Transplant Oncology Research Group

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Transplant Oncology

Our research group is exploring liver transplantation as a treatment option for patients with primary and secondary liver malignancies.

About the group

The research group for Transplant Oncology is exploring liver transplantation as a treatment option for patients with primary or secondary liver malignancies that currently are treated by palliative care due to lack of surgical possibilities. 

The group has been leading the field of liver transplant for colorectal liver metastases (CRLM), and transplant oncology has become an emerging field in liver transplantation with international traction. The reserch group for transplant oncology is currently running prospective study protocols in liver transplantation in colorectal liver metastasis, intrahepatic cholangiocarcinoma and hilar cholangiocarcinoma, and is also tightly involved in liver metastases from neuroendocrine tumors.

Members of the research group are transplant surgeons, oncologists, radiologists, nuclear medicine specialists, liver surgeons and thorax surgeons and nurses.  The research group also has an established cooperation with academic expertise in health economics.

Current projects/studies

  • Contribution to "Consensus guidelines of the International Hepato-Pancreato-Biliary Association (IHPBA), 2021
  • A new study on health-related life quality for colorectal cancer patients who have undergone liver transplantion
  • A study on health-economic aspects of liver transplantation compared to standard therapy for liver metastases
  • A multicentre study that evaluates a surgery technique RAPID introduced in 2015
  • A 3-year project funded by the South-Eastern Norway Regional Health Authority on Improved long term survival of patients with colorectal liver metastases by individualized risk assessment for allocation to surgical therapy" (2022-)
  • "Elucidating basic molecular mechanisms relevant for treatment of patients liver transplanted for CRLM", in cooperation with Professor Ragnhild Lothe
  • Open call grant from The Norwegian Cancer Society (2023-27) – Converting inoperable to curable metastatic cancer on behalf of the respective research groups, project leaders: Anita Sveen and Pål-Dag Line

Cooperation

We have a number of national and international partners.

National

  • Gudrun Bjørnelv, The Institute of Health and Society, NTNU
  • Eline Aas, The Institute of Health and Society, University of Oslo
  • Professor Ragnhild Lothe, University of Oslo
  • Professor Anita Sveen, University of Oslo

International

  • Professor Julia Johansen, Herlev University Hospital, Denmark
  • Professor Karen-Lise Spindler, Aarhus University, Denmark
  • Professor Krishna Menon, King’s College Hospital, London, UK
  • Professor Silvio Nadalin, Univerity of Tübingen, Germany
  • Professor Utz Settmacher, Univeristy of Jena, Germany
  • Professor Umberto Cillo, University of Padova, Italy
  • Professor Roberto Hernandez Alejandro, URMC, Rochester NY, USA
  • Associate Professor Gonzalo Sapisochin, UHN Toronto General Hospital, Toronto, Canada

Publications

  • Smedman TM, Guren TK, Tveit KM, et al. Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy. Transplant Int 2022; 35: 10404.
  • Bjørnelv GMW, Zolic-Karlsson Z, Dueland S, Line P-D, Aas E. Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal livermetastases. Brit J Surg 2022. DOI:10.1093/bjs/znac022.
  • Dueland S, Smedman TM, Røsok B, et al. Treatment of relapse and survival outcomes after liver transplantation in patients with colorectal liver metastases. Transplant Int 2021; 34: 2205–13.
  • Line P-D. Liver transplantation for colorectal secondaries: on the way to validation. Curr Opin Organ Tran 2022; 27: 329–36.
  • Settmacher U, Ali-Deeb A, Coubeau L, et al. Auxilliary Liver Transplantation According to the RAPID Procedure in Non-cirrhotic Patients – Technical Aspects and Early Outcomes. Ann Surg 2022; Publish Ahead of Print. DOI:10.1097/sla.0000000000005726.
  • Salcedo M, Vinaixa C, Javle M, Trapero-Marugán M, Bustamante J, Line P-D. Evaluation and Management of Liver Transplant Candidates With Prior Nonhepatic Cancer: Guidelines From the ILTS/SETH Consensus Conference. Transplantation 2022; 106: e3–11.
  • Eshmuminov D, Studer DJ, Lopez VL, et al. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal. Ann Surg 2022; Publish Ahead of Print. DOI:10.1097/sla.0000000000005663.
  • Lanari J, Hagness M, Sartori A, et al. Liver transplantation versus liver resection for colorectal liver metastasis: a survival benefit analysis in patients stratified according to tumor burden score. Transplant Int 2021; 34: 1722–32.
  • Dueland S, Yaqub S, Line P-D. No Strong Evidence on Liver Transplant for Colorectal Cancer Liver Metastasis Over Portal Vein Embolization Associated With Liver Resection—Reply. Jama Surg 2022; 157. DOI:10.1001/jamasurg.2021.5127.

 

Published Aug. 10, 2018 10:20 AM - Last modified Sep. 8, 2023 1:30 PM

Contact

Group leader

Participants

Detailed list of participants

 
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