Translational Neurodegeneration Research & Neuropathology
Jens Pahnke Group leaderThis combined research and diagnostic lab is located at Rikshospitalet. We provide daily diagnostic service for brain biopsy diagnostics, muscle disease diagnostics, routine autopsy diagnostics for adults, kids and fetuses, and forensic neuropathology consultations. Our research focuses on basic and molecular neurodegeneration research, translational projects, patient-related treatment and diagnostic research. We have several unique mouse lines located at the Radium Hospital mouse facility.
Currently Externally Funded Projects
PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier (JPND / EU / NFR)
PhytoAD: St. John’s wort as Alzheimer’s treatment – New ways of identification, exploitation and use of natural resources (SAW Leibniz Society Grant / EFRE)
Blood-brain barrier ABCG2 function in Alzheimer´s disease – LSC14-008 funded
ABC-HC: The importance of ABC transporters for the pathogenesis and treatment of Huntington’s disease (HSØ)
ABC-S1P: S1P and ABC transporters – synergistic treatment targets for Alzheimer´s disease (HSØ)
REPURPOSE-DMF: Dimethyl fumarate – Repurposing a MS drug to treat AD (Nationalforeningen)
ShortAbeta: Short Aβ-related peptides in the pathogenesis of Alzheimer’s disease – new avenues for treatment (LZPP Latvia)
Establishment of comprehensive molecular diagnostics for kids’ brain tumours in Norway (Barnekreftforeningen)
Stefan SM, Pahnke J, Namasivayam V(2023) HD_BPMDS: a curated binary pattern multitarget dataset of Huntington's disease-targeting agents J Cheminform, 15(1), 109 DOI 10.1186/s13321-023-00775-z, PubMed 37978560
Mairinger S, Leterrier S, Filip T, Löbsch M, Pahnke J, Hernández-Lozano I, Stanek J, Tournier N, Zeitlinger M, Hacker M, Langer O, Wanek T(2023) [11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier J Cereb Blood Flow Metab, 271678X231202336(in press) DOI 10.1177/0271678X231202336, PubMed 37728771
Möhle L, Stefan K, Bascuñana P, Brackhan M, Brüning T, Eiriz I, El Menuawy A, van Genderen S, Santos-García I, Górska AM, Villa M, Wu J, Stefan SM, Pahnke J(2023) ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease Biology (Basel), 12(7) DOI 10.3390/biology12070932, PubMed 37508364