubMed 27504122 -
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways
Oncotarget, 7 (29), 46187-46202
DOI 10.18632/oncotarget.10070, PubMed 27323822
Publications 2015
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Engineering therapeutic cancer vaccines that activate antitumor immunity
Methods Mol Biol, 1218, 263-8
DOI 10.1007/978-1-4939-1538-5_15, PubMed 25319656 -
A facile method for interfering with off-target silencing mediated by the sense strand
Methods Mol Biol, 1218, 293-300
DOI 10.1007/978-1-4939-1538-5_18, PubMed 25319659 -
Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells
Hum Vaccin Immunother, 11 (11), 2664-73
DOI 10.1080/21645515.2015.1056952, PubMed 26185907 -
RNA interference: mechanisms, technical challenges, and therapeutic opportunities
Methods Mol Biol, 1218, 1-15
DOI 10.1007/978-1-4939-1538-5_1, PubMed 25319642 -
Cytoplasmic delivery of siRNAs to monocytes and dendritic cells via electroporation
Methods Mol Biol, 1218, 107-15
DOI 10.1007/978-1-4939-1538-5_6, PubMed 25319647 -
Strategies for siRNA navigation to desired cells
Methods Mol Biol, 1218, 201-16
DOI 10.1007/978-1-4939-1538-5_12, PubMed 25319653 -
Overcoming the challenges of siRNA activation of innate immunity: design better therapeutic siRNAs
Methods Mol Biol, 1218, 301-19
DOI 10.1007/978-1-4939-1538-5_19, PubMed 25319660 -
Modified 2'-ribose small RNAs function as Toll-like receptor-7/8 antagonists
Methods Mol Biol, 1218, 483-9
DOI 10.1007/978-1-4939-1538-5_28, PubMed 25319669 -
Immunosuppressive factor blockade in dendritic cells via siRNAs results in objective clinical responses
Methods Mol Biol, 1218, 269-76
DOI 10.1007/978-1-4939-1538-5_16, PubMed 25319657 -
Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells
Mol Ther Methods Clin Dev, 2, 15043
DOI 10.1038/mtm.2015.43, PubMed 26605373 -
Modulating the tumor microenvironment with RNA interference as a cancer treatment strategy
Methods Mol Biol, 1218, 143-61
DOI 10.1007/978-1-4939-1538-5_9, PubMed 25319650
Publications 2014
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Engineering better immunotherapies via RNA interference
Hum Vaccin Immunother, 10 (11), 3165-74
DOI 10.4161/hv.29754, PubMed 25483669
Publications 2013
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Exosome-derived miRNAs and cellular miRNAs activate innate immunity
J Innate Immun, 6 (1), 105-10
DOI 10.1159/000351460, PubMed 23774807 -
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett, 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608 -
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients
Int J Oncol, 43 (1), 280-8
DOI 10.3892/ijo.2013.1922, PubMed 23620105 -
A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells
FASEB J, 27 (8), 3272-83
DOI 10.1096/fj.12-224758, PubMed 23671272 -
Inhibition of stromal PlGF suppresses the growth of prostate cancer xenografts
Int J Mol Sci, 14 (9), 17958-71
DOI 10.3390/ijms140917958, PubMed 24005860
Publications 2012
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Efficient siRNA targeted delivery into cancer cells by gastrin-releasing peptides
Bioconjug Chem, 23 (5), 1040-9
DOI 10.1021/bc300050j, PubMed 22443209 -
Selective killing of cancer cells by peptide-targeted delivery of an anti-microbial peptide
Biochem Pharmacol, 84 (9), 1123-32
DOI 10.1016/j.bcp.2012.08.002, PubMed 22922046
Publications 2011
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Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-γ production
J Leukoc Biol, 91 (3), 461-7
DOI 10.1189/jlb.0711361, PubMed 22167721 -
Promises and challenges in developing RNAi as a research tool and therapy
Methods Mol Biol, 703, 173-87
DOI 10.1007/978-1-59745-248-9_12, PubMed 21125490 -
New insights into mesenchymal stromal cell-mediated T-cell suppression through galectins
Scand J Immunol, 73 (2), 79-84
DOI 10.1111/j.1365-3083.2010.02491.x, PubMed 21198747
Publications 2010
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Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma
Int J Cancer, 126 (6), 1339-52
DOI 10.1002/ijc.24859, PubMed 19711348 -
Presence of STRA-STRB linked streptomycin-resistance genes in clinical isolate of Escherichia coil 2418
Arch Inst Pasteur Tunis, 87 (1-2), 77-81
PubMed 21598829 -
Increased miR-21 expression during human monocyte differentiation into DCs
Front Biosci (Elite Ed), 2 (3), 818-28
DOI 10.2741/e143, PubMed 20515755 -
Recent advances in hematopoietic stem cell transplantation and perspectives of RNAi applications
Methods Mol Biol, 629, 507-23
DOI 10.1007/978-1-60761-657-3_30, PubMed 20387168 -
Cell wall anchoring of the 37-kilodalton oncofetal antigen by Lactobacillus plantarum for mucosal cancer vaccine delivery
Appl Environ Microbiol, 76 (21), 7359-62
DOI 10.1128/AEM.01031-10, PubMed 20851975 -
A combined immunostimulatory and immunoinhibitory short interference RNA reduces hypercoagulability in a rat model of acute promyelocytic leukaemia
Thromb Haemost, 104 (2), 350-4
DOI 10.1160/TH09-12-0816, PubMed 20539915 -
Optimized protocols for siRNA delivery into monocytes and dendritic cells
Methods Mol Biol, 629, 71-85
DOI 10.1007/978-1-60761-657-3_5, PubMed 20387143 -
Recent advances in small interfering RNA sensing by the immune system
N Biotechnol, 27 (3), 236-42
DOI 10.1016/j.nbt.2010.02.015, PubMed 20219711 -
Advances in RNA sensing by the immune system: separation of siRNA unwanted effects from RNA interference
Methods Mol Biol, 629, 33-52
DOI 10.1007/978-1-60761-657-3_3, PubMed 20387141 -
What are the key targeted delivery technologies of siRNA now?
Methods Mol Biol, 629, 93-107
DOI 10.1007/978-1-60761-657-3_7, PubMed 20387145 -
Development of TLR7/8 small RNA antagonists
Methods Mol Biol, 629, 387-94
DOI 10.1007/978-1-60761-657-3_25, PubMed 20387163 -
Modulation of dendritic cell maturation and function by siRNA-bearing 5'-triphosphate
Methods Mol Biol, 629, 395-404
DOI 10.1007/978-1-60761-657-3_26, PubMed 20387164 -
Overcoming self-tolerance to tumour cells
Methods Mol Biol, 629, 495-505
DOI 10.1007/978-1-60761-657-3_29, PubMed 20387167 -
RNA therapeutics: function, design, and delivery. Preface
Methods Mol Biol, 629, v-vii
DOI 10.1007/978-1-60761-657-3, PubMed 20394129 -
Profiling of miRNA expression and prediction of target genes
Methods Mol Biol, 629, 257-71
DOI 10.1007/978-1-60761-657-3_16, PubMed 20387154 -
Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation
Scand J Immunol, 71 (4), 267-74
DOI 10.1111/j.1365-3083.2010.02378.x, PubMed 20384870 -
Mesenchymal stem cell-mediated T cell suppression occurs through secreted galectins
Int J Oncol, 38 (2), 385-90
DOI 10.3892/ijo.2010.869, PubMed 21165555 -
Systemic delivery of synthetic siRNAs
Methods Mol Biol, 629, 87-91
DOI 10.1007/978-1-60761-657-3_6, PubMed 20387144
Publications 2009
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Targeting stromal-cancer cell interactions with siRNAs
Methods Mol Biol, 487, 243-66
DOI 10.1007/978-1-60327-547-7_12, PubMed 19301651 -
Monitoring B cell response to immunoselected phage-displayed peptides by microarrays
Methods Mol Biol, 524, 273-85
DOI 10.1007/978-1-59745-450-6_20, PubMed 19377952 -
Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase
Immunology, 128 (1 Suppl), e837-48
DOI 10.1111/j.1365-2567.2009.03093.x, PubMed 19740345 -
Evidence for the involvement of FAM110C protein in cell spreading and migration
Cell Signal, 21 (12), 1866-73
DOI 10.1016/j.cellsig.2009.08.001, PubMed 19698782 -
Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells
Transl Oncol, 2 (4), 242-6
DOI 10.1593/tlo.09154, PubMed 19956385 -
Deciphering the code of innate immunity recognition of siRNAs
Methods Mol Biol, 487, 41-59
DOI 10.1007/978-1-60327-547-7_2, PubMed 19301641 -
Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells
Methods Mol Biol, 487, 61-82
DOI 10.1007/978-1-60327-547-7_3, PubMed 19301642 -
Does our current understanding of immune tolerance, autoimmunity, and immunosuppressive mechanisms facilitate the design of efficient cancer vaccines?
Scand J Immunol, 70 (6), 516-25
DOI 10.1111/j.1365-3083.2009.02326.x, PubMed 19906192 -
Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs
Int J Mol Med, 23 (1), 33-9
DOI 10.3892/ijmm_00000098, PubMed 19082504 -
NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation
J Leukoc Biol, 85 (6), 939-46
DOI 10.1189/jlb.1008650, PubMed 19244164
Publications 2008
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Host CD147 blockade by small interfering RNAs suppresses growth of human colon cancer xenografts
Front Biosci, 13, 5571-9
DOI 10.2741/3100, PubMed 18508606 -
The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling
Oncogene, 27 (39), 5182-94
DOI 10.1038/onc.2008.157, PubMed 18469852 -
Mucosal vaccination with phage-displayed tumour antigens identified through proteomics-based strategy inhibits the growth and metastasis of 4T1 breast adenocarcinoma
Int J Oncol, 32 (1), 241-7
PubMed 18097564 -
Does the understanding of immune activation by RNA predict the design of safe siRNAs?
Front Biosci, 13, 4379-92
DOI 10.2741/3011, PubMed 18508517 -
Expression profiling of microRNAs in cancer cells: technical considerations
Methods Mol Biol, 439, 179-90
DOI 10.1007/978-1-59745-188-8_12, PubMed 18370103 -
Vector-based delivery of siRNAs: in vitro and in vivo challenges
Front Biosci, 13, 3488-93
DOI 10.2741/2943, PubMed 18508450
Publications 2007
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Target validation using RNA interference in solid tumors
Methods Mol Biol, 361, 227-38
DOI 10.1385/1-59745-208-4:227, PubMed 17172715 -
Protein arrays: a versatile toolbox for target identification and monitoring of patient immune responses
Methods Mol Biol, 360, 335-48
DOI 10.1385/1-59745-165-7:335, PubMed 17172738 -
Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands
Immunology, 123 (2), 263-71
DOI 10.1111/j.1365-2567.2007.02695.x, PubMed 17725606 -
Discovery of differentially expressed genes: technical considerations
Methods Mol Biol, 360, 115-29
DOI 10.1385/1-59745-165-7:115, PubMed 17172727 -
Main approaches to target discovery and validation
Methods Mol Biol, 360, 1-12
DOI 10.1385/1-59745-165-7:1, PubMed 17172722 -
An overview of the immune system and technical advances in tumor antigen discovery and validation
Methods Mol Biol, 360, 277-318
DOI 10.1385/1-59745-165-7:277, PubMed 17172735 -
RNA interference and innate immunity
Adv Drug Deliv Rev, 59 (2-3), 153-63
DOI 10.1016/j.addr.2007.03.006, PubMed 17459518 -
TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1-type response
Eur J Immunol, 37 (10), 2834-46
DOI 10.1002/eji.200737112, PubMed 17853407 -
Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs
Biochem Biophys Res Commun, 361 (1), 122-6
DOI 10.1016/j.bbrc.2007.06.177, PubMed 17658482 -
Druggable signaling proteins
Methods Mol Biol, 361, 1-24
DOI 10.1385/1-59745-208-4:1, PubMed 17172705 -
Treatment options and individualized medicine
Methods Mol Biol, 361, 327-40
DOI 10.1385/1-59745-208-4:327, PubMed 17172721 -
Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway
Cancer Res, 67 (3), 1038-45
DOI 10.1158/0008-5472.CAN-06-2295, PubMed 17283136
Publications 2006
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Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model
J Neurosurg, 104 (1), 109-17
DOI 10.3171/jns.2006.104.1.109, PubMed 16509154 -
Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
J Mol Biol, 365 (1), 90-108
DOI 10.1016/j.jmb.2006.09.034, PubMed 17054988 -
Design of bifunctional siRNAs: combining immunostimulation and gene-silencing in one single siRNA molecule
Biochem Biophys Res Commun, 352 (3), 642-9
DOI 10.1016/j.bbrc.2006.11.059, PubMed 17150189 -
Transcriptional targeting of small interfering RNAs into cancer cells
Biochem Biophys Res Commun, 350 (4), 854-9
DOI 10.1016/j.bbrc.2006.09.127, PubMed 17034763 -
Innate sensing of self and non-self RNAs by Toll-like receptors
Trends Mol Med, 12 (4), 167-76
DOI 10.1016/j.molmed.2006.02.004, PubMed 16530484 -
Ribozymes and siRnas: from structure to preclinical applications
Handb Exp Pharmacol (173), 223-42
DOI 10.1007/3-540-27262-3_11, PubMed 16594618 -
Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses
Eur J Immunol, 36 (5), 1222-30
DOI 10.1002/eji.200535708, PubMed 16609928 -
RNA interference below the immune radar
Nat Biotechnol, 24 (5), 521-2
DOI 10.1038/nbt0506-521, PubMed 16680132 -
RNAi therapy: antibodies guide the way
Gene Ther, 13 (3), 194-5
DOI 10.1038/sj.gt.3302634, PubMed 17243203 -
Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage
J Mol Biol, 364 (5), 945-54
DOI 10.1016/j.jmb.2006.09.054, PubMed 17049554 -
Molecular basis for the immunostimulatory potency of small interfering RNAs
J Biomed Biotechnol, 2006 (4), 23429
DOI 10.1155/JBB/2006/23429, PubMed 17057361 -
RNA interference
J Biomed Biotechnol, 2006 (4), 89018
DOI 10.1155/JBB/2006/89018, PubMed 17057373
Publications 2005
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Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization
Oncogene, 24 (7), 1159-73
DOI 10.1038/sj.onc.1208267, PubMed 15580290 -
Systematic search for natural antisense transcripts in eukaryotes (review)
Int J Mol Med, 15 (2), 197-203
PubMed 15647831 -
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
J Mol Biol, 348 (5), 1079-90
DOI 10.1016/j.jmb.2005.03.013, PubMed 15854645 -
siRNA delivery in vivo
Methods Mol Biol, 309, 237-49
DOI 10.1385/1-59259-935-4:237, PubMed 15990404 -
On the delivery of small interfering RNAs into mammalian cells
Expert Opin Drug Deliv, 2 (4), 639-51
DOI 10.1517/17425247.2.4.639, PubMed 16296791 -
Ribozymes, DNAzymes and small interfering RNAs as therapeutics
Curr Drug Targets, 6 (6), 647-53
DOI 10.2174/1389450054863653, PubMed 16178798 -
High-throughput analysis of microRNA gene expression using sensitive probes
Methods Mol Biol, 309, 311-20
DOI 10.1385/1-59259-935-4:311, PubMed 15990410 -
Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs
Methods Mol Biol, 309, 83-91
DOI 10.1385/1-59259-935-4:083, PubMed 15990399
Publications 2004
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Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
Cancer Res, 64 (15), 5378-84
DOI 10.1158/0008-5472.CAN-04-0961, PubMed 15289345 -
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-82
DOI 10.1002/pmic.200300768, PubMed 15352232 -
Repetitive 5-aminolevulinic acid mediated photodynamic therapy of rat glioma
P SOC PHOTO-OPT INS, 5312, 405-414
DOI 10.1117/12.527395 -
Inhibition of gene expression by nucleic acid enzymes in rodent models of human disease
Methods Mol Biol, 252, 451-6
DOI 10.1385/1-59259-746-7:451, PubMed 15017070 -
Identification of genes differentially expressed in breast cancer cell line SKBR3: potential identification of new prognostic biomarkers
Int J Mol Med, 14 (2), 217-22
PubMed 15254768 -
Gene-array analysis of glioma cells after treatment with an anti-PKCalpha siRNA: a general protocol
Methods Mol Biol, 252, 493-500
DOI 10.1385/1-59259-746-7:493, PubMed 15017074 -
An experimental approach for systematic identification of antisense transcripts
Discov Med, 4 (20), 58-60
PubMed 20705023 -
Selection of peptides for specific delivery of oligonucleotides into cancer cells
Methods Mol Biol, 252, 569-80
DOI 10.1385/1-59259-746-7:569, PubMed 15017081 -
Therapeutic siRNAs
Trends Pharmacol Sci, 25 (1), 22-8
DOI 10.1016/j.tips.2003.11.006, PubMed 14723975 -
Ribozyme- and siRNA-mediated mRNA degradation: a general introduction
Methods Mol Biol, 252, 1-8
DOI 10.1385/1-59259-746-7:001, PubMed 15017038 -
Therapeutic potential of small interfering RNAs
Drug Future, 29 (7), 741-750
DOI 10.1358/dof.2004.029.07.854171 -
Potential design rules and enzymatic synthesis of siRNAs
Methods Mol Biol, 252, 457-69
DOI 10.1385/1-59259-746-7:457, PubMed 15017071 -
Profiling microRNA expression using sensitive cDNA probes and filter arrays
Biotechniques, 37 (4), 574-6, 578-80
DOI 10.2144/04374ST01, PubMed 15517969 -
Systemic delivery of synthetic siRNAs
Methods Mol Biol, 252, 515-22
DOI 10.1385/1-59259-746-7:515, PubMed 15017077
Publications 2003
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Probing the specificity of human myeloma proteins with a random peptide phage library
Scand J Immunol, 57 (6), 583-90
DOI 10.1046/j.1365-3083.2003.01254.x, PubMed 12791097 -
Systematic identification of sense-antisense transcripts in mammalian cells
Nat Biotechnol, 22 (1), 104-8
DOI 10.1038/nbt925, PubMed 14704709 -
Selective targeting of cancer cells using synthetic peptides
Drug Resist Updat, 6 (6), 363-71
DOI 10.1016/j.drup.2003.11.002, PubMed 14744500 -
Generation of an effective anti-tumor immunity after immunization with xenogeneic antigens
Eur J Immunol, 33 (1), 38-45
DOI 10.1002/immu.200390005, PubMed 12594830 -
Cationic liposome-mediated delivery of siRNAs in adult mice
Biochem Biophys Res Commun, 312 (4), 1220-5
DOI 10.1016/j.bbrc.2003.11.057, PubMed 14652004 -
Gene silencing by systemic delivery of synthetic siRNAs in adult mice
J Mol Biol, 327 (4), 761-6
DOI 10.1016/s0022-2836(03)00181-5, PubMed 12654261
Publications 2002
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Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth
Blood, 99 (11), 4147-53
DOI 10.1182/blood.v99.11.4147, PubMed 12010819 -
[Tyrosine kinase receptor-ras-ERK signal transduction pathway as therapeutic tarfet in cancer]
Tidsskr Nor Laegeforen, 122 (2), 178-82
PubMed 11873574 -
Gene silencing in mammalian cells by preformed small RNA duplexes
Biochem Biophys Res Commun, 295 (3), 744-8
DOI 10.1016/s0006-291x(02)00736-2, PubMed 12099702 -
Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells
FASEB J, 17 (2), 256-8
DOI 10.1096/fj.02-0280fje, PubMed 12490548 -
How does autoimmunity cause tumor regression? A potential mechanism involving cross-reaction through epitope mimicry
Mol Med, 8 (3), 115-9
DOI 10.1007/BF03402004, PubMed 12142543 -
Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma
Neoplasia, 4 (6), 474-9
DOI 10.1038/sj.neo.7900271, PubMed 12407440
Publications 2001
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Antigen-specific IgG antibodies in stage IV long-time survival breast cancer patients
Mol Med, 7 (4), 230-9
DOI 10.1007/BF03401842, PubMed 11471567 -
Identification of immunogenic antigens using a phage-displayed cDNA library from an invasive ductal breast carcinoma tumour
Int J Oncol, 19 (6), 1303-9
DOI 10.3892/ijo.19.6.1303, PubMed 11713604 -
DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
Am J Physiol Heart Circ Physiol, 281 (5), H2211-7
DOI 10.1152/ajpheart.2001.281.5.H2211, PubMed 11668085 -
Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes
BMC Cell Biol, 2, 13
DOI 10.1186/1471-2121-2-13, PubMed 11495629 -
An anti-leukemic single chain Fv antibody selected from a synthetic human phage antibody library
Biochem Biophys Res Commun, 280 (2), 548-52
DOI 10.1006/bbrc.2000.4158, PubMed 11162553 -
Nucleic acid enzymes as a novel generation of anti-gene agents
Curr Mol Med, 1 (5), 575-88
DOI 10.2174/1566524013363366, PubMed 11899232 -
Profiling the immune response in patients with breast cancer by phage-displayed cDNA libraries
Eur J Immunol, 31 (3), 716-25
DOI 10.1002/1521-4141(200103)31:3<716::aid-immu716>3.0.co;2-9, PubMed 11241275
Publications 2000
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Probing antinuclear antibody specificities by peptide phage display libraries
Clin Exp Rheumatol, 18 (4), 465-72
PubMed 10949721 -
Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells
Stem Cells, 18 (4), 261-72
DOI 10.1634/stemcells.18-4-261, PubMed 10924092 -
Protein kinase Calpha isoform regulates the activation of the MAP kinase ERK1/2 in human glioma cells: involvement in cell survival and gene expression
Mol Cell Biol Res Commun, 4 (2), 106-10
DOI 10.1006/mcbr.2000.0259, PubMed 11170840 -
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow
Blood, 95 (2), 510-8
DOI 10.1182/blood.V95.2.510, PubMed 10627456 -
Profiling the immune responses in patient sera with peptide and cDNA display libraries
Int J Mol Med, 6 (2), 123-8
DOI 10.3892/ijmm.6.2.123, PubMed 10891554 -
Design of nuclease resistant protein kinase calpha DNA enzymes with potential therapeutic application
J Mol Biol, 296 (3), 937-47
DOI 10.1006/jmbi.2000.3491, PubMed 10677293 -
Therapeutic RNA and DNA enzymes
Biochem Pharmacol, 60 (8), 1023-6
DOI 10.1016/s0006-2952(00)00395-6, PubMed 11007937
Publications 1999
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Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells
Br J Cancer, 80 (10), 1558-64
DOI 10.1038/sj.bjc.6690560, PubMed 10408397 -
Application of preformed hammerhead ribozymes in the gene therapy of cancer (review)
Int J Mol Med, 3 (4), 381-4
DOI 10.3892/ijmm.3.4.381, PubMed 10085409 -
Substitution of the 2'-hydroxyl group at position 2.1 by an amino group interferes with Mg(2+) binding and efficient cleavage by hammerhead ribozyme
Biochem Biophys Res Commun, 262 (2), 461-6
DOI 10.1006/bbrc.1999.1236, PubMed 10462497
Publications 1998
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Modulation of granulocyte-macrophage colony-stimulating factor gene expression by a tumor necrosis factor specific ribozyme in juvenile myelomonocytic leukemic cells
Blood, 92 (11), 4263-8
DOI 10.1182/blood.V92.11.4263.422k46_4263_4268, PubMed 9834232 -
High cleavage activity and stability of hammerhead ribozymes with a uniform 2'-amino pyrimidine modification
Biochem Biophys Res Commun, 250 (1), 171-4
DOI 10.1006/bbrc.1998.9286, PubMed 9735351 -
Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
Clin Exp Rheumatol, 16 (2), 125-34
PubMed 9536387 -
A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth
Nat Biotechnol, 16 (6), 556-61
DOI 10.1038/nbt0698-556, PubMed 9624687
Publications 1997
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Probing for cerebrospinal fluid antibody specificities by a panel of random peptide libraries
Autoimmunity, 25 (2), 85-9
DOI 10.3109/08916939708996274, PubMed 9189009 -
Effects of variations in length of hammerhead ribozyme antisense arms upon the cleavage of longer RNA substrates
Nucleic Acids Res, 25 (2), 333-8
DOI 10.1093/nar/25.2.333, PubMed 9016562 -
A minimised hammerhead ribozyme with activity against interleukin-2 in human cells
Biochem Biophys Res Commun, 231 (2), 397-402
DOI 10.1006/bbrc.1997.6099, PubMed 9070287
Publications 1996
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Increased serum and synovial fluid antibodies to immunoselected peptides in patients with rheumatoid arthritis
Ann Rheum Dis, 55 (7), 437-41
DOI 10.1136/ard.55.7.437, PubMed 8774161 -
Antibody epitopes probed by immunoselected phage-display library peptides in members of a family with various rheumatic manifestations
Clin Exp Rheumatol, 14 (6), 607-11
PubMed 8978954 -
Ribozyme modulation of lipopolysaccharide-induced tumor necrosis factor-alpha production by peritoneal cells in vitro and in vivo
Eur J Immunol, 26 (5), 1026-31
DOI 10.1002/eji.1830260511, PubMed 8647163 -
Selection of ligands for polyclonal antibodies from random peptide libraries: potential identification of (auto)antigens that may trigger B and T cell responses in autoimmune diseases
Clin Immunol Immunopathol, 79 (2), 105-14
DOI 10.1006/clin.1996.0057, PubMed 8620616 -
Enhancement of hammerhead ribozyme catalysis by glyceraldehyde-3-phosphate dehydrogenase
J Mol Biol, 257 (4), 775-89
DOI 10.1006/jmbi.1996.0201, PubMed 8636981 -
[Psychiatric disorders and endocrine diseases. Apropos of a 8 cases]
Tunis Med, 74 (12), 549-52
PubMed 9506057
Publications 1995
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Peptide phage libraries can be an efficient tool for identifying antibody ligands for polyclonal antisera
Clin Exp Immunol, 102 (2), 438-42
DOI 10.1111/j.1365-2249.1995.tb03802.x, PubMed 7586703 -
Structural characterization of peptides that bind synovial fluid antibodies from RA patients: a novel strategy for identification of disease-related epitopes using a random peptide library
Clin Immunol Immunopathol, 75 (1), 45-50
DOI 10.1006/clin.1995.1051, PubMed 7533685 -
Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet
Scand J Rheumatol, 24 (2), 85-93
DOI 10.3109/03009749509099290, PubMed 7747149 -
Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet
Ann Rheum Dis, 54 (3), 221-4
DOI 10.1136/ard.54.3.221, PubMed 7748020 -
Evidence for monoclonal expansion of synovial T cells bearing V alpha 2.1/V beta 5.5 gene segments and recognizing a synthetic peptide that shares homology with a number of putative autoantigens
Immunology, 86 (2), 168-75
PubMed 7490114 -
Freshly isolated tumour-infiltrating T-lymphocytes have a high cytotoxic potential, as measured by their ability to induce apoptosis in the target cell
Scand J Immunol, 41 (1), 42-8
DOI 10.1111/j.1365-3083.1995.tb03531.x, PubMed 7824887 -
[Cerebrovascular accidents in Horton's disease. Apropos of a case]
Tunis Med, 73 (5), 195-9
PubMed 9507283 -
[Antiphospholipid syndrome]
Tunis Med, 73 (2), 95-103
PubMed 9506150
Publications 1994
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T-CELL RECEPTOR VARIABLE GENE REPERTOIRE IN RHEUMATOID SYNOVIAL T-CELLS RESPONDING TO BCG
NATO ADV SCI INST SE, 80, 191-196 -
Limited heterogeneity in the T-cell receptor V-gene usage in lymphocytes infiltrating human colorectal tumours
Br J Cancer, 69 (6), 1078-82
DOI 10.1038/bjc.1994.211, PubMed 8198973 -
Interaction between tumour necrosis factor alpha ribozyme and cellular proteins. Involvement in ribozyme stability and activity
J Mol Biol, 242 (5), 619-29
DOI 10.1006/jmbi.1994.1612, PubMed 7932719 -
Characterization of naturally occurring autoantibodies against tumour necrosis factor-alpha (TNF-alpha): in vitro function and precise epitope mapping by phage epitope library
Clin Exp Immunol, 98 (3), 520-5
DOI 10.1111/j.1365-2249.1994.tb05522.x, PubMed 7994916 -
In vivo decay kinetic parameters of hammerhead ribozymes
Nucleic Acids Res, 22 (25), 5571-5
DOI 10.1093/nar/22.25.5571, PubMed 7838709 -
Three new cross-reacting idiotopes as markers for the products of two distinct human VH3 genes expressed in the early repertoire
Scand J Immunol, 40 (6), 681-90
DOI 10.1111/j.1365-3083.1994.tb03524.x, PubMed 7527936 -
[Iatrogenic accidents in the hospital environment]
Tunis Med, 72 (11), 625-30
PubMed 7762090
Publications 1993
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Identification of new B cell epitopes in the sera of rheumatoid arthritis patients using a random nanopeptide phage library
Eur J Immunol, 23 (12), 3189-93
DOI 10.1002/eji.1830231222, PubMed 7504991 -
T cell receptor variable region gene usage in juvenile chronic arthritis
Clin Exp Rheumatol, 11 Suppl 9, S43-6
PubMed 8354007 -
Selective activation of resting human gamma delta T lymphocytes by interleukin-2
Eur J Immunol, 23 (9), 2092-9
DOI 10.1002/eji.1830230908, PubMed 8370391 -
Differentiation of human lambda I variable regions with a monoclonal antibody to a defined, germ-line-encoded idiotope correlates with V lambda Ia chemical structure
J Immunol, 150 (12), 5466-75
PubMed 8515071
Publications 1992
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Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid
Eur J Immunol, 22 (5), 1315-22
DOI 10.1002/eji.1830220529, PubMed 1577070 -
Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells
Eur J Immunol, 22 (9), 2413-8
DOI 10.1002/eji.1830220934, PubMed 1387614 -
Preformed ribozyme destroys tumour necrosis factor mRNA in human cells
J Mol Biol, 223 (4), 831-5
DOI 10.1016/0022-2836(92)90244-e, PubMed 1538398 -
Spontaneous in vivo gene transcription of interleukin-2, interleukin-3, interleukin-4, interleukin-6, interferon-gamma, interleukin-2 receptor (CD25) and proto-oncogene c-myc by rheumatoid synovial T lymphocytes
Scand J Immunol, 36 (6), 865-73
DOI 10.1111/j.1365-3083.1992.tb03148.x, PubMed 1462123
Publications 1991
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Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme
Proc Natl Acad Sci U S A, 88 (16), 7303-7
DOI 10.1073/pnas.88.16.7303, PubMed 1871136 -
T cell receptor delta diversity of freshly isolated T lymphocytes in rheumatoid synovitis
Eur J Immunol, 21 (1), 239-41
DOI 10.1002/eji.1830210137, PubMed 1825059 -
Immune responses to 18.6 and 30-kDa mycobacterial antigens in rheumatoid patients, and V beta usage by specific synovial T-cell lines and fresh T cells
Scand J Immunol, 34 (6), 803-12
DOI 10.1111/j.1365-3083.1991.tb01605.x, PubMed 1836278
Publications 1990
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The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes
J Clin Invest, 86 (4), 1320-8
DOI 10.1172/JCI114841, PubMed 2170450 -
The V delta gene usage by freshly isolated T lymphocytes from synovial fluids in rheumatoid synovitis: a preliminary report
Scand J Immunol, 31 (4), 415-21
DOI 10.1111/j.1365-3083.1990.tb02787.x, PubMed 1692153
Publications 1989
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Studies on DNA polymerases and topoisomerases in archaebacteria
Can J Microbiol, 35 (1), 228-33
DOI 10.1139/m89-035, PubMed 2541877 -
Immunoregulatory T cell subsets and T cell activation in rheumatoid arthritis. A need for analysis on the clonal and molecular level
Springer Semin Immunopathol, 11 (3), 273-87
DOI 10.1007/BF00197307, PubMed 2575800 -
Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium
Biochemistry, 28 (9), 3638-41
DOI 10.1021/bi00435a002, PubMed 2751986
Publications 1988
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Inhibitors of DNA topoisomerase II induce topological changes in an archaebacterial plasmid in vivo
Biochem Pharmacol, 37 (9), 1879-80
DOI 10.1016/0006-2952(88)90492-3, PubMed 2837247 -
Novobiocin induces positive supercoiling of small plasmids from halophilic archaebacteria in vivo
Nucleic Acids Res, 16 (4), 1379-91
DOI 10.1093/nar/16.4.1379, PubMed 3347494 -
Novobiocin induces accumulation of a single strand of plasmid pGRB-1 in the archaebacterium Halobacterium GRB
Nucleic Acids Res, 16 (16), 7833-42
DOI 10.1093/nar/16.16.7833, PubMed 3419901 -
Coumarin and quinolone action in archaebacteria: evidence for the presence of a DNA gyrase-like enzyme
J Bacteriol, 170 (2), 946-53
DOI 10.1128/jb.170.2.946-953.1988, PubMed 2828337
Publications 1987
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Antitumor drugs inhibit the growth of halophilic archaebacteria
Eur J Biochem, 169 (2), 231-6
DOI 10.1111/j.1432-1033.1987.tb13602.x, PubMed 3121311 -
Effects of the antitumor drug VP16 (etoposide) on the archaebacterial Halobacterium GRB 1.7 kb plasmid in vivo
Nucleic Acids Res, 15 (20), 8217-34
DOI 10.1093/nar/15.20.8217, PubMed 3671082
Publications 1986
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beta-Mannosidase in human serum and urine. A comparative study
Int J Biochem, 18 (11), 1065-8
DOI 10.1016/0020-711x(86)90255-7, PubMed 3803698