Helga Sanner

  • Group leader, Professor; MD, PhD
  • +47 412 56 664

Research interests

I have a broad background in clinical, translational, and epidemiological research, with a primary focus on juvenile-onset rheumatic diseases. My dedication lies in advancing our understanding of environmental risk factors, gene-environment interactions, disease mechanisms and prognosis in this context to ultimately improve patient care and outcomes.

PROJECTS: PREVENT-JIA, NorJDM, Physical fitness in JIA, PREDICT-JIA, MyJIA, NorChildCTD, NorSLE, translation of PROMIS tools, several international collaborative projects 

 

Publications 2024

Essouma M, de Araujo DB, Day J, Conticini E, Riopel MA, Elias AM, Paula VT, Omori CH, Guimarães JB, Gibson D, Saad-Magalhaes C, Appenzeller S, Schiffenbauer A, Machado PM, Feldman BM, Paik JJ, Christopher-Stine L, Rider LG, Reed A, van der Kooi AJ, Marrani E, Naddaf E, Kirkhus E, Sanner H, Bauer-Ventura I et al. (2024)
A protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies
Rheumatol Int, 44 (11), 2403-2409
DOI 10.1007/s00296-024-05649-7, PubMed 38976028

Haukeland H, Moe SR, Brunborg C, Botea A, Damjanic N, Wivestad GÅ, Øvreås HK, Bøe TB, Orre A, Torhild G, Sanner H, Lerang K, Molberg Ø (2024)
Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway
RMD Open, 10 (3)
DOI 10.1136/rmdopen-2024-004395, PubMed 39160088

Hestetun SV, Rudsari HK, Jaholkowski P, Shadrin A, Haftorn KL, Andersen S, Rygg M, Nordal E, Frei O, Andreassen OA, Selvaag AM, Størdal K, Sanner H (2024)
Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude
Arthritis Rheumatol (in press)
DOI 10.1002/art.43040, PubMed 39431377

Publications 2023

Berger SG, Witczak BN, Reiseter S, Schwartz T, Andersson H, Hetlevik SO, Berntsen KS, Sanner H, Lilleby V, Gunnarsson R, Molberg Ø, Sjaastad I, Stokke MK (2023)
Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study
Rheumatol Int, 43 (6), 1055-1065
DOI 10.1007/s00296-023-05308-3, PubMed 36933069

Hestetun S, Andersen S, Sanner H, Størdal K (2023)
Antibiotic exposure in prenatal and early life and risk of juvenile idiopathic arthritis: a nationwide register-based cohort study
RMD Open, 9 (3)
DOI 10.1136/rmdopen-2023-003333, PubMed 37648397

Marstein HS, Witczak BN, Godang K, Olarescu NC, Schwartz T, Flatø B, Molberg Ø, Bollerslev J, Sjaastad I, Sanner H (2023)
Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
RMD Open, 9 (1)
DOI 10.1136/rmdopen-2022-002815, PubMed 36828644

Marstein HS, Witczak BN, Godang K, Schwartz T, Flatø B, Bollerslev J, Sjaastad I, Sanner H (2023)
Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis
Rheumatology (Oxford), 62 (SI2), SI196-SI204
DOI 10.1093/rheumatology/keac293, PubMed 35575380

Publications 2022

Deakin CT, Bowes J, Rider LG, Miller FW, Pachman LM, Sanner H, Rouster-Stevens K, Mamyrova G, Curiel R, Feldman BM, Huber AM, Reed AM, Schmeling H, Cook CG, Marshall LR, Ll Wilkinson MG, Eyre S, Raychaudhuri S, Wedderburn LR, Juvenile Dermatomyositis Cohort and Biomarker Study, the Childhood Myositis Heterogeneity Study Group, and the Myositis Genetics Consortium (MYOGEN) (2022)
Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis
Hum Mol Genet, 31 (14), 2471-2481
DOI 10.1093/hmg/ddac019, PubMed 35094092

Giancane G, Papa R, Vastert S, Bagnasco F, Swart JF, Quartier P, Antón J, Kamphuis S, Sanner H, Glerup M, De Benedetti F, Tsitsami E, Remesal A, Moreno E, De Inocencio J, Myrup C, Pallotti C, Koné-Paut I, Franck-Larsson K, Malmström H, Cederholm S, Pistorio A, Wulffraat N, Ruperto N, Paediatric Rheumatology International Trials Organisation (PRINTO) (2022)
Anakinra in Patients With Systemic Juvenile Idiopathic Arthritis: Long-term Safety From the Pharmachild Registry
J Rheumatol, 49 (4), 398-407
DOI 10.3899/jrheum.210563, PubMed 35105709

Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, Glintborg B, Westerlind H, Grondal G, Loft IC, Sorensen SB, Lie BA, Brink M, Ärlestig L, Arnthorsson AO, Baecklund E, Banasik K, Bank S, Bjorkman LI, Ellingsen T, Erikstrup C, Frei O, Gjertsson I, Gudbjartsson DF, Gudjonsson SA et al. (2022)
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Ann Rheum Dis, 81 (8), 1085-1095
DOI 10.1136/annrheumdis-2021-221754, PubMed 35470158

van Dijkhuizen EHP, Ridella F, Naddei R, Trincianti C, Avrusin I, Mazzoni M, Sutera D, Ayaz NA, Penades IC, Constantin T, Herlin T, Oliveira SK, Rygg M, Sanner H, Susic G, Sztajnbok F, Varbanova B, Ruperto N, Ravelli A, Consolaro A, Paediatric Rheumatology International Trials Organisation (PRINTO) (2022)
Validity and Reliability of Four Parent/Patient-Reported Outcome Measures for Juvenile Idiopathic Arthritis Remote Monitoring
Arthritis Care Res (Hoboken), 75 (2), 391-400
DOI 10.1002/acr.24855, PubMed 35015379

Witczak BN, Bollerslev J, Godang K, Schwartz T, Flatø B, Molberg Ø, Sjaastad I, Sanner H (2022)
Body composition in long-standing juvenile dermatomyositis: associations with disease activity, muscle strength and cardiometabolic measures
Rheumatology (Oxford), 61 (7), 2959-2968
DOI 10.1093/rheumatology/keab805, PubMed 34718443

Witczak BN, Schwartz T, Barth Z, Taraldsrud E, Lund MB, Aaløkken TM, Flatø B, Sjaastad I, Sanner H (2022)
Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis-a cross-sectional study
Rheumatol Int, 42 (7), 1213-1220
DOI 10.1007/s00296-021-05071-3, PubMed 34984516

Publications 2021

Marstein HS, Godang K, Flatø B, Sjaastad I, Bollerslev J, Sanner H (2021)
Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study
Pediatr Rheumatol Online J, 19 (1), 56
DOI 10.1186/s12969-021-00543-z, PubMed 33902632

Publications 2020

Berntsen KS, Raastad T, Marstein H, Kirkhus E, Merckoll E, Cumming KT, Flatø B, Sjaastad I, Sanner H (2020)
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: A Controlled Cross-Sectional Study
Arthritis Rheumatol, 72 (5), 837-848
DOI 10.1002/art.41174, PubMed 31746550

Giancane G, Swart JF, Castagnola E, Groll AH, Horneff G, Huppertz HI, Lovell DJ, Wolfs T, Herlin T, Dolezalova P, Sanner H, Susic G, Sztajnbok F, Maritsi D, Constantin T, Vargova V, Sawhney S, Rygg M, K Oliveira S, Cattalini M, Bovis F, Bagnasco F, Pistorio A, Martini A, Wulffraat N et al. (2020)
Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
Arthritis Res Ther, 22 (1), 71
DOI 10.1186/s13075-020-02167-2, PubMed 32264969

Marstein H, Schwartz T, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2020)
Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease
Rheumatology (Oxford), 59 (8), 1862-1870
DOI 10.1093/rheumatology/kez531, PubMed 31740970

Publications 2019

Barth Z, Schwartz T, Flatø B, Aaløkken TM, Koller A, Lund MB, Sjaastad I, Sanner H (2019)
Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium to Longstanding Juvenile Dermatomyositis
Arthritis Care Res (Hoboken), 71 (4), 492-497
DOI 10.1002/acr.23687, PubMed 29953739

Berntsen KS, Edvardsen E, Hansen BH, Flatø B, Sjaastad I, Sanner H (2019)
Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease
Rheumatology (Oxford), 58 (3), 492-501
DOI 10.1093/rheumatology/key342, PubMed 30508195

Blom KB, Bergo KK, Espe EKS, Rosseland V, Grøtta OJ, Mjøen G, Åsberg A, Bergan S, Sanner H, Bergersen TK, Bjørnerheim R, Skauby M, Seljeflot I, Waldum-Grevbo B, Dahle DO, Sjaastad I, Birkeland JA (2019)
Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study
Blood Press, 29 (2), 123-134
DOI 10.1080/08037051.2019.1684817, PubMed 31718316

Risum K, Edvardsen E, Godang K, Selvaag AM, Hansen BH, Molberg Ø, Bollerslev J, Holm I, Dagfinrud H, Sanner H (2019)
Physical Fitness in Patients With Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis Diagnosed in the Era of Biologics: A Controlled Cross-Sectional Study
Arthritis Care Res (Hoboken), 71 (12), 1611-1620
DOI 10.1002/acr.23818, PubMed 30474929

Risum K, Edvardsen E, Selvaag AM, Dagfinrud H, Sanner H (2019)
Measurement properties and performance of an eight-minute submaximal treadmill test in patients with juvenile idiopathic arthritis: a controlled study
Pediatr Rheumatol Online J, 17 (1), 14
DOI 10.1186/s12969-019-0316-7, PubMed 30961626

Witczak BN, Hetlevik SO, Sanner H, Barth Z, Schwartz T, Flatø B, Lilleby V, Sjaastad I (2019)
Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study
J Rheumatol, 46 (7), 739-747
DOI 10.3899/jrheum.180526, PubMed 30877222

Publications 2018

Barth Z, Witczak BN, Flatø B, Koller A, Sjaastad I, Sanner H (2018)
Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup
Arthritis Care Res (Hoboken), 70 (5), 768-776
DOI 10.1002/acr.23338, PubMed 28805016

Risum K, Hansen BH, Selvaag AM, Molberg Ø, Dagfinrud H, Sanner H (2018)
Physical activity in patients with oligo- and polyarticular juvenile idiopathic arthritis diagnosed in the era of biologics: a controlled cross-sectional study
Pediatr Rheumatol Online J, 16 (1), 64
DOI 10.1186/s12969-018-0281-6, PubMed 30333025

Publications 2017

Berntsen KS, Tollisen A, Schwartz T, Kirkhus E, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2017)
Submaximal Exercise Capacity in Juvenile Dermatomyositis after Longterm Disease: The Contribution of Muscle, Lung, and Heart Involvement
J Rheumatol, 44 (6), 827-834
DOI 10.3899/jrheum.160997, PubMed 28365577

Bottai M, Tjärnlund A, Santoni G, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Danko K, Dimachkie MM, Feldman BM, García-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA et al. (2017)
EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report
RMD Open, 3 (2), e000507
DOI 10.1136/rmdopen-2017-000507, PubMed 29177080

Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Garcia-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA et al. (2017)
2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups
Arthritis Rheumatol, 69 (12), 2271-2282
DOI 10.1002/art.40320, PubMed 29106061

Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Torre IG, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA et al. (2017)
2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups
Ann Rheum Dis, 76 (12), 1955-1964
DOI 10.1136/annrheumdis-2017-211468, PubMed 29079590

Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, Weitzman S, Espada G, Gao YJ, Anton J, Kitoh T, Kasapcopur O, Sanner H, Merino R, Astigarraga I, Alessio M, Jeng M, Chasnyk V, Nichols KE, Huasong Z, Li C, Micalizzi C, Ruperto N, Martini A, Cron RQ et al. (2017)
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome
J Pediatr, 189, 72-78.e3
DOI 10.1016/j.jpeds.2017.06.005, PubMed 28807357

Publications 2016

Schwartz T, Diederichsen LP, Lundberg IE, Sjaastad I, Sanner H (2016)
Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies
RMD Open, 2 (2), e000291
DOI 10.1136/rmdopen-2016-000291, PubMed 27752355

Publications 2015

Barth Z, Nomeland Witczak B, Schwartz T, Gjesdal K, Flatø B, Koller A, Sanner H, Sjaastad I (2015)
In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years after symptom onset
Rheumatology (Oxford), 55 (3), 535-43
DOI 10.1093/rheumatology/kev376, PubMed 26500284

Publications 2014

Lilleby V, Haydon J, Sanner H, Krossness BK, Ringstad G, Flatø B (2014)
Severe macrophage activation syndrome and central nervous system involvement in juvenile dermatomyositis
Scand J Rheumatol, 43 (2), 171-3
DOI 10.3109/03009742.2013.863968, PubMed 24588361

Minoia F, Davì S, Horne A, Demirkaya E, Bovis F, Li C, Lehmberg K, Weitzman S, Insalaco A, Wouters C, Shenoi S, Espada G, Ozen S, Anton J, Khubchandani R, Russo R, Pal P, Kasapcopur O, Miettunen P, Maritsi D, Merino R, Shakoory B, Alessio M, Chasnyk V, Sanner H et al. (2014)
Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients
Arthritis Rheumatol, 66 (11), 3160-9
DOI 10.1002/art.38802, PubMed 25077692

Sanner H, Schwartz T, Flatø B, Vistnes M, Christensen G, Sjaastad I (2014)
Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage
PLoS One, 9 (3), e92171
DOI 10.1371/journal.pone.0092171, PubMed 24647150

Sanner H, Sjaastad I, Flatø B (2014)
Disease activity and prognostic factors in juvenile dermatomyositis: a long-term follow-up study applying the Paediatric Rheumatology International Trials Organization criteria for inactive disease and the myositis disease activity assessment tool
Rheumatology (Oxford), 53 (9), 1578-85
DOI 10.1093/rheumatology/keu146, PubMed 24692575

Schwartz T, Sjaastad I, Flatø B, Vistnes M, Christensen G, Sanner H (2014)
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction
Rheumatology (Oxford), 53 (12), 2214-22
DOI 10.1093/rheumatology/keu256, PubMed 24996906

Publications 2013

Schwartz T, Sanner H, Gjesdal O, Flatø B, Sjaastad I (2013)
In juvenile dermatomyositis, cardiac systolic dysfunction is present after long-term follow-up and is predicted by sustained early skin activity
Ann Rheum Dis, 73 (10), 1805-10
DOI 10.1136/annrheumdis-2013-203279, PubMed 23881732

Publications 2012

Tollisen A, Sanner H, Flatø B, Wahl AK (2012)
Quality of life in adults with juvenile-onset dermatomyositis: a case-control study
Arthritis Care Res (Hoboken), 64 (7), 1020-7
DOI 10.1002/acr.21637, PubMed 22328537

Publications 2011

Sanner H (2011)
Outcomes and prognostic factors in juvenile dermatomyositis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1064, 1 b. (flere pag.)
BIBSYS 111117275, ISBN 978-82-8072-549-3

Schwartz T, Sanner H, Husebye T, Flatø B, Sjaastad I (2011)
Cardiac dysfunction in juvenile dermatomyositis: a case-control study
Ann Rheum Dis, 70 (5), 766-71
DOI 10.1136/ard.2010.137968, PubMed 21216816

Publications 2010

Sanner H, Kirkhus E, Merckoll E, Tollisen A, Røisland M, Lie BA, Taraldsrud E, Gran JT, Flatø B (2010)
Long-term muscular outcome and predisposing and prognostic factors in juvenile dermatomyositis: A case-control study
Arthritis Care Res (Hoboken), 62 (8), 1103-11
DOI 10.1002/acr.20203, PubMed 20506141

Sanner H, Aaløkken TM, Gran JT, Sjaastad I, Johansen B, Flatø B (2010)
Pulmonary outcome in juvenile dermatomyositis: a case-control study
Ann Rheum Dis, 70 (1), 86-91
DOI 10.1136/ard.2010.131433, PubMed 20805295

Publications 2009

Sanner H, Gran JT, Sjaastad I, Flatø B (2009)
Cumulative organ damage and prognostic factors in juvenile dermatomyositis: a cross-sectional study median 16.8 years after symptom onset
Rheumatology (Oxford), 48 (12), 1541-7
DOI 10.1093/rheumatology/kep302, PubMed 19776224

Publications 1996

Borchgrevink-Lund CF, Sanner H (1996)
Kompendium i hygiene og mikrobiologi
In Kompendium, Medisinsk basislitteratur, Oslo, 6 (7. utg. [sic.]), 160 s.
BIBSYS 962046027, ISBN 82-91562-11-3