Karoline Lerang

  • Postdoc; MD, PhD
  • +47 930 16 698

Research interests

My research centers on epidemiology and translational medicine in Systemic Lupus Erythematosus (SLE). Specifically, I am intrigued by the environmental factors that trigger the onset of the disease, the outcomes observed in rigorously validated population-based studies, and the quest for biomarkers that can enhance both diagnosis and monitoring processes.

PROJECTS: NorSLE, Biomarker development for early–diagnosis of lupus nephritis using liquid biopsies, NorChildCTD

 

Publications 2024

Bolla E, Semb AG, Kerola AM, Ikdahl E, Petri M, Pons-Estel GJ, Karpouzas GA, Sfikakis PP, Quintana R, Misra DP, Borba EF, Garcia-de la Torre I, Popkova TV, Artim-Esen B, Troldborg A, Fragoso-Loyo H, Ajeganova S, Yazici A, Aroca-Martinez G, Direskeneli H, Ugarte-Gil MF, Mosca M, Goyal M, Svenungsson E, Macieira C et al. (2024)
Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries
Lancet Rheumatol, 6 (7), e447-e459
DOI 10.1016/S2665-9913(24)00090-0, PubMed 38878780

Haukeland H, Moe SR, Brunborg C, Botea A, Damjanic N, Wivestad GÅ, Øvreås HK, Bøe TB, Orre A, Garen T, Molberg Ø, Lerang K (2024)
Declining Incidence of Systemic Lupus Erythematosus in Norway 1999-2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification
Arthritis Rheumatol, 76 (5), 715-725
DOI 10.1002/art.42775, PubMed 38108106

Publications 2023

Hedenstedt A, Reid S, Sayadi A, Eloranta ML, Skoglund E, Bolin K, Frodlund M, Lerang K, Jönsen A, Rantapää-Dahlqvist S, Bengtsson AA, Rudin A, Molberg Ø, Sjöwall C, Sandling JK, Leonard D (2023)
B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Lupus Sci Med, 10 (2)
DOI 10.1136/lupus-2023-000926, PubMed 37844960

Moe SR, Haukeland H, Brunborg C, Botea A, Damjanic N, Wivestad GÅ, Øvreås H, Bøe T, Orre A, Garen T, Lilleby V, Provan SA, Molberg Ø, Lerang K (2023)
Persisting mortality gap in systemic lupus erythematosus; a population-based study on juvenile- and adult-onset SLE in Norway 1999-2022
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/kead519, PubMed 37769251

Publications 2022

Mariette X, Barone F, Baldini C, Bootsma H, Clark KL, De Vita S, Gardner DH, Henderson RB, Herdman M, Lerang K, Mistry P, Punwaney R, Seror R, Stone J, van Daele P, van Maurik A, Wisniacki N, Roth DA, Tak PP (2022)
A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome
JCI Insight, 7 (23)
DOI 10.1172/jci.insight.163030, PubMed 36477362

Publications 2021

Bolin K, Imgenberg-Kreuz J, Leonard D, Sandling JK, Alexsson A, Pucholt P, Haarhaus ML, Almlöf JC, Nititham J, Jönsen A, Sjöwall C, Bengtsson AA, Rantapää-Dahlqvist S, Svenungsson E, Gunnarsson I, Syvänen AC, Lerang K, Troldborg A, Voss A, Molberg Ø, Jacobsen S, Criswell L, Rönnblom L, Nordmark G (2021)
Variants in BANK1 are associated with lupus nephritis of European ancestry
Genes Immun, 22 (3), 194-202
DOI 10.1038/s41435-021-00142-8, PubMed 34127828

Reid S, Hagberg N, Sandling JK, Alexsson A, Pucholt P, Sjöwall C, Lerang K, Jönsen A, Gunnarsson I, Syvänen AC, Troldborg AM, Voss A, Bengtsson AA, Molberg Ø, Jacobsen S, Svenungsson E, Rönnblom L, Leonard D (2021)
Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
Ann Rheum Dis, 80 (9), 1183-1189
DOI 10.1136/annrheumdis-2020-219727, PubMed 33766895

Reppe Moe S, Haukeland H, Molberg Ø, Lerang K (2021)
Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts
J Clin Med, 10 (19)
DOI 10.3390/jcm10194306, PubMed 34640322

Publications 2020

Sandling JK, Pucholt P, Hultin Rosenberg L, Farias FHG, Kozyrev SV, Eloranta ML, Alexsson A, Bianchi M, Padyukov L, Bengtsson C, Jonsson R, Omdal R, Lie BA, Massarenti L, Steffensen R, Jakobsen MA, Lillevang ST, ImmunoArray Development Consortium and DISSECT consortium, Lerang K, Molberg Ø, Voss A, Troldborg A, Jacobsen S, Syvänen AC, Jönsen A et al. (2020)
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Ann Rheum Dis, 80 (1), 109-117
DOI 10.1136/annrheumdis-2020-218636, PubMed 33037003

Publications 2019

Garen T, Lerang K, Hoffmann-Vold AM, Andersson H, Midtvedt Ø, Brunborg C, Kilian K, Gudbrandsson B, Gunnarsson R, Norby G, Chaudhary A, Thoen J, Forseth KØ, Fresjar K, Førre Ø, Haugen M, Haga HJ, Gran JT, Gilboe IM, Molberg Ø, Palm Ø (2019)
Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides
Rheumatology (Oxford), 58 (2), 313-320
DOI 10.1093/rheumatology/key285, PubMed 30281089

Reppe Moe SE, Molberg Ø, Strøm EH, Lerang K (2019)
Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort
Lupus, 28 (7), 818-825
DOI 10.1177/0961203319847275, PubMed 31072277

Publications 2014

Lerang K, Gilboe IM, Steinar Thelle D, Gran JT (2014)
Mortality and years of potential life loss in systemic lupus erythematosus: a population-based cohort study
Lupus, 23 (14), 1546-52
DOI 10.1177/0961203314551083, PubMed 25209070

Publications 2012

Lerang K, Gilboe I, Garen T, Thelle DS, Gran JT (2012)
High incidence and prevalence of systemic lupus erythematosus in Norway
Lupus, 21 (12), 1362-9
DOI 10.1177/0961203312458168, PubMed 22914817

Publications 2011

Lerang K, Gilboe IM, Gran JT (2011)
Differences between rheumatologists and other internists regarding diagnosis and treatment of systemic lupus erythematosus
Rheumatology (Oxford), 51 (4), 663-9
DOI 10.1093/rheumatology/ker318, PubMed 22157467

Publications 2010

Norby GE, Lerang K, Holdaas H, Gran JT, Strøm EH, Draganov B, Os I, Hartmann A, Gilboe IM (2010)
[Lupus-nephritis--diagnosis and treatment]
Tidsskr Nor Laegeforen, 130 (11), 1140-4
DOI 10.4045/tidsskr.09.0583, PubMed 20531500

Publications 2004

Juliebø V, Lerang K, Skanke H, Mowé M, Wyller TB (2004)
[A new delirium severity scale]
Tidsskr Nor Laegeforen, 124 (17), 2276
PubMed 15356704

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