Publications 2021

Boye K, Longhi A, Guren T, Lorenz S, Naess S, Pierini M, Taksdal I, Lobmaier I, Cesari M, Paioli A, Londalen AM, Setola E, Hompland I, Meza-Zepeda LA, Hall KS, Palmerini E (2021)
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Cancer Immunol. Immunother., 70 (9), 2617-2624
DOI 10.1007/s00262-021-02876-w

Publications 2020

Wise JF, Nakken S, Steen CB, Vodak D, Troen G, Johannessen B, Lingjxrde OC, Hilden V, Blaker YN, Bai BY, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppa S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv., 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325

Publications 2019

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjallquist U, Linnarsson S, Patel S, Tasken K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat. Commun., 10, 514
DOI 10.1038/s41467-019-08384-x

Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ (2019)
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J. Immunol., 202 (3), 736-746
DOI 10.4049/jimmunol.1801146

Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fane A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Walchli S (2019)
NK cells specifically TCR-dressed to kill cancer cells
EBioMedicine, 40, 106-117
DOI 10.1016/j.ebiom.2019.01.031

Panagopoulos I, Brunetti M, Stoltenberg M, Strandabo RAU, Staurseth J, Andersen K, Kostolomov I, Hveem TS, Lorenz S, Nystad TA, Flaegstad T, Micci F, Heim S (2019)
Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype
Exp. Hematol. Oncol., 8, 12
DOI 10.1186/s40164-019-0136-y

Pfefferle A, Jacobs B, Netskar H, Ask EH, Lorenz S, Clancy T, Goodridge JP, Sohlberg E, Malmberg KJ (2019)
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Cell Reports, 29 (8), 2284-+
DOI 10.1016/j.celrep.2019.10.058

Wardekker A, Lorenz S (2019)
The visual framing of climate change impacts and adaptation in the IPCC assessment reports
Clim. Change, 156 (1-2), 273-292
DOI 10.1007/s10584-019-02522-6

Publications 2018

Kostas M, Haugsten EM, Zhen Y, Sorensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J (2018)
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol. Cell. Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538

Kresse SH, Namlos HM, Lorenz S, Berner JM, Myklebost O, Bjerkehagen B, Meza-Zepeda LA (2018)
Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples
PLoS One, 13 (5), e0197456
DOI 10.1371/journal.pone.0197456

Namlos HM, Boye K, Mishkin SJ, Baroy T, Lorenz S, Bjerkehagen B, Stratford EW, Munthe E, Kudlow BA, Myklebost O, Meza-Zepeda LA (2018)
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Mol. Cancer Ther., 17 (11), 2473-2480
DOI 10.1158/1535-7163.MCT-18-0174

Vodak D, Lorenz S, Nakken S, Aasheim LB, Holte H, Bai B, Myklebost O, Meza-Zepeda LA, Hovig E (2018)
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8, 5307
DOI 10.1038/s41598-018-23563-4

Publications 2017

Rodriguez M, Bajo-Santos C, Hessvik NP, Lorenz S, Fromm B, Berge V, Sandvig K, Line A, Llorente A (2017)
Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes
Mol. Cancer, 16, 156
DOI 10.1186/s12943-017-0726-4

Publications 2016

Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, Maki RG, Brohl AS, Myklebost O, Stratford EW, Lorenz S, Ahn SM, Ahn JH, Kim JE, Shanley S, Beshay V, Randall RL, Judson I, Seddon B, Campbell IG, Young MA et al. (2016)
Monogenic and polygenic determinants of sarcoma risk: an international genetic study
Lancet Oncol., 17 (9), 1261-1271
DOI 10.1016/S1470-2045(16)30147-4

Baroy T, Chilamakuri CSR, Lorenz S, Sun JC, Bruland OS, Myklebost O, Meza-Zepeda LA (2016)
Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
DOI 10.1371/journal.pone.0163859

Hanes R, Grad I, Lorenz S, Stratford EW, Munthe E, Reddy CCS, Meza-Zepeda LA, Myklebost O (2016)
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma
Oncotarget, 7 (34), 54583-54595
DOI 10.18632/oncotarget.10518

Lorenz S, Baroy T, Sun JC, Nome T, Vodak D, Bryne JC, Hakelien AM, Fernandez-Cuesta L, Mohlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GOS, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Oncotarget, 7 (5), 5273-5288
DOI 10.18632/oncotarget.6567

Publications 2015

Chymkowitch P, Nguea PA, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res., 25 (6), 897-906
DOI 10.1101/gr.185793.114

Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schottle J, Ullrich RT, Altmuller J, Becker C, Nurnberg P, Seidel H, Bohm D, Goke F, Ansen S, Russell PA, Wright GM, Wainer Z et al. (2015)
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genome Biol., 16, 7
DOI 10.1186/s13059-014-0558-0

Publications 2014

Chilamakuri CSR, Lorenz S, Madoui MA, Vodak D, Sun JC, Hovig E, Myklebost O, Meza-Zepeda LA (2014)
Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15, 449
DOI 10.1186/1471-2164-15-449

Hakelien AM, Bryne JC, Harstad KG, Lorenz S, Paulsen J, Sun JC, Mikkelsen TS, Myklebost O, Meza-Zepeda LA (2014)
The Regulatory Landscape of Osteogenic Differentiation
Stem Cells, 32 (10), 2780-2793
DOI 10.1002/stem.1759

Skarn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namlos HM, Hakelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O (2014)
Generation and Characterization of an Immortalized Human Mesenchymal Stromal Cell Line
Stem Cells Dev., 23 (19), 2377-2389
DOI 10.1089/scd.2013.0599

Publications 2013

Schee K, Lorenz S, Worren MM, Gunther CC, Holden M, Hovig E, Fodstad O, Meza-Zepeda LA, Flatmark K (2013)
Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer
PLoS One, 8 (6), e66165
DOI 10.1371/journal.pone.0066165

Publications 2012

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjoras M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc. Natl. Acad. Sci. U. S. A., 109 (26), 10450-10455
DOI 10.1073/pnas.1200067109