Prosjekter

TUMOR EVOLUTION

The LATE project is a collaboration with Naume/Campell/Yates a.o. where we are performing in-depth molecular characterization of breast cancer tumors at during the disease cours; at diagnosis (multi-regional sequencing), during early dissemination (single tumor cells in bonmarrow, DTCs) and metastasis (bulk sequencing of FFPE material). Read more...

 

SN - Sentinel Lymph Node in Breast Cancer- revealing the interaction between tumor subtypes and host immune response

This project focus on the interaction between the host immunesystem and a primary tumor (immune response in regional lymhnodes related to features of the primary tumor in the breast) and the immunresponse within lymphnodes with metastatic tumor cells within the node. Read more...

 

CARMA: Copy Aberration Regional Mapping Analysis

A main theme of the group is DNA analyses and in particular to decipher DNA copy-number alterations (CNAs). Read more...

 

 

LATE: Characterizing in time and space the metastatic process of hormone receptor positive breast cancer. This project is a collaboration with Naume/Campell/Yates a.o. where we are performing in-depth molecular characterization of breast cancer tumors at during the disease cours; at diagnosis (multi-regional sequencing), during early dissemination (single tumor cells in bonmarrow, DTCs) and metastasis (bulk sequencing of FFPE material). Main aim is to reveal clonal evolution and address tumorcell dormancy in particular in patient with late relapse of the disease (>5 years). We have done major improvements in cell identification end selection (compared performance of CellSearch/DepArray, micromanipulation and FACS). We have identified dormancy in DTCs measured by either tumor cell and/or plasma biomarkers in bone marrow, to be of particular interest in breast cancer patients (a separate collaboration with Naume/Aguirre-Ghiso, paper accepted, Nature Cancer). In collaboration with the Norwegian Cancer Registery we have also investigated risk factors for late relapse by using the National Mammography database (paper accepted, Breast Cancer Research).

 
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