Developing novel complement activation assays for application in basic and clinical research
Studying the cross-talk between complement and TLRs, in particular to the co-receptor CD14
Investigating the effect on inflammation by inhibiting complement activation and CD14 using human whole blood in vitro models and in vivo animal models of human diseases
Studying the “Thromboinflammation” and new complex whole blood models to reveal cross-talk between biological systems ex vivo
Studying complement activation in patients with diseases being tentative candidates for future complement intervention
Develop tools for evaluation of the effect of complement therapy in the clinic
Sandvig HV, Saltvedt I, Edwin TH, Aam S, Alme KN, Eldholm RS, Lydersen S, Mollnes TE, Munthe-Kaas R, Ueland PM, Ulvik A, Wethal T, Knapskog AB(2025) Associations between systemic inflammation and cognitive trajectories post-stroke Sci Rep, 15(1), 42791 DOI 10.1038/s41598-025-27119-1, PubMed 41315409
Freiin von Münchhausen B, Groven RVM, Peniche Silva CJ, Greven J, Mert Ü, Mollnes TE, Huber-Lang M, Horst K, Hildebrand F, van Griensven M, Balmayor ER(2025) Immune modulation mimics damage control orthopaedics' upregulation of anti-inflammatory miRNA-21/23a/27a and miRNA-30b in the lung after polytrauma in pigs Eur J Trauma Emerg Surg, 51(1), 356 DOI 10.1007/s00068-025-03005-3, PubMed 41307688
de Boer E, Strandmoe AL, Sokolova M, Michelsen TM, Quach HQ, Chaban V, Nakstad ER, Andersen GØ, Torp MS, Stensløkken KO, Mollnes TE, Pischke SE(2025) Extracellular mitochondrial DNA activates complement and is associated with complement activation in patients with out-of-hospital cardiac arrest Sci Rep, 15(1), 41000 DOI 10.1038/s41598-025-24705-1, PubMed 41266540
