PREVENT-JIA
In this unique study, we seek to expand our understanding of early-life environmental factors' role in JIA development and phenotype, alongside their interaction with genetic risk. We also investigate mother-father-child triads to pinpoint genetic factors associated with JIA and to gain a deeper understanding of phenotypic variation and family-related factors. We utilize data from the large MoBa pregnancy cohort and registries, examining environmental exposures like socioeconomic, perinatal and early-childhood factors, with several ongoing subprojects.
As part of the overall project “MoBaRheuma”, we also study the impact of genetics and environmental factors on adult-onset rheumatic disease. We adopt an interdisciplinary approach with two current PhD students and two postdocs, each with diverse backgrounds.
To achieve our objectives, we collaborate closely with national and international expert groups in relevant fields. Our long-term goal is to facilitate preventive strategies for JIA, and our study will provide valuable insights into disease mechanisms not only in JIA but also in other rheumatic diseases.