Pediatric Radiology Research Group

Lil-Sofie Ording MüllerGroup leader
Lil-Sofie Ording Müller
Group leader

The group was founded in January 2015.
Pediatric radiology is a wide and diverse branch of the specialty of Radiology, and includes diagnostic and interventional procedures of the whole body in children and adolescents, aged 0-18 years. Paediatric radiology is a multimodality specialty where ultrasonography, fluoroscopy, radiography, computed tomography (CT) and magnetic resonance imaging (MRI) as well as nuclear medicine techniques are used. Technical advances in ultrasonography, CT, and MRI are crucial in pediatric diagnostics especially in the cardiac- and oncology imaging. Children constitute a vast and important part of the patients at Oslo University Hospital.

Currently there are two PhD-candidates holding 50% research posts within the Paediatric research group and further three PhD-candidates from other hospitals are co-supervised by members of the group. The group has no full-time researchers, but the group members are actively involved in several projects and has been awarded two HSØ PhD-grants over the last five years. One of the HSØ-funded projects is still ongoing and one PhD was obtained in 2023. In addition, one PhD has been obtained funded by OUS and external grants.

Aims

High quality clinical practice in paediatric radiology must be based on knowledge gained from research. The majority of diseases affecting children are specific for the paediatric age group. Further, children have specific age-related anatomy and physiological as well as pathophysiological processes may be different as compared to adults. Therefore, knowledge from research performed on an adult population cannot automatically be transferred to children. 

The main goal for our research group is to stimulate high quality research to improve, validate and further develop imaging techniques applied to children. Validation of radiological methods for use in the paediatric population has been the one of the focuses for the research conducted within in this group with emphases on reliability of methods, development of child-specific scoring systems and development of normal age-specific imaging standards to differentiate true pathology from normal findings. 

In this research group, we would like to gather active researchers, PhD students and other research-interested colleagues from the Department of Radiology and Nuclear Medicine as well as colleagues from other departments involved in the pediatric care at Oslo University Hospital. We also invite colleagues from other hospitals in our region and from other parts of Norway and we encourage members to participate in international collaboration such as task forces. This gives us the possibility to exchange knowledge and ideas in between different groups of specializations as well as establish research with larger cohorts of pediatric populations in different, both rare and common diseases. Several of the members of this research group already have international research collaborations. 

Current projects

  • Determining the value of chest radiographs in preschool children with pneumonia: An enhancement of The Norwegian Antibiotics for Pneumonia in Children study (REK 2017/1863) 
  • Whole Body Magnetic Resonance Imaging (MRI) in children. Novel work on age related normative findings to identify true pathology (REK 2016/1696). 
  • MRI study after arterial switch operation in patients with transposition of the great arteries using 3T MRI imaging of coronary arteries and myocardial function (REK 2011/1422). 
  • The Fontan circulation – Imaging function and long-term effects in the heart and liver, with US elastography, hepatic and cardiac MRI (REK 2013/1331).
  • Three-dimentional printing and display of heart models new tools for planning surgery and interventions in congenital heart disease (REK 2017/1079)
  • Data modelling to secure the diagnostic process in congenital heart diseases, NORCE 4D flow (Rek saksnummer 148926). 
  • MRI in myocarditis following Covid-19-vaccination (REK 434476). 
  • Participation in the RECEPTOR –study. Multicentre study, PI based in UK, comparing conventional radiography and CT for detection of rib fractures in non-accidental trauma (International REK, kun anonyme data). 
  • Participation in PhD project to evaluate the effect of Sirolimus-treatment of lymphatic malformations.
  • Surveillance of children with antenatally detected pelvoureteral junction obstruction who are conservatively treated children (watchful waiting). A quality assurance study (No REK number).
  • HARMONIC. European multicenter cohort study assessing the long-term effects of ionizing radiation in patients with congenital heart disease
  • Active participation in European task forces. The current research-group leader chairs the European Society for Pediatric Radiology Abdominal Task Force group. 

Contact information:
Group leader: Lil-Sofie Ording Muller

Visiting address/postal address: Division of Radiology and Nuclear Medicine, Rikshospitalet, Unit for Pediatric Radiology,Oslo University Hospital, PO box 4950 Nydalen, 0424 Oslo, Norway

Phone +47 2307000 / 92828097

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