TRICXY-MINDS
Clinical insight into sex TRIsomies for enhanced psychiatric Care in individuals with X and Y chromosomal aneuploidies
1 in 400 is born with an atypical number of sex chromosomes (sex chromosome aneuplodies (SCAs)) – only ~25 % are genetically detected. Many experience behavioral and cognitive challenges, reflected in odds ratio for several mental disorders of >2. This indicates a substantial subgroup in the psychiatric services (1-2 in 200 patients) that may have specific characteristics with potential for precision medicine. The lack of data and huge heterogeneity has hindered the development of tailored guidelines for care and specific interventions. TRICXY_MINDS will map disease & longitudinal health trajectories in Norwegian SCA carriers representing an estimated 3-4% of Norway's SCA population. Also, we are conducting a digital pilot of social management training (SMT) for persons with Klinefelter. The SMT is designed to target improvement of cognitive functions to enhance mental health.