Pål Kristian Selbo's project group Light-controlled delivery of cancer immunotherapeutics
The main goal of our project group is to develop and explore novel light-controlled strategies to enhance the efficacy, specificity and safety of cancer immunotherapies.
We are using the intracellular drug delivery technology, photochemical internalisation (PCI) to release immunotherapeutic agents, e.g. cancer stem cell-targeting monoclonal antibodies linked to protein toxins (immunotoxins) or cancer vaccine antigens, from endosomes and/or lysosomes into the cytosol of cancer cells. We are also exploring the effect of combining the PCI method with clinically approved anti-cancer medicines to enhance their efficacy against therapy resistant cancers.
- PCI of immunotoxins targeting cancer stem cells
- PCI of cancer vaccine antigens
- PCI in combination with clinically approved anti-cancer drugs