Pål Kristian Selbo
- Project leader, Senior scientist; PhD
- +47 22 78 14 69
Room: K03 071
Research profiles: Orcid iD | ResearcherID | Google Scholar | Researchgate
Curriculum vitae
Degree-Granting Education
2001 University of Oslo, Norway, Dr. philos./ PhD, Biochemistry
1994 Norwegian University of Science and Technology (NTNU), Norway, Cand. scient./MS, Cell Biology
1993 Norwegian University of Science and Technology (NTNU), Norway, BS, Biology
PhD project: Photochemical internalisation: a novel drug delivery system.
Project place: Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital
Postdoc training
2001-2002: | Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway (Grants from The Norwegian Radium Hospital Research Foundation) |
2002-2003: | Research Fellow at Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA (Grants from NIH/NCI) |
2004-2007: | Research Fellow at Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway (Grants from The Norwegian Cancer Society) |
Honors & Awards
2013 Claude Rimington Commemorative Prize
Societies
Norwegian Biochemical Society
Norwegian Society for Photobiology and Photomedicine
European Society for Photobiology
European Society for Medical Oncology
American Society for Photobiology
International Photodynamic Association
Administration and Boards
2021-present | President of the Norwegian Society for Photobiology and Photomedicine |
2021-present | Elected officer of the Executive Committee, ESP |
2019-present | Scientific Advisory Board (SAB) member, European Society for Photobiology (ESP) |
2019-present | Advisory board member, Department of Comparative Medicine, Oslo University Hospital, Mandate from the Cancer Clinic (Deputy advisory board, 2015-2019) |
2017-present | Head of Communication work group, ESP |
2017-present | Member of the Membership work group, ESP |
2015-present | Vice President of the Norwegian Society for Photobiology and Photomedicine |
2015-2019 | Elected officer of the Executive Committee, ESP |
2015-2017 | Member of ESP Teaching and Education Committee, ESP |
2011-2015 | Scientific Advisory Board (SAB) member, ESP |
2010-2015 | President of the Norwegian Society for Photobiology and Photomedicine |
Organisation of scientific meetings
2021 | Symposium Chair at the 19th Congress of the European Society for Photobiology, August 30. to September 3., 2021, WWW + Salzburg, AT |
2020 | Organiser of the scientific and annual meeting of the Norwegian Society for Photobiology and Photomedicine (NOFFOF), Oslo, Norway |
2019 | Head organiser of the pop-science symposium “International Day of Light”, Litteraturhuset, Oslo, Norway. |
2019 | World congress on Light and Life (Joint ESP and IUPB meeting), Participated in the initial planning as EC member of the ESP. 25-30. Aug., Barcelona, Spain |
2017 | Session Chair, 17th Congress of the European Society for Photobiology, 4. – 8. September 2017, Pisa, Italy |
2015 | Organiser of the scientific and annual meeting of the Norwegian Society for Photobiology and Photomedicine (NOFFOF), Oslo, Norway |
2015 | Head organiser of International year of light (IYL 2015) popular science seminar at Litteraturhuset in Oslo, Norway |
2014 | Co-organizer and session chair, 37th Congress of the American Society for Photobiology, 14. – 18. June 2014, San Diego, California, USA |
Publications
86 publications, including 62 PubMed papers, 9 book chapters, 2 books (M.Sc. and Ph.D. thesis), 5 patents/patent applications and 8 meeting abstracts.
Research interests
Photomedicine, Photochemical internalization, Photodynamic therapy, Controlled drug delivery and Cancer stem cells, Therapeutic cancer vaccination and Cancer therapy.
Description of primary research
Go to: Research projects
Publications 2024
Topical collection on photodynamic therapy-enhanced antitumour immunity
Photochem Photobiol Sci, 23 (2), 213-214
DOI 10.1007/s43630-024-00549-y, PubMed 38381362
Publications 2022
Photochemical Internalization of Gemcitabine Is Safe and Effective in Locally Advanced Inoperable Cholangiocarcinoma
Oncologist, 27 (6), 430-e433
DOI 10.1093/oncolo/oyab074, PubMed 35675633
All-trans retinoic acid enhances the anti-tumour effects of fimaporfin-based photodynamic therapy
Biomed Pharmacother, 155, 113678
DOI 10.1016/j.biopha.2022.113678, PubMed 36108391
Publications 2021
Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers
Front Immunol, 11, 576756
DOI 10.3389/fimmu.2020.576756, PubMed 33488576
Efficacy and Selectivity of FGF2-Saporin Cytosolically Delivered by PCI in Cells Overexpressing FGFR1
Cells, 10 (6)
DOI 10.3390/cells10061476, PubMed 34204611
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
Biochem Pharmacol, 194, 114837
DOI 10.1016/j.bcp.2021.114837, PubMed 34780750
Light-controlled elimination of PD-L1+ cells
J Photochem Photobiol B, 225, 112355
DOI 10.1016/j.jphotobiol.2021.112355, PubMed 34768077
Publications 2020
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J Clin Med, 9 (2)
DOI 10.3390/jcm9020528, PubMed 32075165
Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines
Cancers (Basel), 12 (1)
DOI 10.3390/cancers12010165, PubMed 31936595
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965
High aldehyde dehydrogenase activity does not protect colon cancer cells against TPCS2a-sensitized photokilling
Photochem Photobiol Sci, 19 (3), 308-312
DOI 10.1039/c9pp00453j, PubMed 32108197
Publications 2019
Combination light-based therapies to treat pancreatic cancer: a proof of concept
PROC SPIE, 11070, UNSP 1107045
DOI 10.1117/12.2525305
Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
J Clin Med, 9 (1)
DOI 10.3390/jcm9010068, PubMed 31888091
Publications 2018
Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins
Photochem Photobiol Sci, 17 (5), 539-551
DOI 10.1039/C7PP00358G, PubMed 29565434
Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination
Front Immunol, 9, 650
DOI 10.3389/fimmu.2018.00650, PubMed 29670624
Photochemical internalization enhances cytosolic release of antibiotic and increases its efficacy against staphylococcal infection
J Control Release, 283, 214-222
DOI 10.1016/j.jconrel.2018.06.004, PubMed 29883696
Publications 2017
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
J Exp Clin Cancer Res, 36 (1), 187
DOI 10.1186/s13046-017-0662-6, PubMed 29258566
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290
Publications 2016
Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery
In Handbook of Porphyrin Science (Kadish KM, Smith KM, Guilard R, eds.), World Scientific Publishing Co, Singapore, 43, 245-300
DOI 10.1142/9789813149632_0004, PublikaID 252, ISBN 978-981-3149-63-2
Publications 2015
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem Photobiol Sci, 14 (8), 1433-50
DOI 10.1039/c5pp00027k, PubMed 25805311
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem Photobiol Sci, 14 (8), 1465-75
DOI 10.1039/c5pp00029g, PubMed 25849953
Publications 2014
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization
Mol Pharm, 11 (8), 2764-76
DOI 10.1021/mp500129t, PubMed 24960585
Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells
J Control Release, 198, 10-7
DOI 10.1016/j.jconrel.2014.11.032, PubMed 25482339
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
DOI 10.4161/mabs.28207, PubMed 24525727
177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice
PLoS One, 9 (7), e103070
DOI 10.1371/journal.pone.0103070, PubMed 25068508
Publications 2013
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J Control Release, 168 (3), 317-26
DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040
Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen
J Control Release, 174, 143-50
DOI 10.1016/j.jconrel.2013.11.017, PubMed 24280261
Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
Free Radic Biol Med, 65, 1300-1309
DOI 10.1016/j.freeradbiomed.2013.09.010, PubMed 24076428
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966
Vascular endothelial cells as targets for photochemical internalization (PCI)
Photochem Photobiol, 89 (5), 1185-92
DOI 10.1111/php.12126, PubMed 23819771
Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
Biochim Biophys Acta, 1830 (3), 2659-70
DOI 10.1016/j.bbagen.2012.11.010, PubMed 23671927
Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417
DOI 10.1016/j.bbagen.2013.05.002
Publications 2012
Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells
Cancer Lett, 321 (2), 120-7
DOI 10.1016/j.canlet.2012.01.014, PubMed 22266098
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
J Control Release, 159 (2), 197-203
DOI 10.1016/j.jconrel.2012.02.003, PubMed 22349185
Publications 2011
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
Photochem Photobiol Sci, 10 (10), 1637-51
DOI 10.1039/c1pp05128h, PubMed 21773635
Photochemical internalization of tumor-targeted protein toxins
Lasers Surg Med, 43 (7), 721-33
DOI 10.1002/lsm.21084, PubMed 22057500
Publications 2010
Photochemical internalization: a new tool for gene and oligonucleotide delivery
Top Curr Chem, 296, 251-81
DOI 10.1007/128_2010_63, PubMed 21504105
The Potential of Photochemical Internalixation (PCI) for the Cytosolic Delivery of Nanomedicines
In Organelle-Specific Pharmaceutical Nanotechnology (Weissing V, D'Souza, eds.), John Wiley and Sons Inc, New Jersey, USA, 311-322
PublikaID 72
Photochemical internalization (PCI): a technology for drug delivery
Methods Mol Biol, 635, 133-45
DOI 10.1007/978-1-60761-697-9_10, PubMed 20552345
[Photochemical internalisation (PCI): a further development of photodynamic therapy for the treatment of skin cancer]
Praxis (Bern 1994), 99 (23), 1423-8
DOI 10.1024/1661-8157/a000310, PubMed 21082595
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
J Control Release, 148 (1), 2-12
DOI 10.1016/j.jconrel.2010.06.008, PubMed 20600406
Publications 2009
Photochemical internalization (PCI) in cancer therapy: from bench towards bedside medicine
J Photochem Photobiol B, 96 (2), 83-92
DOI 10.1016/j.jphotobiol.2009.04.012, PubMed 19467605
Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel
PLoS One, 4 (8), e6691
DOI 10.1371/journal.pone.0006691, PubMed 19690617
Photodynamic therapy targets the mTOR signaling network in vitro and in vivo
Mol Pharm, 6 (1), 255-64
DOI 10.1021/mp800156e, PubMed 19125612
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver
J Control Release, 142 (3), 347-53
DOI 10.1016/j.jconrel.2009.11.017, PubMed 19932724
Publications 2008
Photochemical Internalization
In Advances in Photodynamic therapy; basic, translational , and clinical (Hamblin MR, Mroz P, eds.), Norwood: Artech House, Norwood MA, USA, 299-312
PublikaID 71
Publications 2007
Photochemical internalization: a new tool for drug delivery
Curr Pharm Biotechnol, 8 (6), 362-72
DOI 10.2174/138920107783018354, PubMed 18289045
Evaluation of the binding of radiolabeled rituximab to CD20-positive lymphoma cells: an in vitro feasibility study concerning low-dose-rate radioimmunotherapy with the alpha-emitter 227Th
Cancer Biother Radiopharm, 22 (4), 469-79
DOI 10.1089/cbr.2007.371, PubMed 17803441
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
Biochem Pharmacol, 74 (2), 226-35
DOI 10.1016/j.bcp.2007.04.018, PubMed 17531956
Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells
Mol Pharm, 4 (2), 241-51
DOI 10.1021/mp060105u, PubMed 17263556
Publications 2006
Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
Med Laser Appl, 21, 239-251
DOI 10.1016/j.mla.2006.08.004, PublikaID 73
Photochemical internalization (PCI): a new modality for light activation of endocytosed therapeuticals
J Environ Pathol Toxicol Oncol, 25 (1-2), 521-36
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.330, PubMed 16566739
Photochemical internalization of therapeutic macromolecular agents: a novel strategy to kill multidrug-resistant cancer cells
J Pharmacol Exp Ther, 319 (2), 604-12
DOI 10.1124/jpet.106.109165, PubMed 16902053
Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer
Cancer Res, 66 (11), 5633-40
DOI 10.1158/0008-5472.CAN-06-0604, PubMed 16740700
Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin
J Control Release, 111 (1-2), 165-73
DOI 10.1016/j.jconrel.2005.12.002, PubMed 16466823
Publications 2005
Porphyrin-related photosensitizers for cancer imaging and therapeutic applications
J Microsc, 218 (Pt 2), 133-47
DOI 10.1111/j.1365-2818.2005.01471.x, PubMed 15857375
Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
Br J Cancer, 92 (11), 2004-9
DOI 10.1038/sj.bjc.6602600, PubMed 15886704
Publications 2004
Photochemical drug and gene delivery
Curr Opin Mol Ther, 6 (3), 279-87
PubMed 15264430
Photochemical internalisation in drug and gene delivery
Adv Drug Deliv Rev, 56 (1), 95-115
DOI 10.1016/j.addr.2003.08.016, PubMed 14706447
Publications 2003
Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles
Oftalmologia, 56 (1), 67-71
PubMed 12886687
Light directed gene transfer by photochemical internalisation
Curr Gene Ther, 3 (2), 89-112
DOI 10.2174/1566523034578438, PubMed 12653404
Publications 2002
Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy
Br J Cancer, 86 (4), 652-7
DOI 10.1038/sj.bjc.6600138, PubMed 11870551
Photochemical internalisation: a novel drug delivery system
Tumour Biol, 23 (2), 103-12
DOI 10.1159/000059713, PubMed 12065848
Publications 2001
Photochemical internalisation: a novel drug delivery system
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 158, 1 b. (flere pag.)
BIBSYS 011828625
5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro
Photochem Photobiol, 74 (2), 303-10
DOI 10.1562/0031-8655(2001)074<0303:aabpio>2.0.co;2, PubMed 11547569
In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
Int J Cancer, 92 (5), 761-6
DOI 10.1002/1097-0215(20010601)92:5<761::aid-ijc1238>3.0.co;2-4, PubMed 11340584
Publications 2000
Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
Biochim Biophys Acta, 1475 (3), 307-13
DOI 10.1016/s0304-4165(00)00082-9, PubMed 10913830
Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
Int J Cancer, 87 (6), 853-9
DOI 10.1002/1097-0215(20000915)87:6<853::aid-ijc15>3.0.co;2-0, PubMed 10956397
Publications 1999
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
Cancer Res, 59 (6), 1180-3
PubMed 10096543
Publications 1997
Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture
Cancer Res, 57 (8), 1481-6
PubMed 9108449
Publications 1996
Extracellular phospholipase A2 expression in sarcoidosis
Sarcoidosis Vasc Diffuse Lung Dis, 13 (1), 70-6
PubMed 8865415
Publications 1994
"Cellulær lokalisering av mRNA for ikke-pancreatisk fosfolipase A2 ved in situ hybridisering i human lunge, placenta og hud"
P.K. Selbo, Trondheim, 84 bl.
BIBSYS 950581887